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RTOG 1010 Protocol Information

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A Phase III Trial Evaluating the Addition of Trastuzumab to Trimodality Treatment of Her2-Overexpressing Esophageal Adenocarcinoma
Principal Investigator: Howard Safran, MD
Primary Objective:

To determine if trastuzumab increases disease-free survival when combined with trimodality treatment (radiation plus chemotherapy followed by surgery) for patients with HER2-overexpressing esophageal adenocarcinoma

Patient Population:

Pathologically confirmed HER2 expressing adenocarcinoma of the esophagus centrally assessed within 56 days prior to Step 2 registration; primary adenocarcinoma of the esophagus involving the mid (up to 25 cm), distal and/or esophagogastric junction.

Target Accrual: 160
Current Accrual: 424
Status: Open to Accrual
Date: 12/30/2010
Participating Sites:
21st Century Oncology Las Vegas NV
Abbott Northwestern Hospital Minneapolis MN
Adena Regional Medical Center Chillicothe OH
Akron City Hospital Akron OH
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
Alta Bates Summit Medical Center - Summit Campus Oakland CA
Aria Health Philadelphia PA
Assarian Cancer Center Novi MI
Baptist Hospital of Miami Miami FL
Barnes Jewish West County Hospital St. Louis MO
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute CCOP Oakland CA
Benefis Healthcare-Sletten Cancer Institute Great Falls MT
Berkshire Medical Center Pittsfield MA
Beth Israel Medical Center New York NY
Billings Clinic Cancer Center Billings MT
Bixby Medical Center Adrian MI
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
California Pacific Medical Center San Francisco CA
Cancer Care Center, Inc Salem OH
Cancer Centers of the Carolinas-Andrews Greenville SC
Cancer Centers of the Carolinas-Faris Road Greenville SC
Cancer Centers of the Carolinas-Greer Radiation Oncology Greer SC
Cancer Centers of the Carolinas-Seneca Seneca SC
Cancer Centers of the Carolinas-Spartanburg Spartanburg SC
Cancer Treatment Center Wooster OH
Carolina Medical Center-Northeast Concord NC
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Carolinas Medical Center-Union Monroe NC
Cedars-Sinai Medical Center Los Angeles CA
Central Baptist Hospital Lexington KY
Central Maine Medical Center Lewiston ME
Christiana Care Health Services, Inc. CCOP Newark DE
City of Hope Medical Center Duarte CA
Columbia-Presbyterian Medical Center New York NY
Columbus Community Clinical Oncology Program Columbus OH
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Henderson Henderson NV
Comprehensive Cancer Ctrs of Nevada - Northwest Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Summerlin Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Sunset Las Vegas NV
Concord Hospital Payson Center for Cancer Care Concord NH
Cooper Health System Camden NJ
Cooper Health System-Voorhees Voorhees NJ
Cox Health System Springfield MO
Dana Farber/Brigham & Woman's CC at Milford Regional Milford MA
Dana Farber/Brigham & Women's Center at South Shore South Weymouth MA
Danville Regional Medical Center Danville VA
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Cancer Center East St. George UT
Doctor's Hospital Columbus OH
Door County Cancer Center Sturgeon Bay WI
East Bay Radiation Oncology Center Castro Valley CA
Elkhart General Hospital Elkhart IN
Epic Care Dublin - Partners in Cancer Care Dublin CA
Epic Care Pleasant Hill - Partners in Cancer Care Pleasant Hill CA
Fairview Ridges Hospital Burnsville MN
Fairview Southdale Hospital Edina MN
Florida Hospital Orlando FL
Flower Hospital Sylvania OH
Fox Chase Cancer Center Philadelphia PA
Fox Chase Virtua Health Cancer Treatment Center Voorhees NJ
Freeman Health System Joplin MO
Geisinger Medical Center CCOP Danville PA
Geisinger Wyoming Valley Medical Center Wilkes Barre PA
Genesis Healthcare System Zainesville OH
Genesys Regional Medical Center Flint MI
Grady Memorial Hospital Delaware OH
Grant Medical Center Columbus OH
Greater Baltimore Medical Center Baltimore MD
Greenville CCOP - Cancer Centers of the Carolinas-Eastside Greenville SC
Gulf Coast MB-CCOP-Cancer Center at Providence Hospital Mobile AL
Heartland Regional Medical Center St. Joseph MO
