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RTOG 0522 Protocol Information

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A Randomized Phase III Trial of Concurrent Accelerated Radiation and Cisplatin versus Concurrent Accelerated Radiation, Cisplatin, and Cetuximab (C225) [Followed by Surgery for Selected Patients] for Stage III and IV Head and Neck Carcinomas
Protocol Documents
Current Version Date: 1/14/2014
Principal Investigator: Kian Ang, MD
Primary Objective:

Evaluate whether the addition of cetuximab to a concurrent radiation-cisplatin regimen will improve progression-free survival in patients with locally advanced squamous cell carcinoma (SCC) of the oropharynx, hypopharynx, or larynx;

Patient Population:

Squamous cell carcinoma of the oropharynx, hypopharynx, or larynx; selected stage III-IV disease (T2N2-3M0, T3-4 any N M0)

Target Accrual: 945
Current Accrual: 940
Status: Closed to Accrual
Date: 3/3/2009
Participating Sites:
Abbott Northwestern Hospital Minneapolis MN
ACR Clinical Research Center Philadelphia PA
Adena Regional Medical Center Chillicothe OH
Adventist Medical Center Portland OR
Advocate Good Samaritan Hospital Downers Grove IL
Advocate Good Shepherd Hospital Barrington IL
Akron City Hospital Akron OH
Akron General Medical Center Akron OH
Albert Einstein Medical Center Philadelphia PA
Allan Blair Cancer Centre Regina, SK
Allegiance Health/W.A. Foote Memorial Hospital Jackson MI
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
Alta Bates Summit Medical Center - Summit Campus Oakland CA
Asante Health System Medford OR
Asante Three Rivers Medical Center Grants Pass OR
Atlanta VA Medical Center Decatur GA
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Auburn Radiation Oncology Center Auburn CA
Baptist Cancer Institute Jacksonville FL
Barnes Jewish West County Hospital St. Louis MO
Baton Rouge General Medical Center Baton Rouge LA
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute CCOP Oakland CA
Bay Medical Center Panama City FL
Beaumont CCOP Royal Oak MI
Blanchard Valley Regional Health Center Findlay OH
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Bozeman Deaconess Hospital Cancer Center Bozeman MT
British Columbia Cancer Agency-Vancouver Cancer Center Vancouver, BC
Bronson Methodist Hospital Kalamazoo MI
Brooke Army Medical Center Fort Sam Houston TX
Brooklyn MB-CCOP/SUNY Downstate Brooklyn NY
California Cancer Center CGOP Fresno CA
California Pacific Medical Center San Francisco CA
Cancer Care Manitoba Foundation Winnipeg, Manitoba
Cancer Research for the Ozarks CCOP Springfield MO
Cancer Treatment Center Wooster OH
Cape Radiation Oncology Cape Girardeau MO
Carle Cancer Center CCOP Urbana IL
Center for Cancer Care @ Goshen Health System Goshen IN
Centre Hospitalier de l`Université de Montréal-Notre Dame Montreal Quebec
Cheshire Medical Center Keene NH
Christiana Care Health Services, Inc. CCOP Newark DE
City of Hope Medical Center Duarte CA
Columbia River CCOP Portland OR
Columbia St. Mary's Hospital Ozaukee, Inc Mequon WI
Columbus Community Clinical Oncology Program Columbus OH
Community Cancer Center Normal IL
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Northwest Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Summerlin Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Sunset Las Vegas NV
Concord Hospital Payson Center for Cancer Care Concord NH
Cottonwood Hospital Murray UT
Cox Health System Springfield MO
Dakota Cancer Institute Fargo ND
Danville Regional Medical Center Danville VA
Dartmouth Hitchcock Medical Center Lebanon NH
David Grant USAF Medical Center Travis AFB CA
Dayton CCOP Kettering OH
Department of Veterans Affairs Dayton OH
Dickinson County Healthcare System Iron Mountain MI
Dixie Medical Cancer Center East St. George UT
Doctor's Hospital Columbus OH
Dubs Cancer Center @ Rogue Valley Medical Center Medford OR
East Bay Radiation Oncology Center Castro Valley CA
East Carolina Medical School Greenville NC
Elkhart General Hospital Elkhart IN
Elliot Hospital Manchester NH
Emory University Atlanta GA
Emory University Hospital Midtown Atlanta GA
Evergreen Radiation Oncology Kirkland WA
Fairview Ridges Hospital Burnsville MN
Fairview Southdale Hospital Edina MN
Forsyth Regional Medical Center Winston Salem NC
