Translational Research Program

RTOG Translational Research Program (TRP) Committee

The goal of the RTOG Translational Research Program (TRP) is to promote communication of scientific ideas from the research laboratory into RTOG clinical trials by informing the basic science committees on important emerging research in tumor biology, chemical and biological modifiers, and pathology. To that end, specimens derived from RTOG clinical trials are viewed as our most valuable and precious resource, limited and nonrenewable. It is the TRP Committee's highest priority to encourage, optimize and prudently prioritize the use of this resource. To meet this goal RTOG employs a comprehensive application process to allocate biospecimen material. Requests for Application (RFP) are issued for our largest trials.

Requests for Application: RTOG 0617

Biospecimen Availability – Inventory of biospecimens from RTOG clinical trials

Policies/Procedures

Biospecimen Request Procedures – Procedures for submitting an application to use RTOG biospecimens

RTOG Policy on Letters of Support for Grant Funding – Investigators requesting a letter of support (LOS) from RTOG must follow this policy

Forms - Note: Requests to use materials from the RTOG Biospecimen Repository are processed on a quarterly basis. Letters of support for grant applications that plan to use RTOG biospecimens cannot be provided unless the TRP application has been approved by RTOG and NCI. This process can take 4 - 6 months.

RTOG Resource Request Application Form – Investigators requesting biospecimen materials, clinical data, dosimetric data, and/or statistical analysis must submit this form

Biospecimen Feasibility Letter of Intent (LOI) Form – Investigators requesting the use of biospecimen material must submit this form together with their RTOG Resource Request Application Form. The project will receive an initial review for specimen availability and feasibility upon submission of this form. If this initial review is favorable the investigator will be asked to submit a TRP Biospecimen Access Application Form.

TRP Biospecimen Access Application Form– Investigators responding to a posted RTOG RFA or who have received approval of their LOI submit this form to begin the formal review process.

Cooperative Group Banking (CGB) Biospecimen Access Application Form – This form is used to request Biospecimen material from the Cooperative Group Banking repositories.

TRP Committee Liaisons

Chair

Adam P. Dicker, MD, PhD, adamdicker@mac.com

Bioinformatics

Ying Xiao, PhD, ying.xiao@jefferson.edu

Soren Benzon, DSc, PhD, bentzen@humonc.wisc.edu

Brain Tumors

Arnab Chakravarti, MD, arnab.chakravarti@osumc.edu

Breast Cancer

Wendy Woodward, MD, PhD, wwoodward@mdanderson.org

GI Cancers

Chandan Guha, MD, cguha@montefiore.org