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RTOG 0522 Protocol Information

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A Randomized Phase III Trial of Concurrent Accelerated Radiation and Cisplatin versus Concurrent Accelerated Radiation, Cisplatin, and Cetuximab (C225) [Followed by Surgery for Selected Patients] for Stage III and IV Head and Neck Carcinomas
Protocol Documents
Current Version Date: 1/26/2016
Principal Investigator: Kian Ang, MD
Primary Objective:

Evaluate whether the addition of cetuximab to a concurrent radiation-cisplatin regimen will improve progression-free survival in patients with locally advanced squamous cell carcinoma (SCC) of the oropharynx, hypopharynx, or larynx;

Patient Population:

Squamous cell carcinoma of the oropharynx, hypopharynx, or larynx; selected stage III-IV disease (T2N2-3M0, T3-4 any N M0)

Target Accrual: 945
Current Accrual: 940
Status: Closed to Accrual
Date: 3/3/2009
Participating Sites:
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Abbott-Northwestern Hospital Minneapolis MN
ACR Clinical Research Center Philadelphia PA
Adena Regional Medical Center Chillicothe OH
Adventist Medical Center Portland OR
Advocate Good Samaritan Hospital Downers Grove IL
Advocate Good Shepherd Hospital Barrington IL
Advocate Illinois Masonic Medical Center Chicago IL
Akron General Medical Center Akron OH
Allan Blair Cancer Centre Regina, SK
Allegiance Health Jackson MI
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
Alta Bates Summit Medical Center - Summit Campus Oakland CA
Asante Health System Medford OR
Asante Three Rivers Medical Center Grants Pass OR
Atlanta VA Medical Center Decatur GA
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Baton Rouge General Medical Center Baton Rouge LA
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute Oakland CA
Bay Medical Center Panama City FL
Beaumont Hospital-Dearborn Dearborn MI
Blanchard Valley Hospital Findlay OH
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Bozeman Deaconess Hospital Cancer Center Bozeman MT
British Columbia Cancer Agency-Vancouver Cancer Center Vancouver, BC
Bronson Methodist Hospital Kalamazoo MI
Brooke Army Medical Center Fort Sam Houston TX
California Cancer Center CGOP Fresno CA
California Pacific Medical Center-Pacific Campus San Francisco CA
Cancer Care Manitoba Foundation Winnipeg, Manitoba
Cancer Treatment Center Wooster OH
Cape Radiation Oncology Cape Girardeau MO
Carle Cancer Center Urbana IL
Centre Hospitalier de l`Universite de Montreal-Notre Dame Montreal Quebec
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
CHI Health Good Samaritan Kearney NE
Christiana Care Health System-Christiana Hospital Newark DE
CHUM - Centre Hospitalier de l'Universite de Montreal Montreal
City of Hope Comprehensive Cancer Center Duarte CA
Columbia Saint Mary's Hospital - Ozaukee Mequon WI
Columbus CCOP Columbus OH
Community Cancer Center Foundation Normal IL
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Comprehensive Cancer Centers of Nevada Las Vegas NV
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas NV
Comprehensive Cancer Centers of Nevada - Northwest Las Vegas NV
Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas NV
Concord Hospital Payson Center for Cancer Care Concord NH
Cottonwood Hospital Medical Center Murray UT
Covenant Medical Center-Lakeside Lubbock TX
CoxHealth South Hospital Springfield MO
Danville Regional Medical Center Danville VA
Dartmouth Hitchcock Medical Center Lebanon NH
David Grant United States Air Force Medical Center Travis AFB CA
Dayton CCOP Kettering OH
Delbert Day Cancer Institute at PCRMC Rolla MO
Dickinson County Healthcare System Iron Mountain MI
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Hospital Columbus OH
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo CA
Dubs Cancer Center @ Rogue Valley Medical Center Medford OR
Duke Women's Cancer Care Raleigh Raleigh NC
East Carolina University Greenville NC
East Bay Radiation Oncology Center Castro Valley CA
Einstein Medical Center Philadelphia Philadelphia PA
