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RTOG 0436 Protocol Information

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A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients With Esophageal Cancer Who Are Treated Without Surgery
Principal Investigator: Mohan Suntharalingam MD
Primary Objective:

To evaluate if the addition of cetuximab to paclitaxel, cisplatin, and radiation improves overall survival compared to paclitaxel, cisplatin, and radiation alone in patients with esophageal cancer who are treated without surgery

 

Patient Population:

Histologic proof of primary squamous cell or adenocarcinoma of the esophagus or gastroesophageal junction Involvement of the GE junction with Siewert type I or II tumors Stage T1N1M0; T2-4, Any N, M0; Any T, Any N, M1a

 

 

Target Accrual: 420
Current Accrual: 344
Status: Closed to Accrual
Date: 2/8/2013
Participating Sites:
21st Century Oncology Las Vegas NV
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Abbott-Northwestern Hospital Minneapolis MN
Academic Urology Prostate Center King of Prussia PA
ACR Clinical Research Center Philadelphia PA
Adams Cancer Center Gettysburg PA
Adventist Medical Center Portland OR
Advocate Lutheran General Hospital Downers Grove IL
Akron General Medical Center Akron OH
Allegheny General Hospital Pittsburgh PA
Allegheny Valley Hospital Natrona Heights PA
Allegiance Health Jackson MI
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
AnMed Health Cancer Center Anderson SC
Aria Health Philadelphia PA
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Aultman Hospital Canton OH
Baptist Cancer Institute Jacksonville FL
Baptist Hospital of Miami Miami FL
Baptist Medical Center South Jacksonville FL
Bay Area Medical Center Marinette WI
Beaumont Hospital-Dearborn Dearborn MI
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Beth Israel Medical Center New York NY
Billings Clinic Cancer Center Billings MT
Blanchard Valley Hospital Findlay OH
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Bozeman Deaconess Hospital Cancer Center Bozeman MT
Bronson Battle Creek Battle Creek MI
Bronson Methodist Hospital Kalamazoo MI
Broward Health Medical Center Fort Lauderdale FL
Bryn Mawr Hospital Bryn Mawr PA
California Cancer Center CGOP Fresno CA
California Pacific Medical Center-Pacific Campus San Francisco CA
Cancer Care Center, Inc Salem OH
Cancer Treatment Center Wooster OH
Cape Radiation Oncology Cape Girardeau MO
Carle Cancer Center Urbana IL
CaroMont Regional Medical Center Gastonia NC
Case Western Reserve University Cleveland OH
Cherry Tree Cancer Center Hanover PA
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Christiana Care Health System-Christiana Hospital Newark DE
Clackamas Radiation Oncology Center Clackamas OR
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland OH
Cleveland Clinic Cancer Center-Independence Independence OH
Cleveland Clinic Foundation Cleveland OH
Cleveland Clinic Foundation- Parma Parma OH
Cleveland Clinic Wooster Specialty Center Wooster OH
Cleveland Clinic-Strongsville Strongsville OH
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Compass Oncology Vancouver Vancouver WA
Comprehensive Cancer Centers of Nevada Las Vegas NV
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas NV
Comprehensive Cancer Centers of Nevada - Henderson Henderson NV
Comprehensive Cancer Centers of Nevada - Northwest Las Vegas NV
Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas NV
Concord Hospital Payson Center for Cancer Care Concord NH
Cooper Health System-Voorhees Voorhees NJ
Cooper Hospital University Medical Center Camden NJ
Covenant Medical Center-Lakeside Lubbock TX
CoxHealth South Hospital Springfield MO
D'Amour Center for Cancer Care Springfield MA
Danville Regional Medical Center Danville VA
Dartmouth Hitchcock Medical Center Lebanon NH
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Delbert Day Cancer Institute at PCRMC Rolla MO
Dixie Medical Center Regional Cancer Center East St. George UT
Einstein Medical Center Philadelphia Philadelphia PA
Elkhart General Hospital Elkhart IN
Elliot Hospital Manchester NH
Emory University Hospital Midtown Atlanta GA
Emory University Hospital/Winship Cancer Institute Atlanta GA
Enloe Medical Center Chico CA
Exeter Hospital Exeter NH
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Fox Chase Cancer Center Philadelphia PA
Fox Chase Cancer Center Buckingham Furlong PA
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Freeman Health System Joplin MO
Froedtert and the Medical College of Wisconsin Milwaukee WI
Geisinger Medical Center Danville PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes Barre PA
