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RTOG 0614 Protocol Information

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A Randomized, Phase III, Double-Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy---RTOG CCOP Study
Protocol Documents
Current Version Date: 10/25/2007
Principal Investigator: Paul D. Brown, MD
Primary Objective:

Determine whether the addition of memantine to WBRT preserves cognitive function, specifically memory as measured by the Hopkins Verbal Learning Test-Revised for delayed recall (HVLT-R delayed recall), over that of placebo and WBRT in patients with brain metastases at 24 weeks from the start of drug treatment.

Patient Population:

Pathologically proven solid tumor malignancy and brain metastases. Patients must be classified as RTOG RPA class I or RPA class II with controlled systemic disease for 3 months or more prior to study entry. Prior surgical resection and/or radiosurgery are allowed. Prior systemic therapy must be completed > 14 days prior to study entry.

Target Accrual: 536
Current Accrual: 554
Status: Terminated
Date: 12/15/2016
Participating Sites:
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Abbott-Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
Adams Cancer Center Gettysburg PA
Albert Lea Medical Center Albert Lea MN
Allegiance Health Jackson MI
Alta Bates Summit Medical Center - Summit Campus Oakland CA
AnMed Health Cancer Center Anderson SC
Arizona Oncology Services Foundation Scottsdale AZ
Asante Health System Medford OR
Asante Three Rivers Medical Center Grants Pass OR
Atlanta VA Medical Center Decatur GA
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute Oakland CA
Bay Medical Center Panama City FL
Beaumont Hospital - Dearborn Dearborn MI
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Billings Clinic Cancer Center Billings MT
Bixby Medical Center Adrian MI
Blanchard Valley Hospital Findlay OH
Boston Medical Center MBCCOP Boston MA
Bozeman Deaconess Hospital Cancer Center Bozeman MT
Bronson Battle Creek Battle Creek MI
Bryn Mawr Hospital Bryn Mawr PA
Cancer Institute of New Mexico Santa Fe NM
Cancer Treatment Center Wooster OH
Cape Radiation Oncology Cape Girardeau MO
Carle Cancer Center Urbana IL
CarolinaEast Medical Center New Burn NC
Case Western Reserve University Cleveland OH
Cedars-Sinai Medical Center Los Angeles CA
Central Maryland Radiation Oncology in Howard County Columbia MD
Centre Hospitalier de l`Universite de Montreal-Notre Dame Montreal Quebec
Cherry Tree Cancer Center Hanover PA
CHI Health Good Samaritan Kearney NE
Christiana Care Health System-Christiana Hospital Newark DE
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Quebec
CHUM - Centre Hospitalier de l'Universite de Montreal Montreal
City of Hope Comprehensive Cancer Center Duarte CA
CIUSSSEMTL-Hopital Maisonneuve-Rosemont Montreal, Quebec
Cleveland Clinic Akron General Akron OH
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland OH
Cleveland Clinic Cancer Center-Independence Independence OH
Cleveland Clinic Foundation Cleveland OH
Cleveland Clinic Wooster Specialty Center Wooster OH
Coborn Cancer Center at Saint Cloud Hospital St. Cloud MN
Community Cancer Center East Indianapolis IN
Community Cancer Center North Indianapolis IN
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Concord Hospital Payson Center for Cancer Care Concord NH
Cooper Health System-Voorhees Voorhees NJ
Cooper Hospital University Medical Center Camden NJ
CoxHealth South Hospital Springfield MO
Danville Regional Medical Center Danville VA
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo CA
Dubs Cancer Center @ Rogue Valley Medical Center Medford OR
Duke Women's Cancer Care Raleigh Raleigh NC
East Bay Radiation Oncology Center Castro Valley CA
Einstein Medical Center Philadelphia Philadelphia PA
Elkhart General Hospital Elkhart IN
Elliot Hospital Manchester NH
Emory University Hospital Midtown Atlanta GA
Emory University Hospital/Winship Cancer Institute Atlanta GA
Enloe Medical Center Chico CA
EvergreenHealth Medical Center Kirkland WA
