#4

SUMMARY OF CHANGES

RTOG 96-07 Misoprostol April 30, 1999



The following correction is in effect:

Cover Page - Dr. Hanson is no longer at an RTOG institution and was deleted as co-study chair.

Section 7.3.5 - The phone and fax numbers for Neli Giofreda at Searle are (847) 506-8740 and (847) 506-8761. Unused tablets will be returned to Searle.



10/22/98 A new supply of Misoprostol is available and accrual can resume effective immediately. IMPORTANT NOTICE! 10/13/98 The Misoprostal study 9607 is temporarily closed for lack of drug availability.





#3

SUMMARY OF CHANGES

RTOG 96-07 Misoprostol May 13, 1998



The following correction is in effect:

Section 6.2.1 deleted "...during the first week of radiation..." to fit with Section 12.1.

All amendments to this study must be submitted to your IRB for approval





#2

SUMMARY OF CHANGES

RTOG 96-07 Misoprostol January 21, 1998



The following changes are in effect:

Eligibility Checklist

a) Three additional questions were added after Q18 to verify eligibility

b) Whether any component of the patient's care was given at a VA or military facility will also be requested at registration

Section 1.2, paragraph 3, line 5 "versus placebo" was deleted.

Section 5.1

Patients may not be registered onsite via modem for this study; misoprostol cannot be shipped for any patient registered by this method.

Section 7.0 The RTOG's IND number was added (IND #54,684)

All amendments to this study must be
submitted to your IRB for approval