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RTOG 1008 Protocol Information

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A Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors
Principal Investigator: Cristina Rodriguez, MD David J. Adelstein, MD
Primary Objective:
  • Determine the feasibility of conducting a cooperative group prospective clinical trial in patients with resected malignant salivary gland tumors
  • Acquire preliminary efficacy data comparing postoperative radiotherapy alone to concurrent chemotherapy and radiation using weekly cisplatin.
     
Patient Population:
 
Patients with salivary gland carcinomas involving the major (parotid, submandibular, or sublingual glands) and minor salivary glands of the head and neck with the following histologies: intermediate-grade adenocarcinoma or intermediate-grade mucoepidermoid carcinoma; high-grade adenocarcinoma or high-grade mucoepidermoid carcinoma or salivary duct carcinoma; high-grade acinic cell carcinoma or high-grade (>30% solid component) adenoid cystic carcinoma; patients with no evidence of hematogenous metastasis, who have undergone curative intent surgical resection and are found to have the following risk factors for recurrence: T3-4, or N1-3 disease, or T1-2 N0 patients with positive or close (< = 1mm) microscopic margins of resection
Target Accrual: 120
Current Accrual: 109
Status: Open to Accrual
Date: 8/5/2011
Participating Sites:
21st Century Oncology Las Vegas NV
Abbott Northwestern Hospital Minneapolis MN
ACR Clinical Research Center Philadelphia PA
Adventist Medical Center Portland OR
Akron City Hospital Akron OH
Allegiance Health/W.A. Foote Memorial Hospital Jackson MI
Arizona Oncology - Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Auburn Radiation Oncology Center Auburn CA
Aultman Hospital Canton OH
Bay Area Medical Center Marinette WI
Beth Israel Medical Center New York NY
Bixby Medical Center Adrian MI
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
Cancer Care Center, Inc Salem OH
Cancer Treatment Center Wooster OH
Center for Cancer Care @ Goshen Health System Goshen IN
Centre Hospitalier de l`Université de Montréal-Notre Dame Montreal Quebec
Christiana Care Health Services, Inc. CCOP Newark DE
Christiana Care Health System-Christiana Hospital Newark DE
City of Hope Medical Center Duarte CA
Clackamas Radiation Oncology Center Clackamas OR
Cleveland Clinic Foundation Cleveland OH
Cleveland Clinic Foundation Cleveland OH
Columbia River CCOP Portland OR
Community Medical Center Toms River NJ
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Henderson Henderson NV
Comprehensive Cancer Ctrs of Nevada - Northwest Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Summerlin Las Vegas NV
Comprehensive Cancer Ctrs of Nevada - Sunset Las Vegas NV
Cross Cancer Institute Edmonton, Alberta
Dixie Medical Cancer Center East St. George UT
Door County Cancer Center Sturgeon Bay WI
Duke University Medical Center Durham NC
Emory University Atlanta GA
Emory University Hospital Midtown Atlanta GA
Emory University Hospital Midtown Atlanta GA
Emory University/Winship Cancer Institute Atlanta GA
Fairbanks Memorial Hospital Fairbanks AK
Fairview Ridges Hospital Burnsville MN
Fairview Southdale Hospital Edina MN
Flower Hospital Sylvania OH
Fox Chase Cancer Center Philadelphia PA
Fox Chase Cancer Center Philadelphia PA
Fox Chase Cancer Center-Buckingham Furlong PA
Fox Chase Virtua Health Cancer Treatment Center Voorhees NJ
Genesys Regional Medical Center Flint MI
Grady Memorial Hospital Atlanta GA
Greater Baltimore Medical Center Baltimore MD
Green Bay Oncology at St. Vincent Hospital Green Bay WI
Greenville Health System Cancer Institute-Andrews Greenville SC
Greenville Health System Cancer Institute-Faris Greenville SC
Greenville Health System Cancer Institute-Greer Radiation Greer SC
Greenville Health System Cancer Institute-International Greenville SC
Greenville Health System Cancer Institute-Seneca Seneca SC
Greenville Health System Cancer Institute-Spartanburg Spartanburg SC