Hennepin County Medical Center Minneapolis MN
Hurley Cancer Center Flint MI
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Ingalls Memorial Hospital Harvey IL
Intermountain Medical Center Murray UT
JC Robinson, MD Regional Cancer Center San Pablo CA
Joe Arrington Cancer Research & Treatment Center Lubbock TX
Kaiser Permanent Northern California-Rancho Cordova Rancho Cordova CA
Kaiser Permanente Northern California Santa Clara CA
Kaiser Permanente Northern California-Oakland Oakland CA
Kaiser Permanente Northern California-Rohnert Park Rohnert Park CA
Kaiser Permanente Northern California-Roseville Roseville CA
Kaiser Permanente Northern California-South Sacramento Sacramento CA
Kaiser Permanente Northern California-South San Francisco South San Francisco CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kalispell Regional Medical Center Kalispell MT
Kansas City CCOP Prairie Village KS
La Porte Hospital La Porte IN
LAC + USC Medical Center Los Angeles CA
Lake/University Seidman Cancer Center Mentor OH
Lakeland Regional Health System St. Joseph MI
Lankenau Hospital Wynnewood PA
LDS Hospital Salt Lake City UT
Levine Cancer Institute-Pineville Charlotte NC
Lewis Cancer & Research Pavilion at St. Joseph's/Candler Savannah GA
Liberty Radiation Oncology Clinic Liberty MO
Licking Memorial Hospital Newark OH
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
Loyola University Chicago Maywood IL
Main Line CCOP Wynnewood PA
Maine Medical Center Scarborough ME
Maplewood Cancer Center Maplewood MN
Marietta Memorial Hospital Marietta OH
Massachusetts General Hospital Boston MA
Matthews Radiation Oncology Center Matthews NC
McKay-Dee Hospital Ogden UT
Medical University of Ohio Toledo OH
Memorial Hospital South Bend IN
Memorial Medical Center Savannah GA
Memorial Sloan Kettering Cancer Center (MSKCC) at Phelps Sleepy Hollow NY
Memorial Sloan Kettering of Rockville Center Rockville NY
Memorial Sloan Kettering-Basking Ridge Basking Ridge NJ
Memorial Sloan-Kettering Cancer Center New York NY
Memorial Sloan-Kettering Cancer Center at Commack Commack NY
Menorah Medical Center Overland Park KS
Mercy Cancer Center Elyria OH
Mercy Cancer Center at St. Ann Toledo OH
Mercy Hospital Coon Rapids MN
Mercy Hospital Port Huron Port Huron MI
Mercy Hospital St. Louis St Louis MO
Mercy Hospital-Joplin Joplin MO
Mercy-Springfield Springfield MO
Methodist Cancer Center Omaha NE
Metro-MN CCOP St. Louis Park MN
Michiana Hematology-Oncology, P.C. Mishawaka IN
Michigan Cancer Research Consortium CCOP Ann Arbor MI
Mid Ohio Oncology Hematology Inc- Mark H. Zangmeister Ctr Cols OH
Mills-Peninsula Health Services San Mateo CA
Montana Cancer Consortium CCOP Billings MT
Morristown Memorial Hospital Morristown NJ
Mount Carmel Medical Center-State Street Columbus OH
Mount Carmel-St. Ann's Cancer Center Westerville OH
Nevada Cancer Research Foundation CCOP Las Vegas NV
Newark Beth Israel Medical Center Newark NJ
North Kansas City Hospital North Kansas City MO
North Main Radiation Oncology Providence RI
North Memorial Medical Center Robbinsdale MN
Northeast Georgia Medical Center Gainesville GA
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium CCOP South Bend IN
Northwest Community Hospital Arlington Heights IL
Northwestern Memorial Hospital Chicago IL
Oakwood Healthcare Inc Dearborn MI
Ochsner Clinic CCOP New Orleans LA
Ohio State University Medical Center Columbus OH
Paoli Memorial Hospital Paoli PA
Parkview Cancer Center - Parkview Hospital Fort Wayne IN
PeaceHealth St. Joseph Cancer Center Bellingham WA
Peninsula Regional Medical Center Salisbury MD
Penrose Cancer Center, Penrose-St. Francis Health Services Colorado Springs CO
Phelps County Regional Medical Center Rolla MO
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Poudre Valley Hospital Radiation Oncology Fort Collins CO
Presbyterian Hospital Charlotte NC
Providence Hospital Southfield MI
Radiation Oncology Associates Fort Wayne IN
Radiation Oncology Centers of Las Vegas Las Vegas NV
Regions Radiation Therapy St. Paul MN
Renown Regional Medical Center Reno NV
Research Medical Center Kansas City MO
Rex Cancer Center Raleigh NC
Rhode Island Hospital Providence RI
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Rock Hill Radiation Therapy Center Rock HIll SC
