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RTOG 0424 Protocol Information

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A Phase II Study of a Temozolomide-Based Chemoradiotherapy Regimen for High Risk Low-Grade Gliomas
Principal Investigator: Barbara J. Fisher, MD
Primary Objective:

To compare the 3-year survival of this regimen to the 3-year survival of the EORTC high-risk low-grade glioma population described by Pignatti et al.

Patient Population:

Histologic proof of supratentorial WHO grade II astrocytoma, oligodendroglioma or oligoastrocytoma confirmed by central pathology review prior to registration. Patient must have at least three of the following risk factors:  Age >/= 40;  Largest preoperative diameter of tumor >/= 6 cm;  Tumor crosses midline;  Tumor subtype of astrocytoma (astrocytoma dominant);  Preoperative Neurological Function Status > 1.

Target Accrual: 135
Current Accrual: 136
Status: Closed to Accrual
Date: 8/11/2009
Participating Sites:
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Abbott-Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
Adena Regional Medical Center Chillicothe OH
Adventist Medical Center Portland OR
Allegiance Health Jackson MI
AnMed Health Cancer Center Anderson SC
Anne Arundel Medical Center Annapolis MD
Arizona Oncology Services Foundation Scottsdale AZ
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Aultman Hospital Canton OH
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Bay Area Medical Center Marinette WI
Beaumont Hospital-Dearborn Dearborn MI
Beth Israel Deaconess Medical Center Boston MA
Beth Israel Medical Center New York NY
Bixby Medical Center Adrian MI
Blanchard Valley Hospital Findlay OH
Borgess Medical Center Kalamazoo MI
Brigham and Women's Hospital Boston MA
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
California Cancer Center CGOP Fresno CA
Cancer Care Center, Inc Salem OH
Cancer Treatment Center Wooster OH
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Central Maryland Radiation Oncology in Howard County Columbia MD
Centre Hospitalier de l`Universite de Montreal-Notre Dame Montreal Quebec
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Christiana Care Health System-Christiana Hospital Newark DE
Cleveland Clinic Foundation Cleveland OH
Columbus CCOP Columbus OH
Compass Oncology Rose Quarter Portland OR
Compass Oncology Vancouver Vancouver WA
Cottonwood Hospital Medical Center Murray UT
CoxHealth South Hospital Springfield MO
Cross Cancer Institute Edmonton, Alberta
Danville Regional Medical Center Danville VA
Dartmouth Hitchcock Medical Center Lebanon NH
Dayton CCOP Kettering OH
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Hospital Columbus OH
Einstein Medical Center Philadelphia Philadelphia PA
EvergreenHealth Medical Center Kirkland WA
Fairbanks Memorial Hospital Fairbanks AK
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Faxton-Saint Luke's Healthcare Utica NY
Finley Hospital Dubuque IA
Firelands Regional Medical Center Sandusky OH
Flower Hospital Sylvania OH
Fox Chase Cancer Center Philadelphia PA
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Froedtert and the Medical College of Wisconsin Milwaukee WI
Froedtert Memorial Lutheran Hospital Milwaukee WI
Genesys Hurley Cancer Institute Flint MI
Good Samaritan Hospital - Dayton Dayton OH
Grady Memorial Hospital Delaware OH
Grandview Hospital Dayton OH
Grant Medical Center Columbus OH
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Greenville Health System Cancer Institute-Andrews Greenville SC
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Heartland Regional Medical Center St. Joseph MO
Hennepin County Medical Center Minneapolis MN
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Hillcrest Hospital Cancer Center Mayfield Heights OH
Holy Cross Hospital Fort Lauderdale FL
Hurley Medical Center Flint MI
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intermountain Medical Center Murray UT
John B Amos Cancer Center Columbus GA
John F Kennedy Medical Center Edison NJ
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
Lake Huron Medical Center Port Huron MI
Lankenau Medical Center Wynnewood PA
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Legacy Emanuel Hospital & Health Center Portland OR
Legacy Good Samaritan Hospital & Medical Center Portland OR
Legacy Meridian Park Hospital Tualatin OR
Legacy Mount Hood Medical Center Gresham OR
Lehigh Valley Hospital-Cedar Crest Allentown PA
Liberty Hospital Liberty MO
Liberty Radiation Oncology Center Liberty MO
Licking Memorial Hospital Newark OH
