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RTOG 0522 Protocol Information

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A Randomized Phase III Trial of Concurrent Accelerated Radiation and Cisplatin versus Concurrent Accelerated Radiation, Cisplatin, and Cetuximab (C225) [Followed by Surgery for Selected Patients] for Stage III and IV Head and Neck Carcinomas
Protocol Documents
Current Version Date: 1/14/2014
Principal Investigator: Kian Ang, MD
Primary Objective:

Evaluate whether the addition of cetuximab to a concurrent radiation-cisplatin regimen will improve progression-free survival in patients with locally advanced squamous cell carcinoma (SCC) of the oropharynx, hypopharynx, or larynx;

Patient Population:

Squamous cell carcinoma of the oropharynx, hypopharynx, or larynx; selected stage III-IV disease (T2N2-3M0, T3-4 any N M0)

Target Accrual: 945
Current Accrual: 940
Status: Closed to Accrual
Date: 3/3/2009
Participating Sites:
Akron City Hospital Akron OH
Allan Blair Cancer Centre Regina, SK
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
Barnes Jewish West County Hospital St. Louis MO
Bay Area Medical Center Marinette WI
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
California Pacific Medical Center San Francisco CA
Cancer Care Manitoba Foundation Winnipeg, Manitoba
Cancer Research for the Ozarks CCOP Springfield MO
Cancer Treatment Center Wooster OH
Carle Cancer Center CCOP Urbana IL
Centre Hospitalier de l`Université de Montréal-Notre Dame Montreal Quebec
City of Hope Medical Center Duarte CA
Community Cancer Center Normal IL
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Northwest Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Summerlin Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Sunset Las Vegas NV
Cox Health System Springfield MO
Dixie Medical Cancer Center East St. George UT
East Carolina Medical School Greenville NC
Elkhart General Hospital Elkhart IN
Elliot Hospital Manchester NH
Florida Radiation Oncology Group - Baptist Regional Jacksonville FL
Fox Chase Cancer Center Philadelphia PA
Freeman Health System Joplin MO
Geisinger Medical Center CCOP Danville PA
Geisinger Wyoming Valley Medical Center Wilkes Barre PA
Genesys Regional Medical Center Flint MI
Greenville CCOP - Cancer Centers of the Carolinas-Eastside Greenville SC
H. Lee Moffitt Cancer Center & Research Institute Tampa FL
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Holy Cross Hospital Inc. Fort Lauderdale FL
Hurley Cancer Center Flint MI
ICON – Baptist Medical Center South Jacksonville FL
ICON – Cancer Center of Putnam Palatka FL
ICON – Flagler Cancer Center St Augustine FL
ICON – Florida Cancer Center - Beaches Jacksonville Beach FL
ICON – Orange Park Cancer Center Orange Park FL
ICON – Southside Cancer Center Jacksonville FL
Illinois Oncology Research Association CCOP Peoria IL
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University Health Methodist Hospital Indianapolis IN
Intermountain Medical Center Murray UT
Joe Arrington Cancer Research & Treatment Center Lubbock TX
John H. Stroger, Jr. Hospital of Cook County MBCCOP Chicago IL
John Muir Medical Center - Concord Campus Concord CA
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
La Porte Hospital La Porte IN
Lakeland Regional Health System St. Joseph MI
LDS Hospital Salt Lake City UT
Logan Regional Hospital Logan UT
Lutheran General Hospital Park Ridge IL
Mass General/ North Shore Cancer Center Danvers MA
Mayo Clinic Rochester MN
Mayo Clinic in Arizona Scottsdale AZ
McGill University Montreal
McKay-Dee Hospital Ogden UT
MD Anderson Cancer Center Orlando Orlando FL
Medical University of South Carolina Charleston SC
Memorial Hospital South Bend IN
Memorial Medical Center Savannah GA
Memorial Mission-St. Joseph`s Asheville NC
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy Hospital Port Huron Port Huron MI
Mercy Hospital St. Louis St Louis MO
Mercy Hospital-Joplin Joplin MO
Mercy-Springfield Springfield MO
Michigan Cancer Research Consortium CCOP Ann Arbor MI
Mills-Peninsula Health Services San Mateo CA
Mount Sinai Comprehensive Cancer Center CCOP Miami Beach FL
Naval Medical Center-Portsmouth Portsmouth VA
Nevada Cancer Research Foundation CCOP Las Vegas NV
Northeast Radiation Oncology Center Dunmore PA
Northeastern Ontario Regional Cancer Centre Sudbury, Ontario
Northern Indiana Cancer Research Consortium CCOP South Bend IN
Nova Scotia Cancer Centre Halifax, Nova Scotia
Oakwood Healthcare Inc Dearborn MI
Ocean Medical Center Brick NJ
OSF Saint Francis Medical Center Radiation Oncology Peoria IL
Pekin Cancer Treatment Center Pekin IL
Phelps County Regional Medical Center Rolla MO
Piedmont Hospital Atlanta GA
Pocono Cancer Center East Strousburg PA
Presbyterian Hospital Charlotte NC
Princess Margaret Hospital Toronto, Ontario
Radiation Oncology Center of Walnut Creek - John Muir Med Ct Concord CA
Radiation Oncology Centers of Las Vegas Las Vegas NV
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Riddle Memorial Hospital Media PA
Riverview Medical Center/Riverview Regional Cancer Center Red Bank NJ
Saint Alphonsus Regional Medical Center Boise ID
Saint Francis Medical Center Peoria IL
Saint Joseph Regional Medical Center - Mishawaka Mishawaka IN
Sentara Norfolk General Hospital Norfolk VA
Shaw Regional Cancer Center Edwards CO
Siteman Cancer Center/Barnes Jewish St. Peters Hospital St. Peters MO
Sparrow Regional Cancer Center Lansing MI
Sparta Cancer Center Sparta NJ
St Francis Hospital & Medical Center Hartford CT
St Johns Hospital, Cancer Institute Springfield IL
St. Agnes Healthcare Baltimore MD
St. Johns Hospital & Medical Center Grosse Pointe Woods MI
St. Joseph Mercy Hospital Ann Arbor MI
St. Joseph Mercy Oakland Pontac MI
St. Lukes Hospital Association of Duluth Duluth MN
St. Mary Mercy Hospital Livonia MI
St. Mary`s Medical Center Saginaw MI
St. Mary's Hospital Medical Center Green Bay WI
St. Vincent Regional Cancer Center CCOP Green Bay WI
Summa Health System Barberton Hospital Barberton OH
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Solano Medical Center Vallejo CA
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Regional Cancer Center at Singing River Hospital System Pascagoula MS
Thedacare Cancer Institute Appleton WI
Thomas Jefferson University Hospital Philadelphia PA
UCSD – University of California, San Diego LaJolla CA
UMDNJ-New Jersey Medical School Newark NJ
Univ of Kansas Comprehensive Cancer Center Kansas City KS
University of California Davis Medical Center Sacramento CA
University of California San Francisco San Francisco CA
University of Colorado Denver Aurora CO
University of Miami Miller School of Medicine Miami FL
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Texas Southwestern Medical School Dallas TX
University of Texas-MD Anderson Cancer Center Houston TX
University of Utah Health Science Center Salt Lake City UT
Upper Delaware Valley Cancer Center Milford PA
Utah Cancer Specialists Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virginia Commonwealth University Richmond VA
Virginia Mason CCOP Seattle WA
Washington University St. Louis MO
Wausau Hospital Center Wausau WI
Webber Cancer Center Warren MI
York Cancer Center York PA
Updated: 2/11/2014

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