Rocky Mountain Oncology Center Casper WY
Saint Alphonsus Regional Medical Center Boise ID
Saint John's Hospital - HealthEast Maplewood MN
Saint Joseph Regional Medical Center - Mishawaka Mishawaka IN
Saint Vincent Mercy Medical Center Toledo OH
Salem Hospital Salem OR
Siteman Cancer Center - South County St Louis MO
Siteman Cancer Center/Barnes Jewish St. Peters Hospital St. Peters MO
Skagit Valley Hospital Mount Vernon WA
Southern Ohio Medical Center - Cancer Center Portsmouth OH
Southwest Virginia Regional Cancer Center Norton VA
Sparrow Regional Cancer Center Lansing MI
Sparta Cancer Center Sparta NJ
Springfield Regional Medical Center Springfield OH
St Francis Hospital & Medical Center Hartford CT
St Luke's Hospital Kansas City MO
St Luke's-Roosevelt Hospital Center New York NY
St. Charles Mercy Hospital Oregon OH
St. Francis Hospital Federal Way WA
St. Johns Hospital & Medical Center Grosse Pointe Woods MI
St. Joseph Mercy Hospital Ann Arbor MI
St. Joseph Mercy Oakland Pontac MI
St. Mary Mercy Hospital Livonia MI
St. Mary`s Medical Center Saginaw MI
St. Mary's Hospital Medical Center Green Bay WI
St. Vincent Regional Cancer Center CCOP Green Bay WI
Stanford University Medical Center Palo Alto CA
Summa Health Center at Lake Medina Medina OH
Summa Health System Barberton Hospital Barberton OH
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Solano Medical Center Vallejo CA
Swedish Cancer Institute Seattle WA
Swedish Cancer Institute-Issaquah Issaquah wa
The Kirklin Clinic at Acton Road Birmingham AL
The University of Arizona Medical Center - University Campus Tucson AZ
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers - Adrian Adrian MI
Toledo Clinic Cancer Centers - Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Trinity Cancer Care Center Minot ND
UH Seidman Cancer Center at Southwest General Middleburgh OH
UHHS - Chagrin Highlands Orange Village OH
UHHS - Westlake Medical Center Westlake OH
UMDNJ-New Jersey Medical School Newark NJ
United Hospital St. Paul MN
Unity Hospital Fridley MN
Univ of Kansas Comprehensive Cancer Center Kansas City KS
University Hospitals of Cleveland Cleveland OH
University of Alabama at Birmingham Medical Center Birmingham AL
University of California, Irvine Orange CA
University of Cincinnati Cincinnati OH
University of Illinois at Chicago Chicago IL
University of Iowa Hospitals and Clinics Iowa City IA
University of Kansas Cancer Center - Southwest Overland Park KS
University of Kansas Cancer Center-East Lee's Summit MO
University of Kansas Cancer Center-North Kansas City MO
University of Kansas Cancer Center-South Kansas City MO
University of Maryland Medical Systems Baltimore MD
University of Michigan Medical Center Ann Arbor MI
University of Mississippi Medical Center Jackson MS
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Southern California Los Angeles CA
University of Texas Medical Branch Galveston TX
University of Washington Medical Center Seattle WA
University Pointe-Precision Radiotherapy West Chester OH
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centre at UPMC Northwest Seneca PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC- Passavant Hospital Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-HVHS Cancer Center (Moon) Coraopolis PA
UPMC-Jameson Memorial Hospital New Castle PA
UPMC-McKeesport Hospital McKeesport PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-St. Margaret Pittsburgh PA
UPMC-The Washington Hospital Washington PA
USON-Cancer Care Northwest - Spokane Spokane WA
Utah Cancer Specialists Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
UTMB Cancer Center at Victory Lakes League City TX
Valley Medical Oncology Consultants Pleasanton CA
Virtua-Memorial Hospital Burlington County, Inc. Mount Holly NJ
Washington University St. Louis MO
Webber Cancer Center Warren MI
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Medical Center Kingsport TN
Wenatchee Valley Medical Center P.S. Wenatchee WA
Wentworth-Douglass Hospital Dover NH
Westfields Hospital New Richmond WI
William W. Backus Hospital Norwich CT
Yale University New Haven CT
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 4/17/2014

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