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RTOG 1005 Protocol Information

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A Phase III Trial Of Accelerated Whole Breast Irradiation With Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost For Early-Stage Breast Cancer
Principal Investigator: Frank A. Vicini, MD FACR (New e-mail: favicini@botsford.org)
Primary Objective:

To determine whether an accelerated course of hypofractionated WBI including a concomitant boost to the tumor bed in 15 fractions following lumpectomy will prove to be non-inferior in local control to a regimen of standard WBI with a sequential boost following lumpectomy for early-stage breast cancer patients.

 

 

 

Patient Population:

pStage 0, I, II Breast Cancer resected by lumpectomy

pStage 0, I,II Breast Cancer resected by lumpectomy that followed neoadjuvant systemic therapy

 

 

 

Target Accrual: 2312
Current Accrual: 2079
Status: Open to Accrual
Date: 5/24/2011
Participating Sites:
21st Century Oncology Las Vegas NV
21st Century Oncology-Bradenton Bradenton FL
21st Century Oncology-Clarkston, MI Clarkston MI
21st Century Oncology-El Segundo El Segundo CA
21st Century Oncology-Farmington Hills Farmington Hills MI
21st Century Oncology-Scottsdale Scottsdale AZ
21st Century Oncology-Troy, MI Troy MI
Abington Memorial Hospital Abington PA
Adams Cancer Center Gettysburg PA
Adena Regional Medical Center Chillicothe OH
Akron General Medical Center Akron OH
Albert Lea Medical Center Albert Lea MN
Allan Blair Cancer Centre Regina, SK
Allegheny General Hospital Pittsburgh PA
Allegheny Valley Hospital Natrona Heights PA
Anne Arundel Medical Center Annapolis MD
Annie Penn Memorial Hospital Reidsville NC
Arizona Oncology - Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Assarian Cancer Center Novi MI
Auburn Radiation Oncology Center Auburn CA
Barnes Jewish West County Hospital St. Louis MO
Bay Area Medical Center Marinette WI
Beaumont CCOP Royal Oak MI
Beloit Memorial Hospital Beloit WI
Berkshire Medical Center Pittsfield MA
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Botsford Hospital Farmington Hills MI
British Columbia Cancer Agency-Vancouver Cancer Center Vancouver, BC
Bronson Battle Creek Battle Creek MI
Bronson Methodist Hospital Kalamazoo MI
Brooke Army Medical Center Fort Sam Houston TX
Cancer Care Manitoba Foundation Winnipeg, Manitoba
Cancer Centers of the Carolinas-Andrews Greenville SC
Cancer Centers of the Carolinas-Faris Road Greenville SC
Cancer Centers of the Carolinas-Greer Radiation Oncology Greer SC
Cancer Centers of the Carolinas-Seneca Seneca SC
Cancer Centers of the Carolinas-Spartanburg Spartanburg SC
Canton Hospital of Aarau Aarau
Cape Radiation Oncology Cape Girardeau MO
Carle Cancer Center CCOP Urbana IL
CarolinaEast Health System New Burn NC
Cedars-Sinai Medical Center Los Angeles CA
Center for Cancer Care @ Goshen Health System Goshen IN
CentraCare Health System/Coborn Cancer Center St. Cloud MN
Central DuPage Hospital Cancer Center Warrenville IL
Central Maryland Oncology at Howard County Hospital Columbia MD
Centre Hospitalier de l`Université de Montréal-Notre Dame Montreal Quebec
Centre Hospitalier Universitaire de Sherbrooke Sherbrooke, Quebec
Cherry Tree Cancer Center Hanover PA
Cheshire Medical Center Keene NH
City of Hope Medical Center Duarte CA
City of Hope-South Pasadena Cancer Center South Pasadena CA
Clackamas Radiation Oncology Center Clackamas OR
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland OH
Cleveland Clinic Cancer Center-Independence Independence OH
Cleveland Clinic Foundation Cleveland OH
Cleveland Clinic Wooster Specialty Center Wooster OH
Cleveland Clinic-Strongsville Strongsville OH
Coastal Carolina Radiation Oncology Center Wilmington NC
Coleman Radiation Center-Carteret General Hospital Morehead City NC
