Minimize
 

RTOG 0539 Protocol Information

Minimize
Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas
Principal Investigator: C. Leland Rogers, MD
Primary Objective:

To estimate the rates of progression-free survival (PFS) at 3 years in each of the patient risk groups.

Patient Population:

Histopathologically confirmed meningioma, confirmed by central pathology review prior to STEP 2 registration. Risk categories are defined as follows:

  • Low (Group I): Patients with a newly diagnosed gross totally resected (Simpson’s grade I, II, or III resections with no residual nodular enhancement on postoperative imaging) or subtotally resected (residual nodular enhancement or Simpson grade IV or V excision) World Health Organization (WHO) grade I meningioma. The extent of resection will be based upon the neurosurgeon’s assessment and postoperative MR imaging.
  • Intermediate (Group II): Patients with a newly diagnosed gross totally resected WHO grade II meningioma or a recurrent WHO grade I meningioma irrespective of the resection extent. Resection extent will be assessed according to Simpson’s grade on the same basis described above for the low-risk group.
  • High (Group III): Patients with high-risk features including a newly diagnosed or recurrent WHO grade III meningioma of any resection extent; a recurrent WHO grade II meningioma of any resection extent; or a newly diagnosed subtotally resected WHO grade II meningioma. Resection extent will be recorded on the same basis described above for the low-risk group.
Target Accrual: 165
Current Accrual: 244
Status: Closed to Accrual
Date: 6/19/2009
Participating Sites:
Abbott Northwestern Hospital Minneapolis MN
ACR Clinical Research Center Philadelphia PA
Adena Regional Medical Center Chillicothe OH
Akron City Hospital Akron OH
Allegiance Health/W.A. Foote Memorial Hospital Jackson MI
Anderson Memorial Hospital Anderson SC
Arizona Oncology - Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Baptist Hospital of Miami Miami FL
Barnes Jewish West County Hospital St. Louis MO
Bay Area Medical Center Marinette WI
Baystate Health-D'Amour Springfield MA
Benefis Healthcare-Sletten Cancer Institute Great Falls MT
Beth Israel Deaconess Medical Center Boston MA
Billings Clinic Cancer Center Billings MT
Boca Raton Community Hospital-Lynn Regional Cancer Center Boca Raton FL
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Bozeman Deaconess Hospital Cancer Center Bozeman MT
Bronson Methodist Hospital Kalamazoo MI
Cape Radiation Oncology Cape Girardeau MO
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Central Maryland Oncology at Howard County Hospital Columbia MD
Centre Hospitalier de l`Université de Montréal-Notre Dame Montreal Quebec
Cheshire Medical Center Keene NH
City of Hope Medical Center Duarte CA
Cleveland Clinic Foundation Cleveland OH
Columbus Community Clinical Oncology Program Columbus OH
Community Memorial Hospital Menomonee Falls WI
Cross Cancer Institute Edmonton, Alberta
Dan Rudy Cancer Center St. Thomas Cancer Center Nashville TN
Dartmouth Hitchcock Medical Center Lebanon NH
Dixie Medical Cancer Center East St. George UT
Doctor's Hospital Columbus OH
Door County Cancer Center Sturgeon Bay WI
Emory University Atlanta GA
Emory University Hospital Midtown Atlanta GA
Fairview Ridges Hospital Burnsville MN
Fairview Southdale Hospital Edina MN
Genesis Healthcare System Zainesville OH
Genesys Regional Medical Center Flint MI
Grady Memorial Hospital Delaware OH
Grady Memorial Hospital Atlanta GA
Grant Medical Center Columbus OH
Great Falls Clinic Great Falls MT
Gunderson Clinic La Crosse WI
H. Lee Moffitt Cancer Center & Research Institute Tampa FL
Heartland Regional Medical Center St. Joseph MO
Hennepin County Medical Center Minneapolis MN
Henry Ford Hospital Detroit MI
Henry Ford Macomb Hospital Clinton Township MI
Highland Hospital Rochester NY
Hurley Cancer Center Flint MI
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University Medical Center Indianapolis IN
Intermountain Medical Center Murray UT
James Graham Brown Cancer Ctr at University of Louisville Louisville KY
John Muir Medical Center - Concord Campus Concord CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Lake/University Seidman Cancer Center Mentor OH
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
Liberty Radiation Oncology Clinic Liberty MO
Licking Memorial Hospital Newark OH
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Long Island Jewish Hospital Lake Success NY
Maine Medical Center Scarborough ME
Maplewood Cancer Center Maplewood MN
Marietta Memorial Hospital Marietta OH
Mary Bird Perkins Cancer Center Baton Rouge LA
Massachusetts General Hospital Boston MA
Mayo Clinic Rochester MN
Mayo Clinic Arizona Phoenix AZ
Mayo Clinic in Arizona Scottsdale AZ
Mayo Clinic in Florida Jacksonville FL
McGill University Montreal
McKay-Dee Hospital Ogden UT
McMaster Univ, Juravinski Can Ctr, Hamilton Health Sciences Hamilton, Ontario
Medical College of Wisconsin Milwaukee WI
Medical University of South Carolina Charleston SC
Memorial Medical Center Savannah GA
Menorah Medical Center Overland Park KS
