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RTOG 0411 Protocol Information

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A Phase II Study of Bevacizumab with Concurrent Capecitabine and Radiation Followed by Maintenance Gemcitabine and Bevacizumab for Locally Advanced Pancreatic Cancer
Protocol Documents
Current Version Date: 4/21/2006
Principal Investigator: Christopher Crane MD
Primary Objective:

The primary goal of this study is to compare overall survival at one year to a historical control for bevacizumab combined with capecitabine and concurrent radiation followed by maintenance gemcitabine and bevacizumab.

Patient Population:
  • Patients must have unresectable disease based on institutional standardized criteria of unresectability.
  • There must be no evidence of metastatic disease in the major viscera and no peritoneal seeding or ascites.
  • All malignant disease must be encompassable within a single irradiation field.
  • Zubrod performance status 0-1.
Target Accrual: 82
Current Accrual: 94
Status: Terminated
Date: 6/30/2010
Participating Sites:
Abbott-Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
Advocate Good Samaritan Hospital Downers Grove IL
Advocate Good Shepherd Hospital Barrington IL
Advocate Illinois Masonic Medical Center Chicago IL
Advocate Lutheran General Hospital Park Ridge IL
Allegiance Health Jackson MI
Alta Bates Summit Medical Center-Herrick Campus Berkeley CA
Arlington Cancer Center Arlington TX
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Baptist Cancer Institute Jacksonville FL
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute Oakland CA
Beaumont Hospital - Dearborn Dearborn MI
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
Broward Health Medical Center Fort Lauderdale FL
Bryn Mawr Hospital Bryn Mawr PA
California Pacific Medical Center-Pacific Campus San Francisco CA
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Christiana Care Health System-Christiana Hospital Newark DE
Cleveland Clinic Foundation Cleveland OH
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Concord Hospital Payson Center for Cancer Care Concord NH
Cooper Hospital University Medical Center Camden NJ
Cottonwood Hospital Medical Center Murray UT
CoxHealth South Hospital Springfield MO
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
East Bay Radiation Oncology Center Castro Valley CA
Elkhart General Hospital Elkhart IN
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Finley Hospital Dubuque IA
Fox Chase Cancer Center Philadelphia PA
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Froedtert and the Medical College of Wisconsin Milwaukee WI
Genesys Hurley Cancer Institute Flint MI
Good Samaritan Hospital - Dayton Dayton OH
Grandview Hospital Dayton OH
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Gulf Coast Cancer Treatment Center Panama City FL
Holy Cross Hospital Fort Lauderdale FL
Hurley Medical Center Flint MI
Ingalls Memorial Hospital Harvey IL
Inspira Medical Center Vineland Vineland NJ
IU Health La Porte Hospital La Porte IN
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
Lakeland Medical Center Saint Joseph St Joseph MI
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Legacy Emanuel Hospital and Health Center Portland OR
Legacy Good Samaritan Hospital and Medical Center Portland OR
Legacy Meridian Park Hospital Tualatin OR
Legacy Mount Hood Medical Center Gresham OR
Lehigh Valley Hospital-Cedar Crest Allentown PA
Liberty Hospital Liberty MO
Lifespan Providence RI
Loma Linda University Medical Center Loma Linda CA
M D Anderson Cancer Center Houston TX
Mainline Health CCOP Wynnewood PA
Margaret R Pardee Memorial Hospital Hendersonville NC
McKay-Dee Hospital Center Ogden UT
Memorial Hospital South Bend IN
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood FL
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy Hospital Coon Rapids MN
Mercy Hospital Springfield Springfield MO
Metro-Minnesota CCOP St. Louis Park MN
Miami Valley Hospital Dayton OH
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Monmouth Medical Center Long Branch NJ
Mount Sinai Medical Center Miami Beach FL
Nevada Cancer Research Foundation CCOP Las Vegas NV
North Memorial Medical Health Center Robbinsdale MN
Northern Indiana Cancer Research Consortium South Bend IN
Northwestern University Chicago IL
Novant Health Presbyterian Medical Center Charlotte NC
Ochsner Medical Center Jefferson New Orleans LA
Paoli Memorial Hospital Paoli PA
Parkview Hospital Randallia Fort Wayne IN
PeaceHealth Southwest Medical Center Vancouver WA
Penn State Milton S Hershey Medical Center Hershey PA
Providence Holy Cross Medical Center Mission Hills CA
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank CA
Providence Saint Vincent Medical Center Portland OR
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
Radiological Associates of Sacramento Sacramento CA
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Rhode Island Hospital Providence RI
Ridgeview Medical Center Waconia MN
Roswell Park Cancer Institute Buffalo NY
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint John Medical Center Tulsa OK
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Regional Medical Center South Bend In
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary's of Michigan Saginaw MI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Singing River Hospital Pascagoula MS
Sparrow Hospital Lansing MI
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Health Western Division Cancer Research Group Novato CA
Tallahassee Memorial HealthCare Tallahassee FL
Thomas Jefferson University Hospital Philadelphia PA
Torrance Memorial Medical Center Torrance CA
UF Cancer Center at Orlando Health Orlando FL
United Hospital St. Paul MN
Unity Hospital Fridley MN
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Rochester Rochester NY
University of Virginia Cancer Center Charlottesville VA
University of Wisconsin Hospital and Clinics Madison WI
Upper Valley Medical Center Troy OH
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Veteran Affairs Medical Center Dayton OH
Virtua Memorial Mount Holly NJ
Washington University School of Medicine St. Louis MO
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
WellSpan Health-York Hospital York PA
Western Oncology Research Consortium Portland OR
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Yale University New Haven CT
Yale-New Haven Hospital Saint Raphael Campus New Haven CT
Updated: 4/8/2011

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