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RTOG 0233 Protocol Information

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A Phase II Randomized Trial for Patients With Muscle-Invading Bladder Cancer Evaluating Transurethral Surgery and BID Irradiation Plus Either Paclitaxel and Cisplatin or 5-Fluorouracil and Cisplatin Followed by Selective Bladder Preservation and Gemcitabi
Protocol Documents
Current Version Date: 3/29/2010
Principal Investigator: Anthony L. Zietman, M.D.
Primary Objective:

To estimate the safety and tolerance of induction chemoradiotherapy including paclitaxel, cisplatin, and irradiation (TCI) or 5-Fluorouracil, cisplatin, and irradiation (FCI); chemoradiotherapy will be followed by radical cystectomy if the initial tumor response is incomplete or by consolidation chemoradiotherapy if the tumor has cleared. Four cycles of outpatient adjuvant gemcitabine-paclitaxel chemotherapy is then given.

Patient Population:

Operable patients with muscularis propria invasion carcinoma of the bladder, all histologies

Target Accrual: 96
Current Accrual: 97
Status: Closed to Accrual
Date: 1/11/2008
Participating Sites:
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Allegiance Health Jackson MI
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
AnMed Health Cancer Center Anderson SC
Arizona Oncology Services Foundation Scottsdale AZ
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Bay Medical Center Panama City FL
Beaumont Hospital-Dearborn Dearborn MI
Bixby Medical Center Adrian MI
Blanchard Valley Hospital Findlay OH
Boca Raton Community Hospital-Lynn Regional Cancer Center Boca Raton FL
Borgess Medical Center Kalamazoo MI
Brigham and Women's Hospital Boston MA
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
California Pacific Medical Center-Pacific Campus San Francisco CA
Carle Cancer Center Urbana IL
Case Western Reserve University Cleveland OH
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Cleveland Clinic Foundation Cleveland OH
Cottonwood Hospital Medical Center Murray UT
Dartmouth Hitchcock Medical Center Lebanon NH
Dixie Medical Center Regional Cancer Center East St. George UT
Emerson Hospital/MGH Cancer Center Concord MA
Finley Hospital Dubuque IA
Firelands Regional Medical Center Sandusky OH
Flower Hospital Sylvania OH
Fox Chase Cancer Center Philadelphia PA
Genesys Hurley Cancer Institute Flint MI
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Holy Cross Hospital Fort Lauderdale FL
Hurley Medical Center Flint MI
Inspira Medical Center Vineland Vineland NJ
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intermountain Medical Center Murray UT
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Lake Huron Medical Center Port Huron MI
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
Lowell General Hospital Lowell MA
Mainline Health CCOP Wynnewood PA
Massachusetts General Hospital Boston MA
Massachusetts General Hospital Boston MA
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute - Flint Flint MI
Medical University of South Carolina Charleston SC
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood FL
Memorial University Medical Center Savannah GA
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Pittsburgh PA
Mercy Saint Anne Hospital Toledo OH
Mercy San Juan Medical Center Carmichael CA
Methodist Hospital Philadelphia PA
Methodist Medical Center of Illinois Peoria IL
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Mount Sinai Medical Center Miami Beach FL
Norris Cotton Cancer Center Saint Johnsbury VT
Northeast Radiation Oncology Center Dunmore PA
Northwestern University Chicago IL
Novant Health Forsyth Medical Center Winston Salem NC
Paoli Memorial Hospital Paoli PA
Parkview Hospital Randallia Fort Wayne IN
Pocono Medical Center East Strousburg PA
Radiation Oncology Associates PC Fort Wayne IN
Radiological Associates of Sacramento Sacramento CA
Rapid City Regional Hospital Rapid City SD
Riverview Medical Center/Booker Cancer Center Red Bank NJ
Rush-Copley Medical Center Aurora IL
Rutherford Hospital Rutherfordton NC
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Charles Hospital Oregon OH
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Sandra L Maxwell Cancer Center Cedar City UT
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Sparrow Hospital Lansing MI
Spartanburg Medical Center Spartanburg SC
St Johns Hospital, Cancer Institute Springfield IL
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Medical Center Sacramento Sacramento CA
The Research Institute of the McGill University Health Centr Montreal
The Toledo Hospital/Toledo Children's Hospital Toledo OH
Thomas Jefferson University Hospital Philadelphia PA
Toledo Community Hospital Oncology Program CCOP Toledo OH
UCHealth Memorial Hospital Central Colorado Springs CO
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Colorado Hospital Aurora CO
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Kentucky/Markey Cancer Center Lexington KY
University of Missouri - Ellis Fischel Columbia MO
University of Texas Medical Branch Galveston TX
University of Vermont Medical Center Burlington VT
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Veterans Administration Hospital-East Orange Campus East Orange NJ
Virtua Memorial Mount Holly NJ
Virtua Voorhees Voorhees NJ
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
West Penn Hospital Pittsburgh PA
Wilmed Radiation Oncology Services Wilson NC
Updated: 3/21/2014

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