Columbia St. Mary's Hospital Ozaukee, Inc Mequon WI
Columbia-Presbyterian Medical Center New York NY
Columbia-Saint Mary's Milwaukee Milwaukee WI
Columbus Community Clinical Oncology Program Columbus OH
Community Hospital East Indianapolis IN
Community Hospitals of Indiana Regional Cancer Care North Indianapolis IN
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Henderson Henderson NV
Comprehensive Cancer Ctrs of Nevada - Northwest Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Summerlin Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Sunset Las Vegas NV
Cone Health Cancer Center Greensboro NC
Cross Cancer Institute Edmonton, Alberta
D.N. Greenwald Mukwonago WI
Dartmouth Hitchcock Medical Center Lebanon NH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Cancer Center East St. George UT
Doctor's Hospital Columbus OH
Door County Cancer Center Sturgeon Bay WI
Dubs Cancer Center @ Rogue Valley Medical Center Medford OR
Duke University Medical Center Durham NC
East Carolina Medical School Greenville NC
Elkhart General Hospital Elkhart IN
Emory University Atlanta GA
Emory University Hospital Midtown Atlanta GA
Enloe Medical Center Chico CA
Florida Hospital Orlando FL
Florida Radiation Oncology Group - Baptist Regional Jacksonville FL
Fox Chase Cancer Center Philadelphia PA
Fox Chase Virtua Health Cancer Treatment Center Voorhees NJ
Geisinger Medical Center CCOP Danville PA
Genesis Healthcare System Zainesville OH
Genesys Regional Medical Center Flint MI
Gibbs Cancer Center-Pelham Greer SC
Grady Memorial Hospital Delaware OH
Grady Memorial Hospital Atlanta GA
Grand Rapids Clinical Oncology Program (GRCOP) Grand Rapids MI
Grand River Regional Cancer Centre at Grand River Hospital Kitchener, Ontario
Grant Medical Center Columbus OH
Greater Baltimore Medical Center Baltimore MD
Greenville CCOP - Cancer Centers of the Carolinas-Eastside Greenville SC
Heartland Regional Medical Center St. Joseph MO
Hematology-Oncology Associates of CNY CCOP East Syracuse NY
Henry Ford Hospital Detroit MI
Henry Ford Macomb Hospital Clinton Township MI
Highland Hospital Rochester NY
Hillcrest Hospital Cancer Center Mayfield Heights OH
Holy Cross Hospital Inc. Fort Lauderdale FL
Holy Redeemer Hospital Meadowbrook PA
Hopital de la Cite-de-la-Sante Laval, Quebec
Hospital Maisonneuve-Rosemont Montreal, Quebec
Hudson Valley Oncology Associates Poughkeepsie NY
Hurley Cancer Center Flint MI
Huron Valley Hospital Commerce Township MI
ICON – Baptist Medical Center South Jacksonville FL
ICON – Cancer Center of Putnam Palatka FL
ICON – Flagler Cancer Center St Augustine FL
ICON – Florida Cancer Center - Beaches Jacksonville Beach FL
ICON – Orange Park Cancer Center Orange Park FL
ICON – Southside Cancer Center Jacksonville FL
Immanuel-St Joseph's Hospital Mankato MN
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University Medical Center Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Inova Alexandria Hospital Alexandria VA
Inova Fairfax Hospital Falls Church VA
Intermountain Medical Center Murray UT
Iredell Memorial Hospital Statesville NC
Irving Greenberg Family Cancer Centre Ottawa, ON
IU Health University West Avon IN
Jersey Shore University Medical Center Neptune NJ
John H. Stroger, Jr. Hospital of Cook County MBCCOP Chicago IL
Jupiter Medical Center Jupiter FL
Kaiser Permanent Northern California-Rancho Cordova Rancho Cordova CA
Kaiser Permanente Northern California Santa Clara CA
Kaiser Permanente Northern California-Oakland Oakland CA
Kaiser Permanente Northern California-Rohnert Park Rohnert Park CA
Kaiser Permanente Northern California-Roseville Roseville CA
Kaiser Permanente Northern California-South Sacramento Sacramento CA
Kaiser Permanente Northern California-South San Francisco South San Francisco CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
