RTOG 0518 Protocol Information

A Phase III Randomized Trial to Evaluate the Efficacy of Zometa® for the Prevention of Osteoporosis and Associated Fractures in Patients Receiving Radiation Therapy and Long Term LHRH Agonists for High-Grade and/or Locally Advanced Prostate Cancer---RTOG CCOP Study
Protocol Documents
Current Version Date: 9/7/2011
Principal Investigator: Colleen Lawton, MD
Primary Objective:

To evaluate the potential benefit of bisphosphonate therapy in the prevention of bone fracture (defined as any fractures of the bone) in patients receiving LHRH and radiation therapy for locally advanced adenocarcinoma of the prostate

Patient Population:

Histologically confirmed adenocarcinoma of the prostate; any one of the following clinical stages:

 >=T3 disease, any N stage, M0 with any Gleason score and any PSA;

< T3 stage, any N stage, M0 with Gleason's score >= 8 and any PSA;

 <T3 stage, any N stage, M0 with Gleason’s score 7 and PSA > 15 nanograms/ml;

< T3 stage, any N stage, M0 with Gleason’s score <7 and PSA >= 20 nanograms/ml

Target Accrual: 1272
Current Accrual: 109
Status: Terminated
Date: 11/17/2014
Participating Sites:
21st Century Oncology Ft. Myers FL
21st Century Oncology - Plantation Plantation FL
Abington Memorial Hospital Abington PA
Adams Cancer Center Gettysburg PA
Allan Blair Cancer Centre Regina, SK
Alta Bates Summit Medical Center - Summit Campus Oakland CA
AMITA Health Alexian Brothers Medical Center Elk Grove Village IL
AnMed Health Cancer Center Anderson SC
Ascension Columbia Saint Mary's Hospital Ozaukee Mequon WI
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Aurora Saint Luke's Medical Center Milwaukee WI
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute Oakland CA
BCCA-Cancer Centre for the Southern Interior Kelowna, BC
BCCA-Fraser Valley Cancer Centre Surrey, BC
BCCA-Vancouver Island Cancer Centre Victoria, BC
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Billings Clinic Cancer Center Billings MT
Blanchard Valley Hospital Findlay OH
Borgess Medical Center Kalamazoo MI
Boston Medical Center Boston MA
Bozeman Deaconess Hospital Cancer Center Bozeman MT
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
Cancer Institute of New Mexico Santa Fe NM
Cancer Treatment Center Wooster OH
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont Sherbrooke, Quebec
Champlain Valley Physicians Hospital Medical Center Plattsburgh NY
Cherry Tree Cancer Center Hanover PA
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Christiana Care Health System-Christiana Hospital Newark DE
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Quebec
CHUM - Centre Hospitalier de l'Universite de Montreal Montreal Quebec
CIUSSSEMTL-Hopital Maisonneuve-Rosemont Montreal, Quebec
Cleveland Clinic Akron General Akron OH
Coborn Cancer Center at Saint Cloud Hospital St. Cloud MN
Community Memorial Hospital Menomonee Falls WI
Cooper Hospital University Medical Center Camden NJ
CoxHealth South Hospital Springfield MO
Cross Cancer Institute Edmonton, Alberta
Danville Regional Medical Center Danville VA
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
David Grant United States Air Force Medical Center Travis AFB CA
Dayton CCOP Kettering OH
Dayton Veterans Affairs Medical Center Dayton OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Doctor H. Bliss Murphy Cancer Centre St. John's, NL
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo CA
Duke Women's Cancer Care Raleigh Raleigh NC
East Bay Radiation Oncology Center Castro Valley CA
Einstein Medical Center Philadelphia Philadelphia PA
Enloe Medical Center Chico CA
EvergreenHealth Medical Center Kirkland WA
Fairview-Southdale Hospital Edina MN
Fox Chase Cancer Center Philadelphia PA
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Franciscan St. James Health-Olympia Fields Campus Olympia Fields IL
Good Samaritan Hospital - Dayton Dayton OH
Goshen Center for Cancer Care Goshen IN
Grandview Hospital Dayton OH
Great Falls Clinic Great Falls MT
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Greenville Health System Cancer Institute-Andrews Greenville SC
Harbin Clinic Rome GA
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse NY
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Hillcrest Hospital Cancer Center Mayfield Heights OH
Huron Valley-Sinai Hospital Commerce Township MI
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Ingalls Memorial Hospital-Tinley Campus Tinley Park IL