Fairbanks Memorial Hospital Fairbanks AK
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Flower Hospital Sylvania OH
Fox Chase Cancer Center Philadelphia PA
Fox Chase Cancer Center Buckingham Furlong PA
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Froedtert and the Medical College of Wisconsin Milwaukee WI
Geisinger Medical Center Danville PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes Barre PA
Genesys Hurley Cancer Institute Flint MI
Good Samaritan Hospital - Dayton Dayton OH
Goshen Center for Cancer Care Goshen IN
Grady Health System Atlanta GA
Grand Rapids Clinical Oncology Program Grand Rapids MI
Grandview Hospital Dayton OH
Great Falls Clinic Great Falls MT
Greater Baltimore Medical Center Baltimore MD
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Gulf Coast MBCCOP Mobile AL
Guthrie Medical Group PC-Robert Packer Hospital Sayre PA
Helen Denit Cancer Center Olney MD
Hennepin County Medical Center Minneapolis MN
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Hillcrest Hospital Cancer Center Mayfield Heights OH
Holy Cross Hospital Fort Lauderdale FL
Hudson Valley Oncology Associates Poughkeepsie NY
Hurley Medical Center Flint MI
Huron Valley Hospital Commerce Township MI
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Indiana University Health Bloomington Bloomington IN
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Innovative Healthcare Research Consortium Glendale CA
Inspira Medical Center Vineland Vineland NJ
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intermountain Medical Center Murray UT
IU Health Central Indiana Cancer Centers Indianapolis IN
IU Health La Porte Hospital La Porte IN
John B Amos Cancer Center Columbus GA
John F Kennedy Medical Center Edison NJ
John H Stroger Jr Hospital of Cook County Chicago IL
John Muir Medical Center-Concord Concord CA
John Muir Medical Center-Walnut Creek Concord CA
Jupiter Medical Center Jupiter FL
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario
Kaiser Permanente Los Angeles Medical Center Los Angeles CA
Kettering Medical Center Dayton OH
Kings County Hospital Brooklyn NY
Lake Huron Medical Center Port Huron MI
Lake/University Seidman Cancer Center Mentor OH
Lakeland Regional Health System St. Joseph MI
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Long Island Jewish Medical Center Lake Success NY
Los Angeles County-USC Medical Center Los Angeles CA
Lovelace Medical Center-Downtown Albuquerque NM
Mainline Health CCOP Wynnewood PA
Mayo Clinic Rochester MN
Mayo Clinic Health System-Franciscan Healthcare LaCrosse WI
Mayo Clinic Health Systems-Mankato Mankato MN
Mayo Clinic Hospital Phoenix AZ
Mayo Clinic in Arizona Scottsdale AZ
Mayo Clinic in Florida Jacksonville FL
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute - Flint Flint MI
Medical University of Ohio Toledo OH
Medical University of South Carolina Charleston SC
Memorial Hospital South Bend IN
Mercy Cancer Center Elyria OH
Mercy General Radiation Oncology Center Sacramento CA
Mercy Health Mercy Campus Muskegon MI
Mercy Health Saint Mary's Grand Rapids MI
Mercy Hospital Coon Rapids MN
Mercy Hospital Saint Louis St Louis MO
Mercy Hospital Springfield Springfield MO
Mercy Saint Anne Hospital Toledo OH
Mercy San Juan Medical Center Carmichael CA
Methodist Cancer Center Omaha NE
Methodist Hospital Philadelphia PA
Metro-Minnesota CCOP St. Louis Park MN
Miami Valley Hospital Dayton OH
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Mission Hospital-Memorial Campus Asheville NC
Monmouth Medical Center Long Branch NJ
Montana Cancer Consortium CCOP Billings MT
Mount Sinai Medical Center Miami Beach FL
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Nevada Cancer Research Foundation CCOP Las Vegas NV
New Hanover Regional Medical Center/Zimmer Cancer Center Wilmington NC
New York Oncology Hematology PC - Albany Albany NY
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
NHRMC Radiation Oncology - 16th Street Wilmington NC
NHRMC Radiation Oncology - Supply Supply NC
North Coast Cancer Care Sandusky OH