Mercy Hospital Coon Rapids MN
Mercy Hospital Port Huron Port Huron MI
Mercy Hospital St. Louis St Louis MO
Methodist Cancer Center Omaha NE
Methodist Hospital Philadelphia PA
Metro-MN CCOP St. Louis Park MN
Michigan Cancer Research Consortium CCOP Ann Arbor MI
Moffitt South Cancer Center Tampa FL
Montana Cancer Consortium CCOP Billings MT
Montefiore Medical Center - Moses Campus Bronx NY
Mount Carmel Medical Center-State Street Columbus OH
Mount Carmel-St. Ann's Cancer Center Westerville OH
New York Methodist Hospital Brooklyn NY
Norris Cotton Cancer Center Saint Johnsbury VT
North Kansas City Hospital North Kansas City MO
North Memorial Medical Center Robbinsdale MN
North Shore University Hospital CCOP Manhasset NY
Northern Rockies Radiation Oncology Center Billings MT
Northwestern Memorial Hospital Chicago IL
Northwestern University Chicago IL
Norton Cancer Institute Louisville KY
Oakwood Healthcare Inc Dearborn MI
Oconomowoc Memorial Hospital - ProHealth Care Inc. Oconomowoc WI
Ohio State University Medical Center Columbus OH
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
Radiation Oncology Center of Walnut Creek - John Muir Med Ct Concord CA
Radiological Physics Center (RPC) Houston TX
Regions Radiation Therapy St. Paul MN
Research Medical Center Kansas City MO
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Rocky Mountain Oncology Center Casper WY
Rutherford Hospital Inc. Rutherfordton NC
Saint Alphonsus Regional Medical Center Boise ID
Sandra L. Maxwell Cancer Center Cedar City UT
Siteman Cancer Center/Barnes Jewish St. Peters Hospital St. Peters MO
Southside Hospital Bayshore NY
Southwest Virginia Regional Cancer Center Norton VA
Sparrow Regional Cancer Center Lansing MI
Spartanburg Regional Medical Center Spartanburg SC
Springfield Regional Medical Center Springfield OH
St Francis Hospital & Medical Center Hartford CT
St Luke's Hospital Kansas City MO
St. Anthony's Health Alton IL
St. Francis Hospital Federal Way WA
St. Johns Hospital & Medical Center Grosse Pointe Woods MI
St. Joseph Mercy Hospital Ann Arbor MI
St. Joseph Mercy Oakland Pontac MI
St. Lukes Hospital Bethlehem PA
St. Mary Mercy Hospital Livonia MI
St. Mary`s Medical Center Saginaw MI
St. Mary's Hospital Medical Center Green Bay WI
St. Vincent Regional Cancer Center CCOP Green Bay WI
Summa Health System Barberton Hospital Barberton OH
Tate Cancer Center - North Arundel Hospital Glen Burnie MD
Tel-Aviv Sourasky Medical Center Tel-Aviv
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Rector and Visitors of the University of Virginia Charlottesville VA
The Schiffler Cancer Center Wheeling WV
The University of Arizona Medical Center - University Campus Tucson AZ
Thomas Jefferson University Hospital Philadelphia PA
United Hospital St. Paul MN
Unity Hospital Fridley MN
Univ of Kansas Comprehensive Cancer Center Kansas City KS
University Hospitals of Cleveland Cleveland OH
University of California San Francisco San Francisco CA
University of California, Irvine Orange CA
University of Colorado Denver Aurora CO
University of Florida College of Medicine Gainesville FL
University of Kansas Cancer Center - Southwest Overland Park KS
University of Kansas Cancer Center-East Lee's Summit MO
University of Kansas Cancer Center-North Kansas City MO
University of Kansas Cancer Center-South Kansas City MO
University of Maryland Medical Systems Baltimore MD
University of Michigan Medical Center Ann Arbor MI
University of Nebraska Medical Center Omaha NE
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Texas at San Antonio San Antonio TX
University of Texas Medical Branch San Antonio TX
University of Texas Medical Branch Galveston TX
University of Texas-MD Anderson Cancer Center Houston TX
University of Utah Health Science Center Salt Lake City UT
University of Washington Medical Center Seattle WA
University of Wisconsin Cancer Center Johnson Creek Johnson Creek WI
University of Wisconsin Hospital Madison WI
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centre at Clarion Hospital Clarion PA
UPMC Cancer Centre at UPMC Northwest Seneca PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC- Passavant Hospital Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-HVHS Cancer Center (Moon) Coraopolis PA
UPMC-Jameson Memorial Hospital New Castle PA
UPMC-Magee Women's Hospital Pittsburgh PA
UPMC-McKeesport Hospital McKeesport PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-St. Margaret Pittsburgh PA
UPMC-The Washington Hospital Washington PA
UPMC-Uniontown / Robert E. Eberly Pavilion Uniontown PA
Upstate Carolina CCOP - Gibbs Regional Cancer Center Spartanburg SC
Utah Cancer Specialists Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virginia Commonwealth University Richmond VA
Virginia Mason CCOP Seattle WA
Washington University St. Louis MO
Waukesha Memorial Hospital Waukesha WI
Webber Cancer Center Warren MI
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Medical Center Kingsport TN
Yale University New Haven CT
Updated: 9/24/2012

You must be logged in to view this file.

Login  |  Close

You must be logged in to view this file.

Login  |  Close