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RTOG 0412 Protocol Information

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Phase III Randomized Trial of Preoperative Chemotherapy Versus Preoperative Concurrent Chemotherapy and Thoracic Radiotherapy Followed by Surgical Resection and Consolidation Chemotherapy in Favorable Prognosis Patients with Stage IIIa (N2) Non-Small Cell
Protocol Documents
Current Version Date: 2/14/2007
Principal Investigator: Maria Werner-Wasik, MD
Primary Objective:

To prove that the preoperative regimen, consisting of thoracic radiation therapy given concurrently with chemotherapy followed by surgical resection, results in a significant improvement in overall survival compared to preoperative chemotherapy alone followed by surgical resection, with both arms receiving postoperative consolidation therapy.

 

Patient Population:

Single, newly diagnosed primary lung parenchymal lesion of Stage IIIA (T1-T3) with ipsilateral involved mediastinal lymph nodes measuring </= 3 cm; N2 nodes must be separate from primary tumor.

Target Accrual: 574
Current Accrual: 19
Status: Terminated
Date: 2/19/2009
Participating Sites:
Abbott-Northwestern Hospital Minneapolis MN
Adena Regional Medical Center Chillicothe OH
Advocate Christ Medical Center Oak Lawn IL
Advocate Good Samaritan Hospital Downers Grove IL
Advocate Good Shepherd Hospital Barrington IL
Advocate Illinois Masonic Medical Center Chicago IL
Advocate Lutheran General Hospital Park Ridge IL
Allegheny General Hospital Pittsburgh PA
Allegheny Valley Hospital Natrona Heights PA
Allegiance Health Jackson MI
Alta Bates Summit Medical Center-Herrick Campus Berkeley CA
AnMed Health Cancer Center Anderson SC
Ascension Providence Hospitals - Southfield Southfield MI
Ascension Saint John Hospital Grosse Pointe Woods MI
Atlanta Regional CCOP Atlanta GA
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Aultman Health Foundation Canton OH
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute Oakland CA
Beaumont Hospital - Dearborn Dearborn MI
Boca Raton Regional Hospital Boca Raton FL
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
California Pacific Medical Center-Pacific Campus San Francisco CA
Cape Radiation Oncology Cape Girardeau MO
Carle Cancer Center Urbana IL
Case Western Reserve University Cleveland OH
CHI Health Good Samaritan Kearney NE
Christiana Care Health System-Christiana Hospital Newark DE
City of Hope Comprehensive Cancer Center Duarte CA
Cleveland Clinic Foundation Cleveland OH
Colorado Cancer Research Program CCOP Denver CO
Columbus CCOP Columbus OH
Community Howard Regional Health Kokomo IN
Cottonwood Hospital Medical Center Murray UT
CoxHealth South Hospital Springfield MO
Dayton CCOP Kettering OH
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Hospital Columbus OH
Duke University Medical Center Durham NC
East Carolina University Greenville NC
East Bay Radiation Oncology Center Castro Valley CA
Einstein Medical Center Philadelphia Philadelphia PA
Elkhart General Hospital Elkhart IN
Emory Saint Joseph's Hospital Atlanta GA
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Faxton-Saint Luke's Healthcare Utica NY
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Genesys Hurley Cancer Institute Flint MI
Glens Falls Hospital Queenbury NY
Good Samaritan Hospital - Dayton Dayton OH
Goshen Center for Cancer Care Goshen IN
Grady Memorial Hospital Delaware OH
Grandview Hospital Dayton OH
Grant Medical Center Columbus OH
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Greenville Health System Cancer Institute-Andrews Greenville SC
Greenville Health System Cancer Institute-Eastside Greenville SC
Gundersen Lutheran Medical Center La Crosse WI
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse NY
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Holy Cross Hospital Fort Lauderdale FL
Hurley Medical Center Flint MI
Illinois CancerCare-Peoria Peoria IL
Intercommunity Cancer Center Monroeville PA
IU Health La Porte Hospital La Porte IN
John Muir Medical Center-Concord Concord CA
John Muir Medical Center-Walnut Creek Concord CA
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
Lakeland Medical Center Saint Joseph St Joseph MI
Lancaster Radiation Oncology Lancaster OH
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Legacy Emanuel Hospital and Health Center Portland OR
Legacy Good Samaritan Hospital and Medical Center Portland OR
Legacy Meridian Park Hospital Tualatin OR
Legacy Mount Hood Medical Center Gresham OR
Lehigh Valley Hospital-Cedar Crest Allentown PA
Liberty Hospital Liberty MO
Licking Memorial Hospital Newark OH
Long Island Jewish Medical Center Lake Success NY
Loyola University Medical Center Maywood IL
M D Anderson Cancer Center Houston TX
Marietta Memorial Hospital Marietta OH
Massachusetts General Hospital Cancer Center Boston MA
Mayo Clinic Rochester MN
Mayo Clinic in Arizona Scottsdale AZ
Mayo Clinic in Florida Jacksonville FL
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Medical University of Ohio Toledo OH