Greenville Health System Cancer Institute-Spartanburg Spartanburg SC
Helen F Graham Cancer Center Newark DE
Hennepin County Medical Center Minneapolis MN
Highland Hospital Rochester NY
Hurley Cancer Center Flint MI
Image-Guided Therapy QA Center (ITC) St. Louis MO
Interim LSU Public Hospital (ILH-NO) New Orleans LA
Intermountain Medical Center Murray UT
James Graham Brown Cancer Ctr at University of Louisville Louisville KY
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
King Faisal Specialist Hospital and Research Centre Riyadh 11211
LAC + USC Medical Center Los Angeles CA
Lake/University Seidman Cancer Center Mentor OH
Lankenau Hospital Wynnewood PA
LDS Hospital Salt Lake City UT
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Loyola University Chicago Maywood IL
LSU Health Science Center-New Orleans MB-CCOP New Orleans LA
Maimonides Medical Center Brooklyn NY
Main Line CCOP Wynnewood PA
Maplewood Cancer Center Maplewood MN
Marshall Radiation Oncology Center Cameron Park CA
Mary Bird Perkins Cancer Center Baton Rouge LA
McGill University Montreal
McKay-Dee Hospital Ogden UT
MD Anderson Cancer Center Orlando Orlando FL
Medical College of Wisconsin Milwaukee WI
Medical University of Ohio Toledo OH
Medical University of South Carolina Charleston SC
Memorial Sloan Kettering Cancer Center New York NY
Memorial Sloan Kettering Cancer Center (MSKCC) at Phelps Sleepy Hollow NY
Memorial Sloan Kettering Cancer Center Commack Commack NY
Memorial Sloan Kettering of Rockville Center Rockville NY
Memorial Sloan Kettering-Basking Ridge Basking Ridge NJ
Memorial Sloan-Kettering Cancer Center New York NY
Memorial Sloan-Kettering Cancer Center at Commack Commack NY
Mercy Cancer Center Elyria OH
Mercy Cancer Center at St. Ann Toledo OH
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Coon Rapids MN
Mercy Hospital Port Huron Port Huron MI
Mercy San Juan Radiation Oncology Center Carmichael CA
Methodist Cancer Center Omaha NE
Metro-MN CCOP St. Louis Park MN
Michigan Cancer Research Consortium CCOP Ann Arbor MI
Mount Sinai School of Medicine New York NY
Nevada Cancer Research Foundation CCOP Las Vegas NV
New Mexico Cancer Care Alliance Albuquerque NM
North Coast Cancer Care Sandusky OH
North Memorial Medical Center Robbinsdale MN
Northeastern Ontario Regional Cancer Centre Sudbury, Ontario
Northwest Cancer Specialists-Vancouver Vancouver WA
Northwestern Memorial Hospital Chicago IL
Oakwood Healthcare Inc Dearborn MI
Ohio State University Medical Center Columbus OH
Oregon Health & Science University Portland OR
Paoli Memorial Hospital Paoli PA
PeaceHealth Southwest Medical Center Vancouver WA
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
Penrose Cancer Center, Penrose-St. Francis Health Services Colorado Springs CO
Princess Margaret Hospital Toronto, Ontario
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Portland Medical Center Portland OR
Providence Saint Vincent Medical Center Portland OR
Providence St. Vincent Medical Center Portland OR
Radiation Oncology Centers of Las Vegas Las Vegas NV
Radiological Associates of Sacramento Sacramento CA
Radiological Physics Center (RPC) Houston TX
Rapid City Regional Hospital Rapid City SD
Regions Radiation Therapy St. Paul MN
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Roseville Radiation Oncology Center Roseville CA
Saint Alphonsus Regional Medical Center Boise ID
Saint John's Hospital Springfield IL
Saint John's Hospital - HealthEast Maplewood MN
Saint Mary's Hospital Green Bay WI
Saint Vincent Mercy Medical Center Toledo OH
Sandra L. Maxwell Cancer Center Cedar City UT
Sentara Cancer Institute at Sentara CarePlex Hospital Hampton VA
Sentara Norfolk General Hospital Norfolk VA
Sentara Virginia Beach General Hospital Virginia Beach VA
Solano Radiation Oncology Center Vacaville CA
Southwest Virginia Regional Cancer Center Norton VA
Sparrow Regional Cancer Center Lansing MI
Sparta Cancer Center Sparta NJ
St Francis Hospital & Medical Center Hartford CT
St Johns Hospital, Cancer Institute Springfield IL
St Mary's Hospital & Medical Center Grand Junction CO
