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RTOG 0020 Protocol Information

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A Randomized Phase II Trial of Weekly Gemcitabine, Paclitaxel and External Irradiation (50.4 Gy) Followed by the Farnesyl Transferase Inhibitor R115777 (NSC #702818) for Locally Advanced Pancreatic Cancer
Protocol Documents
Current Version Date: 7/15/2005
Principal Investigator: Tyvin Rich, M.D.
Primary Objective:

To determine the one-year survival rates of patients treated with paclitaxel, gemcitabine, and radiation with or without R115777.

Patient Population:

Pathologically confirmed, unresectable, non-metastatic adenocarcinoma of the pancreas.
Patients with biliary or gastro-duodenal obstruction must have drainage prior to starting chemoradiation.
All malignant disease must be encompassable within a single irradiation field (15 x 15 cm maximum).
No malignancy (within the past two years) except for non-melanomatous skin cancer or carcinoma in situ of the cervix, uterus, or bladder.
No previous chemotherapy for pancreatic cancer (Gemzar® or Taxol®).

Target Accrual: 154
Current Accrual: 195
Status: Terminated
Date: 12/1/2003
Participating Sites:
Abington Memorial Hospital Abington PA
Advocate Good Samaritan Hospital Downers Grove IL
Advocate Good Shepherd Hospital Barrington IL
Advocate Illinois Masonic Medical Center Chicago IL
Akron General Medical Center Akron OH
Allegheny General Hospital Pittsburgh PA
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
Arlington Cancer Center Arlington TX
Atlanta Regional CCOP Atlanta GA
AtlantiCare Regional Medical Center Pomona NJ
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Hospital of Miami Miami FL
Bay Area Tumor Institute Oakland CA
Boston Medical Center MBCCOP Boston MA
Butler Regional Cancer Center Butler PA
California Pacific Medical Center-Pacific Campus San Francisco CA
Cancer Care Center, Inc Salem OH
Cancer Treatment Center Wooster OH
Cape Cod Hospital Hyannis MA
Central Illinois CCOP Decatur IL
Cleveland Clinic Foundation Cleveland OH
Clifton Springs Hospital and Clinic Clifton Springs NY
Columbus Regional Hospital Columbus IN
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Cottonwood Hospital Medical Center Murray UT
Dayton CCOP Kettering OH
Deaconess Medical Center Spokane WA
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Don & Sybil Harrington Cancer Center Amarillo TX
East Bay Radiation Oncology Center Castro Valley CA
Finley Hospital Dubuque IA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Greater Baltimore Medical Center Baltimore MD
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Harbin Clinic Rome GA
Highland Hospital Rochester NY
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Inspira Medical Center Vineland Vineland NJ
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Lehigh Valley Hospital - Muhlenberg Bethlehem PA
Lehigh Valley Hospital-Cedar Crest Allentown PA
Liberty Hospital Liberty MO
Lifespan Providence RI
Loma Linda University Medical Center Loma Linda CA
Louisiana State University Health Science Center New Orleans LA
Lutheran General Hospital Park Ridge IL
Mainline Health CCOP Wynnewood PA
Mary Bird Perkins Cancer Center Baton Rouge LA
McKay-Dee Hospital Center Ogden UT
Mercy Hospital Pittsburgh PA
Methodist Cancer Center Omaha NE
Metro-Minnesota CCOP St. Louis Park MN
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Mobile Infirmary Medical Center Mobile AL
Monmouth Medical Center Long Branch NJ
Mount Sinai Medical Center Miami Beach FL
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Nevada Cancer Research Foundation CCOP Las Vegas NV
Newark Beth Israel Medical Center Newark NJ
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northridge Hospital Medical Center Northridge CA
Northwestern Ontario Regional Cancer Centre Thunder Bay, Ontario
Northwestern University Chicago IL
Ochsner Medical Center Jefferson New Orleans LA
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Pomona Valley Hospital Medical Center Pomona CA
Pottstown Scanning & Treatment Center Pottstown PA
Providence Holy Cross Medical Center Mission Hills CA
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
Radiological Associates of Sacramento Sacramento CA
Reading Hospital Reading PA
Rhode Island Hospital Providence RI
Richard L. Roudebush VA Medical Center Indianapolis IN
Saint John Medical Center Tulsa OK
Saint John Regional Hospital Saint John, NB
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Santa Rosa Memorial Hospital CCOP Santa Rosa CA
Southeast Cancer Control Consortium CCOP Winston Salem NC
St. Louis University Hospital St. Louis MO
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Health Western Division Cancer Research Group Novato CA
The James Graham Brown Cancer Center at University of Louisville Louisville KY
Thomas Jefferson University Hospital Philadelphia PA
Trinity Cancer Care Center Minot ND
Trinity's Tony Teramana Cancer Center Steubenville OH
Tulane University Medical Center New Orleans LA
UCHealth Memorial Hospital Central Colorado Springs CO
Union Hospital Terre Haute IN
United Hospital St. Paul MN
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Hawaii Cancer Center Honolulu HI
University of Rochester Rochester NY
University of Texas Medical Branch Galveston TX
University of Utah Health Science Center Salt Lake City UT
University of Wisconsin Hospital and Clinics Madison WI
Upstate Carolina CCOP Spartanburg SC
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Virtua Memorial Mount Holly NJ
Warren Radiation Therapy Center Warren NJ
Washington University School of Medicine St. Louis MO
WellSpan Health-York Hospital York PA
West Allis Memorial Hospital West Allis WI
West Penn Hospital Pittsburgh PA
Western Oncology Research Consortium Portland OR
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
William Beaumont Hospital-Royal Oak Royal Oak MI
Updated: 11/7/2011

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