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RTOG 0627 Protocol Information

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Phase II Trial of Dasatinib in Patients with Recurrent Glioblastoma Multiforme
Principal Investigator: Andrew B. Lassman, MD
Primary Objective:

To determine the therapeutic efficacy of dasatinib in all patients (i.e., stages 1B and 2 combined) with recurrent/progressive GBM as measured by 6-month progression-free survival.

Patient Population:

Patients with GBM who have progressive/recurrent disease despite treatment with radiotherapy and temozolomide. Patients accrued to stage 1 (closed to accrual) or stage 1B (opened to accrual May 5, 2009) require overexpression/activity in at least two of the following SRC, KIT, PDGFR, and EPHA2. Patients accrued to stage 2 (cohort closed; not currently applicable) do not require overexpression/activity.

Target Accrual: 84
Current Accrual: 64
Status: Closed to Accrual
Date: 3/22/2011
Participating Sites:
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Abbott-Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
Adams Cancer Center Gettysburg PA
Akron General Medical Center Akron OH
Allan Blair Cancer Centre Regina, SK
Allegiance Health Jackson MI
AnMed Health Cancer Center Anderson SC
Arizona Oncology Services Foundation Scottsdale AZ
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Aultman Hospital Canton OH
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Bay Area Medical Center Marinette WI
Bay Medical Center Panama City FL
Beaumont Hospital-Dearborn Dearborn MI
Blanchard Valley Hospital Findlay OH
Boca Raton Community Hospital-Lynn Regional Cancer Center Boca Raton FL
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Bronson Methodist Hospital Kalamazoo MI
Cancer Care Center, Inc Salem OH
Cancer Treatment Center Wooster OH
Cape Radiation Oncology Cape Girardeau MO
Cherry Tree Cancer Center Hanover PA
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Christiana Care Health System-Christiana Hospital Newark DE
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Quebec
City of Hope Comprehensive Cancer Center Duarte CA
Covenant Medical Center-Lakeside Lubbock TX
CoxHealth South Hospital Springfield MO
Dartmouth Hitchcock Medical Center Lebanon NH
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Froedtert and the Medical College of Wisconsin Milwaukee WI
Genesys Hurley Cancer Institute Flint MI
Good Samaritan Hospital - Dayton Dayton OH
Grandview Hospital Dayton OH
Greater Baltimore Medical Center Baltimore MD
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Greene Memorial Hospital Xenia OH
Greenville Health System Cancer Institute-Andrews Greenville SC
Greenville Health System Cancer Institute-Eastside Greenville SC
Gundersen Lutheran Medical Center La Crosse WI
Highland Hospital Rochester NY
Holy Cross Hospital Fort Lauderdale FL
Hurley Medical Center Flint MI
Indiana University Health Methodist Hospital Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Ingalls Memorial Hospital-Tinley Campus Tinley Park IL
Innovative Healthcare Research Consortium Glendale CA
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intermountain Medical Center Murray UT
John B Amos Cancer Center Columbus GA
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
King Faisal Specialist Hospital and Research Centre Riyadh 11211
Lake Huron Medical Center Port Huron MI
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
London Regional Cancer Program London Ontario
M D Anderson Cancer Center Houston TX
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Medical University of South Carolina Charleston SC
Memorial Sloan Kettering Cancer Center New York NY
Memorial University Medical Center Savannah GA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Coon Rapids MN
Mercy Hospital Springfield Springfield MO
Mercy San Juan Medical Center Carmichael CA
Methodist Cancer Center Omaha NE
Metro-Minnesota CCOP St. Louis Park MN
Miami Valley Hospital Dayton OH
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Mobile Infirmary Medical Center Mobile AL
Mount Sinai Medical Center Miami Beach FL
Norris Cotton Cancer Center Saint Johnsbury VT
North Memorial Medical Health Center Robbinsdale MN
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northeast Radiation Oncology Center Dunmore PA
Novant Health Presbyterian Medical Center Charlotte NC
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Parkridge University Radiation Oncology Rochester NY
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
Radiological Associates of Sacramento Sacramento CA
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Regions Hospital St. Paul MN
Reid Health Richmond IN
Renown Regional Medical Center Reno NV
Ridgeview Medical Center Waconia MN
Rutherford Hospital Rutherfordton NC
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Salem Hospital Salem OR
Sandra L Maxwell Cancer Center Cedar City UT
Sands Cancer Center Canandaigua NY
Sentara Norfolk General Hospital Norfolk VA
Singing River Hospital Pascagoula MS
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Southwest VA Regional Cancer Center Norton VA
Sparrow Hospital Lansing MI
Sparta Cancer Center Sparta NJ
Spartanburg Medical Center Spartanburg SC
St Johns Hospital, Cancer Institute Springfield IL
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
The James Graham Brown Cancer Center at University of Louisville Louisville KY
Thompson Cancer Survival Center Knoxville TN
Thompson Cancer Survival Center - West Knoxville TN
Thompson Cancer Survival Center at Methodist Oak Ridge TN
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange CA
United Hospital St. Paul MN
Unity Hospital Fridley MN
University of Arizona Medical Center-University Campus Tucson AZ
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Texas Medical Branch Galveston TX
University of Utah Health Science Center Salt Lake City UT
University of Vermont Medical Center Burlington VT
University of Wisconsin Hospital and Clinics Madison WI
University Pointe-Precision Radiotherapy West Chester OH
Upper Delaware Valley Cancer Center Milford PA
Upper Valley Medical Center Troy OH
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Veteran Affairs Medical Center Dayton OH
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virtua Memorial Mount Holly NJ
Virtua Voorhees Voorhees NJ
Washington University School of Medicine St. Louis MO
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
WellSpan Health-York Hospital York PA
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Updated: 2/16/2017

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