Genesys Hurley Cancer Institute Flint MI
Glens Falls Hospital Queenbury NY
Good Samaritan Hospital - Dayton Dayton OH
Goshen Center for Cancer Care Goshen IN
Grady Health System Atlanta GA
Grand Rapids Clinical Oncology Program Grand Rapids MI
Grandview Hospital Dayton OH
Great Falls Clinic Great Falls MT
Greater Baltimore Medical Center Baltimore MD
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Greenville Health System Cancer Institute-Andrews Greenville SC
Greenville Health System Cancer Institute-Eastside Greenville SC
Greenville Health System Cancer Institute-Faris Greenville SC
Greenville Health System Cancer Institute-Greer Greer SC
Greenville Health System Cancer Institute-Seneca Seneca SC
Greenville Health System Cancer Institute-Spartanburg Spartanburg SC
Greenville Memorial Hospital Greenville SC
Gundersen Lutheran Medical Center La Crosse WI
Hennepin County Medical Center Minneapolis MN
Henry Ford Hospital Detroit MI
Henry Ford Macomb Hospital-Clinton Township Clinton Township MI
Highland Hospital Rochester NY
Hillcrest Hospital Cancer Center Mayfield Heights OH
Holy Cross Hospital Fort Lauderdale FL
Hudson Valley Oncology Associates Poughkeepsie NY
Hurley Medical Center Flint MI
Huron Valley Hospital Commerce Township MI
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Indiana University Health Bloomington Bloomington IN
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Inova Alexandria Hospital Alexandria VA
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intercommunity Cancer Center Monroeville PA
Intermountain Medical Center Murray UT
IU Health Central Indiana Cancer Centers Indianapolis IN
IU Health La Porte Hospital La Porte IN
IU Health University West Avon IN
John B Amos Cancer Center Columbus GA
John H Stroger Jr Hospital of Cook County Chicago IL
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kalispell Regional Medical Center Kalispell MT
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
Kings County Hospital Brooklyn NY
Lake Huron Medical Center Port Huron MI
Lake/University Seidman Cancer Center Mentor OH
Lakeland Hospital St Joseph MI
Lakeland Regional Health System St. Joseph MI
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah GA
Liberty Hospital Liberty MO
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Long Island Jewish Medical Center Lake Success NY
Louisiana State University Health Science Center New Orleans LA
Louisiana State University Health Science Center New Orleans LA
Lovelace Medical Center-Downtown Albuquerque NM
Loyola University Medical Center Maywood IL
Lutheran General Hospital Park Ridge IL
Mainline Health CCOP Wynnewood PA
Marin General Hospital Greenbrae CA
Mary Bird Perkins Cancer Center Baton Rouge LA
Mayo Clinic Rochester MN
Mayo Clinic in Florida Jacksonville FL
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Medical University of South Carolina Charleston SC
Memorial Hermann Memorial City Medical Center Houston TX
Memorial Hospital South Bend IN
Memorial Sloan Kettering Basking Ridge Basking Ridge NJ
Memorial Sloan Kettering Cancer Center New York NY
Memorial Sloan Kettering Commack Commack NY
Memorial Sloan Kettering Rockville Centre Rockville NY
Memorial Sloan Kettering Sleepy Hollow Sleepy Hollow NY
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Health Mercy Campus Muskegon MI
Mercy Health Saint Mary's Grand Rapids MI
Mercy Hospital Pittsburgh PA
Mercy Hospital Coon Rapids MN
Mercy Hospital Joplin Joplin MO
Mercy Hospital Saint Louis St Louis MO
Mercy Hospital Springfield Springfield MO
Mercy Medical Center Canton OH
Mercy San Juan Medical Center Carmichael CA
Methodist Cancer Center Omaha NE
Methodist Hospital Philadelphia PA
Methodist Medical Center of Illinois Peoria IL
MetroHealth Medical Center Cleveland OH
Metro-Minnesota CCOP St. Louis Park MN
Miami Valley Hospital Dayton OH
Michiana Hematology Oncology PC-Mishawaka Mishawaka IN
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Mission Hospital-Memorial Campus Asheville NC
Monmouth Medical Center Long Branch NJ
Montana Cancer Consortium CCOP Billings MT
Montefiore Medical Center - Moses Campus Bronx NY
Mount Sinai Medical Center Miami Beach FL
MultiCare Auburn Medical Center Auburn WA
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Nevada Cancer Research Foundation CCOP Las Vegas NV
New York Oncology Hematology PC - Albany Albany NY
Norris Cotton Cancer Center Saint Johnsbury VT
North Coast Cancer Care Sandusky OH
North Main Radiation Oncology Providence RI
North Memorial Medical Health Center Robbinsdale MN
