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RTOG 0525 Protocol Information

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Phase III Trial Comparing Conventional Adjuvant Temozolomide With Dose-Intensive Temozolomide in Patients With Newly Diagnosed Glioblastoma
Protocol Documents
Current Version Date: 10/30/2007
Principal Investigator: Mark R. Gilbert, MD
Primary Objective:

To determine if dose-intensifying (increasing the "dose-density") the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy as measured by overall survival.

Patient Population:

Histopathologically confirmed glioblastoma (WHO Grade IV) confirmed by central tissue evaluation. The tumor must have a supratentorial component. Tumor tissue block must be available for analysis.

Target Accrual: 1153
Current Accrual: 1174
Status: Terminated
Date: 12/15/2016
Participating Sites:
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Abbott-Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
Adena Regional Medical Center Chillicothe OH
Adventist Medical Center Portland OR
Allan Blair Cancer Centre Regina, SK
Allegheny General Hospital Pittsburgh PA
Allegheny Valley Hospital Natrona Heights PA
Allegiance Health Jackson MI
Alta Bates Summit Medical Center-Herrick Campus Berkeley CA
AnMed Health Cancer Center Anderson SC
Anne Arundel Medical Center Annapolis MD
Aria Health-Torresdale Campus Philadelphia PA
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Associates-West Orange Grove Tucson AZ
Arizona Oncology Services Foundation Scottsdale AZ
Arlington Cancer Center Arlington TX
Ascension Providence Hospitals - Southfield Southfield MI
Ascension Saint John Hospital Grosse Pointe Woods MI
Aspirus Regional Cancer Center Wausau WI
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Aultman Health Foundation Canton OH
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Bay Area Medical Center Marinette WI
Bay Medical Center Panama City FL
Beaumont Hospital - Dearborn Dearborn MI
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Billings Clinic Cancer Center Billings MT
Bixby Medical Center Adrian MI
Blanchard Valley Hospital Findlay OH
Boca Raton Regional Hospital Boca Raton FL
Borgess Medical Center Kalamazoo MI
Bozeman Deaconess Hospital Cancer Center Bozeman MT
Brigham and Women's Hospital Boston MA
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
California Pacific Medical Center-Pacific Campus San Francisco CA
Cancer Treatment Center Wooster OH
CancerCare Manitoba Winnipeg, Manitoba
Cape Cod Hospital Hyannis MA
Cape Radiation Oncology Cape Girardeau MO
Carle Cancer Center Urbana IL
Case Western Reserve University Cleveland OH
Central Maryland Radiation Oncology in Howard County Columbia MD
Champlain Valley Physicians Hospital Medical Center Plattsburgh NY
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
CHI Health Good Samaritan Kearney NE
Christiana Care Health System-Christiana Hospital Newark DE
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Quebec
CHUM - Centre Hospitalier de l'Universite de Montreal Montreal
CHUM - Hopital Notre-Dame Montreal Quebec
City of Hope Comprehensive Cancer Center Duarte CA
Clackamas Radiation Oncology Center Clackamas OR
Cleveland Clinic Akron General Akron OH
Cleveland Clinic Cancer Center Independence Independence OH
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland OH
Cleveland Clinic Foundation Cleveland OH
Coborn Cancer Center at Saint Cloud Hospital St. Cloud MN
Columbia Saint Mary's Hospital - Ozaukee Mequon WI
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Columbus CCOP Columbus OH
Community Cancer Center Foundation Normal IL
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Compass Oncology Rose Quarter Portland OR
Compass Oncology Vancouver Vancouver WA
Concord Hospital Payson Center for Cancer Care Concord NH
Cooper Health System-Voorhees Voorhees NJ
Cooper Hospital University Medical Center Camden NJ
Cottonwood Hospital Medical Center Murray UT
Covenant Medical Center-Lakeside Lubbock TX
CoxHealth South Hospital Springfield MO
Cross Cancer Institute Edmonton, Alberta
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Hospital Columbus OH
Einstein Medical Center Philadelphia Philadelphia PA
Elkhart General Hospital Elkhart IN
EvergreenHealth Medical Center Kirkland WA
Exeter Hospital Exeter NH
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Firelands Regional Medical Center Sandusky OH