St. Charles Mercy Hospital Oregon OH
St. Francis Hospital Federal Way WA
St. Johns Hospital & Medical Center Grosse Pointe Woods MI
St. Joseph Mercy Hospital Ann Arbor MI
St. Joseph Mercy Oakland Pontac MI
St. Louis University Hospital St. Louis MO
St. Mary Mercy Hospital Livonia MI
St. Mary`s Medical Center Saginaw MI
St. Mary's Hospital Medical Center Green Bay WI
St. Vincent Regional Cancer Center CCOP Green Bay WI
Stanford University Medical Center Palo Alto CA
State University of New York Upstate Medical University Syracuse NY
Summa Health Center at Lake Medina Medina OH
Summa Health System Barberton Hospital Barberton OH
SUNY Upstate Medical University Syracuse NY
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Kirklin Clinic at Acton Road Birmingham AL
The Prostate Center King of Prussia PA
The Schiffler Cancer Center Wheeling WV
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers - Adrian Adrian MI
Toledo Clinic Cancer Centers - Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Touro Infirmary New Orleans LA
UCSD – University of California, San Diego LaJolla CA
UCSF-Mount Zion San Francisco CA
UH Seidman Cancer Center at Southwest General Middleburgh OH
UMDNJ-New Jersey Medical School Newark NJ
United Hospital St. Paul MN
Unity Hospital Fridley MN
Univ of Kansas Comprehensive Cancer Center Kansas City KS
Univ. of Miami Sylvester Comp Cancer Ctr-Deerfield Beach Deerfield Beach FL
University Health Network-Princess Margaret Hospital Toronto
University Hospitals of Cleveland Cleveland OH
University of Alabama at Birmingham Birmingham AL
University of Alabama at Birmingham Medical Center Birmingham AL
University of California Davis Medical Center Sacramento CA
University of California San Francisco San Francisco CA
University of Cincinnati Cincinnati OH
University of Cincinnati Cincinnati OH
University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora CO
University of Colorado Denver Aurora CO
University of Florida College of Medicine Gainesville FL
University of Florida Health Science Center Jacksonville FL
University of Iowa Hospitals and Clinics Iowa City IA
University of Kansas Cancer Center - Southwest Overland Park KS
University of Kansas Cancer Center-East Lee's Summit MO
University of Kansas Cancer Center-North Kansas City MO
University of Kansas Cancer Center-South Kansas City MO
University of Kentucky Hospital Lexington KY
University of Miami Miller School of Medicine Miami FL
University of Michigan Medical Center Ann Arbor MI
University of Mississippi Medical Center Jackson MS
University of North Carolina - Chapel Hill Chapel Hill NC
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Southern California Los Angeles CA
University of Texas Southwestern Medical Center Dallas TX
University of Texas Southwestern Medical School Dallas TX
University of Texas-MD Anderson Cancer Center Houston TX
University of Utah Health Science Center Salt Lake City UT
University of Wisconsin Hospital Madison WI
University Pointe West Chester OH
University Pointe-Precision Radiotherapy West Chester OH
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centre at UPMC Northwest Seneca PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC- Passavant Hospital Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-HVHS Cancer Center (Moon) Coraopolis PA
UPMC-Jameson Memorial Hospital New Castle PA
UPMC-Magee Women's Hospital Pittsburgh PA
UPMC-McKeesport Hospital McKeesport PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-St. Margaret Pittsburgh PA
UPMC-The Washington Hospital Washington PA
UPMC-Uniontown / Robert E. Eberly Pavilion Uniontown PA
Utah Cancer Specialists Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virginia Mason CCOP Seattle WA
Virtua-Memorial Hospital Burlington County, Inc. Mount Holly NJ
Webber Cancer Center Warren MI
Wellmont Holston Valley Medical Center Kingsport TN
Wellmont Medical Associates Oncology and Hematology-Kingsport Kingsport TN
William W. Backus Hospital Norwich CT
Updated: 5/7/2014

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