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RTOG 0539 Protocol Information

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Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas
Principal Investigator: C. Leland Rogers, MD
Primary Objective:

To estimate the rates of progression-free survival (PFS) at 3 years in each of the patient risk groups.

Patient Population:

Histopathologically confirmed meningioma, confirmed by central pathology review prior to STEP 2 registration. Risk categories are defined as follows:

  • Low (Group I): Patients with a newly diagnosed gross totally resected (Simpson’s grade I, II, or III resections with no residual nodular enhancement on postoperative imaging) or subtotally resected (residual nodular enhancement or Simpson grade IV or V excision) World Health Organization (WHO) grade I meningioma. The extent of resection will be based upon the neurosurgeon’s assessment and postoperative MR imaging.
  • Intermediate (Group II): Patients with a newly diagnosed gross totally resected WHO grade II meningioma or a recurrent WHO grade I meningioma irrespective of the resection extent. Resection extent will be assessed according to Simpson’s grade on the same basis described above for the low-risk group.
  • High (Group III): Patients with high-risk features including a newly diagnosed or recurrent WHO grade III meningioma of any resection extent; a recurrent WHO grade II meningioma of any resection extent; or a newly diagnosed subtotally resected WHO grade II meningioma. Resection extent will be recorded on the same basis described above for the low-risk group.
Target Accrual: 165
Current Accrual: 244
Status: Closed to Accrual
Date: 6/19/2009
Participating Sites:
Abbott-Northwestern Hospital Minneapolis MN
ACR Clinical Research Center Philadelphia PA
Adena Regional Medical Center Chillicothe OH
Allegiance Health Jackson MI
AnMed Health Cancer Center Anderson SC
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Baptist Hospital of Miami Miami FL
Bay Area Medical Center Marinette WI
Beaumont Hospital-Dearborn Dearborn MI
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Beth Israel Deaconess Medical Center Boston MA
Billings Clinic Cancer Center Billings MT
Boca Raton Community Hospital-Lynn Regional Cancer Center Boca Raton FL
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Bozeman Deaconess Hospital Cancer Center Bozeman MT
Bronson Methodist Hospital Kalamazoo MI
Cape Radiation Oncology Cape Girardeau MO
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Case Western Reserve University Cleveland OH
Central Maryland Radiation Oncology in Howard County Columbia MD
Centre Hospitalier de l`Universite de Montreal-Notre Dame Montreal Quebec
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
City of Hope Comprehensive Cancer Center Duarte CA
Cleveland Clinic Foundation Cleveland OH
Columbus CCOP Columbus OH
Community Memorial Hospital Menomonee Falls WI
Cross Cancer Institute Edmonton, Alberta
D'Amour Center for Cancer Care Springfield MA
Dartmouth Hitchcock Medical Center Lebanon NH
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Hospital Columbus OH
Emory University Hospital Midtown Atlanta GA
Emory University Hospital/Winship Cancer Institute Atlanta GA
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Froedtert and the Medical College of Wisconsin Milwaukee WI
Genesis Healthcare System Cancer Care Center Zainesville OH
Genesys Hurley Cancer Institute Flint MI
Grady Health System Atlanta GA
Grady Memorial Hospital Delaware OH
Grant Medical Center Columbus OH
Great Falls Clinic Great Falls MT
Gundersen Lutheran Medical Center La Crosse WI
Heartland Regional Medical Center St. Joseph MO
Hennepin County Medical Center Minneapolis MN
Henry Ford Hospital Detroit MI
Henry Ford Macomb Hospital-Clinton Township Clinton Township MI
Highland Hospital Rochester NY
Hurley Medical Center Flint MI
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Intermountain Medical Center Murray UT
John Muir Medical Center-Concord Concord CA
John Muir Medical Center-Walnut Creek Concord CA
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Lake Huron Medical Center Port Huron MI
Lake/University Seidman Cancer Center Mentor OH
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
Liberty Radiation Oncology Center Liberty MO
Licking Memorial Hospital Newark OH
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Long Island Jewish Medical Center Lake Success NY
M D Anderson Cancer Center Houston TX
Maine Medical Center- Scarborough Campus Scarborough ME
Marietta Memorial Hospital Marietta OH
Mary Bird Perkins Cancer Center Baton Rouge LA
Massachusetts General Hospital Boston MA