Fox Chase Cancer Center Philadelphia PA
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Franciscan St. James Health-Olympia Fields Campus Olympia Fields IL
Froedtert and the Medical College of Wisconsin Milwaukee WI
Geisinger Medical Center Danville PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes Barre PA
Genesys Hurley Cancer Institute Flint MI
Good Samaritan Hospital - Dayton Dayton OH
Grady Memorial Hospital Delaware OH
Grandview Hospital Dayton OH
Grant Medical Center Columbus OH
Great Falls Clinic Great Falls MT
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Greenville Health System Cancer Institute-Andrews Greenville SC
Greenville Health System Cancer Institute-Eastside Greenville SC
Gundersen Lutheran Medical Center La Crosse WI
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse NY
Hennepin County Medical Center Minneapolis MN
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Hillcrest Hospital Cancer Center Mayfield Heights OH
Holy Cross Hospital Fort Lauderdale FL
Holy Family Memorial Hospital Manitowoc WI
Horizon Health Network-Saint John Regional Hospital Saint John, NB
Hudson Valley Oncology Associates Poughkeepsie NY
Huntsman Cancer Institute/University of Utah Salt Lake City UT
Hurley Medical Center Flint MI
Illinois CancerCare-Peoria Peoria IL
Ingalls Memorial Hospital Harvey IL
Ingalls Memorial Hospital-Tinley Campus Tinley Park IL
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intercommunity Cancer Center Monroeville PA
Intermountain Medical Center Murray UT
IU Health Central Indiana Cancer Centers-East Indianapolis IN
IU Health La Porte Hospital La Porte IN
Jameson Health System North Campus New Castle PA
John B Amos Cancer Center Columbus GA
John H Stroger Jr Hospital of Cook County Chicago IL
Jupiter Medical Center Jupiter FL
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario
Kaiser Permanente Los Angeles Medical Center Los Angeles CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
King Faisal Specialist Hospital and Research Centre Riyadh 11211
Lake Huron Medical Center Port Huron MI
Lakeland Medical Center Saint Joseph St Joseph MI
Lakeland Regional Health System St. Joseph MI
Lankenau Medical Center Wynnewood PA
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Legacy Emanuel Hospital and Health Center Portland OR
Legacy Good Samaritan Hospital and Medical Center Portland OR
Legacy Meridian Park Hospital Tualatin OR
Legacy Mount Hood Medical Center Gresham OR
Lehigh Valley Hospital-Cedar Crest Allentown PA
Liberty Hospital Liberty MO
Licking Memorial Hospital Newark OH
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
Loma Linda University Medical Center Loma Linda CA
London Regional Cancer Program London Ontario
Long Island Jewish Medical Center Lake Success NY
Loyola University Medical Center Maywood IL
M D Anderson Cancer Center Houston TX
Maimonides Medical Center Brooklyn NY
Mainline Health CCOP Wynnewood PA
Marietta Memorial Hospital Marietta OH
Marin General Hospital Greenbrae CA
Massachusetts General Hospital Cancer Center Boston MA
Mayo Clinic Rochester MN
Mayo Clinic Health System-Franciscan Healthcare LaCrosse WI
Mayo Clinic Hospital Phoenix AZ
Mayo Clinic in Arizona Scottsdale AZ
Mayo Clinic in Florida Jacksonville FL
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Medical University of Ohio Toledo OH
Medical University of South Carolina Charleston SC
Memorial Health University Medical Center Savannah GA
Memorial Hospital of South Bend South Bend IN
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood FL
Memorial Sloan Kettering Cancer Center New York NY
Mercy Cancer Center-Elyria Elyria OH
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Coon Rapids MN
Mercy Hospital Joplin Joplin MO
Mercy Hospital Saint Louis St Louis MO
Mercy Hospital Springfield Springfield MO
Mercy Saint Anne Hospital Toledo OH
Mercy San Juan Medical Center Carmichael CA
Methodist Hospital Philadelphia PA
Methodist Medical Center of Illinois Peoria IL
Metro-Minnesota CCOP St. Louis Park MN
Miami Cancer Institute Miami FL
Miami Valley Hospital Dayton OH
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Mission Hospital Inc-Memorial Campus Asheville NC
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Moffitt Cancer Center Tampa FL
Moffitt South Cancer Center Tampa FL
Monmouth Medical Center Long Branch NJ
