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RTOG 1010 Protocol Information

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A Phase III Trial Evaluating the Addition of Trastuzumab to Trimodality Treatment of Her2-Overexpressing Esophageal Adenocarcinoma
Principal Investigator: Howard Safran, MD
Primary Objective:

To determine if trastuzumab increases disease-free survival when combined with trimodality treatment (radiation plus chemotherapy followed by surgery) for patients with HER2-overexpressing esophageal adenocarcinoma

Patient Population:

Pathologically confirmed HER2 expressing adenocarcinoma of the esophagus centrally assessed within 56 days prior to Step 2 registration; primary adenocarcinoma of the esophagus involving the mid (up to 25 cm), distal and/or esophagogastric junction.

Target Accrual: 160
Current Accrual: 454
Status: Open to Accrual
Date: 12/30/2010
Participating Sites:
21st Century Oncology Las Vegas NV
Abbott Northwestern Hospital Minneapolis MN
ACR Clinical Research Center Philadelphia PA
Adena Regional Medical Center Chillicothe OH
Adventist Medical Center Portland OR
Akron City Hospital Akron OH
Akron General Medical Center Akron OH
Allegiance Health/W.A. Foote Memorial Hospital Jackson MI
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
Alta Bates Summit Medical Center - Summit Campus Oakland CA
Aria Health Philadelphia PA
Assarian Cancer Center Novi MI
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Auburn Radiation Oncology Center Auburn CA
Aurora BayCare Medical Center Green Bay WI
Baptist Hospital of Miami Miami FL
Barnes Jewish West County Hospital St. Louis MO
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute CCOP Oakland CA
Baystate Health-D'Amour Springfield MA
Beebe Medical Center Lewes DE
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Benefis Healthcare-Sletten Cancer Institute Great Falls MT
Berkshire Medical Center Pittsfield MA
Beth Israel Medical Center New York NY
Billings Clinic Cancer Center Billings MT
Bixby Medical Center Adrian MI
Blanchard Valley Regional Health Center Findlay OH
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Bozeman Deaconess Hospital Cancer Center Bozeman MT
Brigham and Women's Hospital/Dana Farber Cancer Institute Boston MA
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
California Pacific Medical Center San Francisco CA
Cancer Care Center, Inc Salem OH
Cancer Research for the Ozarks CCOP Springfield MO
Cancer Treatment Center Wooster OH
Cape Radiation Oncology Cape Girardeau MO
Capital Health Medical Center-Hopewell Pennington NJ
Capital Health Medical Center-Hopewell Pennington NJ
Carolina Medical Center-Northeast Concord NC
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Carolinas Medical Center-Union Monroe NC
Case Western Reserve University Cleveland OH
Cedars-Sinai Medical Center Los Angeles CA
Cedars-Sinai Medical Center Los Angeles CA
Central Baptist Hospital Lexington KY
Central Maine Medical Center Lewiston ME
Central Maryland Oncology at Howard County Hospital Columbia MD
Christiana Care Health Services, Inc. CCOP Newark DE
Christiana Care Health System-Christiana Hospital Newark DE
City of Hope Medical Center Duarte CA
Clackamas Radiation Oncology Center Clackamas OR
Columbia River CCOP Portland OR
Columbia-Presbyterian Medical Center New York NY
Columbus Community Clinical Oncology Program Columbus OH
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Henderson Henderson NV
Comprehensive Cancer Ctrs of Nevada - Northwest Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Summerlin Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Sunset Las Vegas NV
Concord Hospital Payson Center for Cancer Care Concord NH