KCC Radiation Oncology at Monroe Cancer Center Monroe MI
L Hotel-Dieu de Quebec Quebec
La Porte Hospital La Porte IN
LAC + USC Medical Center Los Angeles CA
Lakeland Regional Health System St. Joseph MI
Lancaster General Hospital Lancaster PA
LDS Hospital Salt Lake City UT
Liberty Radiation Oncology Clinic Liberty MO
Licking Memorial Hospital Newark OH
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Long Island Jewish Hospital Lake Success NY
Lowell General Hospital Cancer Center Lowell MA
Loyola University Chicago Maywood IL
Lutheran General Hospital Park Ridge IL
Maimonides Medical Center Brooklyn NY
Marietta Memorial Hospital Marietta OH
Marshall Radiation Oncology Center Cameron Park CA
Mass General/ North Shore Cancer Center Danvers MA
Massachusetts General Hospital Boston MA
Mayo Clinic Rochester MN
Mayo Clinic Arizona Phoenix AZ
Mayo Clinic Health System Eau Claire Hospital, Inc. Eau Claire WI
Mayo Clinic Health System-Franciscan Healthcare LaCrosse WI
Mayo Clinic in Arizona Scottsdale AZ
McGill University Montreal
McKay-Dee Hospital Ogden UT
MD Anderson Cancer Center Orlando Orlando FL
Medical College of Wisconsin Milwaukee WI
Medical University of South Carolina Charleston SC
Memorial Hospital South Bend IN
Memorial Ikard Cancer Treatment Center Las Cruces NM
Memorial Sloan Kettering Cancer Center (MSKCC) at Phelps Sleepy Hollow NY
Memorial Sloan Kettering of Rockville Center Rockville NY
Memorial Sloan Kettering-Basking Ridge Basking Ridge NJ
Memorial Sloan-Kettering Cancer Center New York NY
Memorial Sloan-Kettering Cancer Center at Commack Commack NY
Menorah Medical Center Overland Park KS
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Health Partners-Johnson Family Center Muskegon MI
Mercy Hospital Port Huron Port Huron MI
Mercy San Juan Radiation Oncology Center Carmichael CA
Methodist Cancer Center Omaha NE
Methodist Medical Center of Illinois Peoria IL
Michiana Hematology-Oncology, P.C. Mishawaka IN
Michigan Cancer Research Consortium CCOP Ann Arbor MI
Mid Ohio Oncology Hematology Inc- Mark H. Zangmeister Ctr Cols OH
Monmouth Medical Center Long Branch NJ
Montefiore Medical Center - Moses Campus Bronx NY
Morristown Memorial Hospital Morristown NJ
Mount Carmel Medical Center-State Street Columbus OH
Mount Carmel-St. Ann's Cancer Center Westerville OH
Mount Nittany Medical Center - Penn State Cancer Institute State College PA
Mount Sinai Comprehensive Cancer Center CCOP Miami Beach FL
National University Cancer Institute Singapore Singapore
Naval Medical Center-Portsmouth Portsmouth VA
Nevada Cancer Research Foundation CCOP Las Vegas NV
New Hanover Regional Medical Center Wilmington NC
New Mexico Cancer Care Alliance Albuquerque NM
Newton-Wellesley Hospital Newton MA
Norris Cotton Cancer Center Saint Johnsbury VT
North Coast Cancer Care Sandusky OH
North Kansas City Hospital North Kansas City MO
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium CCOP South Bend IN
Northside Hospital Cancer Center Atlanta GA
Northwest Cancer Specialists-Vancouver Vancouver WA
Northwestern Memorial Hospital Chicago IL
Oakwood Healthcare Inc Dearborn MI
Ocean Medical Center Brick NJ
Ochsner Clinic CCOP New Orleans LA
Oconomowoc Memorial Hospital - ProHealth Care Inc. Oconomowoc WI
Ohio State University Medical Center Columbus OH
Olympic Medical Center - Cancer Care Center Sequim WA
Parkridge University Radiation Oncology Rochester NY
Parkview Cancer Center - Parkview Hospital Fort Wayne IN
PeaceHealth Southwest Medical Center Vancouver WA
Peninsula Regional Medical Center Salisbury MD
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
Penrose Cancer Center, Penrose-St. Francis Health Services Colorado Springs CO
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Pocono Cancer Center East Strousburg PA
Providence Hospital Southfield MI
Providence Portland Medical Center Portland OR
