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RTOG 1008 Protocol Information

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A Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors
Principal Investigator: Cristina Rodriguez, MD David J. Adelstein, MD
Primary Objective:
  • Determine the feasibility of conducting a cooperative group prospective clinical trial in patients with resected malignant salivary gland tumors
  • Acquire preliminary efficacy data comparing postoperative radiotherapy alone to concurrent chemotherapy and radiation using weekly cisplatin.
     
Patient Population:
 
Patients with salivary gland carcinomas involving the major (parotid, submandibular, or sublingual glands) and minor salivary glands of the head and neck with the following histologies: intermediate-grade adenocarcinoma or intermediate-grade mucoepidermoid carcinoma; high-grade adenocarcinoma or high-grade mucoepidermoid carcinoma or salivary duct carcinoma; high-grade acinic cell carcinoma or high-grade (>30% solid component) adenoid cystic carcinoma; patients with no evidence of hematogenous metastasis, who have undergone curative intent surgical resection and are found to have the following risk factors for recurrence: T3-4, or N1-3 disease, or T1-2 N0 patients with positive or close (< = 1mm) microscopic margins of resection
Target Accrual: 120
Current Accrual: 91
Status: Open to Accrual
Date: 8/5/2011
Participating Sites:
Abbott Northwestern Hospital Minneapolis MN
Akron City Hospital Akron OH
Arizona Oncology - Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Auburn Radiation Oncology Center Auburn CA
Aultman Hospital Canton OH
Bay Area Medical Center Marinette WI
Bixby Medical Center Adrian MI
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
Cancer Care Center, Inc Salem OH
Cancer Centers of the Carolinas-Andrews Greenville SC
Cancer Centers of the Carolinas-Faris Road Greenville SC
Cancer Centers of the Carolinas-Greer Radiation Oncology Greer SC
Cancer Centers of the Carolinas-Seneca Seneca SC
Cancer Centers of the Carolinas-Spartanburg Spartanburg SC
Cancer Treatment Center Wooster OH
Center for Cancer Care @ Goshen Health System Goshen IN
Christiana Care Health Services, Inc. CCOP Newark DE
Cleveland Clinic Foundation Cleveland OH
Cross Cancer Institute Edmonton, Alberta
Door County Cancer Center Sturgeon Bay WI
Emory University Atlanta GA
Emory University Hospital Midtown Atlanta GA
Fairview Ridges Hospital Burnsville MN
Fairview Southdale Hospital Edina MN
Flower Hospital Sylvania OH
Fox Chase Cancer Center Philadelphia PA
Fox Chase Virtua Health Cancer Treatment Center Voorhees NJ
Genesys Regional Medical Center Flint MI
Greater Baltimore Medical Center Baltimore MD
Greenville CCOP - Cancer Centers of the Carolinas-Eastside Greenville SC
Hennepin County Medical Center Minneapolis MN
Hurley Cancer Center Flint MI
James Graham Brown Cancer Ctr at University of Louisville Louisville KY
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
LAC + USC Medical Center Los Angeles CA
Lima Memorial Hospital Lima OH
London Regional Cancer Program London Ontario
Loyola University Chicago Maywood IL
Maplewood Cancer Center Maplewood MN
Marshall Radiation Oncology Center Cameron Park CA
MD Anderson Cancer Center Orlando Orlando FL
Medical College of Wisconsin Milwaukee WI
Medical University of Ohio Toledo OH
Medical University of South Carolina Charleston SC
Mercy Cancer Center at St. Ann Toledo OH
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Coon Rapids MN
Mercy Hospital Port Huron Port Huron MI
Mercy San Juan Radiation Oncology Center Carmichael CA
Methodist Cancer Center Omaha NE
Metro-MN CCOP St. Louis Park MN
Michigan Cancer Research Consortium CCOP Ann Arbor MI
North Memorial Medical Center Robbinsdale MN
Northeastern Ontario Regional Cancer Centre Sudbury, Ontario
Northwestern Memorial Hospital Chicago IL
Oakwood Healthcare Inc Dearborn MI
Oregon Health & Science University Portland OR
Penrose Cancer Center, Penrose-St. Francis Health Services Colorado Springs CO
Princess Margaret Hospital Toronto, Ontario
Radiological Associates of Sacramento Sacramento CA
Rapid City Regional Hospital Rapid City SD
Regions Radiation Therapy St. Paul MN
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Roseville Radiation Oncology Center Roseville CA
Saint Alphonsus Regional Medical Center Boise ID
Saint John's Hospital - HealthEast Maplewood MN
Saint Vincent Mercy Medical Center Toledo OH
Sentara Cancer Institute at Sentara CarePlex Hospital Hampton VA
Sentara Norfolk General Hospital Norfolk VA
Sentara Virginia Beach General Hospital Virginia Beach VA
Solano Radiation Oncology Center Vacaville CA
Southwest Virginia Regional Cancer Center Norton VA
Sparrow Regional Cancer Center Lansing MI
Sparta Cancer Center Sparta NJ
St Francis Hospital & Medical Center Hartford CT
St Johns Hospital, Cancer Institute Springfield IL
St. Charles Mercy Hospital Oregon OH
St. Johns Hospital & Medical Center Grosse Pointe Woods MI
St. Joseph Mercy Hospital Ann Arbor MI
St. Joseph Mercy Oakland Pontac MI
St. Mary Mercy Hospital Livonia MI
St. Mary`s Medical Center Saginaw MI
St. Mary's Hospital Medical Center Green Bay WI
St. Vincent Regional Cancer Center CCOP Green Bay WI
Summa Health Center at Lake Medina Medina OH
Summa Health System Barberton Hospital Barberton OH
SUNY Upstate Medical University Syracuse NY
The Kirklin Clinic at Acton Road Birmingham AL
The Schiffler Cancer Center Wheeling WV
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers - Adrian Adrian MI
Toledo Clinic Cancer Centers - Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
UH Seidman Cancer Center at Southwest General Middleburgh OH
United Hospital St. Paul MN
Unity Hospital Fridley MN
Univ of Kansas Comprehensive Cancer Center Kansas City KS
University Hospitals of Cleveland Cleveland OH
University of Alabama at Birmingham Medical Center Birmingham AL
University of Cincinnati Cincinnati OH
University of Colorado Denver Aurora CO
University of Florida College of Medicine Gainesville FL
University of Iowa Hospitals and Clinics Iowa City IA
University of Kansas Cancer Center - Southwest Overland Park KS
University of Kansas Cancer Center-East Lee's Summit MO
University of Kansas Cancer Center-North Kansas City MO
University of Kansas Cancer Center-South Kansas City MO
University of Michigan Medical Center Ann Arbor MI
University of Mississippi Medical Center Jackson MS
University of Southern California Los Angeles CA
University of Texas-MD Anderson Cancer Center Houston TX
University Pointe-Precision Radiotherapy West Chester OH
Virtua-Memorial Hospital Burlington County, Inc. Mount Holly NJ
Webber Cancer Center Warren MI
Wellmont Holston Valley Medical Center Kingsport TN
Updated: 3/25/2014

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