Minimize
 

RTOG 0227 Protocol Information

Minimize
Phase I/II Study of Pre-Irradiation Chemotherapy with Methotrexate, Rituximab, and Temozolomide and Post-Irradiation Temozolomide for Primary Central Nervous System Lymphoma
Protocol Documents
Current Version Date: 3/24/2010
Principal Investigator: Jon Glass, MD
Primary Objective:

To assess the maximum tolerated dose (MTD) of temozolomide (TMZ) in combination with methotrexate (MTX) and rituximab (RTX) when administered prior to twice daily fractionated whole brain radiation therapy (WBRT) in patients with primary central nervous system lymphoma.

Patient Population:

Primary CNS lymphoma based on positive biopsy, or CSF, or vitreous cytology (in association with measurable intraparenchymal tumor).

Target Accrual: 52-64
Current Accrual: 60
Status: Terminated
Date: 12/15/2016
Participating Sites:
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Abbott-Northwestern Hospital Minneapolis MN
Adventist Medical Center Portland OR
Allegiance Health Jackson MI
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
Alta Bates Summit Medical Center - Summit Campus Oakland CA
AnMed Health Cancer Center Anderson SC
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute Oakland CA
Beaumont Hospital-Dearborn Dearborn MI
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
California Pacific Medical Center-Pacific Campus San Francisco CA
Carle Cancer Center Urbana IL
Case Western Reserve University Cleveland OH
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Clackamas Radiation Oncology Center Clackamas OR
Cleveland Clinic Foundation Cleveland OH
Community Memorial Hospital Menomonee Falls WI
Compass Oncology Rose Quarter Portland OR
Compass Oncology Vancouver Vancouver WA
Cottonwood Hospital Medical Center Murray UT
Dartmouth Hitchcock Medical Center Lebanon NH
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo CA
East Bay Radiation Oncology Center Castro Valley CA
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Finley Hospital Dubuque IA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Genesys Hurley Cancer Institute Flint MI
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay WI
Gundersen Lutheran Medical Center La Crosse WI
Hennepin County Medical Center Minneapolis MN
Hurley Medical Center Flint MI
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intermountain Medical Center Murray UT
John F Kennedy Medical Center Edison NJ
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
King Faisal Specialist Hospital and Research Centre Riyadh 11211
Lake Huron Medical Center Port Huron MI
LDS Hospital Salt Lake City UT
Legacy Emanuel Hospital & Health Center Portland OR
Legacy Good Samaritan Hospital & Medical Center Portland OR
Legacy Meridian Park Hospital Tualatin OR
Legacy Mount Hood Medical Center Gresham OR
Liberty Hospital Liberty MO
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
M D Anderson Cancer Center Houston TX
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Medical University of South Carolina Charleston SC
Mercy Hospital Pittsburgh PA
Mercy Hospital Coon Rapids MN
Methodist Hospital Philadelphia PA
Metro-Minnesota CCOP St. Louis Park MN
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Mobile Infirmary Medical Center Mobile AL
Nevada Cancer Research Foundation CCOP Las Vegas NV
Norris Cotton Cancer Center Saint Johnsbury VT
North Memorial Medical Health Center Robbinsdale MN
Palo Alto Medical Foundation Health Care Palo Alto CA
PeaceHealth Southwest Medical Center Vancouver WA
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Saint Vincent Medical Center Portland OR
Regions Hospital St. Paul MN
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Rutherford Hospital Rutherfordton NC
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint John's Hospital - Healtheast Maplewood MN
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sandra L Maxwell Cancer Center Cedar City UT
Sentara Norfolk General Hospital Norfolk VA
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital St. Louis MO
Southeast Cancer Control Consortium CCOP Winston Salem NC
Sparrow Hospital Lansing MI
Spartanburg Medical Center Spartanburg SC
St Johns Hospital, Cancer Institute Springfield IL
Sutter Health Western Division Cancer Research Group Novato CA
Tel-Aviv Sourasky Medical Center Tel-Aviv
The Cancer Center for Southern Kentucky Bowling Green KY
Thomas Jefferson University Hospital Philadelphia PA
Union Hospital Terre Haute IN
United Hospital St. Paul MN
United Hospital St. Paul MN
Unity Hospital Fridley MN
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Southern California Los Angeles CA
Upper Delaware Valley Cancer Center Milford PA
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Virtua Memorial Mount Holly NJ
Washington University School of Medicine St. Louis MO
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Western Oncology Research Consortium Portland OR
William Beaumont Hospital-Royal Oak Royal Oak MI
Wilmed Radiation Oncology Services Wilson NC
Updated: 12/15/2016

You must be logged in to view this file.

Login  |  Close

You must be logged in to view this file.

Login  |  Close