Fox Chase Cancer Center Philadelphia PA
Franciscan St. Francis Health-Beech Grove Beech Grove IN
Franciscan St. James Health-Olympia Fields Campus Olympia Fields IL
Freeman Health System Joplin MO
Geisinger Medical Center CCOP Danville PA
Geisinger Wyoming Valley Medical Center Wilkes Barre PA
Genesys Regional Medical Center Flint MI
Glens Falls Hospital Queenbury NY
Good Samaritan Health Systems Kearney NE
Good Samaritan Hospital Dayton OH
Grady Memorial Hospital Delaware OH
Grady Memorial Hospital Atlanta GA
Grand Rapids Clinical Oncology Program (GRCOP) Grand Rapids MI
Grandview Hospital & Medical Center Dayton OH
Grant Medical Center Columbus OH
Great Falls Clinic Great Falls MT
Greater Baltimore Medical Center Baltimore MD
Green Bay Oncology at St. Vincent Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Greenville Health System Cancer Institute-Andrews Greenville SC
Greenville Health System Cancer Institute-International Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gunderson Clinic La Crosse WI
H. Lee Moffitt Cancer Center & Research Institute Tampa FL
Harbin Clinic, LLC Rome GA
Hematology-Oncology Associates of CNY CCOP East Syracuse NY
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Holy Cross Hospital Inc. Fort Lauderdale FL
Holy Family Memorial Hospital Manitowoc WI
Hunter Holmes McGuire Veterans Hospital Richmond VA
Hurley Cancer Center Flint MI
ICON – Baptist Medical Center South Jacksonville FL
ICON – Cancer Center of Putnam Palatka FL
ICON – Flagler Cancer Center St Augustine FL
ICON – Florida Cancer Center - Beaches Jacksonville Beach FL
ICON – Orange Park Cancer Center Orange Park FL
ICON – Southside Cancer Center Jacksonville FL
Illinois Masonic Medical Center Chicago IL
Illinois Oncology Research Association CCOP Peoria IL
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University Medical Center Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Ingalls Memorial Hospital-Tinley Campus Tinley Park IL
Inova Alexandria Hospital Alexandria VA
Interim LSU Public Hospital (ILH-NO) New Orleans LA
Intermountain Medical Center Murray UT
Iredell Memorial Hospital Statesville NC
IU Health Central Indiana Cancer Centers Indianapolis IN
James Graham Brown Cancer Ctr at University of Louisville Louisville KY
JC Robinson, MD Regional Cancer Center San Pablo CA
Joe Arrington Cancer Research & Treatment Center Lubbock TX
John H. Stroger, Jr. Hospital of Cook County MBCCOP Chicago IL
John Muir Medical Center - Concord Campus Concord CA
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
La Porte Hospital La Porte IN
Lakeland Hospital St Joseph MI
Lakeland Regional Health System St. Joseph MI
LDS Hospital Salt Lake City UT
Legacy Emanuel Hospital & Health Center Portland OR
Legacy Good Samaritan Hospital & Medical Center Portland OR
Legacy Meridian Park Hospital Tualatin OR
Legacy Mount Hood Medical Center Gresham OR
Lehigh Valley Hospital Allentown PA
Liberty Hospital Liberty MO
Licking Memorial Hospital Newark OH
Logan Regional Hospital Logan UT
Long Island Jewish Hospital Lake Success NY
Loyola University Chicago Maywood IL
LSU Health Science Center-New Orleans MB-CCOP New Orleans LA
Lutheran General Hospital Park Ridge IL
Maimonides Medical Center Brooklyn NY
Maplewood Cancer Center Maplewood MN
Margaret R. Pardee Memorial Hospital Hendersonville NC
Marietta Memorial Hospital Marietta OH
Marin General Hospital Greenbrae CA
Marquette General Hospital Marquette MI
Marshall Radiation Oncology Center Cameron Park CA
Mary Bird Perkins Cancer Center Baton Rouge LA
Mass General/ North Shore Cancer Center Danvers MA
Mayo Clinic Rochester MN
Mayo Clinic in Arizona Scottsdale AZ
Mayo Clinic in Florida Jacksonville FL
McGill University Montreal
McKay-Dee Hospital Ogden UT
McLaren Cancer Institute - Flint Flint MI
McLaren Northern Michigan Petoskey MI
MD Anderson Cancer Center Orlando Orlando FL
Medical College of Wisconsin Milwaukee WI
Medical University of South Carolina Charleston SC
Memorial Cancer Institute Hollywood FL
Memorial Hospital South Bend IN
Memorial Hospital Colorado Springs CO
Memorial Medical Center Savannah GA
Memorial Mission-St. Joseph`s Asheville NC
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Coon Rapids MN
Mercy Hospital Port Huron Port Huron MI
Mercy Hospital St. Louis St Louis MO