Cooper Health System Camden NJ
Cooper Health System-Voorhees Voorhees NJ
Cox Health System Springfield MO
Dana Farber/Brigham & Woman's CC at Milford Regional Milford MA
Dana Farber/Brigham & Women's Center at South Shore South Weymouth MA
Danville Regional Medical Center Danville VA
Dayton CCOP Kettering OH
Decatur Memorial Hospital Decatur IL
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Cancer Center East St. George UT
Doctor's Hospital Columbus OH
Door County Cancer Center Sturgeon Bay WI
East Bay Radiation Oncology Center Castro Valley CA
Elkhart General Hospital Elkhart IN
Emory University Atlanta GA
Emory University Hospital Midtown Atlanta GA
Enloe Medical Center Chico CA
Epic Care Dublin - Partners in Cancer Care Dublin CA
Epic Care Pleasant Hill - Partners in Cancer Care Pleasant Hill CA
Fairview Ridges Hospital Burnsville MN
Fairview Southdale Hospital Edina MN
Florida Hospital Orlando FL
Flower Hospital Sylvania OH
Flower Hospital Sylvania OH
Fox Chase Cancer Center Philadelphia PA
Fox Chase Cancer Center Philadelphia PA
Fox Chase Virtua Health Cancer Treatment Center Voorhees NJ
Franciscan St. Francis Health-Beech Grove Beech Grove IN
Freeman Health System Joplin MO
Geisinger Medical Center CCOP Danville PA
Geisinger Wyoming Valley Medical Center Wilkes Barre PA
Genesis Healthcare System Zainesville OH
Genesys Regional Medical Center Flint MI
Good Samaritan Community Hospital
Good Samaritan Hospital Dayton OH
Good Samaritan Hospital - Dayton Dayton OH
Grady Memorial Hospital Delaware OH
Grady Memorial Hospital Atlanta GA
Grandview Hospital & Medical Center Dayton OH
Grant Medical Center Columbus OH
Greater Baltimore Medical Center Baltimore MD
Green Bay Oncology - Escanaba Escanaba MI
Green Bay Oncology at St. Vincent Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Greenville Health System Cancer Institute-Andrews Greenville SC
Greenville Health System Cancer Institute-Faris Greenville SC
Greenville Health System Cancer Institute-Greer Radiation Greer SC
Greenville Health System Cancer Institute-International Greenville SC
Greenville Health System Cancer Institute-Seneca Seneca SC
Greenville Health System Cancer Institute-Spartanburg Spartanburg SC
Gulf Coast MB-CCOP-Cancer Center at Providence Hospital Mobile AL
Gunderson Clinic La Crosse WI
Heartland Regional Medical Center St. Joseph MO
Hennepin County Medical Center Minneapolis MN
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Hurley Cancer Center Flint MI
Hurley Medical Center Flint MI
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Ingalls Memorial Hospital Harvey IL
Intermountain Medical Center Murray UT
JC Robinson, MD Regional Cancer Center San Pablo CA
Joe Arrington Cancer Research & Treatment Center Lubbock TX
Kaiser Permanent Northern California-Rancho Cordova Rancho Cordova CA
Kaiser Permanente Cancer Treatment Center South San Francisco CA
Kaiser Permanente Northern California Santa Clara CA
Kaiser Permanente Northern California-Oakland Oakland CA
Kaiser Permanente Northern California-Rohnert Park Rohnert Park CA
Kaiser Permanente Northern California-Roseville Roseville CA
Kaiser Permanente Northern California-South Sacramento Sacramento CA
Kaiser Permanente Northern California-South San Francisco South San Francisco CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kalispell Regional Medical Center Kalispell MT
Kansas City Cancer Centers - North Kansas City MO
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
Kraemer Cancer Center West Bend WI
La Porte Hospital La Porte IN
LAC + USC Medical Center Los Angeles CA
Lake/University Seidman Cancer Center Mentor OH
Lakeland Regional Cancer Center Lakeland FL
