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RTOG 0619 Protocol Information

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A Randomized Phase II Trial of Chemoradiotherapy Versus Chemoradiotherapy and Vandetanib For High-Risk Postoperative Advanced Squamous Cell Carcinoma of the Head and Neck
Protocol Documents
Current Version Date: 2/25/2010
Principal Investigator: David Raben, MD
Primary Objective:

To screen for an indication that the addition of vandetanib to chemoradiotherapy may prolong disease-free survival as compared to a combination of chemoradiotherapy in patients with resected, high-risk head and neck squamous cell carcinoma

Patient Population:

AJCC pathological stage III or IV squamous cell carcinoma of the oral cavity, oropharynx, larynx, or hypopharynx (excluding lip, nasopharynx, or sinuses) Complete tumor resection (with curative intent) must be completed within 3 to 6 weeks of registration

Target Accrual: 170
Current Accrual: 34
Status: Terminated
Date: 8/3/2011
Participating Sites:
ACR Clinical Research Center Philadelphia PA
Adams Cancer Center Gettysburg PA
Allegiance Health Jackson MI
Alta Bates Summit Medical Center - Summit Campus Oakland CA
AnMed Health Cancer Center Anderson SC
Aria Health Philadelphia PA
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute Oakland CA
Beaumont Hospital-Dearborn Dearborn MI
Bixby Medical Center Adrian MI
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
Cape Radiation Oncology Cape Girardeau MO
Case Western Reserve University Cleveland OH
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Christiana Care Health System-Christiana Hospital Newark DE
City of Hope Comprehensive Cancer Center Duarte CA
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland OH
Cleveland Clinic Foundation Cleveland OH
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
CoxHealth South Hospital Springfield MO
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo CA
East Carolina University Greenville NC
East Bay Radiation Oncology Center Castro Valley CA
Einstein Medical Center Philadelphia Philadelphia PA
Elkhart General Hospital Elkhart IN
Emory University Hospital Midtown Atlanta GA
Emory University Hospital/Winship Cancer Institute Atlanta GA
Flower Hospital Sylvania OH
Fox Chase Cancer Center Philadelphia PA
Fox Chase Cancer Center Buckingham Furlong PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Geisinger Medical Center Danville PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes Barre PA
Genesys Hurley Cancer Institute Flint MI
Grady Health System Atlanta GA
Greater Baltimore Medical Center Baltimore MD
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Gundersen Lutheran Medical Center La Crosse WI
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Hillcrest Hospital Cancer Center Mayfield Heights OH
Hurley Medical Center Flint MI
Huron Valley Hospital Commerce Township MI
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University Health Methodist Hospital Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Intermountain Medical Center Murray UT
IU Health La Porte Hospital La Porte IN
John H Stroger Jr Hospital of Cook County Chicago IL
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Lake Huron Medical Center Port Huron MI
Lake/University Seidman Cancer Center Mentor OH
Lakeland Medical Center Saint Joseph St Joseph MI
Lakeland Regional Health System St. Joseph MI
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
Lima Memorial Hospital Lima OH
London Regional Cancer Program London Ontario
Los Angeles County-USC Medical Center Los Angeles CA
M D Anderson Cancer Center Houston TX
Maimonides Medical Center Brooklyn NY
Mayo Clinic Rochester MN
Mayo Clinic Health Systems-Mankato Mankato MN
Mayo Clinic in Arizona Scottsdale AZ
Mayo Clinic in Florida Jacksonville FL
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Medical University of Ohio Toledo OH
Medical University of South Carolina Charleston SC
Memorial Hospital South Bend IN
Memorial Sloan Kettering Basking Ridge Basking Ridge NJ
Memorial Sloan Kettering Cancer Center New York NY
Memorial Sloan Kettering Commack Commack NY
Memorial Sloan Kettering Rockville Centre Rockville NY
Memorial Sloan Kettering Sleepy Hollow Sleepy Hollow NY
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Saint Louis St Louis MO
Mercy Saint Anne Hospital Toledo OH
Mercy San Juan Medical Center Carmichael CA
Methodist Hospital Philadelphia PA
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Moffitt Cancer Center Tampa FL
Norris Cotton Cancer Center-North Saint Johnsbury VT
North Coast Cancer Care Sandusky OH
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium South Bend IN
Novant Health Presbyterian Medical Center Charlotte NC
Ohio State University Comprehensive Cancer Center Columbus OH
Oregon Health and Science University Portland OR
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Penrose-Saint Francis Healthcare Colorado Springs CO
Portland VA Medical Center Portland OR
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
Providence Hospital Mobile AL
Radiation Oncology Associates of Albuquerque Albuquerque NM
Radiological Associates of Sacramento Sacramento CA
Radiological Physics Center (RPC) Houston TX
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Renown Regional Medical Center Reno NV
Roswell Park Cancer Institute Buffalo NY
Rutherford Hospital Rutherfordton NC
Saint Charles Hospital Oregon OH
Saint Elizabeth Regional Medical Center Lincoln NE
Saint Francis Hospital Federal Way WA
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Saint Vincent Mercy Medical Center Toledo OH
Sandra L Maxwell Cancer Center Cedar City UT
Seattle Cancer Care Alliance Seattle WA
Sentara Norfolk General Hospital Norfolk VA
Singing River Hospital Pascagoula MS
Siteman Cancer Center at West County Hospital St. Louis MO
Southeast Missouri Hospital Cape Girardeau MO
Sparrow Hospital Lansing MI
Sparta Cancer Center Sparta NJ
Spartanburg Medical Center Spartanburg SC
St Johns Hospital, Cancer Institute Springfield IL
St. Anthony's Health Alton IL
St. Vincent Hospital and Health Care Centers, Inc. Indianapolis IN
Stanford Cancer Institute Palo Alto Palo Alto CA
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Reverend Roger Patrick Dorcy Cancer Center Pueblo CO
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers-Adrian Adrian MI
Toledo Clinic Cancer Centers-Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
UC San Diego Moores Cancer Center LaJolla CA
UCSF Medical Center-Mount Zion San Francisco CA
UF Cancer Center at Orlando Health Orlando FL
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Kansas Cancer Center Kansas City KS
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of New Mexico Cancer Center Albuquerque NM
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Pennsylvania Medical Center Philadelphia PA
University of Rochester Rochester NY
University of Southern California Los Angeles CA
University of Texas Southwestern Medical School Dallas TX
University of Utah Health Science Center Salt Lake City UT
University of Virginia Cancer Center Charlottesville VA
University of Washington Medical Center Seattle WA
University of Wisconsin Hospital and Clinics Madison WI
University Pointe-Precision Radiotherapy West Chester OH
Upper Delaware Valley Cancer Center Milford PA
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Wake Forest University Health Sciences Winston-Salem NC
Washington University School of Medicine St. Louis MO
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wayne State University/Karmanos Cancer Institute Detroit MI
WellSpan Health-York Hospital York PA
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
William Backus Hospital Norwich CT
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 8/4/2011

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