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RTOG 0815 Protocol Information

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A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy with or without Short-Term Androgen Deprivation Therapy for Patients with Intermediate-Risk Prostate Cancer
Principal Investigator: Alvaro A. Martinez, MD, FACR
Primary Objective:

To demonstrate an overall survival (OS) advantage for the addition of short-term (6 months) ADT to dose-escalated RT for patients with intermediate-risk prostate cancer. The events for OS will be defined as death due to any cause.

Patient Population:

Clinically localized, lymph node negative adenocarcinoma of the prostate diagnosed within 6 months* prior to registration at intermediate risk for recurrence as determined by harboring one or more of the following intermediate-risk features: Gleason Score 7; PSA >10 but ≤20; Clinical Stage T2b-T2c. 

*Patients previously diagnosed with low risk (Gleason score 6, clinical stage < T2a, and PSA < 10) prostate cancer undergoing active surveillance who are re-biopsied and found to have intermediate risk disease according to the protocol criteria are eligible for enrollment within 6 months of the repeat biopsy procedure.

ACE-27

Target Accrual: 1520
Current Accrual: 1166
Status: Open to Accrual
Date:
Participating Sites:
21st Century Oncology-Clarkston, MI Clarkston MI
21st Century Oncology-Farmington Hills Farmington Hills MI
21st Century Oncology-Scottsdale Scottsdale AZ
21st Century Oncology-Troy, MI Troy MI
Abbott Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
Adams Cancer Center Gettysburg PA
Adena Regional Medical Center Chillicothe OH
Akron City Hospital Akron OH
Akron General Medical Center Akron OH
Allan Blair Cancer Centre Regina, SK
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
Anderson Memorial Hospital Anderson SC
Anne Arundel Medical Center Annapolis MD
Annie Penn Memorial Hospital Reidsville NC
Arizona Center for Cancer Care Peoria AZ
Arizona Oncology - Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Atlanta VA Medical Center Decatur GA
Auburn Radiation Oncology Center Auburn CA
Augusta Health Cancer Center Fishersville VA
Bay Area Medical Center Marinette WI
Baystate Health-D'Amour Springfield MA
BC Cancer Agency Center for Southern Interior Kelowna, BC
Bellin Memorial Hospital, Inc. Green Bay WI
Benefis Healthcare-Sletten Cancer Institute Great Falls MT
Berkshire Medical Center Pittsfield MA
Billings Clinic Cancer Center Billings MT
Bixby Medical Center Adrian MI
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Bronson Battle Creek Battle Creek MI
Bronson Methodist Hospital Kalamazoo MI
Broward General Medical Center Fort Lauderdale FL
California Pacific Medical Center San Francisco CA
Cancer Care Center, Inc Salem OH
Cancer Centers of the Carolinas-Andrews Greenville SC
Cancer Centers of the Carolinas-Faris Road Greenville SC
Cancer Centers of the Carolinas-Greer Radiation Oncology Greer SC
Cancer Centers of the Carolinas-Seneca Seneca SC
Cancer Centers of the Carolinas-Spartanburg Spartanburg SC
Cancer Research for the Ozarks CCOP Springfield MO
Cancer Treatment Center Wooster OH
Cape Cod Hospital Hyannis MA
Carolina Regional Cancer Center Myrtle Beach SC
CarolinaEast Health System New Burn NC
Center for Cancer Care @ Goshen Health System Goshen IN
Center for Cancer Care at Exeter Hospital Exeter NH
Central Baptist Hospital Lexington KY
Central Maine Medical Center Lewiston ME
Central Maryland Oncology at Howard County Hospital Columbia MD
Centre Hospitalier de l`Université de Montréal-Notre Dame Montreal Quebec
Centre Hospitalier Universitaire de Sherbrooke Sherbrooke, Quebec
Cherry Tree Cancer Center Hanover PA
Coastal Carolina Radiation Oncology Center Wilmington NC
Coleman Radiation Center-Carteret General Hospital Morehead City NC
Columbia St. Mary's Hospital Ozaukee, Inc Mequon WI