North Memorial Medical Health Center Robbinsdale MN
North Shore-LIJ Health System CCOP Manhasset NY
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northeast Georgia Medical Center-Gainesville Gainesville GA
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium South Bend IN
Northern Rockies Radiation Oncology Center Billings MT
Northwest Community Hospital Arlington Heights IL
Northwestern Ontario Regional Cancer Centre Thunder Bay, Ontario
Northwestern University Chicago IL
Norton Hospital Pavilion and Medical Campus Louisville KY
Norton Suburban Hospital and Medical Campus Louisville KY
Novant Health Presbyterian Medical Center Charlotte NC
Ocean Medical Center Brick NJ
Ohio State University Comprehensive Cancer Center Columbus OH
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Paoli Memorial Hospital Paoli PA
Parkridge University Radiation Oncology Rochester NY
Parkview Hospital Randallia Fort Wayne IN
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
Piedmont Hospital Atlanta GA
Pomona Valley Hospital Medical Center Pomona CA
Poudre Valley Hospital Radiation Oncology Fort Collins CO
Princeton Radiation Oncology Center Jamesburg NJ
Providence Holy Cross Medical Center Mission Hills CA
Providence Hospital Mobile AL
Providence Medford Medical Center Medford OR
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank CA
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
QEII Health Sciences Centre/Nova Scotia Health Authority Halifax, Nova Scotia
RadAmerica II, LLC Baltimore MD
Radamerica-Franklin Square, LLC Baltimore MD
Radiation Oncology Associates Reno NV
Radiation Oncology Associates of Albuquerque Albuquerque NM
Radiation Oncology Associates PC Fort Wayne IN
Radiological Associates of Sacramento Sacramento CA
Rapid City Regional Hospital Rapid City SD
Regions Hospital St. Paul MN
Reid Health Richmond IN
Renown Regional Medical Center Reno NV
Ridgeview Medical Center Waconia MN
Riverview Medical Center/Booker Cancer Center Red Bank NJ
Rochester General Hospital Rochester NY
Rocky Mountain Cancer Centers-Aurora Aurora CO
Rocky Mountain Oncology Casper WY
Roswell Park Cancer Institute Buffalo NY
Rutherford Hospital Rutherfordton NC
Saint Agnes Hospital Baltimore MD
Saint Barnabas Medical Center Livingston NJ
Saint Charles Hospital Oregon OH
Saint Francis Hospital Federal Way WA
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint John's Hospital - Healtheast Maplewood MN
Saint Joseph Hospital - Orange Orange CA
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Peter's University Hospital New Brunswick NJ
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Saint Vincent Mercy Medical Center Toledo OH
Samuel S. Stratton VA Medical Center Albany NY
Sandra L Maxwell Cancer Center Cedar City UT
Sands Cancer Center Canandaigua NY
Sentara Norfolk General Hospital Norfolk VA
Singing River Hospital Pascagoula MS
Southeast Missouri Hospital Cape Girardeau MO
Southside Hospital Bayshore NY
Southwest VA Regional Cancer Center Norton VA
Sparrow Hospital Lansing MI
Sparta Cancer Center Sparta NJ
Spartanburg Medical Center Spartanburg SC
Spectrum Health at Butterworth Campus Grand Rapids MI
St Anne's Hospital Fall River MA
St Johns Hospital, Cancer Institute Springfield IL
St. Anthony's Health Alton IL
St. Joseph Medical Center Towson MD
St. Vincent Hospital and Health Care Centers, Inc. Indianapolis IN
Stanford Cancer Institute Palo Alto Palo Alto CA
Stanford Emanuel Radiation Oncology Center Turlock CA
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Medical Center Sacramento Sacramento CA
Tate Cancer Center Glen Burnie MD
Texas Cancer Center - Medical City Dallas Dallas TX
Texas Cancer Center-Sherman Sherman TX
Texas Oncology Bedford Bedford TX
Texas Oncology Cancer Center Sugar Land Sugarland TX
Texas Oncology Methodist Charlton Cancer Center Dallas TX
Texas Oncology-Arlington South Arlington TX
Texas Oncology-Denton South Denton TX
Texas Oncology-Longview Cancer Center Longview TX
The Coleman Radiation Center-Carteret General Hospital Morehead City NC
