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RTOG 0246 Protocol Information

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A Phase II Study of a Paclitaxel-Based Chemoradiotherapy Regimen with Selective Surgical Salvage for Resectable Loco-Regionally Advanced Carcinoma of the Esophagus
Protocol Documents
Current Version Date: 3/24/2010
Principal Investigator: Stephen G. Swisher, M.D.
Primary Objective:

Determine feasibility and ability to accrue to a non-operative approach with definitive chemotherapy, concurrent chemoradiation, and selective surgical salvage

Patient Population:

Histologic proof of primary squamous cell or adenocarcinoma of the esophagus or gastroesophageal junction (no tumor extension beyond 2 cm into stomach);
Locoregionally advanced resectable carcinoma of esophagus without systemic metastases (except T1NO);
Celiac adenopathy (<=2 cm) is allowed. Palpable supraclavicular nodes must have biopsy proof of “no cancer” before study entry;
Excludes patients with TE fistula or invasion into mucosa of trachea or major bronchi, systemic metastatic disease, or uncontrolled serious medical or mental illnesses;
Zubrod Performance Status 0-1

Target Accrual: 42
Current Accrual: 43
Status: Terminated
Date: 12/15/2016
Participating Sites:
Abbott-Northwestern Hospital Minneapolis MN
Allegheny General Hospital Pittsburgh PA
Allegheny Valley Hospital Natrona Heights PA
Allegiance Health Jackson MI
AnMed Health Cancer Center Anderson SC
Ascension Saint John Hospital Grosse Pointe Woods MI
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute Oakland CA
Beaumont Hospital - Dearborn Dearborn MI
Bryn Mawr Hospital Bryn Mawr PA
Cancer Treatment Center Wooster OH
Community Medical Center Toms River NJ
Cottonwood Hospital Medical Center Murray UT
Cox Medical Center Springfield MO
CoxHealth South Hospital Springfield MO
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
East Bay Radiation Oncology Center Castro Valley CA
Einstein Medical Center Philadelphia Philadelphia PA
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Finley Hospital Dubuque IA
Fox Chase Cancer Center Philadelphia PA
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Genesys Hurley Cancer Institute Flint MI
Good Samaritan Hospital - Dayton Dayton OH
Grandview Hospital Dayton OH
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Harbin Clinic Rome GA
Hennepin County Medical Center Minneapolis MN
Huntsman Cancer Institute/University of Utah Salt Lake City UT
Hurley Medical Center Flint MI
Intercommunity Cancer Center Monroeville PA
Kettering Medical Center Dayton OH
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Lovelace Medical Center-Downtown Albuquerque NM
M D Anderson Cancer Center Houston TX
Mainline Health CCOP Wynnewood PA
McKay-Dee Hospital Center Ogden UT
Memorial Health University Medical Center Savannah GA
Mercy Hospital Coon Rapids MN
Mercy Hospital Springfield Springfield MO
Metro-Minnesota CCOP St. Louis Park MN
Miami Cancer Institute Miami FL
Miami Valley Hospital Dayton OH
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Monmouth Medical Center Long Branch NJ
Mount Sinai Hospital Chicago IL
Nevada Cancer Research Foundation CCOP Las Vegas NV
North Memorial Medical Health Center Robbinsdale MN
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Ochsner Medical Center Jefferson New Orleans LA
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Paoli Memorial Hospital Paoli PA
Providence Holy Cross Medical Center Mission Hills CA
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
Queen's Medical Center Honolulu HI
Radiation Oncology Associates of Albuquerque Albuquerque NM
Radiation Oncology Center Alliance OH
Regions Hospital St. Paul MN
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Riverview Medical Center/Booker Cancer Center Red Bank NJ
Rutherford Hospital Rutherfordton NC
Saint John Macomb-Oakland Hospital Warren MI
Saint John's Hospital - Healtheast Maplewood MN
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Mary's of Michigan Saginaw MI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Singing River Hospital Pascagoula MS
Sparrow Hospital Lansing MI
Spartanburg Medical Center Spartanburg SC
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
The Cancer Center for Southern Kentucky Bowling Green KY
The Cancer Center of Hawaii-Liliha Honolulu HI
Thomas Jefferson University Hospital Philadelphia PA
Trinity's Tony Teramana Cancer Center Steubenville OH
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
United Hospital St. Paul MN
United Hospital St. Paul MN
Unity Hospital Fridley MN
University of Colorado Hospital Aurora CO
University of Hawaii Cancer Center Honolulu HI
University of New Mexico Cancer Center Albuquerque NM
Upper Valley Medical Center Troy OH
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Veteran Affairs Medical Center Dayton OH
Virtua Memorial Mount Holly NJ
Washington University School of Medicine St. Louis MO
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Wilmed Radiation Oncology Services Wilson NC
Yale-New Haven Hospital Saint Raphael Campus New Haven CT
Updated: 12/15/2016

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