Columbia-Saint Mary's Milwaukee Milwaukee WI
Columbus Community Clinical Oncology Program Columbus OH
Community Memorial Hospital Menomonee Falls WI
Cone Health Cancer Center Greensboro NC
Cox Health System Springfield MO
Cross Cancer Institute Edmonton, Alberta
Danville Regional Medical Center Danville VA
Dartmouth Hitchcock Medical Center Lebanon NH
David Grant USAF Medical Center Travis AFB CA
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Cancer Center East St. George UT
Doctor's Hospital Columbus OH
Door County Cancer Center Sturgeon Bay WI
Dubs Cancer Center @ Rogue Valley Medical Center Medford OR
Edward Hines, Jr. VA Hospital Hines IL
Elliot Hospital Manchester NH
Emory University Atlanta GA
Emory University Hospital Midtown Atlanta GA
Enloe Medical Center Chico CA
Fairbanks Memorial Hospital Fairbanks AK
Fairview Ridges Hospital Burnsville MN
Fairview Southdale Hospital Edina MN
Florida Hospital Orlando FL
Flower Hospital Sylvania OH
Fox Chase Cancer Center Philadelphia PA
Fox Chase Virtua Health Cancer Treatment Center Voorhees NJ
Freeman Health System Joplin MO
Geisinger Medical Center CCOP Danville PA
Geisinger Wyoming Valley Medical Center Wilkes Barre PA
Genesis Healthcare System Zainesville OH
Genesys Regional Medical Center Flint MI
Gibbs Cancer Center-Pelham Greer SC
Grady Memorial Hospital Atlanta GA
Grady Memorial Hospital Delaware OH
Grand Rapids Clinical Oncology Program (GRCOP) Grand Rapids MI
Grand River Regional Cancer Centre at Grand River Hospital Kitchener, Ontario
Grant Medical Center Columbus OH
Greenville CCOP - Cancer Centers of the Carolinas-Eastside Greenville SC
Hennepin County Medical Center Minneapolis MN
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Hospital Maisonneuve-Rosemont Montreal, Quebec
Hurley Cancer Center Flint MI
Indiana University Health Bloomington Bloomington IN
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University Medical Center Indianapolis IN
Intermountain Medical Center Murray UT
Jackson Memorial Hospital Miami FL
James A. Haley Veteran's Hospital Tampa FL
James Graham Brown Cancer Ctr at University of Louisville Louisville KY
Jersey Shore University Medical Center Neptune NJ
Kaiser Permanent Northern California-Rancho Cordova Rancho Cordova CA
Kaiser Permanente Northern California Santa Clara CA
Kaiser Permanente Northern California-Oakland Oakland CA
Kaiser Permanente Northern California-Rohnert Park Rohnert Park CA
Kaiser Permanente Northern California-Roseville Roseville CA
Kaiser Permanente Northern California-South Sacramento Sacramento CA
Kaiser Permanente Northern California-South San Francisco South San Francisco CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
L Hotel-Dieu de Quebec Quebec
LAC + USC Medical Center Los Angeles CA
Lake/University Seidman Cancer Center Mentor OH
LDS Hospital Salt Lake City UT
Licking Memorial Hospital Newark OH
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
Long Island Jewish Hospital Lake Success NY
Lowell General Hospital Cancer Center Lowell MA
Maine Medical Center Scarborough ME
Maplewood Cancer Center Maplewood MN
Marietta Memorial Hospital Marietta OH
Marin General Hospital Greenbrae CA
Marshall Radiation Oncology Center Cameron Park CA
Mass General/ North Shore Cancer Center Danvers MA
Massachusetts General Hospital Boston MA
Mayo Clinic Rochester MN
Mayo Clinic Health System-Franciscan Healthcare LaCrosse WI
McGill University Montreal
McKay-Dee Hospital Ogden UT
Medical College of Wisconsin Milwaukee WI
Medical University of Ohio Toledo OH
Memorial Ikard Cancer Treatment Center Las Cruces NM
Mercy Cancer Center Elyria OH
Mercy Cancer Center at St. Ann Toledo OH
Mercy General Radiation Oncology Center Sacramento CA
Mercy Health Partners-Johnson Family Center Muskegon MI
Mercy Hospital Coon Rapids MN
Mercy Hospital Port Huron Port Huron MI
Mercy Hospital St. Louis St Louis MO