Elkhart General Hospital Elkhart IN
Elliot Hospital Manchester NH
Emory University Hospital Midtown Atlanta GA
Emory University Hospital/Winship Cancer Institute Atlanta GA
Essentia Health Cancer Center-South University Clinic Fargo ND
EvergreenHealth Medical Center Kirkland WA
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Finley Hospital Dubuque IA
Fox Chase Cancer Center Philadelphia PA
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Franciscan St. James Health-Olympia Fields Campus Olympia Fields IL
Freeman Health System Joplin MO
Froedtert and the Medical College of Wisconsin Milwaukee WI
Geisinger Medical Center Danville PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes Barre PA
Genesys Hurley Cancer Institute Flint MI
Glens Falls Hospital Queenbury NY
Good Samaritan Hospital - Dayton Dayton OH
Goshen Center for Cancer Care Goshen IN
Grady Health System Atlanta GA
Grady Memorial Hospital Delaware OH
Grand Rapids Clinical Oncology Program Grand Rapids MI
Grandview Hospital Dayton OH
Grant Medical Center Columbus OH
Great Falls Clinic Great Falls MT
Greater Baltimore Medical Center Baltimore MD
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Greenville Health System Cancer Institute-Andrews Greenville SC
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Harbin Clinic Rome GA
Health Sciences North Sudbury, Ontario
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse NY
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Holy Cross Hospital Fort Lauderdale FL
Holy Family Memorial Hospital Manitowoc WI
Hunter Holmes McGuire Veterans Administration Medical Center Richmond VA
Hurley Medical Center Flint MI
Illinois CancerCare-Peoria Peoria IL
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Ingalls Memorial Hospital-Tinley Campus Tinley Park IL
Inova Alexandria Hospital Alexandria VA
Inspira Medical Center Vineland Vineland NJ
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intermountain Medical Center Murray UT
Iredell Memorial Hospital Statesville NC
IU Health Central Indiana Cancer Centers Indianapolis IN
IU Health La Porte Hospital La Porte IN
John B Amos Cancer Center Columbus GA
John H Stroger Jr Hospital of Cook County Chicago IL
John Muir Medical Center-Concord Concord CA
John Muir Medical Center-Walnut Creek Concord CA
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
Lake Huron Medical Center Port Huron MI
Lakeland Hospital St Joseph MI
Lakeland Regional Health System St. Joseph MI
LDS Hospital Salt Lake City UT
Legacy Emanuel Hospital & Health Center Portland OR
Legacy Good Samaritan Hospital & Medical Center Portland OR
Legacy Meridian Park Hospital Tualatin OR
Legacy Mount Hood Medical Center Gresham OR
Lehigh Valley Hospital-Cedar Crest Allentown PA
Liberty Hospital Liberty MO
Licking Memorial Hospital Newark OH
Logan Regional Hospital Logan UT
Long Island Jewish Medical Center Lake Success NY
Louisiana State University Health Science Center New Orleans LA
Loyola University Medical Center Maywood IL
Lutheran General Hospital Park Ridge IL
M D Anderson Cancer Center Houston TX
Maimonides Medical Center Brooklyn NY
Maine General Medical Center-Thayer Waterville ME
Margaret R Pardee Memorial Hospital Hendersonville NC
Marietta Memorial Hospital Marietta OH
Marin General Hospital Greenbrae CA
Mary Bird Perkins Cancer Center Baton Rouge LA
Mass General/ North Shore Cancer Center Danvers MA
Mayo Clinic Rochester MN
Mayo Clinic in Arizona Scottsdale AZ
Mayo Clinic in Florida Jacksonville FL
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute - Flint Flint MI
McLaren Northern Michigan Petoskey MI
Medical University of South Carolina Charleston SC
Memorial Hospital South Bend IN
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood FL
Memorial University Medical Center Savannah GA
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Health Saint Mary's Grand Rapids MI
Mercy Hospital Coon Rapids MN
Mercy Hospital Joplin Joplin MO
Mercy Hospital Saint Louis St Louis MO
Mercy Hospital Springfield Springfield MO
Mercy Regional Cancer Center Redding CA