Lakeland Regional Health System St. Joseph MI
Lankenau Hospital Wynnewood PA
LDS Hospital Salt Lake City UT
Levine Cancer Institute-Pineville Charlotte NC
Lewis Cancer & Research Pavilion at St. Joseph's/Candler Savannah GA
Lewis Cancer & Research Pavilion-Hilton Head/Blufton Hilton Head Island SC
Liberty Hospital Liberty MO
Liberty Radiation Oncology Clinic Liberty MO
Licking Memorial Hospital Newark OH
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
Loyola University Chicago Maywood IL
Main Line CCOP Wynnewood PA
Maine Medical Center Scarborough ME
Maplewood Cancer Center Maplewood MN
Marietta Memorial Hospital Marietta OH
Marshall Radiation Oncology Center Cameron Park CA
Massachusetts General Hospital Boston MA
Matthews Radiation Oncology Center Matthews NC
Mayo Clinic Rochester MN
Mayo Clinic Rochester MN
Mayo Clinic Arizona Phoenix AZ
Mayo Clinic in Arizona Scottsdale AZ
McKay-Dee Hospital Ogden UT
MD Anderson Cancer Center at Cooper-Voorhees Voorhees NJ
Medical College of Wisconsin Milwaukee WI
Medical University of Ohio Toledo OH
Medical University of South Carolina Charleston SC
Medical University of South Carolina Charleston SC
Memorial Hospital South Bend IN
Memorial Medical Center Savannah GA
Memorial Sloan Kettering Cancer Center New York NY
Memorial Sloan Kettering Cancer Center (MSKCC) at Phelps Sleepy Hollow NY
Memorial Sloan Kettering of Rockville Center Rockville NY
Memorial Sloan Kettering-Basking Ridge Basking Ridge NJ
Memorial Sloan-Kettering Cancer Center New York NY
Memorial Sloan-Kettering Cancer Center at Commack Commack NY
Menorah Medical Center Overland Park KS
Mercy Cancer Center Elyria OH
Mercy Cancer Center at St. Ann Toledo OH
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Coon Rapids MN
Mercy Hospital Port Huron Port Huron MI
Mercy Hospital St. Louis St Louis MO
Mercy Hospital-Joplin Joplin MO
Mercy San Juan Radiation Oncology Center Carmichael CA
Mercy-Springfield Springfield MO
Methodist Cancer Center Omaha NE
Metro-MN CCOP St. Louis Park MN
Miami Valley Hospital Dayton OH
Michiana Hematology-Oncology, P.C. Mishawaka IN
Michigan Cancer Research Consortium CCOP Ann Arbor MI
Mid Ohio Oncology Hematology Inc- Mark H. Zangmeister Ctr Cols OH
Mills-Peninsula Health Services San Mateo CA
Montana Cancer Consortium CCOP SOUTH GREAT FALLS MT
Montana Cancer Consortium CCOP Billings MT
Montefiore Medical Center - Moses Campus Bronx NY
Morristown Memorial Hospital Morristown NJ
Mount Carmel Medical Center-Broad Street Columbus OH
Mount Carmel Medical Center-State Street Columbus OH
Mount Carmel-St. Ann's Cancer Center Westerville OH
Nevada Cancer Research Foundation CCOP Las Vegas NV
New Mexico Cancer Care Alliance Albuquerque NM
Newark Beth Israel Medical Center Newark NJ
North Coast Cancer Care Sandusky OH
North Kansas City Hospital North Kansas City MO
North Main Radiation Oncology Providence RI
North Memorial Medical Center Robbinsdale MN
Northeast Georgia Medical Center Gainesville GA
Northeast Radiation Oncology Center Scranton PA
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium CCOP South Bend IN
Northwest Cancer Specialists-Vancouver Vancouver WA
Northwest Community Hospital Arlington Heights IL
Northwestern Memorial Hospital Chicago IL
Oakwood Healthcare Inc Dearborn MI
Ochsner Clinic CCOP New Orleans LA
Ohio State University Medical Center Columbus OH
Ohio State University Medical Center Columbus OH
Olympic Medical Center - Cancer Care Center Sequim WA
Orange Regional Medical Center Middletown NY
Paoli Memorial Hospital Paoli PA
Parkridge University Radiation Oncology Rochester NY
Parkview Cancer Center - Parkview Hospital Fort Wayne IN
Parkview Hospital Fort Wayne IN