Montana Cancer Consortium CCOP Billings MT
Mount Carmel Health Center West Columbus OH
Mount Nittany Medical Center State College PA
Mount Sinai Medical Center Miami Beach FL
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Nebraska Methodist Hospital Omaha NE
Nevada Cancer Institute-Summerlin Campus Las Vegas NV
Nevada Cancer Research Foundation CCOP Las Vegas NV
New York Oncology Hematology PC - Albany Albany NY
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
Norris Cotton Cancer Center-North Saint Johnsbury VT
North Coast Cancer Care Sandusky OH
North Memorial Medical Health Center Robbinsdale MN
North Shore-LIJ Health System CCOP Manhasset NY
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium South Bend IN
Northern Rockies Radiation Oncology Center Billings MT
Northridge Hospital Medical Center Northridge CA
Northwest Community Hospital Arlington Heights IL
Northwestern University Chicago IL
Ochsner Medical Center Jefferson New Orleans LA
OSF Saint Francis Medical Center Peoria IL
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin IL
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria IL
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Pacific Cancer Institute of Maui Wailuku HI
Paoli Memorial Hospital Paoli PA
Parkview Hospital Randallia Fort Wayne IN
PeaceHealth Saint Joseph Medical Center Bellingham WA
PeaceHealth Southwest Medical Center Vancouver WA
Peninsula Regional Medical Center Salisbury MD
Penn State Milton S Hershey Medical Center Hershey PA
Penrose-Saint Francis Healthcare Colorado Springs CO
Piedmont Hospital Atlanta GA
Pocono Medical Center East Strousburg PA
Pomona Valley Hospital Medical Center Pomona CA
Poudre Valley Hospital Radiation Oncology Fort Collins CO
ProHealth D N Greenwald Center Mukwonago WI
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
ProMedica Flower Hospital Sylvania OH
Providence Holy Cross Medical Center Mission Hills CA
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank CA
Providence Saint Vincent Medical Center Portland OR
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
Queen's Medical Center Honolulu HI
Radiation Oncology Associates PC Fort Wayne IN
Radiological Associates of Sacramento Sacramento CA
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Regions Hospital St Paul MN
Regions Hospital St. Paul MN
Reid Health Richmond IN
Rice Memorial Hospital Willmar MN
Riddle Memorial Hospital Media PA
Riddle Memorial Hospital Media PA
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Rochester General Hospital Rochester NY
Rocky Mountain Cancer Centers-Aurora Aurora CO
Rocky Mountain Oncology Casper WY
Roswell Park Cancer Institute Buffalo NY
Rush-Copley Medical Center Aurora IL
Rutherford Hospital Rutherfordton NC
Saint Agnes Hospital Baltimore MD
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Ann's Hospital Westerville OH
Saint Barnabas Medical Center Livingston NJ
Saint Charles Hospital Oregon OH
Saint Francis Hospital Federal Way WA
Saint Francis Medical Center Cape Girardeau MO
Saint John Macomb-Oakland Hospital Warren MI
Saint John's Hospital - Healtheast Maplewood MN
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Joseph Regional Medical Center South Bend In
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Saint Vincent Mercy Medical Center Toledo OH
Salem Hospital Salem OR
Sandra L Maxwell Cancer Center Cedar City UT
Scott and White Memorial Hospital Temple TX
Seattle Cancer Care Alliance Seattle WA
Sentara Norfolk General Hospital Norfolk VA
Sharon Regional Cancer Center Hermitage PA
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital St. Louis MO
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Somerset Oncology Center Somerset PA
South Nassau Communities Oceanside NY
Southeast Missouri Hospital Cape Girardeau MO
Southwest VA Regional Cancer Center Norton VA
Sparrow Hospital Lansing MI
Sparta Cancer Center Sparta NJ
Spartanburg Medical Center Spartanburg SC
Springfield Regional Medical Center Springfield OH
St Johns Hospital, Cancer Institute Springfield IL
St. Anthony's Health Alton IL
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Cancer Research Consortium Novato CA
Swedish Covenant Hospital Chicago IL
Tel Aviv Sourasky Medical Center Tel-Aviv
Temple University Hospital Philadelphia PA
Texas Cancer Center - Medical City Dallas Dallas TX
Texas Cancer Center-Sherman Sherman TX