Mercy San Juan Medical Center Carmichael CA
Methodist Cancer Center Omaha NE
Methodist Hospital Philadelphia PA
Methodist Medical Center of Illinois Peoria IL
Metro-Minnesota CCOP St. Louis Park MN
Miami Valley Hospital Dayton OH
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Mission Hospital-Memorial Campus Asheville NC
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Moffitt Cancer Center Tampa FL
Moffitt South Cancer Center Tampa FL
Montana Cancer Consortium CCOP Billings MT
Mount Carmel Health Center West Columbus OH
Mount Sinai Medical Center Miami Beach FL
Munson Medical Center Traverse City MI
Naval Medical Center - Portsmouth Portsmouth VA
Nevada Cancer Research Foundation CCOP Las Vegas NV
New Mexico Oncology Hematology Consultants Albuquerque NM
New York Oncology Hematology PC - Albany Albany NY
Norris Cotton Cancer Center Saint Johnsbury VT
North Colorado Medical Center Greeley CO
North Memorial Medical Health Center Robbinsdale MN
North Shore-LIJ Health System CCOP Manhasset NY
Northeast Georgia Medical Center-Gainesville Gainesville GA
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium South Bend IN
Northern Rockies Radiation Oncology Center Billings MT
Northwestern Ontario Regional Cancer Centre Thunder Bay, Ontario
Novant Health Forsyth Medical Center Winston Salem NC
Novant Health Presbyterian Medical Center Charlotte NC
Ocean Medical Center Brick NJ
Oregon Health and Science University Portland OR
OSF Saint Francis Medical Center Peoria IL
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin IL
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria IL
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Parkview Hospital Randallia Fort Wayne IN
PeaceHealth Southwest Medical Center Vancouver WA
Penrose-Saint Francis Healthcare Colorado Springs CO
Piedmont Hospital Atlanta GA
Pocono Medical Center East Strousburg PA
Pomona Valley Hospital Medical Center Pomona CA
Poudre Valley Hospital Radiation Oncology Fort Collins CO
Princeton Radiation Oncology Center Jamesburg NJ
Providence Hospital-Southfield Cancer Center Southfield MI
Providence Medford Medical Center Medford OR
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Saint Vincent Medical Center Portland OR
QEII Health Sciences Centre/Nova Scotia Health Authority Halifax, Nova Scotia
Radiation Oncology Associates PC Fort Wayne IN
Radiation Oncology Centers of Nevada Central Las Vegas NV
Radiological Associates of Sacramento Sacramento CA
Radiological Physics Center (RPC) Houston TX
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Reid Health Richmond IN
Research Medical Center Kansas City MO
Rex Cancer Center Raleigh NC
Rhode Island Hospital Providence RI
Richard L. Roudebush VA Medical Center Indianapolis IN
Riddle Memorial Hospital Media PA
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Riverview Medical Center/Booker Cancer Center Red Bank NJ
Robinson Radiation Oncology Ravenna OH
Rocky Mountain Cancer Centers-Aurora Aurora CO
Roswell Park Cancer Institute Buffalo NY
Rush University Medical Center Chicago IL
Rutgers New Jersey Medical School Newark NJ
Saint Agnes Hospital Baltimore MD
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Ann's Hospital Westerville OH
Saint Francis Hospital Federal Way WA
Saint Francis Medical Center Cape Girardeau MO
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Joseph Regional Medical Center South Bend In
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Mary Mercy Hospital Livonia MI
Saint Mary's Hospital and Regional Medical Center Grand Junction CO
Saint Mary's of Michigan Saginaw MI
Saint Peter's University Hospital New Brunswick NJ
Saint Rita's Medical Center Lima OH
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital and Health Care Center Indianapolis IN
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sandra L Maxwell Cancer Center Cedar City UT
Santa Rosa Memorial Hospital CCOP Santa Rosa CA
Sentara Norfolk General Hospital Norfolk VA
Shaw Regional Cancer Center Edwards CO
Singing River Hospital Pascagoula MS