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Loyola University Medical Center Maywood IL
Mainline Health CCOP Wynnewood PA
Margaret R Pardee Memorial Hospital Hendersonville NC
Marietta Memorial Hospital Marietta OH
Massachusetts General Hospital Boston MA
Mayo Clinic Rochester MN
Mayo Clinic in Florida Jacksonville FL
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Medical University of Ohio Toledo OH
Menorah Medical Center Overland Park KS
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy Hospital Coon Rapids MN
Mercy Hospital Springfield Springfield MO
Mercy Saint Anne Hospital Toledo OH
Methodist Cancer Center Omaha NE
Methodist Hospital Philadelphia PA
Metro-Minnesota CCOP St. Louis Park MN
Miami Valley Hospital Dayton OH
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Mission Hospital-Memorial Campus Asheville NC
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Moffitt South Cancer Center Tampa FL
Monmouth Medical Center Long Branch NJ
Mount Carmel Health Center West Columbus OH
Nevada Cancer Research Foundation CCOP Las Vegas NV
New Mexico Oncology Hematology Consultants Albuquerque NM
Norris Cotton Cancer Center Saint Johnsbury VT
North Coast Cancer Care Sandusky OH
North Kansas City Hospital North Kansas City MO
North Memorial Medical Health Center Robbinsdale MN
Northeast Georgia Medical Center-Gainesville Gainesville GA
Northeast Radiation Oncology Center Dunmore PA
Ocean Medical Center Brick NJ
Ochsner Medical Center Jefferson New Orleans LA
Ohio State University Medical Center Columbus OH
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Paoli Memorial Hospital Paoli PA
PeaceHealth Southwest Medical Center Vancouver WA
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Saint Vincent Medical Center Portland OR
Radiation Oncology Center Alliance OH
Rapid City Regional Hospital Rapid City SD
Regions Hospital St. Paul MN
Reid Health Richmond IN
Research Medical Center Kansas City MO
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Roswell Park Cancer Institute Buffalo NY
Rutherford Hospital Rutherfordton NC
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Ann's Hospital Westerville OH
Saint Charles Hospital Oregon OH
Saint Francis Hospital Federal Way WA
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint John Medical Center Tulsa OK
Saint John's Hospital - Healtheast Maplewood MN
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sandra L Maxwell Cancer Center Cedar City UT
Seattle Cancer Care Alliance Seattle WA
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital St. Louis MO
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Southwest VA Regional Cancer Center Norton VA
Sparrow Hospital Lansing MI
Spartanburg Medical Center Spartanburg SC
Springfield Regional Medical Center Springfield OH
St. Louis University Hospital St. Louis MO
St. Vincent Anderson Regional Hospital, Inc. Anderson IN
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Research Institute of the McGill University Health Centr Montreal
The Toledo Hospital/Toledo Children's Hospital Toledo OH
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers-Adrian Adrian MI
Toledo Clinic Cancer Centers-Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Tom Baker Cancer Centre Calgary, Alberta
United Hospital St. Paul MN
Unity Hospital Fridley MN
University of Alabama at Birmingham Cancer Center Birmingham AL
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Chicago Comprehensive Cancer Center Chicago IL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Missouri - Ellis Fischel Columbia MO
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Southern California Los Angeles CA
University of Texas Medical Branch Galveston TX
University of Washington Medical Center Seattle WA
University of Wisconsin Hospital and Clinics Madison WI
University Pointe-Precision Radiotherapy West Chester OH
UP Health System Marquette Marquette MI
Upper Delaware Valley Cancer Center Milford PA
Upper Valley Medical Center Troy OH
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Veteran Affairs Medical Center Dayton OH
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Virtua Memorial Mount Holly NJ
Wake Forest University Health Sciences Winston-Salem NC
Washington University School of Medicine St. Louis MO
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
Western Oncology Research Consortium Portland OR
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
William Beaumont Hospital-Royal Oak Royal Oak MI
Wilmed Radiation Oncology Services Wilson NC
Yale University New Haven CT
Updated: 1/14/2014

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