Mercy Hospital-Joplin Joplin MO
Mercy San Juan Radiation Oncology Center Carmichael CA
Mercy-Springfield Springfield MO
Methodist Cancer Center Omaha NE
Methodist Medical Center of Illinois Peoria IL
Metro-MN CCOP St. Louis Park MN
Michigan Cancer Research Consortium CCOP Ann Arbor MI
Mid Ohio Oncology Hematology Inc- Mark H. Zangmeister Ctr Cols OH
Mills-Peninsula Health Services San Mateo CA
Montana Cancer Consortium CCOP Billings MT
Mount Carmel Medical Center-State Street Columbus OH
Mount Carmel-St. Ann's Cancer Center Westerville OH
Mount Clemens Regional Medical Center Mount Clemens MI
Naval Medical Center-Portsmouth Portsmouth VA
New Hanover Regional Medical Center Wilmington NC
Newark Beth Israel Medical Center Newark NJ
North Memorial Medical Center Robbinsdale MN
Northeast Georgia Medical Center Gainesville GA
Northside Hospital Cancer Center Atlanta GA
Northside Hospital Forsyth Cumming GA
Northwestern Ontario Regional Cancer Centre Thunder Bay, Ontario
Nova Scotia Cancer Centre Halifax, Nova Scotia
Oakwood Healthcare Inc Dearborn MI
Ocean Medical Center Brick NJ
Ochsner Clinic CCOP New Orleans LA
Ohio State University Medical Center Columbus OH
Oncology and Hematology Associates of Southwest Virginia Roanoke VA
Our Lady of Lourdes Memorial Hospital, Inc. Binghamton NY
Parkridge University Radiation Oncology Rochester NY
Parkview Cancer Center - Parkview Hospital Fort Wayne IN
PeaceHealth St. Joseph Cancer Center Bellingham WA
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
Phelps County Regional Medical Center Rolla MO
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Pomona Valley Hospital Medical Center Pomona CA
Poudre Valley Hospital Radiation Oncology Fort Collins CO
Prostate Cancer Center of New Jersey West Orange NJ
Radiation Oncology Associates Fort Wayne IN
Radiological Associates of Sacramento Sacramento CA
Randolph Hospital Ashboro NC
Reading Hospital Reading PA
Regions Radiation Therapy St. Paul MN
Rex Cancer Center Raleigh NC
Rice Memorial Hospital Willmar MN
Rideout Cancer Center Marysville CA
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Riverview Medical Center/Riverview Regional Cancer Center Red Bank NJ
Robinson Radiation Oncology Ravenna OH
Rocky Mountain Oncology Center Casper WY
Roseville Radiation Oncology Center Roseville CA
Roswell Park Cancer Institute Buffalo NY
Saint Alphonsus Regional Medical Center Boise ID
Saint John Regional Hospital Saint John, NB
Saint John's Hospital - HealthEast Maplewood MN
Saint Mary's Health Care/Hospital Grand Rapids MI
Saint Vincent Mercy Medical Center Toledo OH
Sands Cancer Center Canandaigua NY
Saskatoon Cancer Centre Saskatoon, Saskatchew
Seidman Cancer Center – Firelands Regional Medical Center Sandusky OH
Sentara Cancer Institute at Sentara CarePlex Hospital Hampton VA
Sentara Norfolk General Hospital Norfolk VA
Sentara Virginia Beach General Hospital Virginia Beach VA
Shaw Regional Cancer Center Edwards CO
Solano Radiation Oncology Center Vacaville CA
South Atlantic Radiation Oncology Supply NC
Southern Ohio Medical Center - Cancer Center Portsmouth OH
Southside Hospital Bayshore NY
Southwest Virginia Regional Cancer Center Norton VA
Sparrow Regional Cancer Center Lansing MI
Spartanburg Regional Medical Center Spartanburg SC
Spectrum Health-Grand Rapid Clinical Oncology Program Grand Rapids MI
Springfield Regional Medical Center Springfield OH
St Anne's Hospital Fall River MA
St Francis Hospital & Medical Center Hartford CT
St Francis Regional Med Cntr Wichita KS
St Johns Hospital, Cancer Institute Springfield IL
St Mary's Hospital & Medical Center Grand Junction CO
St Peter's Cancer Care Center Albany NY
St. Agnes Healthcare Baltimore MD
St. Charles Mercy Hospital Oregon OH
St. Francis Hospital Federal Way WA
St. Johns Hospital & Medical Center Grosse Pointe Woods MI
St. Joseph Mercy Hospital Ann Arbor MI