PeaceHealth Southwest Medical Center Vancouver WA
PeaceHealth Southwest Medical Center Vancouver WA
PeaceHealth St. Joseph Cancer Center Bellingham WA
Peninsula Regional Medical Center Salisbury MD
Penrose Cancer Center, Penrose-St. Francis Health Services Colorado Springs CO
Phelps County Regional Medical Center Rolla MO
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Poudre Valley Hospital Radiation Oncology Fort Collins CO
Presbyterian Hospital Charlotte NC
Providence Hospital Southfield MI
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence St. Vincent Medical Center Portland OR
Radiation Oncology Associates Fort Wayne IN
Radiation Oncology Centers of Las Vegas Las Vegas NV
Radiological Associates of Sacramento Sacramento CA
Radiological Physics Center (RPC) Houston TX
Reading Hospital Reading PA
Regions Hospital St Paul MN
Regions Radiation Therapy St. Paul MN
Reid Hospital & Health Care Services Richmond IN
Renown Regional Medical Center Reno NV
Research Medical Center Kansas City MO
Rex Cancer Center Raleigh NC
Rhode Island Hospital Providence RI
Rhode Island Hospital Providence RI
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Robinson Radiation Oncology Ravenna OH
Rock Hill Radiation Therapy Center Rock HIll SC
Rocky Mountain Cancer Centers-Aurora Aurora CO
Rocky Mountain Cancer Centers-Boulder Boulder CO
Rocky Mountain Oncology Center Casper WY
Roseville Radiation Oncology Center Roseville CA
Rutgers, The State University of New Jersey New Brunswick NJ
Saint Alphonsus Regional Medical Center Boise ID
Saint Francis Hospital and Medical Center Hartford CT
Saint John's Hospital - HealthEast Maplewood MN
Saint Joseph Mercy Oakland Pontiac MI
Saint Joseph Regional Medical Center - Mishawaka Mishawaka IN
Saint Louis-Cape Girardeau CCOP Saint Louis MO
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Patrick Hospital - Community Hospital Missoula MT
Saint Vincent Hospital Green Bay WI
Saint Vincent Mercy Medical Center Toledo OH
Salem Hospital Salem OR
Sandra L. Maxwell Cancer Center Cedar City UT
Sands Cancer Center Canandaigua NY
Siteman Cancer Center - South County St Louis MO
Siteman Cancer Center/Barnes Jewish St. Peters Hospital St. Peters MO
Skagit Valley Hospital Mount Vernon WA
Solano Radiation Oncology Center Vacaville CA
Southern Ohio Medical Center - Cancer Center Portsmouth OH
Southwest Virginia Regional Cancer Center Norton VA
Sparrow Regional Cancer Center Lansing MI
Sparta Cancer Center Sparta NJ
Springfield Regional Medical Center Springfield OH
St Francis Hospital & Medical Center Hartford CT
St Luke's Hospital Kansas City MO
St Luke's-Roosevelt Hospital Center New York NY
St Mary's Hospital & Medical Center Grand Junction CO
St. Anthony's Health Alton IL
St. Charles Mercy Hospital Oregon OH
St. Francis Hospital Federal Way WA
St. Johns Hospital & Medical Center Grosse Pointe Woods MI
St. Joseph Mercy Hospital Ann Arbor MI
St. Joseph Mercy Oakland Pontac MI
St. Mary Mercy Hospital Livonia MI
St. Mary`s Medical Center Saginaw MI
St. Mary's Hospital Medical Center Green Bay WI
St. Vincent Regional Cancer Center CCOP Green Bay WI
Stanford University Hospitals and Clinics Stanford CA
Stanford University Medical Center Palo Alto CA
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Health Center at Lake Medina Medina OH
Summa Health System Barberton Hospital Barberton OH
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Solano Medical Center Vallejo CA
Sutter Solano Medical Center/Cancer Center Vallejo CA
Swedish Cancer Institute Seattle WA
Swedish Cancer Institute at Swedish Edmonds Edmonds WA
Swedish Cancer Institute-Issaquah Issaquah wa
The Kirklin Clinic at Acton Road Birmingham AL