Mercy Hospital-Joplin Joplin MO
Mercy Regional Cancer Center Redding CA
Mercy San Juan Radiation Oncology Center Carmichael CA
Mercy-Springfield Springfield MO
Methodist Cancer Center Omaha NE
Methodist Hospital Philadelphia PA
Methodist Medical Center of Illinois Peoria IL
Metro-MN CCOP St. Louis Park MN
Miami Valley Hospital Dayton OH
Michigan Cancer Research Consortium CCOP Ann Arbor MI
Mid-Maine Medical Center Waterville ME
Mills-Peninsula Health Services San Mateo CA
Mobile Infirmary Medical Center Mobile AL
Moffitt South Cancer Center Tampa FL
Montana Cancer Consortium CCOP Billings MT
Mount Carmel Medical Center-State Street Columbus OH
Mount Carmel-St. Ann's Cancer Center Westerville OH
Mount Sinai Comprehensive Cancer Center CCOP Miami Beach FL
Munson Medical Center Traverse City MI
Naval Medical Center-Portsmouth Portsmouth VA
Nevada Cancer Research Foundation CCOP Las Vegas NV
New Mexico Oncology Hematology Consultants, Ltd. Albuquerque NM
Norris Cotton Cancer Center Saint Johnsbury VT
North Colorado Medical Center Greeley CO
North Memorial Medical Center Robbinsdale MN
North Shore University Hospital CCOP Manhasset NY
Northeast Georgia Medical Center Gainesville GA
Northeast Radiation Oncology Center Dunmore PA
Northeastern Ontario Regional Cancer Centre Sudbury, Ontario
Northern Indiana Cancer Research Consortium CCOP South Bend IN
Northern Rockies Radiation Oncology Center Billings MT
Northwestern Ontario Regional Cancer Centre Thunder Bay, Ontario
Nova Scotia Cancer Centre Halifax, Nova Scotia
Oakwood Healthcare Inc Dearborn MI
Ocean Medical Center Brick NJ
Oregon Health & Science University Portland OR
OSF Saint Francis Medical Center Radiation Oncology Peoria IL
Parkview Cancer Center - Parkview Hospital Fort Wayne IN
PeaceHealth Southwest Medical Center Vancouver WA
Pekin Cancer Treatment Center Pekin IL
Penrose Cancer Center, Penrose-St. Francis Health Services Colorado Springs CO
Phelps County Regional Medical Center Rolla MO
Piedmont Hospital Atlanta GA
Pocono Cancer Center East Strousburg PA
Pomona Valley Hospital Medical Center Pomona CA
Poudre Valley Hospital Radiation Oncology Fort Collins CO
Presbyterian Hospital Charlotte NC
Princess Margaret Hospital Toronto, Ontario
Princeton Radiation Oncology Center Jamesburg NJ
Providence Cancer Center Medford OR
Providence Hospital Southfield MI
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence St. Vincent Medical Center Portland OR
Radiation Oncology Associates Fort Wayne IN
Radiation Oncology Center of Walnut Creek - John Muir Med Ct Concord CA
Radiation Oncology Centers of Las Vegas Las Vegas NV
Radiological Associates of Sacramento Sacramento CA
Radiological Physics Center (RPC) Houston TX
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Reid Hospital & Health Care Services Richmond IN
Research Medical Center Kansas City MO
Rex Cancer Center Raleigh NC
Rhode Island Hospital Providence RI
Richard L. Roudebush VA Medical Center Indianapolis IN
Riddle Memorial Hospital Media PA
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Riverview Medical Center/Riverview Regional Cancer Center Red Bank NJ
Robinson Radiation Oncology Ravenna OH
Roseville Radiation Oncology Center Roseville CA
Roswell Park Cancer Institute Buffalo NY
Rush University Medical Center Chicago IL
Saint Alphonsus Regional Medical Center Boise ID
Saint Francis Medical Center Peoria IL
Saint Joseph Regional Medical Center South Bend In
Saint Joseph Regional Medical Center - Mishawaka Mishawaka IN
Saint Mary's Health Care/Hospital Grand Rapids MI
Sandra L. Maxwell Cancer Center Cedar City UT
Santa Rosa Memorial Hospital CCOP Santa Rosa CA
Sentara Norfolk General Hospital Norfolk VA
Shaw Regional Cancer Center Edwards CO
Siteman Cancer Center/Barnes Jewish St. Peters Hospital St. Peters MO
Solano Radiation Oncology Center Vacaville CA
South Jersey Hospital Systems Vineland NJ
Southeast Missouri Hospital Cape Girardeau MO
Sparrow Regional Cancer Center Lansing MI
Sparta Cancer Center Sparta NJ
Springfield Regional Medical Center Springfield OH
St Francis Hospital & Medical Center Hartford CT
St Johns Hospital, Cancer Institute Springfield IL
St Mary's Hospital & Medical Center Grand Junction CO
St. Agnes Healthcare Baltimore MD
St. Anthony's Health Alton IL