North Shore-LIJ Health System CCOP Manhasset NY
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northeast Georgia Medical Center-Gainesville Gainesville GA
Northeast Radiation Oncology Center Scranton PA
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium South Bend IN
Northern Rockies Radiation Oncology Center Billings MT
NorthShore University HealthSystem-Evanston Hospital Evanston IL
NorthShore University HealthSystem-Glenbrook Hospital Glenview IL
Northwestern University Chicago IL
Novant Health Presbyterian Medical Center Charlotte NC
Ochsner Medical Center Jefferson New Orleans LA
Ohio State University Medical Center Columbus OH
Orange Regional Medical Center Middletown NY
Oregon Health and Science University Portland OR
Our Lady of Lourdes Memorial Hospital, Inc. Binghamton NY
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Pacific Cancer Institute of Maui Wailuku HI
Palo Alto Medical Foundation Health Care Palo Alto CA
Paoli Memorial Hospital Paoli PA
Parkridge University Radiation Oncology Rochester NY
Parkview Hospital Randallia Fort Wayne IN
PeaceHealth Southwest Medical Center Vancouver WA
Penrose-Saint Francis Healthcare Colorado Springs CO
Pocono Medical Center East Strousburg PA
ProHealth D N Greenwald Center Mukwonago WI
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
Providence Holy Cross Medical Center Mission Hills CA
Providence Hospital Mobile AL
Providence Hospital-Southfield Cancer Center Southfield MI
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Regional Cancer System-Centralia Centralia WA
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank CA
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank CA
Providence Saint Vincent Medical Center Portland OR
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
Queen's Medical Center Honolulu HI
Radiation Oncology Associates of Albuquerque Albuquerque NM
Radiation Oncology Associates PC Fort Wayne IN
Radiation Oncology Centers of Nevada Central Las Vegas NV
Radiological Associates of Sacramento Sacramento CA
Radiological Physics Center (RPC) Houston TX
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Regions Hospital St. Paul MN
Reid Health Richmond IN
Reid Health Richmond IN
Renown Regional Medical Center Reno NV
Rhode Island Hospital Providence RI
Rice Memorial Hospital Willmar MN
Riddle Memorial Hospital Media PA
Ridgeview Medical Center Waconia MN
Robinson Radiation Oncology Ravenna OH
Rocky Mountain Cancer Centers-Aurora Aurora CO
Rocky Mountain Cancer Centers-Littleton Littleton CO
Rocky Mountain Oncology Casper WY
Rush University Medical Center Chicago IL
Rutgers New Jersey Medical School Newark NJ
Rutherford Hospital Rutherfordton NC
Saint Agnes Hospital Baltimore MD
Saint Agnes Medical Center Fresno CA
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Francis Hospital Federal Way WA
Saint Francis Medical Center Cape Girardeau MO
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint John Regional Hospital Saint John, NB
Saint John's Hospital - Healtheast Maplewood MN
Saint Joseph Medical Center Tacoma WA
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Louis-Cape Girardeau CCOP Saint Louis MO
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary Mercy Hospital Livonia MI
Saint Mary's Hospital and Regional Medical Center Grand Junction CO
Saint Mary's of Michigan Saginaw MI
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Salem Hospital Salem OR
Sandra L Maxwell Cancer Center Cedar City UT
Sands Cancer Center Canandaigua NY
Siouxland Regional Cancer Center Sioux City IA
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Southeast Missouri Hospital Cape Girardeau MO
Southwest VA Regional Cancer Center Norton VA
Sparrow Hospital Lansing MI
Sparta Cancer Center Sparta NJ
Sparta Cancer Center Sparta NJ
Spartanburg Medical Center Spartanburg SC
Spectrum Health at Butterworth Campus Grand Rapids MI
St Anne's Hospital Fall River MA
St Johns Hospital, Cancer Institute Springfield IL
St Luke's-Roosevelt Hospital Center New York NY
St. Anthony's Health Alton IL
St. Louis University Hospital St. Louis MO
St. Vincent Anderson Regional Hospital, Inc. Anderson IN
St. Vincent Hospital and Health Care Centers, Inc. Indianapolis IN
Stanford Cancer Institute Palo Alto Palo Alto CA
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Medical Center Sacramento Sacramento CA
Sutter Solano Medical Center Vallejo CA
Texas Cancer Center - Medical City Dallas Dallas TX
Texas Cancer Center-Sherman Sherman TX
Texas Oncology - Central Austin Cancer Center Austin TX
Texas Oncology - Round Rock Cancer Center Round Rock TX
Texas Oncology - South Austin Cancer Center Austin TX
