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RTOG 0129 Protocol Information

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A Phase III Trial of Concurrent Radiation and Chemotherapy (Followed by Surgery for Residual Primary/N2-3 Nodal Disease) for Advanced Head and Neck Carcinomas
Protocol Documents
Current Version Date: 7/16/2014
Principal Investigator: Phuc Felix Nguyen-Tân, MD
Primary Objective:

To determine whether intensification of radiation, relative to conventional fractionation plus cisplatin in the combined therapy setting can further improve the overall survival of patients with advanced HNSCC.

Patient Population:

Histologic proof of squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx

Target Accrual: 720
Current Accrual: 743
Status: Closed to Accrual
Date: 6/23/2005
Participating Sites:
21st Century Oncology - Cape Coral Cape Coral FL
21st Century Oncology - Coral Springs Coral Springs FL
21st Century Oncology- Port Charlotte Port Charlotte FL
21st Century Oncology, Inc. Ft. Myers FL
21st Century Oncology-Arcadia Arcadia FL
21st Century Oncology-Deerfield Beach Deerfield Beach FL
21st Century Oncology-Englewood Englewood FL
21st Century Oncology-Fort Myers Fort Myers FL
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
21st Century Oncology-Plantation Plantation FL
21st Century Oncology-Sarasota Sarasota FL
21st Century Oncology-Venice Venice FL
Abington Memorial Hospital Abington PA
Advocate Good Samaritan Hospital Downers Grove IL
Advocate Good Shepherd Hospital Barrington IL
Advocate Illinois Masonic Medical Center Chicago IL
Akron General Medical Center Akron OH
Allegiance Health Jackson MI
Alta Bates Summit Medical Center - Summit Campus Oakland CA
AnMed Health Cancer Center Anderson SC
Anne Arundel Medical Center Annapolis MD
Annie Penn Memorial Hospital Reidsville NC
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Aultman Hospital Canton OH
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Baton Rouge General Medical Center Baton Rouge LA
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute Oakland CA
Beaumont Hospital-Dearborn Dearborn MI
Beth Israel Deaconess Medical Center Boston MA
Blanchard Valley Hospital Findlay OH
Bon Secours Saint Mary's Hospital Richmond VA
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Brigham and Women's Hospital Boston MA
Bronson Methodist Hospital Kalamazoo MI
Brooke Army Medical Center Fort Sam Houston TX
Bryn Mawr Hospital Bryn Mawr PA
Cancer Care Center, Inc Salem OH
Cancer Treatment Center Wooster OH
Cape Cod Hospital Hyannis MA
Cape Radiation Oncology Cape Girardeau MO
Centre Hospitalier de l`Universite de Montreal-Notre Dame Montreal Quebec
Champlain Valley Physicians Hospital Medical Center Plattsburgh NY
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Christiana Care Health System-Christiana Hospital Newark DE
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Quebec
Clifton Springs Hospital and Clinic Clifton Springs NY
Columbia Saint Mary's Hospital - Ozaukee Mequon WI
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Columbus Regional Hospital Columbus IN
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Comprehensive Cancer Centers of Nevada Las Vegas NV
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas NV
Comprehensive Cancer Centers of Nevada - Northwest Las Vegas NV
Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas NV
Cone Health Cancer Center Greensboro NC
Cottonwood Hospital Medical Center Murray UT
Cox Medical Center Springfield MO
CoxHealth South Hospital Springfield MO
Danville Regional Medical Center Danville VA
Dartmouth Hitchcock Medical Center Lebanon NH
Dayton CCOP Kettering OH
Delbert Day Cancer Institute at PCRMC Rolla MO
Dixie Medical Center Regional Cancer Center East St. George UT
Doctor H. Bliss Murphy Cancer Centre St. John's, NL
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo CA
Don & Sybil Harrington Cancer Center Amarillo TX
East Bay Radiation Oncology Center Castro Valley CA
Einstein Medical Center Philadelphia Philadelphia PA
Elkhart General Hospital Elkhart IN
Emory University Hospital Midtown Atlanta GA
Emory University Hospital/Winship Cancer Institute Atlanta GA
EvergreenHealth Medical Center Kirkland WA
Finley Hospital Dubuque IA
Fox Chase Cancer Center Philadelphia PA
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Freeman Health System Joplin MO
Froedtert and the Medical College of Wisconsin Milwaukee WI
Genesys Hurley Cancer Institute Flint MI
Good Samaritan Hospital - Dayton Dayton OH
Grady Health System Atlanta GA
Grand Rapids Clinical Oncology Program Grand Rapids MI
Grandview Hospital Dayton OH
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Greenville Health System Cancer Institute-Andrews Greenville SC
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Harbin Clinic Rome GA
Health Sciences North Sudbury, Ontario
Holy Cross Hospital Fort Lauderdale FL
Holy Family Memorial Hospital Manitowoc WI
Hunter Holmes McGuire Veterans Administration Medical Center Richmond VA
Hurley Medical Center Flint MI
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Inspira Medical Center Vineland Vineland NJ
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intermountain Medical Center Murray UT
IU Health La Porte Hospital La Porte IN
John B Amos Cancer Center Columbus GA
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
Lake Huron Medical Center Port Huron MI
Lakeland Hospital St Joseph MI
Lakeland Regional Health System St. Joseph MI
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
Logan Regional Hospital Logan UT
Loma Linda University Medical Center Loma Linda CA
London Regional Cancer Program London Ontario
Long Island Jewish Medical Center Lake Success NY
Los Angeles County-USC Medical Center Los Angeles CA