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital St. Louis MO
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Southeast Missouri Hospital Cape Girardeau MO
Sparrow Hospital Lansing MI
Sparta Cancer Center Sparta NJ
Springfield Regional Medical Center Springfield OH
St Johns Hospital, Cancer Institute Springfield IL
St. Anthony's Health Alton IL
St. Louis University Hospital St. Louis MO
St. Lukes Hospital Association of Duluth Duluth MN
St. Luke's Mountain States Tumor Institute Boise ID
St. Vincent Hospital and Health Care Centers, Inc. Indianapolis IN
Stanford Cancer Institute Palo Alto Palo Alto CA
State University of New York Downstate Medical Center Brooklyn NY
State University of New York Upstate Medical University Syracuse NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Medical Center Sacramento Sacramento CA
Sutter Solano Medical Center Vallejo CA
Texas Cancer Center - Medical City Dallas Dallas TX
Texas Cancer Center-Sherman Sherman TX
Texas Oncology Cancer Center Sugar Land Sugarland TX
Texas Oncology Methodist Charlton Cancer Center Dallas TX
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Klabzuba Cancer Center Fort Worth TX
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Research Institute of the McGill University Health Centr Montreal
The Reverend Roger Patrick Dorcy Cancer Center Pueblo CO
The University of Kansas Cancer Center-South Kansas City MO
Thedacare Cancer Institute Appleton WI
ThedaCare Regional Cancer Center Appleton WI
Thomas Jefferson University Hospital Philadelphia PA
Tom Baker Cancer Centre Calgary, Alberta
Torrance Memorial Medical Center Torrance CA
Tulane University Medical Center New Orleans LA
UC San Diego Moores Cancer Center LaJolla CA
UCHealth Memorial Hospital Central Colorado Springs CO
UCSF Medical Center-Mount Zion San Francisco CA
UF Cancer Center at Orlando Health Orlando FL
United Hospital St. Paul MN
Unity Hospital Fridley MN
University Health Network-Princess Margaret Hospital Toronto, Ontario
University Medical Center New Orleans New Orleans LA
University Medical Center of Princeton at Plainsboro Princeton NJ
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Arkansas for Medical Sciences Little Rock AR
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Illinois Chicago IL
University of Iowa/Holden Comprehensive Cancer Center Iowa City IA
University of Kansas Cancer Center Kansas City KS
University of Kansas Cancer Center-Overland Park Overland Park KS
University of Kentucky/Markey Cancer Center Lexington KY
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Southern California Los Angeles CA
University of Texas Health Science Center at San Antonio San Antonio TX
University of Texas Medical Branch Galveston TX
University of Texas Medical Branch San Antonio TX
University of Texas Southwestern Medical School Dallas TX
University of Utah Health Science Center Salt Lake City UT
University of Wisconsin Hospital and Clinics Madison WI
University Pointe-Precision Radiotherapy West Chester OH
UP Health System Marquette Marquette MI
Upper Delaware Valley Cancer Center Milford PA
Upper Valley Medical Center Troy OH
USON-Arizona Radiation Oncology Tucson AZ
USON-Williamette Valley Cancer Center Eugene OR
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Veteran Affairs Medical Center Dayton OH
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Wake Forest University Health Sciences Winston-Salem NC
Washington Cancer Institute Washington DC
Washington University School of Medicine St. Louis MO
Wausau Hospital Center Wausau WI
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wayne State University/Karmanos Cancer Institute Detroit MI
Welch Cancer Center Sheridan WY
WellSpan Health-York Hospital York PA
Western Oncology Research Consortium Portland OR
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Wilford Hall USAF Medical Center Lackland AFB TX
William Beaumont Hospital-Royal Oak Royal Oak MI
Wilmed Radiation Oncology Services Wilson NC
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 2/8/2016

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