Providence St. Vincent Medical Center Portland OR
Rabin Medical Center-Davidoff Cancer Center Petah Tikva
Radiation Oncology Associates Fort Wayne IN
Radiation Oncology Centers of Las Vegas Las Vegas NV
Radiological Associates of Sacramento Sacramento CA
Randolph Hospital Ashboro NC
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Renown Regional Medical Center Reno NV
Research Medical Center Kansas City MO
Riddle Memorial Hospital Media PA
Riverside Methodist Hospital Columbus OH
Riverview Medical Center/Riverview Regional Cancer Center Red Bank NJ
Robinson Radiation Oncology Ravenna OH
Rochester General Hospital Rochester NY
Roseville Radiation Oncology Center Roseville CA
Roswell Park Cancer Institute Buffalo NY
Rush-Copley Medical Center Aurora IL
Saint Alphonsus Regional Medical Center Boise ID
Saint Elizabeth Regional Medical Center Lincoln NE
Saint John Regional Hospital Saint John, NB
Saint Joseph Regional Medical Center - Mishawaka Mishawaka IN
Saint Mary's Health Care/Hospital Grand Rapids MI
Sands Cancer Center Canandaigua NY
Saskatoon Cancer Centre Saskatoon, Saskatchew
Seattle Cancer Care Alliance Seattle WA
Sentara Cancer Institute at Sentara CarePlex Hospital Hampton VA
Sentara Norfolk General Hospital Norfolk VA
Sentara Virginia Beach General Hospital Virginia Beach VA
Severance Hospital-Yonsei University Health System Seoul
Shaw Regional Cancer Center Edwards CO
Sheba Medical Center Tel Hashomer
Siteman Cancer Center - South County St Louis MO
Siteman Cancer Center/Barnes Jewish St. Peters Hospital St. Peters MO
Skagit Valley Hospital Mount Vernon WA
Solano Radiation Oncology Center Vacaville CA
South Atlantic Radiation Oncology Supply NC
South Nassau Communities Hospital Oceanside NY
Southern Ohio Medical Center - Cancer Center Portsmouth OH
Southside Hospital Bayshore NY
Sparrow Regional Cancer Center Lansing MI
Sparta Cancer Center Sparta NJ
Spartanburg Regional Medical Center Spartanburg SC
Spectrum Health-Grand Rapid Clinical Oncology Program Grand Rapids MI
Springfield Regional Medical Center Springfield OH
St Francis Hospital & Medical Center Hartford CT
St Francis Regional Med Cntr Wichita KS
St Luke's Hospital Kansas City MO
St Peter's Cancer Care Center Albany NY
St. Agnes Healthcare Baltimore MD
St. Francis Hospital Federal Way WA
St. Johns Hospital & Medical Center Grosse Pointe Woods MI
St. Joseph Mercy Hospital Ann Arbor MI
St. Joseph Mercy Oakland Pontac MI
St. Luke's Medical Center Milwaukee WI
St. Mary Mercy Hospital Livonia MI
St. Mary`s Medical Center Saginaw MI
St. Mary's Hospital Medical Center Green Bay WI
St. Mary's Regional Medical Center Reno NV
St. Peter's Medical Center New Brunswick NJ
St. Vincent Anderson Regional Hospital, Inc. Anderson IN
St. Vincent Regional Cancer Center CCOP Green Bay WI
SUNY Upstate Medical University Syracuse NY
Tate Cancer Center - North Arundel Hospital Glen Burnie MD
Texas Oncology - Austin Midtown Austin TX
Texas Oncology - Central South Austin Austin TX
Texas Oncology - Round Rock Cancer Center Round Rock TX
Texas Oncology - Seton Williamson Round Rock TX
Texas Oncology - South Austin Austin TX
The Cancer Center of Hawaii-Liliha Honolulu HI
The Comprehensive Cancer Center at JFK Medical Center Lake Worth FL
The Kirklin Clinic at Acton Road Birmingham AL
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Queen's Medical Center Honolulu HI
The Rector and Visitors of the University of Virginia Charlottesville VA
The Regional Cancer Center Erie PA
The Regional Cancer Center at Singing River Hospital System Pascagoula MS
The Schiffler Cancer Center Wheeling WV
The University of Arizona Medical Center - University Campus Tucson AZ
Thedacare Cancer Institute Appleton WI
Thomas Jefferson University Hospital Philadelphia PA
Tulane University Medical Center New Orleans LA