Mayo Clinic Rochester MN
Mayo Clinic Hospital Phoenix AZ
Mayo Clinic in Arizona Scottsdale AZ
Mayo Clinic in Florida Jacksonville FL
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Medical University of South Carolina Charleston SC
Memorial University Medical Center Savannah GA
Menorah Medical Center Overland Park KS
Mercy Hospital Coon Rapids MN
Mercy Hospital Saint Louis St Louis MO
Methodist Cancer Center Omaha NE
Methodist Hospital Philadelphia PA
Metro-Minnesota CCOP St. Louis Park MN
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Moffitt Cancer Center Tampa FL
Moffitt South Cancer Center Tampa FL
Montana Cancer Consortium CCOP Billings MT
Montefiore Medical Center - Moses Campus Bronx NY
Mount Carmel Health Center West Columbus OH
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
Norris Cotton Cancer Center Saint Johnsbury VT
North Kansas City Hospital North Kansas City MO
North Memorial Medical Health Center Robbinsdale MN
North Shore-LIJ Health System CCOP Manhasset NY
Northern Rockies Radiation Oncology Center Billings MT
Northwestern University Chicago IL
Northwestern University Chicago IL
Norton Suburban Hospital and Medical Campus Louisville KY
Ohio State University Medical Center Columbus OH
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
Radiological Physics Center (RPC) Houston TX
Regions Hospital St. Paul MN
Research Medical Center Kansas City MO
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Rocky Mountain Oncology Casper WY
Rutherford Hospital Rutherfordton NC
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Ann's Hospital Westerville OH
Saint Francis Hospital Federal Way WA
Saint Francis Medical Center Cape Girardeau MO
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Thomas Hospital Nashville TN
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sandra L Maxwell Cancer Center Cedar City UT
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital St. Louis MO
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Southside Hospital Bayshore NY
Southwest VA Regional Cancer Center Norton VA
Sparrow Hospital Lansing MI
Spartanburg Medical Center Spartanburg SC
Springfield Regional Medical Center Springfield OH
St. Anthony's Health Alton IL
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Tate Cancer Center Glen Burnie MD
Tel-Aviv Sourasky Medical Center Tel-Aviv
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Research Institute of the McGill University Health Centr Montreal
The University of Kansas Cancer Center-Lee's Summit Lee's Summit MO
The University of Kansas Cancer Center-North Kansas City MO
The University of Kansas Cancer Center-South Kansas City MO
Thomas Jefferson University Hospital Philadelphia PA
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange CA
UCSF Medical Center-Mount Zion San Francisco CA
United Hospital St. Paul MN
Unity Hospital Fridley MN
University of Arizona Medical Center-University Campus Tucson AZ
University of Colorado Hospital Aurora CO
University of Florida Health Science Center - Gainesville Gainesville FL
University of Kansas Cancer Center Kansas City KS
University of Kansas Cancer Center-Overland Park Overland Park KS
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Nebraska Medical Center Omaha NE
University of Nebraska Medical Center Omaha NE
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Texas Health Science Center at San Antonio San Antonio TX
University of Texas Medical Branch Galveston TX
University of Texas Medical Branch San Antonio TX
University of Utah Health Science Center Salt Lake City UT
University of Virginia Cancer Center Charlottesville VA
University of Washington Medical Center Seattle WA
University of Wisconsin Cancer Center Johnson Creek Johnson Creek WI
University of Wisconsin Hospital and Clinics Madison WI
UPMC Cancer Center at UPMC McKeesport McKeesport PA
UPMC Cancer Center at UPMC Northwest Seneca PA
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centre at Clarion Hospital Clarion PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-HVHS Cancer Center (Moon) Coraopolis PA
UPMC-Jameson Memorial Hospital New Castle PA
UPMC-Magee Womens Hospital Pittsburgh PA
UPMC-Passavant Hospital Pittsburgh PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Saint Margaret Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-The Washington Hospital Washington PA
UPMC-Uniontown / Robert E. Eberly Pavilion Uniontown PA
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Washington University School of Medicine St. Louis MO
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Yale University New Haven CT
Updated: 10/27/2014

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