The Mark H Zangmeister Center Columbus OH
The Methodist Hospital Houston TX
The Regional Cancer Center at Singing River Hospital System Pascagoula MS
The Schiffler Cancer Center Wheeling WV
The University of Arizona Medical Center - University Campus Tucson AZ
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers - Adrian Adrian MI
Toledo Clinic Cancer Centers - Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Trinitas Comprehensive Cancer Center Elizabeth NJ
Trinity Cancer Care Center Minot ND
UH Seidman Cancer Center at Geauga Medical Center Chardon OH
UH Seidman Cancer Center at Southwest General Middleburgh OH
UHHS - Chagrin Highlands Orange Village OH
UHHS - Westlake Medical Center Westlake OH
UHHS-Westlake Medical Center Westlake OH
UMDNJ-New Jersey Medical School Newark NJ
United Hospital St. Paul MN
Unity Hospital Fridley MN
Univ of Kansas Comprehensive Cancer Center Kansas City KS
University Hospitals of Cleveland Cleveland OH
University of Alabama at Birmingham Medical Center Birmingham AL
University of California Davis Medical Center Sacramento CA
University of California, Irvine Orange CA
University of Cincinnati Cincinnati OH
University of Illinois at Chicago Chicago IL
University of Iowa Hospitals and Clinics Iowa City IA
University of Iowa Hospitals and Clinics Iowa City IA
University of Kansas Cancer Center - Southwest Overland Park KS
University of Kansas Cancer Center-East Lee's Summit MO
University of Kansas Cancer Center-North Kansas City MO
University of Kansas Cancer Center-South Kansas City MO
University of Kansas Medical Center Kansas City KS
University of Kentucky Hospital Lexington KY
University of Maryland Medical Systems Baltimore MD
University of Michigan Medical Center Ann Arbor MI
University of Mississippi Medical Center Jackson MS
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Rochester Rochester NY
University of Southern California Los Angeles CA
University of Texas Medical Branch Galveston TX
University of Texas Medical Branch Galveston TX
University of Texas Southwestern Medical School Dallas TX
University of Washington Medical Center Seattle WA
University of Washington Medical Center Seattle WA
University Pointe-Precision Radiotherapy West Chester OH
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centre at UPMC Northwest Seneca PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC- Passavant Hospital Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-HVHS Cancer Center (Moon) Coraopolis PA
UPMC-Jameson Memorial Hospital New Castle PA
UPMC-McKeesport Hospital McKeesport PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-St. Margaret Pittsburgh PA
UPMC-The Washington Hospital Washington PA
UPMC-Uniontown / Robert E. Eberly Pavilion Uniontown PA
Upper Valley Medical Center Troy OH
USON-Cancer Care Northwest - Spokane Spokane WA
Utah Cancer Specialists Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
UTMB Cancer Center at Victory Lakes League City TX
Valley Medical Oncology Consultants Pleasanton CA
Virtua-Memorial Hospital Burlington County, Inc. Mount Holly NJ
Washington University St. Louis MO
Webber Cancer Center Warren MI
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Medical Center Kingsport TN
Wenatchee Valley Medical Center P.S. Wenatchee WA
Wentworth-Douglass Hospital Dover NH
Westfields Hospital New Richmond WI
Westfields Hospital/Cancer Center of Western Wisconsin New Richmond WI
William W. Backus Hospital Norwich CT
Yale University New Haven CT
Yale University New Haven CT
Zablocki VA Medical Center-Wood Milwaukee WI
Zablocki Veterans Administration Medical Center Milwaukee WI
Updated: 4/17/2014

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