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RTOG 0421 Protocol Information

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A Phase III Trial for Locally Recurrent, Previously Irradiated Head and Neck Cancer: Concurrent ReIrradiation and Chemotherapy Versus Chemotherapy Alone
Protocol Documents
Current Version Date: 2/14/2007
Principal Investigator: Stuart Wong, MD
Primary Objective:

To determine whether re-irradiation plus concurrent chemotherapy improves overall survival of patients with previously irradiated, non-metastatic, locally recurrent or new primary squamous cell carcinoma of the head and neck (SCCHN) as compared to conventional chemotherapy alone.

Patient Population:

Pathologically confirmed squamous cell carcinoma (SCC) of the oral cavity, oropharynx, hypopharynx, larynx, or recurrent neck metastases with unknown primary; Patients who are potential candidates for complete surgical resection are ineligible for this protocol unless they refuse surgery or surgery is felt not to be in the patient’s best interest by the treating physicians.

Target Accrual: 240
Current Accrual: 15
Status: Terminated
Date: 2/19/2009
Participating Sites:
ACR Clinical Research Center Philadelphia PA
Allegheny General Hospital Pittsburgh PA
Allegheny Valley Hospital Natrona Heights PA
AnMed Health Cancer Center Anderson SC
Aspirus Regional Cancer Center Wausau WI
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Aurora Saint Luke's Medical Center Milwaukee WI
Bixby Medical Center Adrian MI
Blanchard Valley Hospital Findlay OH
Boca Raton Regional Hospital Boca Raton FL
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
Cancer Treatment Center Wooster OH
Carle Cancer Center Urbana IL
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Cleveland Clinic Akron General Akron OH
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Cottonwood Hospital Medical Center Murray UT
Danville Regional Medical Center Danville VA
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Dayton CCOP Kettering OH
Dixie Medical Center Regional Cancer Center East St. George UT
Einstein Medical Center Philadelphia Philadelphia PA
Elkhart General Hospital Elkhart IN
Firelands Regional Medical Center Sandusky OH
Fox Chase Cancer Center Philadelphia PA
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Franciscan St. James Health-Olympia Fields Campus Olympia Fields IL
Froedtert and the Medical College of Wisconsin Milwaukee WI
Good Samaritan Hospital - Dayton Dayton OH
Grandview Hospital Dayton OH
Greater Baltimore Medical Center Baltimore MD
Greene Memorial Hospital Xenia OH
Holy Cross Hospital Fort Lauderdale FL
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Inspira Medical Center Vineland Vineland NJ
IU Health La Porte Hospital La Porte IN
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kettering Medical Center Dayton OH
Lakeland Medical Center Saint Joseph St Joseph MI
LDS Hospital Salt Lake City UT
Lima Memorial Hospital Lima OH
Long Island Jewish Medical Center Lake Success NY
Maine General Medical Center-Thayer Waterville ME
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
McLaren-Greater Lansing Lansing MI
Medical University of South Carolina Charleston SC
Memorial Hospital of South Bend South Bend IN
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood FL
Mercy Fitzgerald Hospital Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Saint Louis St Louis MO
Mercy Saint Anne Hospital Toledo OH
Mercy San Juan Medical Center Carmichael CA
Methodist Medical Center of Illinois Peoria IL
Miami Valley Hospital Dayton OH
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Mount Sinai Medical Center Miami Beach FL
Nebraska Methodist Hospital Omaha NE
Nevada Cancer Research Foundation CCOP Las Vegas NV
Norris Cotton Cancer Center-North Saint Johnsbury VT
North Shore-LIJ Health System CCOP Manhasset NY
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium South Bend IN
Pomona Valley Hospital Medical Center Pomona CA
ProMedica Flower Hospital Sylvania OH
Radiation Oncology Center Alliance OH
Radiological Associates of Sacramento Sacramento CA
Radiological Physics Center (RPC) Houston TX
Rapid City Regional Hospital Rapid City SD
Roswell Park Cancer Institute Buffalo NY
Rush-Copley Medical Center Aurora IL
Rutherford Hospital Rutherfordton NC
Saint Agnes Hospital Baltimore MD
Saint Charles Hospital Oregon OH
Saint John's Hospital Springfield IL
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Southeast Missouri Hospital Cape Girardeau MO
Spartanburg Medical Center Spartanburg SC
St. Anthony's Health Alton IL
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
The Toledo Hospital/Toledo Children's Hospital Toledo OH
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers-Adrian Adrian MI
Toledo Clinic Cancer Centers-Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
University Hospital of Brooklyn at Long Island College Hospital Brooklyn NY
University of Alabama at Birmingham Cancer Center Birmingham AL
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Toledo Toledo OH
University of Wisconsin Hospital and Clinics Madison WI
Upper Valley Medical Center Troy OH
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Veteran Affairs Medical Center Dayton OH
Virtua Memorial Mount Holly NJ
Washington University School of Medicine St. Louis MO
Wayne State University/Karmanos Cancer Institute Detroit MI
West Allis Memorial Hospital West Allis WI
West Virginia University Healthcare Morgantown WV
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wright-Patterson Medical Center Wright-Patterson AFB OH
Updated: 4/8/2011

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