St. Francis Hospital Federal Way WA
St. Johns Hospital & Medical Center Grosse Pointe Woods MI
St. Joseph Mercy Hospital Ann Arbor MI
St. Joseph Mercy Oakland Pontac MI
St. Louis University Hospital St. Louis MO
St. Lukes Hospital Association of Duluth Duluth MN
St. Luke's Mountain States Tumor Institute Boise ID
St. Mary Mercy Hospital Livonia MI
St. Mary`s Medical Center Saginaw MI
St. Mary's Hospital Medical Center Green Bay WI
St. Peter's Medical Center New Brunswick NJ
St. Rita's Medical Center Lima OH
St. Vincent Anderson Regional Hospital, Inc. Anderson IN
St. Vincent Hospital and Health Care Centers, Inc. Indianapolis IN
St. Vincent Regional Cancer Center CCOP Green Bay WI
Stanford University Medical Center Palo Alto CA
Summa Health System Barberton Hospital Barberton OH
SUNY Upstate Medical University Syracuse NY
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Solano Medical Center Vallejo CA
The Medical Center, Inc., John B. Amos Cancer Center Columbus GA
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Regional Cancer Center at Singing River Hospital System Pascagoula MS
The Reverend Roger Patrick Dorcy Cancer Center Pueblo CO
The Schiffler Cancer Center Wheeling WV
The Wendt Regional Cancer Center of the Finley Hospital Dubuque IA
Thedacare Cancer Institute Appleton WI
Thomas Jefferson University Hospital Philadelphia PA
Tom Baker Cancer Centre Calgary, Alberta
Torrance Memorial Medical Center Torrance CA
Tulane University Medical Center New Orleans LA
UCSD – University of California, San Diego LaJolla CA
UMDNJ-New Jersey Medical School Newark NJ
United Hospital St. Paul MN
Unity Hospital Fridley MN
Univ of Kansas Comprehensive Cancer Center Kansas City KS
University Medical Center of Princeton at Plainsboro Princeton NJ
University of Alabama at Birmingham Medical Center Birmingham AL
University of Arkansas Medical Center Little Rock AR
University of California Davis Medical Center Sacramento CA
University of California San Francisco San Francisco CA
University of Cincinnati Cincinnati OH
University of Colorado Denver Aurora CO
University of Illinois at Chicago Chicago IL
University of Iowa Hospitals and Clinics Iowa City IA
University of Kansas Cancer Center - Southwest Overland Park KS
University of Kansas Cancer Center-South Kansas City MO
University of Kentucky Hospital Lexington KY
University of Miami Miller School of Medicine Miami FL
University of Michigan Medical Center Ann Arbor MI
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Southern California Los Angeles CA
University of Texas at San Antonio San Antonio TX
University of Texas Medical Branch Galveston TX
University of Texas Medical Branch San Antonio TX
University of Texas Southwestern Medical School Dallas TX
University of Texas-MD Anderson Cancer Center Houston TX
University of Utah Health Science Center Salt Lake City UT
University of Wisconsin Hospital Madison WI
University Pointe-Precision Radiotherapy West Chester OH
Upper Delaware Valley Cancer Center Milford PA
Upper Valley Medical Center Troy OH
USON- New York Oncology Hematology, P.C. Albany NY
USON- Rocky Mountain Cancer Center-Aurora Aurora CO
USON- Texas Oncology-Sugar Land Sugarland TX
USON-Arizona Radiation Oncology Tucson AZ
USON-Fort Worth Fort Worth TX
USON-Raleigh Hematology Oncology Associates Raleigh NC
USON-Texas Cancer Center - Dallas Southwest Dallas TX
USON-Texas Oncology- Medical City Dallas Dallas TX
USON-Texas Oncology- Sherman Sherman TX
USON-Williamette Valley Cancer Center Eugene OR
Utah Cancer Specialists Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Virginia Commonwealth University Richmond VA
Virginia Mason CCOP Seattle WA
Wake Forest University Baptist Medical Center Winston-Salem NC
Washington Cancer Institute Washington DC
Washington University St. Louis MO
Wausau Hospital Center Wausau WI
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wayne State University-Karmanos Cancer Institute Detroit MI
Webber Cancer Center Warren MI
Welch Cancer Center Sheridan WY
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wilford Hall USAF Medical Center Lackland AFB TX
Wilmed Radiation Oncology Services Wilson NC
York Cancer Center York PA
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 2/11/2014

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