St. Joseph Mercy Oakland Pontac MI
St. Lukes Hospital Bethlehem PA
St. Luke's Medical Center Milwaukee WI
St. Mary Mercy Hospital Livonia MI
St. Mary`s Medical Center Saginaw MI
St. Mary's Hospital Medical Center Green Bay WI
St. Vincent Anderson Regional Hospital, Inc. Anderson IN
St. Vincent Regional Cancer Center CCOP Green Bay WI
Stanford University Medical Center Palo Alto CA
Summa Health Center at Lake Medina Medina OH
Summa Health System Barberton Hospital Barberton OH
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Solano Medical Center Vallejo CA
Tate Cancer Center - North Arundel Hospital Glen Burnie MD
Texas Oncology - Austin Midtown Austin TX
Texas Oncology - Central South Austin Austin TX
Texas Oncology - Round Rock Cancer Center Round Rock TX
Texas Oncology - Seton Williamson Round Rock TX
Texas Oncology - South Austin Austin TX
The Cancer Center of Hawaii-Leeward Ewa Beach HI
The Cancer Center of Hawaii-Liliha Honolulu HI
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Queen's Medical Center Honolulu HI
The Urology Center of Colorado Denver CO
Thedacare Cancer Institute Appleton WI
Thompson Cancer Survival Center Knoxville TN
Toledo Clinic Cancer Centers - Adrian Adrian MI
Toledo Clinic Cancer Centers - Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Tom Baker Cancer Centre Calgary, Alberta
Toronto-Sunnybrook Regional Cancer Centre Toronto, Ontario
Trinity Cancer Care Center Minot ND
Tulane University Medical Center New Orleans LA
UH Seidman Cancer Center at Geauga Medical Center Chardon OH
UH Seidman Cancer Center at Southwest General Middleburgh OH
UHHS - Chagrin Highlands Orange Village OH
UHHS - Westlake Medical Center Westlake OH
UMDNJ-New Jersey Medical School Newark NJ
United Hospital St. Paul MN
Unity Hospital Fridley MN
Univ. of Miami Sylvester Comp Cancer Ctr-Deerfield Beach Deerfield Beach FL
University Hospitals of Cleveland Cleveland OH
University of California Davis Medical Center Sacramento CA
University of California San Francisco San Francisco CA
University of Chicago Chicago IL
University of Colorado Denver Aurora CO
University of Hawaii Cancer Research Center MBCCOP Honolulu HI
University of Kentucky Hospital Lexington KY
University of Maryland Medical Systems Baltimore MD
University of Miami Miller School of Medicine Miami FL
University of Michigan Medical Center Ann Arbor MI
University of Nebraska Medical Center Omaha NE
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Southern California Los Angeles CA
University of Texas Medical Branch Galveston TX
University of Texas Southwestern Medical School Dallas TX
University of Utah Health Science Center Salt Lake City UT
Upstate Carolina CCOP - Gibbs Regional Cancer Center Spartanburg SC
USON- Texas Oncology Longview Cancer Center Longview TX
USON- Texas Oncology-Denton Denton TX
USON- Texas Oncology-PA Bedford Bedford TX
USON- Texas Oncology-Sugar Land Sugarland TX
USON-Arizona Radiation Oncology Tucson AZ
USON-Cancer Care Northwest - Spokane Spokane WA
USON-Cancer Care Northwest-East Holland Spokane WA
USON-Fort Worth Fort Worth TX
USON-Texas Oncology - Houston Memorial City Houston TX
USON-Texas Oncology- Sherman Sherman TX
USON-Texas Oncology-Lewisville Flower Mound TX
USON-Williamette Valley Cancer Center Eugene OR
Utah Valley Regional Medical Center Provo UT
Veterans Administration Hospital Ann Arbor Ann Arbor MI
Virginia Mason CCOP Seattle WA
Virtua-Memorial Hospital Burlington County, Inc. Mount Holly NJ
Washington University St. Louis MO
Webber Cancer Center Warren MI
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Medical Center Kingsport TN
West Allis Memorial Hospital West Allis WI
Yale University New Haven CT
Yale-New Haven Hospital Saint Raphael Campus New Haven CT
York Cancer Center York PA
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 11/18/2013

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