RTOG 0319 Protocol Information

A Phase I/II Trial to Evaluate Three Dimensional Conformal Radiation Therapy (3D-CRT) Confined to the Region of the Lumpectomy Cavity For Stage I And II Breast Carcinoma
Protocol Documents
Current Version Date: 9/30/2003
Principal Investigator: Frank A. Vicini, M.D.
Primary Objective:

This study will evaluate the technical feasibility and reproducibility, cosmetic results, complication rates, and local control rate of 3D-CRT confined to the region of the lumpectomy cavity for patients with Stage I and II (= < 3 cm) carcinoma of the breast (non-lobular histology) treated with tylectomy with histologically assessed negative surgical margins (> 2 mm), up to 3 nodes positive at axillary dissection or sentinel lymph node biopsy, with no extensive intraductal component (EIC) by the Harvard definition.

Patient Population:

Invasive ductal, medullary, papillary, colloid (mucinous), tubular histologies. AJCC Stage I or II (T1N0, T1N1, T2N0, T2N1); lesion <= 3 cm.


This study has a CTEP status of completed (primary endpoint published). Because CTEP does not process amendments for completed studies, updated contact information for Dr. Frank Vicini, Principal Investigator, is provided below: 

Frank A. Vicini, M.D.
Botsford Cancer Center

27900 Grand River Avenue

Suite 120

Farmington Hills, Michigan 48336


Target Accrual: 46
Current Accrual: 58
Status: Terminated
Date: 12/15/2016
Participating Sites:
ACR Clinical Research Center Philadelphia PA
Allegheny General Hospital Pittsburgh PA
Alta Bates Summit Medical Center-Herrick Campus Berkeley CA
Anne Arundel Medical Center Annapolis MD
Annie Penn Memorial Hospital Reidsville NC
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Bay Area Tumor Institute Oakland CA
California Pacific Medical Center-Pacific Campus San Francisco CA
Cancer Treatment Center Wooster OH
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Quebec
CHUM - Centre Hospitalier de l'Universite de Montreal Montreal Quebec
Cleveland Clinic Foundation Cleveland OH
Columbus CCOP Columbus OH
Community Memorial Hospital Menomonee Falls WI
Cone Health Cancer Center Greensboro NC
Cross Cancer Institute Edmonton, Alberta
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
East Bay Radiation Oncology Center Castro Valley CA
Einstein Medical Center Philadelphia Philadelphia PA
Finley Hospital Dubuque IA
Grant Medical Center Columbus OH
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Hillcrest Hospital Cancer Center Mayfield Heights OH
Holy Cross Hospital Fort Lauderdale FL
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Intermountain Medical Center Murray UT
Jupiter Medical Center Jupiter FL
LDS Hospital Salt Lake City UT
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Loyola University Medical Center Maywood IL
M D Anderson Cancer Center Houston TX
Mayo Clinic Rochester MN
Mayo Clinic in Arizona Scottsdale AZ
Mayo Clinic in Florida Jacksonville FL
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute-Flint Flint MI
Medical College of Wisconsin Milwaukee WI
Memorial Sloan Kettering Cancer Center New York NY
Methodist Medical Center of Illinois Peoria IL
Mills-Peninsula Medical Center San Mateo CA
Missouri Valley Cancer Consortium Omaha NE
Mobile Infirmary Medical Center Mobile AL
Mount Sinai Medical Center Miami Beach FL
Northwestern University Chicago IL
Novant Health Forsyth Medical Center Winston Salem NC
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York NY
Ochsner Medical Center Jefferson New Orleans LA
Penn State Milton S Hershey Medical Center Hershey PA
Radiation Oncology Associates of Albuquerque Albuquerque NM
Radiological Physics Center (RPC) Houston TX
Randolph Hospital Ashboro NC
Rex Cancer Center Raleigh NC
Roswell Park Cancer Institute Buffalo NY
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Sandra L Maxwell Cancer Center Cedar City UT
Scott and White Memorial Hospital Temple TX
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southwestern Vermont Medical Center Bennington VT
Summa Health System - Akron Campus Akron OH
Sutter Cancer Research Consortium Novato CA
Thomas Jefferson University Hospital Philadelphia PA
Torrance Memorial Medical Center Torrance CA
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Colorado Hospital Aurora CO
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Rochester Rochester NY
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Virtua Memorial Mount Holly NJ
Washington University School of Medicine St. Louis MO
Wayne State University/Karmanos Cancer Institute Detroit MI
West Penn Hospital Pittsburgh PA
Western Oncology Research Consortium Portland OR
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
William Beaumont Hospital - Troy Troy MI
William Beaumont Hospital-Royal Oak Royal Oak MI
Yale University New Haven CT
Updated: 12/15/2016

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