Medical University of South Carolina Charleston SC
Memorial Health University Medical Center Savannah GA
Memorial Hospital of South Bend South Bend IN
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood FL
Mercy Health System Janesville WI
Mercy Hospital Coon Rapids MN
Mercy Hospital Joplin Joplin MO
Mercy Hospital Saint Louis St Louis MO
Mercy Hospital Springfield Springfield MO
Methodist Medical Center of Illinois Peoria IL
Metro-Minnesota CCOP St. Louis Park MN
Miami Valley Hospital Dayton OH
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Missouri Valley Cancer Consortium Omaha NE
Mobile Infirmary Medical Center Mobile AL
Mount Carmel Health Center West Columbus OH
Mount Sinai Medical Center Miami Beach FL
Nebraska Methodist Hospital Omaha NE
North Memorial Medical Health Center Robbinsdale MN
North Shore-LIJ Health System CCOP Manhasset NY
Northeast Georgia Medical Center-Gainesville Gainesville GA
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium South Bend IN
Northside Hospital Atlanta GA
Novant Health Presbyterian Medical Center Charlotte NC
Ohio State University Comprehensive Cancer Center Columbus OH
Oregon Health and Science University Portland OR
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
PeaceHealth Southwest Medical Center Vancouver WA
Penn State Milton S Hershey Medical Center Hershey PA
Piedmont Hospital Atlanta GA
Porter Adventist Hospital Denver CO
Pottstown Hospital Pottstown PA
Poudre Valley Hospital Radiation Oncology Fort Collins CO
Providence Alaska Medical Center Anchorage AK
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Saint Vincent Medical Center Portland OR
Renown Regional Medical Center Reno NV
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Rush-Copley Medical Center Aurora IL
Rutherford Hospital Rutherfordton NC
Saint Agnes Hospital Baltimore MD
Saint Ann's Hospital Westerville OH
Saint John Macomb-Oakland Hospital Warren MI
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Regional Medical Center South Bend In
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Louis University Hospital St. Louis MO
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary's Hospital and Regional Medical Center Grand Junction CO
Saint Mary's of Michigan Saginaw MI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
SCL Health Saint Joseph Hospital Denver CO
Sharon Regional Cancer Center Hermitage PA
Somerset Oncology Center Somerset PA
South Suburban Oncology Center Quincy MA
Southern Regional Medical Center Riverdale GA
Southwest VA Regional Cancer Center Norton VA
Sparrow Hospital Lansing MI
Spartanburg Medical Center Spartanburg SC
Springfield Regional Medical Center Springfield OH
St Johns Hospital, Cancer Institute Springfield IL
St Mary Regional Cancer Center Langhorne PA
State University of New York Downstate Medical Center Brooklyn NY
State University of New York Upstate Medical University Syracuse NY
Sutter Cancer Research Consortium Novato CA
Test Institution Anywhere
The Christ Hospital Cincinnati OH
The Research Institute of the McGill University Health Centre (MUHC) Montreal
Thedacare Cancer Institute Appleton WI
Thomas Jefferson University Hospital Philadelphia PA
UC San Diego Moores Cancer Center LaJolla CA
UCHealth Memorial Hospital Central Colorado Springs CO
UCSF Medical Center-Mount Zion San Francisco CA
United Hospital St. Paul MN
Unity Hospital Fridley MN
University Hospital of Brooklyn at Long Island College Hospital Brooklyn NY
University of Arkansas for Medical Sciences Little Rock AR
University of California Davis Comprehensive Cancer Center Sacramento CA
University of California Irvine Medical Center Irvine CA
University of California San Diego LaJolla CA
University of Chicago Comprehensive Cancer Center Chicago IL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Kansas Cancer Center Kansas City KS
University of Kentucky/Markey Cancer Center Lexington KY
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Rochester Rochester NY
University of Washington Medical Center Seattle WA
UP Health System Marquette Marquette MI
Upper Valley Medical Center Troy OH
Upstate Carolina CCOP Spartanburg SC
USC / Norris Comprehensive Cancer Center Los Angeles CA
UT Southwestern/Simmons Cancer Center-Dallas Dallas TX
UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth TX
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Hospital Paramus NJ
Valley Medical Oncology Consultants Pleasanton CA
Vanderbilt University/Ingram Cancer Center Nashville TN
Veteran Affairs Medical Center Dayton OH
Veterans Administration New Jersey Health Care System East Orange NJ
Virginia Mason CCOP Seattle WA
Washington University School of Medicine St. Louis MO
Wayne State University/Karmanos Cancer Institute Detroit MI
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
WellSpan Health-York Hospital York PA
Western Oncology Research Consortium Portland OR
William Beaumont Hospital-Royal Oak Royal Oak MI
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 4/8/2011

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