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RTOG 0625 Protocol Information

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A Randomized Phase II Trial of Bevacizumab With Irinotecan or Bevacizumab With Temozolomide in Recurrent Glioblastoma
Protocol Documents
Current Version Date: 1/22/2009
Principal Investigator: Mark R. Gilbert, MD
Primary Objective:

To determine the efficacy of the combination of bevacizumab and irinotecan as measured by the 6-month progression-free survival rate in patients with recurrent glioblastoma. To determine the adverse event profile and tolerability of the combination of bevacizumab and temozolomide in patients with recurrent glioblastoma.

Patient Population:

Patients with histologically proven glioblastoma who have failed external beam radiotherapy with temozolomide chemotherapy.

Target Accrual: 121
Current Accrual: 123
Status: Terminated
Date: 11/5/2013
Participating Sites:
Abbott-Northwestern Hospital Minneapolis MN
Adventist Medical Center Portland OR
Alta Bates Summit Medical Center-Herrick Campus Berkeley CA
Anne Arundel Medical Center Annapolis MD
Arizona Oncology Services Foundation Scottsdale AZ
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Billings Clinic Cancer Center Billings MT
Blanchard Valley Hospital Findlay OH
Boca Raton Regional Hospital Boca Raton FL
Borgess Medical Center Kalamazoo MI
Bozeman Deaconess Hospital Cancer Center Bozeman MT
Bronson Methodist Hospital Kalamazoo MI
California Pacific Medical Center-Pacific Campus San Francisco CA
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
City of Hope Comprehensive Cancer Center Duarte CA
Cleveland Clinic Akron General Akron OH
Cooper Health System-Voorhees Voorhees NJ
Cooper Hospital University Medical Center Camden NJ
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Dayton CCOP Kettering OH
Dixie Medical Center Regional Cancer Center East St. George UT
EvergreenHealth Medical Center Kirkland WA
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Froedtert and the Medical College of Wisconsin Milwaukee WI
Good Samaritan Hospital - Dayton Dayton OH
Grand Rapids Clinical Oncology Program Grand Rapids MI
Grandview Hospital Dayton OH
Great Falls Clinic Great Falls MT
Greene Memorial Hospital Xenia OH
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Indiana University Health Methodist Hospital Indianapolis IN
Intermountain Medical Center Murray UT
John F Kennedy Medical Center Edison NJ
John Muir Medical Center-Concord Concord CA
John Muir Medical Center-Walnut Creek Concord CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
LDS Hospital Salt Lake City UT
Legacy Emanuel Hospital & Health Center Portland OR
Legacy Good Samaritan Hospital & Medical Center Portland OR
Legacy Meridian Park Hospital Tualatin OR
Legacy Mount Hood Medical Center Gresham OR
Liberty Hospital Liberty MO
M D Anderson Cancer Center Houston TX
Marin General Hospital Greenbrae CA
McKay-Dee Hospital Center Ogden UT
Memorial Sloan Kettering Cancer Center New York NY
Mercy General Radiation Oncology Center Sacramento CA
Mercy Health Saint Mary's Grand Rapids MI
Mercy Hospital Coon Rapids MN
Mercy San Juan Medical Center Carmichael CA
Methodist Cancer Center Omaha NE
Methodist Hospital Philadelphia PA
Metro-Minnesota CCOP St. Louis Park MN
Miami Valley Hospital Dayton OH
Mills-Peninsula Medical Center San Mateo CA
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Mission Hospital-Memorial Campus Asheville NC
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Montana Cancer Consortium CCOP Billings MT
New Mexico Oncology Hematology Consultants Albuquerque NM
Norris Cotton Cancer Center-North Saint Johnsbury VT
North Memorial Medical Health Center Robbinsdale MN
Northeast Radiation Oncology Center Dunmore PA
Northern Rockies Radiation Oncology Center Billings MT
Orange Regional Medical Center Middletown NY
PeaceHealth Southwest Medical Center Vancouver WA
Penrose-Saint Francis Healthcare Colorado Springs CO
Piedmont Hospital Atlanta GA
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Saint Vincent Medical Center Portland OR
Radiological Associates of Sacramento Sacramento CA
Reid Health Richmond IN
Rhode Island Hospital Providence RI
Ridgeview Medical Center Waconia MN
Rocky Mountain Oncology Casper WY
Roswell Park Cancer Institute Buffalo NY
Saint Francis Hospital Federal Way WA
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Sandra L Maxwell Cancer Center Cedar City UT
Seattle Cancer Care Alliance Seattle WA
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Sparta Cancer Center Sparta NJ
St. Luke's Mountain States Tumor Institute Boise ID
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Solano Medical Center Vallejo CA
Tel Aviv Sourasky Medical Center Tel-Aviv
The Reverend Roger Patrick Dorcy Cancer Center Pueblo CO
Thomas Jefferson University Hospital Philadelphia PA
United Hospital St. Paul MN
Unity Hospital Fridley MN
University of Arizona Medical Center-University Campus Tucson AZ
University of Chicago Comprehensive Cancer Center Chicago IL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Florida Health Science Center - Gainesville Gainesville FL
University of Iowa/Holden Comprehensive Cancer Center Iowa City IA
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Rochester Rochester NY
University of Texas Medical Branch Galveston TX
University of Utah Health Science Center Salt Lake City UT
University of Washington Medical Center Seattle WA
University of Wisconsin Hospital and Clinics Madison WI
UPMC Cancer Center at UPMC McKeesport McKeesport PA
UPMC Cancer Center at UPMC Northwest Seneca PA
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centre at Clarion Hospital Clarion PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-HVHS Cancer Center (Moon) Coraopolis PA
UPMC-Jameson Memorial Hospital New Castle PA
UPMC-Magee Womens Hospital Pittsburgh PA
UPMC-Passavant Hospital Pittsburgh PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Saint Margaret Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-The Washington Hospital Washington PA
UPMC-Uniontown / Robert E. Eberly Pavilion Uniontown PA
Upper Valley Medical Center Troy OH
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Veteran Affairs Medical Center Dayton OH
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Washington University School of Medicine St. Louis MO
Welch Cancer Center Sheridan WY
Western Oncology Research Consortium Portland OR
William Beaumont Hospital-Royal Oak Royal Oak MI
Yale University New Haven CT
Updated: 11/8/2013

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