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RTOG 0724 Protocol Information

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Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Adjuvant Chemotherapy in High-Risk Patients with Early-Stage Cervical Carcinoma Following Radical Hysterectomy
Principal Investigator: Anuja Jhingran, MD
Primary Objective:

To determine if adjuvant systemic chemotherapy following chemoradiation therapy will improve disease-free survival compared to chemoradiation therapy alone in patients with high-risk earlystage cervical carcinoma found to have positive nodes and/or positive parametria after a radical hysterectomy.

Patient Population:

To determine if adjuvant systemic chemotherapy following chemoradiation therapy will improve disease-free survival compared to chemoradiation therapy alone in patients with high-risk earlystage cervical carcinoma found to have positive nodes and/or positive parametria after a radical hysterectomy.

Patient Population:

Patients with clinical stage IA2, IB or IIA squamous, adenosquamous, or adenocarcinoma of the cervix who have any/all of the following high-risk features after surgery (this corresponds to surgical TNM staging of T1-T2, N1, M0): 

Positive pelvic nodes

Positive parametrium

Positive para-aortic nodes- completely resected, PET/CT negative (PET only required if positive para-aortic nodes during surgery)

Dual Enrollment to RTOG 0724 and RTOG 1203

Patients are permitted to be enrolled onto both RTOG 0724 and RTOG 1203, however careful consideration must be made to the following:

  • In order to avoid protocol deviations, patients MUST be registered to 1203 first. The treatment arm that the patient is assigned to on 1203 will be the same treatment option used for stratification in 0724.
  • Patients MUST meet eligibility criteria for both studies.
  • The radiation guidelines (Section 6) in 1203 should be followed for BOTH studies.