Texas Oncology Bedford Bedford TX
Texas Oncology Cancer Center Sugar Land Sugarland TX
Texas Oncology Methodist Charlton Cancer Center Dallas TX
Texas Oncology-Arlington South Arlington TX
Texas Oncology-Austin Midtown Austin TX
Texas Oncology-Denton South Denton TX
Texas Oncology-Denton South Denton TX
Texas Oncology-Lewisville Flower Mound TX
Texas Oncology-Longview Cancer Center Longview TX
Texas Oncology-Seton Williamson Round Rock TX
The Cancer Center of Hawaii-Liliha Honolulu HI
The Cancer Center of Hawaii-Pali Momi Ewa Beach HI
The Hospital of Central Connecticut New Britain CT
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Kirklin Clinic at Acton Road Birmingham AL
The Klabzuba Cancer Center Fort Worth TX
The Regional Cancer Center Erie PA
The University of Kansas Cancer Center-North Kansas City MO
The University of Kansas Cancer Center-South Kansas City MO
Thomas Jefferson University Hospital Philadelphia PA
Thompson Cancer Survival Center Knoxville TN
Thompson Cancer Survival Center - West Knoxville TN
Thompson Cancer Survival Center at Methodist Oak Ridge TN
Trinity Cancer Care Center Minot ND
Tyler Cancer Center Tyler TX
UF Cancer Center at Orlando Health Orlando FL
UH Seidman Cancer Center at Southwest General Middleburgh OH
UHHS - Chagrin Highlands Orange Village OH
UHHS-Westlake Medical Center Westlake OH
United Hospital St. Paul MN
Unity Hospital Fridley MN
University Health Network-Princess Margaret Hospital Toronto, Ontario
University Health Network-Princess Margaret Hospital Toronto
University of Alabama at Birmingham Cancer Center Birmingham AL
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Chicago Comprehensive Cancer Center Chicago IL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Hawaii Cancer Center Honolulu HI
University of Kansas Cancer Center-Overland Park Overland Park KS
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Mississippi Medical Center Jackson MS
University of New Mexico Cancer Center Albuquerque NM
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Texas Health Science Center at San Antonio San Antonio TX
University of Texas Medical Branch San Antonio TX
University of Utah Health Science Center Salt Lake City UT
University of Vermont Medical Center Burlington VT
University of Virginia Cancer Center Charlottesville VA
University Pointe-Precision Radiotherapy West Chester OH
UPMC Cancer Center at UPMC McKeesport McKeesport PA
UPMC Cancer Center at UPMC Northwest Seneca PA
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centre at Clarion Hospital Clarion PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-HVHS Cancer Center (Moon) Coraopolis PA
UPMC-Jameson Memorial Hospital New Castle PA
UPMC-Magee Womens Hospital Pittsburgh PA
UPMC-Passavant Hospital Pittsburgh PA
UPMC-Saint Margaret Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-The Washington Hospital Washington PA
UPMC-Uniontown / Robert E. Eberly Pavilion Uniontown PA
Upper Delaware Valley Cancer Center Milford PA
Upper Valley Medical Center Troy OH
Upstate Carolina CCOP Spartanburg SC
USON- Cancer Care Centers of South Texas-NE San Antonio TX
USON- FLA Institute of Research, Medicine & Surgery Orlando Orlando FL
USON-Arizona Radiation Oncology Tucson AZ
USON-Cancer Care Northwest - Spokane Spokane WA
USON-Cancer Care Northwest-East Holland Spokane WA
USON-Rocky Mountain Cancer Centers-Colorado Springs Colorado Springs CO
USON-Texas Oncology-Wichita Falls Texoma Cancer Center Wichita Falls TX
USON-Williamette Valley Cancer Center Eugene OR
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Veteran Affairs Medical Center Dayton OH
Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus Brooklyn NY
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virtua Memorial Mount Holly NJ
Virtua Voorhees Voorhees NJ
Washington Cancer Institute Washington DC
Wausau Hospital Center Wausau WI
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wayne State University/Karmanos Cancer Institute Detroit MI
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
WellSpan Health-York Hospital York PA
Wentworth-Douglass Hospital Dover NH
West Texas Cancer Center Odessa TX
Western Oncology Research Consortium Portland OR
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
William Backus Hospital Norwich CT
William Backus Hospital Norwich CT
William Beaumont Hospital-Royal Oak Royal Oak MI
Wilmed Radiation Oncology Services Wilson NC
Yale-New Haven Hospital Saint Raphael Campus New Haven CT
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 3/15/2013

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