Inspira Medical Center Vineland Vineland NJ
Intermountain Medical Center Murray UT
IU Health Methodist Hospital Indianapolis IN
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Lovelace Medical Center-Downtown Albuquerque NM
Mainline Health CCOP Wynnewood PA
Massachusetts General Hospital Cancer Center Boston MA
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
MD Anderson Cancer Center at Cooper-Voorhees Voorhees NJ
Medical College of Wisconsin Milwaukee WI
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Saint Louis St Louis MO
Mercy Hospital Springfield Springfield MO
Mercy San Juan Medical Center Carmichael CA
Miami Valley Hospital Dayton OH
Mission Hospital Asheville NC
Mobile Infirmary Medical Center Mobile AL
Montana Cancer Consortium CCOP Billings MT
Mount Nittany Medical Center State College PA
Naval Medical Center - Portsmouth Portsmouth VA
Nevada Cancer Research Foundation CCOP Las Vegas NV
Norris Cotton Cancer Center-North Saint Johnsbury VT
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northeast Georgia Medical Center-Gainesville Gainesville GA
Northern Rockies Radiation Oncology Center Billings MT
Northridge Hospital Medical Center Northridge CA
Northwest Community Hospital Arlington Heights IL
Oregon Health and Science University Portland OR
Our Lady of Lourdes Memorial Hospital, Inc. Binghamton NY
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Paoli Memorial Hospital Paoli PA
Penrose-Saint Francis Healthcare Colorado Springs CO
Pocono Medical Center East Strousburg PA
Pomona Valley Hospital Medical Center Pomona CA
Prisma Health Cancer Institute - Eastside Greenville SC
Radiation Oncology Associates of Albuquerque Albuquerque NM
Radiological Associates of Sacramento Sacramento CA
Radiology Associates of Appleton/ThedaCare Regional Medical Center Appleton WI
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Reid Health Richmond IN
Renown Regional Medical Center Reno NV
Rex Cancer Center Raleigh NC
Richard L. Roudebush Veterans Affairs Medical Center Indianapolis IN
Rocky Mountain Oncology Casper WY
Roswell Park Cancer Institute Buffalo NY
Rutherford Hospital Rutherfordton NC
Saint Agnes Hospital Baltimore MD
Saint Francis Hospital Federal Way WA
Saint Luke's Hospital of Duluth Duluth MN
Saint Mary's Hospital and Regional Medical Center Grand Junction CO
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sandra L Maxwell Cancer Center Cedar City UT
Sentara Norfolk General Hospital Norfolk VA
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital St. Louis MO
Southeast Missouri Hospital Cape Girardeau MO
Southwest VA Regional Cancer Center Norton VA
Spartanburg Medical Center Spartanburg SC
St. Anthony's Health Alton IL
State University of New York Downstate Medical Center Brooklyn NY
Summa Health System - Akron Campus Akron OH
Summa Health System - Barberton Campus Barberton OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Texas Cancer Clinic San Antonio TX
The Reverend Roger Patrick Dorcy Cancer Center Pueblo CO
Thomas Jefferson University Hospital Philadelphia PA
Thunder Bay Regional Health Science Centre Thunder Bay, Ontario
Tom Baker Cancer Centre Calgary, Alberta
Trinity Cancer Care Center Minot ND
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Kentucky/Markey Cancer Center Lexington KY
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of New Mexico Cancer Center Albuquerque NM
University of Rochester Rochester NY
University of Wisconsin Hospital and Clinics Madison WI
University Pointe West Chester OH
UPMC-Mercy Hospital Pittsburgh PA
Upper Valley Medical Center Troy OH
Upstate Carolina CCOP Spartanburg SC
USC / Norris Comprehensive Cancer Center Los Angeles CA
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
UW Cancer Center Johnson Creek Johnson Creek WI
Valley Medical Oncology Consultants Pleasanton CA
Vancouver Island Cancer Centre Victoria, BC
Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus Brooklyn NY
Virginia Mason CCOP Seattle WA
Washington University School of Medicine St. Louis MO
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wayne State University/Karmanos Cancer Institute Detroit MI
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
WellSpan Health-York Hospital York PA
West Allis Memorial Hospital West Allis WI
Wilmed Radiation Oncology Services Wilson NC
Zablocki Veterans Administration Medical Center Milwaukee WI
Updated: 11/17/2014

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