The Ireland Cancer Center at Community Health Partners Elyria OH
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Klabzuba Cancer Center Fort Worth TX
The Research Institute of the McGill University Health Centr Montreal
The University of Kansas Cancer Center-North Kansas City MO
The University of Kansas Cancer Center-South Kansas City MO
Thedacare Cancer Institute Appleton WI
ThedaCare Regional Cancer Center Appleton WI
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers-Adrian Adrian MI
Toledo Clinic Cancer Centers-Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Torrance Memorial Medical Center Torrance CA
Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus Elizabeth NJ
Trinity Cancer Care Center Minot ND
Tyler Cancer Center Tyler TX
UC San Diego Moores Cancer Center LaJolla CA
UF Cancer Center at Orlando Health Orlando FL
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
UH Seidman Cancer Center at Southwest General Middleburgh OH
UHHS - Chagrin Highlands Orange Village OH
UHHS-Westlake Medical Center Westlake OH
United Hospital St. Paul MN
Unity Hospital Fridley MN
University Medical Center of Princeton at Plainsboro Princeton NJ
University of Arizona Medical Center-University Campus Tucson AZ
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Iowa/Holden Comprehensive Cancer Center Iowa City IA
University of Kansas Cancer Center-Overland Park Overland Park KS
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Nebraska Medical Center Omaha NE
University of Nebraska Medical Center Omaha NE
University of New Mexico Cancer Center Albuquerque NM
University of New Mexico Cancer Center Albuquerque NM
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Southern California Los Angeles CA
University of Texas Health Science Center at San Antonio San Antonio TX
University of Texas Medical Branch San Antonio TX
University of Utah Health Science Center Salt Lake City UT
University of Vermont Medical Center Burlington VT
University of Virginia Cancer Center Charlottesville VA
University of Wisconsin Cancer Center Johnson Creek Johnson Creek WI
University of Wisconsin Hospital and Clinics Madison WI
University Pointe-Precision Radiotherapy West Chester OH
UPMC Cancer Center at UPMC McKeesport McKeesport PA
UPMC Cancer Center at UPMC Northwest Seneca PA
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centre at Clarion Hospital Clarion PA
UPMC Jameson New Castle PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-HVHS Cancer Center (Moon) Coraopolis PA
UPMC-Jameson Memorial Hospital New Castle PA
UPMC-Magee Womens Hospital Pittsburgh PA
UPMC-Passavant Hospital Pittsburgh PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Saint Margaret Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-The Washington Hospital Washington PA
UPMC-Uniontown / Robert E. Eberly Pavilion Uniontown PA
Upper Valley Medical Center Troy OH
Upstate Carolina CCOP Spartanburg SC
USON- Cancer Care Centers of South Texas-NE San Antonio TX
USON- FLA Institute of Research, Medicine & Surgery Orlando Orlando FL
USON-Arizona Radiation Oncology Tucson AZ
USON-Cancer Care Northwest - Spokane Spokane WA
USON-Rocky Mountain Cancer Centers-Colorado Springs Colorado Springs CO
USON-Williamette Valley Cancer Center Eugene OR
UT Southwestern/Simmons Cancer Center-Dallas Dallas TX
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Veteran Affairs Medical Center Dayton OH
Veterans Administration Long Beach Medical Center Long Beach CA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Washington Cancer Institute Washington DC
Wausau Hospital Center Wausau WI
Wayne State University/Karmanos Cancer Institute Detroit MI
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
WellSpan Health-York Hospital York PA
West Allis Memorial Hospital West Allis WI
West Texas Cancer Center Odessa TX
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
William Beaumont Hospital-Royal Oak Royal Oak MI
Yale University New Haven CT
Updated: 12/15/2016

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