Louisiana State University Health Science Center New Orleans LA
Lutheran General Hospital Park Ridge IL
M D Anderson Cancer Center Houston TX
Mainline Health CCOP Wynnewood PA
Marshfield Clinic Marshfield WI
Mary Bird Perkins Cancer Center Baton Rouge LA
Mass General/ North Shore Cancer Center Danvers MA
Massachusetts General Hospital Boston MA
Mayo Clinic Rochester MN
Mayo Clinic in Arizona Scottsdale AZ
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute - Flint Flint MI
McLaren Northern Michigan Petoskey MI
Memorial Hospital South Bend IN
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood FL
Memorial University Medical Center Savannah GA
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Health Saint Mary's Grand Rapids MI
Mercy Hospital Pittsburgh PA
Mercy Hospital Joplin Joplin MO
Mercy Hospital Saint Louis St Louis MO
Mercy Hospital Springfield Springfield MO
Mercy San Juan Medical Center Carmichael CA
Methodist Cancer Center Omaha NE
Methodist Hospital Philadelphia PA
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Monmouth Medical Center Long Branch NJ
Moorehead Memorial Hospital Eden NC
Mount Sinai Hospital Chicago IL
Mount Sinai Medical Center Miami Beach FL
Munson Medical Center Traverse City MI
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Naval Medical Center San Diego CA
Naval Medical Center - Portsmouth Portsmouth VA
Nevada Cancer Research Foundation CCOP Las Vegas NV
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
Norris Cotton Cancer Center Saint Johnsbury VT
North Shore-LIJ Health System CCOP Manhasset NY
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium South Bend IN
Northwest Community Hospital Arlington Heights IL
Northwestern Ontario Regional Cancer Centre Thunder Bay, Ontario
Northwestern University Chicago IL
Ochsner Baptist Medical Center New Orleans LA
Oncology Institute of Greater Lafayette Lafayette IN
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Paoli Memorial Hospital Paoli PA
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
Pomona Valley Hospital Medical Center Pomona CA
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
Providence Holy Cross Medical Center Mission Hills CA
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
QEII Health Sciences Centre/Nova Scotia Health Authority Halifax, Nova Scotia
Radiation Oncology Center Alliance OH
Radiation Oncology Centers of Nevada Central Las Vegas NV
Radiological Associates of Sacramento Sacramento CA
Randolph Hospital Ashboro NC
Rapid City Regional Hospital Rapid City SD
Regional Hospital of Scranton Scranton PA
Reid Health Richmond IN
Renown Regional Medical Center Reno NV
Richard L. Roudebush VA Medical Center Indianapolis IN
Riverview Medical Center/Booker Cancer Center Red Bank NJ
Roswell Park Cancer Institute Buffalo NY
Rutherford Hospital Rutherfordton NC
Saint Agnes Hospital Baltimore MD
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Francis Medical Center Cape Girardeau MO
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint John Medical Center Tulsa OK
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Joseph Regional Medical Center South Bend In
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Rita's Medical Center Lima OH
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sandra L Maxwell Cancer Center Cedar City UT
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital St. Louis MO
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
South Suburban Oncology Center Quincy MA
Southeast Cancer Control Consortium CCOP Winston Salem NC
Sparrow Hospital Lansing MI
Sparta Cancer Center Sparta NJ
Spartanburg Medical Center Spartanburg SC
St Anne's Hospital Fall River MA
St Joseph Hospital Mishawaka IN
St. Louis University Hospital St. Louis MO
State University of New York Downstate Medical Center Brooklyn NY
State University of New York Upstate Medical University Syracuse NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Medical Center Sacramento Sacramento CA
The Cancer Center for Southern Kentucky Bowling Green KY
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Research Institute of the McGill University Health Centr Montreal
Thomas Jefferson University Hospital Philadelphia PA
Trinity Cancer Care Center Minot ND
Tulane University Medical Center New Orleans LA
UCHealth Memorial Hospital Central Colorado Springs CO
UCSF Medical Center-Mount Zion San Francisco CA
University Medical Center New Orleans New Orleans LA
University of Alabama at Birmingham Cancer Center Birmingham AL
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Minnesota/Masonic Cancer Center Minneapolis MN
University of Missouri - Ellis Fischel Columbia MO
University of Southern California Los Angeles CA
University of Texas Medical Branch Galveston TX
University of Utah Health Science Center Salt Lake City UT
University of Vermont Medical Center Burlington VT
University of Wisconsin Hospital and Clinics Madison WI
University Pointe-Precision Radiotherapy West Chester OH
Upper Valley Medical Center Troy OH
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Vanderbilt University/Ingram Cancer Center Nashville TN
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Virtua Memorial Mount Holly NJ
Virtua Voorhees Voorhees NJ
Wake Forest University Health Sciences Winston-Salem NC
Warren Radiation Therapy Center Warren NJ
Washington University School of Medicine St. Louis MO
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wayne State University/Karmanos Cancer Institute Detroit MI
West Allis Memorial Hospital West Allis WI
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Wilford Hall USAF Medical Center Lackland AFB TX
Wilmed Radiation Oncology Services Wilson NC
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 7/23/2014

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