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RTOG 0539 Protocol Information

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Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas
Principal Investigator: C. Leland Rogers, MD
Primary Objective:

To estimate the rates of progression-free survival (PFS) at 3 years in each of the patient risk groups.

Patient Population:

Histopathologically confirmed meningioma, confirmed by central pathology review prior to STEP 2 registration. Risk categories are defined as follows:

  • Low (Group I): Patients with a newly diagnosed gross totally resected (Simpson’s grade I, II, or III resections with no residual nodular enhancement on postoperative imaging) or subtotally resected (residual nodular enhancement or Simpson grade IV or V excision) World Health Organization (WHO) grade I meningioma. The extent of resection will be based upon the neurosurgeon’s assessment and postoperative MR imaging.
  • Intermediate (Group II): Patients with a newly diagnosed gross totally resected WHO grade II meningioma or a recurrent WHO grade I meningioma irrespective of the resection extent. Resection extent will be assessed according to Simpson’s grade on the same basis described above for the low-risk group.
  • High (Group III): Patients with high-risk features including a newly diagnosed or recurrent WHO grade III meningioma of any resection extent; a recurrent WHO grade II meningioma of any resection extent; or a newly diagnosed subtotally resected WHO grade II meningioma. Resection extent will be recorded on the same basis described above for the low-risk group.
Target Accrual: 165
Current Accrual: 244
Status: Closed to Accrual
Date: 6/19/2009
Participating Sites:
Arizona Oncology - Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Barnes Jewish West County Hospital St. Louis MO
Cape Radiation Oncology Cape Girardeau MO
Central Maryland Oncology at Howard County Hospital Columbia MD
Centre Hospitalier de l`Université de Montréal-Notre Dame Montreal Quebec
Cheshire Medical Center Keene NH
Cleveland Clinic Foundation Cleveland OH
Community Memorial Hospital Menomonee Falls WI
Dartmouth Hitchcock Medical Center Lebanon NH
Dixie Medical Cancer Center East St. George UT
Emory University Atlanta GA
Emory University Hospital Midtown Atlanta GA
Heartland Regional Medical Center St. Joseph MO
Henry Ford Hospital Detroit MI
Intermountain Medical Center Murray UT
Kansas City CCOP Prairie Village KS
Lake/University Seidman Cancer Center Mentor OH
LDS Hospital Salt Lake City UT
Liberty Radiation Oncology Clinic Liberty MO
Logan Regional Hospital Logan UT
Long Island Jewish Hospital Lake Success NY
Maine Medical Center Scarborough ME
Mayo Clinic Rochester MN
Mayo Clinic Arizona Phoenix AZ
Mayo Clinic in Arizona Scottsdale AZ
McKay-Dee Hospital Ogden UT
Medical College of Wisconsin Milwaukee WI
Medical University of South Carolina Charleston SC
Memorial Medical Center Savannah GA
Menorah Medical Center Overland Park KS
Norris Cotton Cancer Center Saint Johnsbury VT
North Kansas City Hospital North Kansas City MO
Northwestern Memorial Hospital Chicago IL
Oconomowoc Memorial Hospital - ProHealth Care Inc. Oconomowoc WI
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
Research Medical Center Kansas City MO
Siteman Cancer Center/Barnes Jewish St. Peters Hospital St. Peters MO
Southside Hospital Bayshore NY
St Luke's Hospital Kansas City MO
Tate Cancer Center - North Arundel Hospital Glen Burnie MD
Tel-Aviv Sourasky Medical Center Tel-Aviv
Thomas Jefferson University Hospital Philadelphia PA
Univ of Kansas Comprehensive Cancer Center Kansas City KS
University Hospitals of Cleveland Cleveland OH
University of California San Francisco San Francisco CA
University of Colorado Denver Aurora CO
University of Kansas Cancer Center - Southwest Overland Park KS
University of Kansas Cancer Center-East Lee's Summit MO
University of Kansas Cancer Center-North Kansas City MO
University of Kansas Cancer Center-South Kansas City MO
University of Maryland Medical Systems Baltimore MD
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Texas-MD Anderson Cancer Center Houston TX
University of Utah Health Science Center Salt Lake City UT
University of Washington Medical Center Seattle WA
University of Wisconsin Hospital Madison WI
Utah Cancer Specialists Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virginia Commonwealth University Richmond VA
Washington University St. Louis MO
Waukesha Memorial Hospital Waukesha WI
Updated: 9/24/2012

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