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RTOG 0132 Protocol Information

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A Phase II Trial of Neoadjuvant/Adjuvant STI-571 (Gleevec NSC #716051) for Primary and Recurrent Operable Malignant GIST Expressing the Kit Receptor Tyrosine Kinase (CD117)
Protocol Documents
Current Version Date: 8/10/2007
Principal Investigator: Burton Eisenberg, M.D.
Primary Objective:

Provide a comprehensive correlative evaluation of the biological effects of Gleevec on malignant GIST by comparison of pre and post drug administration tissue samples from individual patients.

Patient Population:

Biopsy-proven diagnosis of either potentially resectable primary (>= 5 cm) or potentially resectable recurrent (local or metastatic [>=2 cm]) GIST. Immunohistochemical documentation of KIT (CD117) expression in tumor

Target Accrual: 63
Current Accrual: 63
Status: Terminated
Date: 11/5/2013
Participating Sites:
AnMed Health Cancer Center Anderson SC
Atlanta Regional CCOP Atlanta GA
Borgess Medical Center Kalamazoo MI
Brigham and Women's Hospital Boston MA
Bronson Methodist Hospital Kalamazoo MI
Carle Cancer Center Urbana IL
Case Western Reserve University Cleveland OH
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Christiana Care Health System-Christiana Hospital Newark DE
City of Hope Comprehensive Cancer Center Duarte CA
Compass Oncology Rose Quarter Portland OR
Compass Oncology Vancouver Vancouver WA
Cottonwood Hospital Medical Center Murray UT
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Dixie Medical Center Regional Cancer Center East St. George UT
Emory Saint Joseph's Hospital Atlanta GA
Fox Chase Cancer Center Philadelphia PA
Gundersen Lutheran Medical Center La Crosse WI
Huntsman Cancer Institute/University of Utah Salt Lake City UT
John B Amos Cancer Center Columbus GA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
LDS Hospital Salt Lake City UT
Legacy Emanuel Hospital and Health Center Portland OR
Legacy Good Samaritan Hospital and Medical Center Portland OR
Legacy Meridian Park Hospital Tualatin OR
Legacy Mount Hood Medical Center Gresham OR
M D Anderson Cancer Center Houston TX
Massachusetts General Hospital Cancer Center Boston MA
Mayo Clinic Rochester MN
Mayo Clinic in Florida Jacksonville FL
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Moffitt South Cancer Center Tampa FL
Monmouth Medical Center Long Branch NJ
Norris Cotton Cancer Center-North Saint Johnsbury VT
Northside Hospital Atlanta GA
Northwest Community Hospital Arlington Heights IL
Northwestern University Chicago IL
Orange Regional Medical Center Middletown NY
Oregon Health and Science University Portland OR
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
PeaceHealth Southwest Medical Center Vancouver WA
Penn State Milton S Hershey Medical Center Hershey PA
Piedmont Hospital Atlanta GA
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Saint Vincent Medical Center Portland OR
Radiation Oncology Associates of Albuquerque Albuquerque NM
Rapid City Regional Hospital Rapid City SD
Roswell Park Cancer Institute Buffalo NY
Rush-Copley Medical Center Aurora IL
Rutherford Hospital Rutherfordton NC
Santa Rosa Memorial Hospital Santa Rosa CA
Scott and White Memorial Hospital Temple TX
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Southern Regional Medical Center Riverdale GA
Spartanburg Medical Center Spartanburg SC
Thomas Jefferson University Hospital Philadelphia PA
Tom Baker Cancer Centre Calgary, Alberta
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Wisconsin Hospital and Clinics Madison WI
UPMC-Presbyterian Hospital Pittsburgh PA
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Veterans Administration New Jersey Health Care System East Orange NJ
Washington University School of Medicine St. Louis MO
Wayne State University/Karmanos Cancer Institute Detroit MI
Western Oncology Research Consortium Portland OR
Wichita CCOP Wichita KS
Yale University New Haven CT
Updated: 11/6/2013

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