Texas Oncology Bedford Bedford TX
Texas Oncology Cancer Center Sugar Land Sugarland TX
Texas Oncology Methodist Charlton Cancer Center Dallas TX
The Cancer Center of Hawaii-Liliha Honolulu HI
The Cancer Center of Hawaii-Pali Momi Ewa Beach HI
The Ireland Cancer Center at Community Health Partners Elyria OH
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Klabzuba Cancer Center Fort Worth TX
The Methodist Hospital System Houston TX
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Research Institute of the McGill University Health Centre (MUHC) Montreal
The Reverend Roger Patrick Dorcy Cancer Center Pueblo CO
The University of Kansas Cancer Center-North Kansas City MO
The University of Kansas Cancer Center-South Kansas City MO
Thedacare Cancer Institute Appleton WI
Thomas Jefferson University Hospital Philadelphia PA
Thompson Cancer Survival Center Knoxville TN
Thompson Cancer Survival Center - West Knoxville TN
Thompson Cancer Survival Center at Methodist Oak Ridge TN
Thunder Bay Regional Health Science Centre Thunder Bay, Ontario
Toledo Clinic Cancer Centers-Adrian Adrian MI
Toledo Clinic Cancer Centers-Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Tom Baker Cancer Centre Calgary, Alberta
Torrance Memorial Medical Center Torrance CA
Trinity Cancer Care Center Minot ND
Trinity's Tony Teramana Cancer Center Steubenville OH
Tulane University Health Sciences Center New Orleans LA
UCHealth Memorial Hospital Central Colorado Springs CO
UCSF Medical Center-Mount Zion San Francisco CA
UF Cancer Center at Orlando Health Orlando FL
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
United Hospital St. Paul MN
United Hospital System Pleasant Praire WI
Unity Hospital Fridley MN
University Health Network-Princess Margaret Hospital Toronto, Ontario
University of Arizona Medical Center-University Campus Tucson AZ
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Chicago Comprehensive Cancer Center Chicago IL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Florida Health Science Center - Gainesville Gainesville FL
University of Hawaii Cancer Center Honolulu HI
University of Iowa/Holden Comprehensive Cancer Center Iowa City IA
University of Kansas Cancer Center-Overland Park Overland Park KS
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Texas Medical Branch Galveston TX
University of Vermont Medical Center Burlington VT
University of Washington Medical Center Seattle WA
University of Wisconsin Hospital and Clinics Madison WI
University Pointe West Chester OH
UPMC Cancer Center at UPMC McKeesport McKeesport PA
UPMC Cancer Center at UPMC Northwest Seneca PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg PA
UPMC Cancer Centre at Clarion Hospital Clarion PA
UPMC Jameson New Castle PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC Uniontown Hospital Radiation Oncology Uniontown PA
UPMC Washington Hospital Radiation Oncology Washington PA
UPMC-Coraopolis/Heritage Valley Radiation Oncology Coraopolis PA
UPMC-Heritage Valley Health System Beaver Beaver PA
UPMC-Johnstown/John P. Murtha Regional Cancer Center Johnstown PA
UPMC-Magee Womens Hospital Pittsburgh PA
UPMC-Mercy Hospital Pittsburgh PA
UPMC-Passavant Hospital Pittsburgh PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Saint Clair Hospital Cancer Center Pittsburgh PA
UPMC-Saint Margaret Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
Upper Delaware Valley Cancer Center Milford PA
Upper Valley Medical Center Troy OH
Upstate Carolina CCOP Spartanburg SC
USON-Williamette Valley Cancer Center Eugene OR
UT Southwestern/Simmons Cancer Center-Dallas Dallas TX
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
UW Cancer Center Johnson Creek Johnson Creek WI
Veteran Affairs Medical Center Dayton OH
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Virtua Memorial Mount Holly NJ
Washington University School of Medicine St. Louis MO
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Weill Medical College of Cornell University New York NY
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
West Allis Memorial Hospital West Allis WI
Western Oncology Research Consortium Portland OR
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Wichita CCOP Wichita KS
William Beaumont Hospital-Royal Oak Royal Oak MI
Wilmed Radiation Oncology Services Wilson NC
Yale University New Haven CT
Updated: 12/15/2016

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