UCLA Medical Center Los Angeles CA
UCSD – University of California, San Diego LaJolla CA
UHHS - Chagrin Highlands Orange Village OH
Univ of Kansas Comprehensive Cancer Center Kansas City KS
Univ. of Miami Sylvester Comp Cancer Ctr-Deerfield Beach Deerfield Beach FL
University of Alabama at Birmingham Medical Center Birmingham AL
University of California Davis Medical Center Sacramento CA
University of Chicago Chicago IL
University of Cincinnati Cincinnati OH
University of Colorado Denver Aurora CO
University of Florida College of Medicine Gainesville FL
University of Florida Health Science Center Jacksonville FL
University of Hawaii Cancer Research Center MBCCOP Honolulu HI
University of Kansas Cancer Center - Southwest Overland Park KS
University of Kansas Cancer Center-East Lee's Summit MO
University of Kansas Cancer Center-North Kansas City MO
University of Kansas Cancer Center-South Kansas City MO
University of Kentucky Hospital Lexington KY
University of Maryland Medical Systems Baltimore MD
University of Miami Miller School of Medicine Miami FL
University of Michigan Medical Center Ann Arbor MI
University of Nebraska Medical Center Omaha NE
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Pennsylvania Medical Center Philadelphia PA
University of Rochester Rochester NY
University of Southern California Los Angeles CA
University of Texas at San Antonio San Antonio TX
University of Texas Southwestern Medical School Dallas TX
University of Utah Health Science Center Salt Lake City UT
University of Washington Medical Center Seattle WA
University of Wisconsin Cancer Center Johnson Creek Johnson Creek WI
University of Wisconsin Hospital Madison WI
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centre at UPMC Northwest Seneca PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC- Passavant Hospital Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-HVHS Cancer Center (Moon) Coraopolis PA
UPMC-Jameson Memorial Hospital New Castle PA
UPMC-Magee Women's Hospital Pittsburgh PA
UPMC-McKeesport Hospital McKeesport PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-St. Margaret Pittsburgh PA
UPMC-The Washington Hospital Washington PA
Upstate Carolina CCOP - Gibbs Regional Cancer Center Spartanburg SC
USON- New York Oncology Hematology, P.C. Albany NY
USON- Texas Oncology Arlington South Arlington TX
USON- Texas Oncology-Denton Denton TX
USON- Texas Oncology-PA Bedford Bedford TX
USON- Texas Oncology-Sugar Land Sugarland TX
USON-Arizona Radiation Oncology Tucson AZ
USON-Cancer Care Northwest - Spokane Spokane WA
USON-Cancer Care Northwest-East Holland Spokane WA
USON-Fort Worth Fort Worth TX
USON-Plano West Cancer Center Plano TX
USON-Texas Oncology - Houston Memorial City Houston TX
USON-Texas Oncology- Sherman Sherman TX
USON-Texas Oncology-Lewisville Flower Mound TX
USON-Williamette Valley Cancer Center Eugene OR
Utah Cancer Specialists Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virginia Commonwealth University Richmond VA
Virginia Mason CCOP Seattle WA
Virtua-Memorial Hospital Burlington County, Inc. Mount Holly NJ
Walter Reed National Military Medical Center Bethesda MD
Warren Cancer Research Foundation-Oklahoma CCOP Tulsa OK
Washington Cancer Institute Washington DC
Washington University St. Louis MO
Waukesha Memorial Hospital Waukesha WI
Wayne State University-Karmanos Cancer Institute Detroit MI
Webber Cancer Center Warren MI
Weisberg Cancer Treatment Center Farmington Hills MI
Wenatchee Valley Medical Center P.S. Wenatchee WA
West Allis Memorial Hospital West Allis WI
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wilford Hall USAF Medical Center Lackland AFB TX
William Beaumont Hospital / Troy Troy MI
Windsor Regional Hospital Windsor, Ontario
York Cancer Center York PA
Updated: 1/9/2014

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