Target Accrual: 400
Current Accrual: 85
Status: Temporarily Closed to Accrual
Date: 2/28/2014
Participating Sites:
Abbott Northwestern Hospital Minneapolis MN
Adena Regional Medical Center Chillicothe OH
Akron General Medical Center Akron OH
Arizona Center for Cancer Care Peoria AZ
Auburn Radiation Oncology Center Auburn CA
Aultman Hospital Canton OH
Bay Area Medical Center Marinette WI
Bixby Medical Center Adrian MI
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
Cancer Research for the Ozarks CCOP Springfield MO
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Christiana Care Health Services, Inc. CCOP Newark DE
Columbus Community Clinical Oncology Program Columbus OH
Cooper Health System Camden NJ
Cooper Health System-Voorhees Voorhees NJ
Cox Health System Springfield MO
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Cancer Center East St. George UT
Doctor's Hospital Columbus OH
Door County Cancer Center Sturgeon Bay WI
Elkhart General Hospital Elkhart IN
Elliot Hospital Manchester NH
Fairview Ridges Hospital Burnsville MN
Fairview Southdale Hospital Edina MN
Florida Hospital Orlando FL
Flower Hospital Sylvania OH
Fox Chase Virtua Health Cancer Treatment Center Voorhees NJ
Freeman Health System Joplin MO
Geisinger Medical Center CCOP Danville PA
Geisinger Wyoming Valley Medical Center Wilkes Barre PA
Genesis Healthcare System Zainesville OH
Genesys Regional Medical Center Flint MI
Grady Memorial Hospital Delaware OH
Grant Medical Center Columbus OH
Greater Baltimore Medical Center Baltimore MD
Hartford Hospital Hartford CT
Hennepin County Medical Center Minneapolis MN
Hurley Cancer Center Flint MI
Intermountain Medical Center Murray UT
Jackson Memorial Hospital Miami FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
La Porte Hospital La Porte IN
Lake/University Seidman Cancer Center Mentor OH
Lakeland Regional Health System St. Joseph MI
LDS Hospital Salt Lake City UT
Lewis Cancer & Research Pavilion at St. Joseph's/Candler Savannah GA
Licking Memorial Hospital Newark OH
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
Maplewood Cancer Center Maplewood MN
Marietta Memorial Hospital Marietta OH
Marshall Radiation Oncology Center Cameron Park CA
McGill University Montreal
McKay-Dee Hospital Ogden UT
Medical College of Wisconsin Milwaukee WI
Medical University of Ohio Toledo OH
Memorial Hospital South Bend IN
Memorial Medical Center Savannah GA
Memorial Sloan-Kettering Cancer Center New York NY
Mercy Cancer Center at St. Ann Toledo OH
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Coon Rapids MN
Mercy Hospital Port Huron Port Huron MI
Mercy Hospital St. Louis St Louis MO
Mercy Hospital-Joplin Joplin MO
Mercy San Juan Radiation Oncology Center Carmichael CA
Mercy-Springfield Springfield MO
Methodist Cancer Center Omaha NE
Methodist Medical Center of Illinois Peoria IL
Metro-MN CCOP St. Louis Park MN
Michiana Hematology-Oncology, P.C. Mishawaka IN
Michigan Cancer Research Consortium CCOP Ann Arbor MI
Mid Ohio Oncology Hematology Inc- Mark H. Zangmeister Ctr Cols OH
Morristown Memorial Hospital Morristown NJ
Mount Carmel Medical Center-State Street Columbus OH
Mount Carmel-St. Ann's Cancer Center Westerville OH
North Memorial Medical Center Robbinsdale MN
Northeast Georgia Medical Center Gainesville GA
Northern Indiana Cancer Research Consortium CCOP South Bend IN
Northwestern Memorial Hospital Chicago IL
Oakwood Healthcare Inc Dearborn MI
Ohio State University Medical Center Columbus OH
Pamela Youde Nethersole Eastern Hospital Chai Wan
Parkview Cancer Center - Parkview Hospital Fort Wayne IN
Penrose Cancer Center, Penrose-St. Francis Health Services Colorado Springs CO
Phelps County Regional Medical Center Rolla MO
Pomona Valley Hospital Medical Center Pomona CA
Poudre Valley Hospital Radiation Oncology Fort Collins CO
Providence Alaska Medical Center, Radiation Oncology Anchorage AK
Radiation Oncology Associates Fort Wayne IN
Radiological Associates of Sacramento Sacramento CA
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Regions Radiation Therapy St. Paul MN
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Robinson Radiation Oncology Ravenna OH
Roseville Radiation Oncology Center Roseville CA
Saint Alphonsus Regional Medical Center Boise ID
Saint John's Hospital - HealthEast Maplewood MN
Saint Joseph Regional Medical Center - Mishawaka Mishawaka IN
Saint Vincent Mercy Medical Center Toledo OH
Seidman Cancer Center – Firelands Regional Medical Center Sandusky OH
Seoul National University Bundang Hospital Seongnam, Gyeonggi-D
Sinai Hospital of Baltimore Baltimore MD
Solano Radiation Oncology Center Vacaville CA
Southern Ohio Medical Center - Cancer Center Portsmouth OH
Sparrow Regional Cancer Center Lansing MI
Springfield Regional Medical Center Springfield OH
St Francis Hospital & Medical Center Hartford CT
St Francis Regional Med Cntr Wichita KS
St. Charles Mercy Hospital Oregon OH
St. Francis Hospital Federal Way WA
St. Johns Hospital & Medical Center Grosse Pointe Woods MI
St. Joseph Hospital Orange CA
St. Joseph Mercy Hospital Ann Arbor MI
St. Joseph Mercy Oakland Pontac MI
St. Luke's Medical Center Milwaukee WI
St. Mary Mercy Hospital Livonia MI
St. Mary`s Medical Center Saginaw MI
St. Mary's Hospital Medical Center Green Bay WI
St. Vincent Hospital and Health Care Centers, Inc. Indianapolis IN
St. Vincent Regional Cancer Center CCOP Green Bay WI
The Hospital of Central Connecticut New Britain CT
The Medical Center, Inc., John B. Amos Cancer Center Columbus GA
The Methodist Hospital Houston TX
The Regional Cancer Center at Singing River Hospital System Pascagoula MS
Toledo Clinic Cancer Centers - Adrian Adrian MI
Toledo Clinic Cancer Centers - Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
UCSD – University of California, San Diego LaJolla CA
UHHS - Chagrin Highlands Orange Village OH
UHHS - Westlake Medical Center Westlake OH
UMDNJ-New Jersey Medical School Newark NJ
United Hospital St. Paul MN
Unity Hospital Fridley MN
Univ of Kansas Comprehensive Cancer Center Kansas City KS
Univ. of Miami Sylvester Comp Cancer Ctr-Deerfield Beach Deerfield Beach FL
University Hospitals of Cleveland Cleveland OH
University of Cincinnati Cincinnati OH
University of Florida College of Medicine Gainesville FL
University of Miami Miller School of Medicine Miami FL
University of Mississippi Medical Center Jackson MS
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Texas Southwestern Medical School Dallas TX
University of Texas-MD Anderson Cancer Center Houston TX
University of Utah Health Science Center Salt Lake City UT
University of Wisconsin Hospital Madison WI
Utah Cancer Specialists Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virtua-Memorial Hospital Burlington County, Inc. Mount Holly NJ
Webber Cancer Center Warren MI
Updated: 3/18/2014

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