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RTOG 0822 Protocol Information

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A Phase II Evaluation of Preoperative Chemoradiotherapy Utilizing Intensity Modulated Radiation Therapy (IMRT) in Combination with Capecitabine and Oxaliplatin for Patients with Locally Advanced Rectal Cancer
Principal Investigator: Michael C. Garofalo, MD
Primary Objective:

To determine whether the incidence of acute (preoperative) grade 2-5 gastrointestinal toxicity associated with preoperative chemoradiotherapy is reduced by inverse-planned IMRT-based radiation treatment (when compared with conventionally delivered radiation treatment as was utilized in the capecitabine and oxaliplatin arm of RTOG 0247).

Patient Population:
  • Pathologically proven diagnosis of adenocarcinoma of the rectum (located up to 12 cm from the anal verge on flexible endoscopy) within 8 weeks of registration
  • Clinically determined to be T3 or T4 and N0-2, M0

 

Target Accrual: 75
Current Accrual: 79
Status: Terminated
Date: 12/15/2016
Participating Sites:
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Abbott-Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
ACR Clinical Research Center Philadelphia PA
Atrium Medical Center-Middletown Regional Hospital Franklin OH
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Bay Medical Center Panama City FL
Blanchard Valley Hospital Findlay OH
Boca Raton Regional Hospital Boca Raton FL
Borgess Medical Center Kalamazoo MI
Boston Medical Center Boston MA
Brigham and Women's Hospital Boston MA
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
California Cancer Center - Fresno Fresno CA
Cancer Treatment Center Wooster OH
Cape Radiation Oncology Cape Girardeau MO
Carle Cancer Center Urbana IL
Central Maine Medical Center Lewiston ME
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
CHUM - Hopital Notre-Dame Montreal Quebec
City of Hope Comprehensive Cancer Center Duarte CA
Columbia Saint Mary's Hospital - Ozaukee Mequon WI
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Community Medical Center Toms River NJ
CoxHealth South Hospital Springfield MO
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Dayton CCOP Kettering OH
Dixie Medical Center Regional Cancer Center East St. George UT
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Franciscan Saint Francis Health-Beech Grove Beech Grove IN
Franciscan St. James Health-Olympia Fields Campus Olympia Fields IL
Froedtert and the Medical College of Wisconsin Milwaukee WI
Good Samaritan Hospital - Dayton Dayton OH
Goshen Center for Cancer Care Goshen IN
Grandview Hospital Dayton OH
Greene Memorial Hospital Xenia OH
Highland Hospital Rochester NY
Image-Guided Therapy QA Center (ITC) St. Louis MO
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Integris Cancer Institute of Oklahoma Oklahoma City OK
Intermountain Medical Center Murray UT
IU Health Ball Memorial Hospital Muncie IN
John B Amos Cancer Center Columbus GA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kettering Medical Center Dayton OH
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Long Island Jewish Medical Center Lake Success NY
Maimonides Medical Center Brooklyn NY
Mainline Health CCOP Wynnewood PA
Massachusetts General Hospital Cancer Center Boston MA
McKay-Dee Hospital Center Ogden UT
Medical University of South Carolina Charleston SC
Memorial Health University Medical Center Savannah GA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Coon Rapids MN
Mercy San Juan Medical Center Carmichael CA
Metro-Minnesota CCOP St. Louis Park MN
Miami Cancer Institute Miami FL
Miami Valley Hospital Dayton OH
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Monmouth Medical Center Long Branch NJ
Nevada Cancer Research Foundation CCOP Las Vegas NV
Norris Cotton Cancer Center-North Saint Johnsbury VT
North Main Radiation Oncology Providence RI
North Memorial Medical Health Center Robbinsdale MN
North Shore-LIJ Health System CCOP Manhasset NY
Northeast Radiation Oncology Center Dunmore PA
Ohio State University Comprehensive Cancer Center Columbus OH
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Paoli Memorial Hospital Paoli PA
Penn State Milton S Hershey Medical Center Hershey PA
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Pocono Medical Center East Strousburg PA
Providence Hospital Mobile AL
Radiation Oncology Center Alliance OH
Radiological Associates of Sacramento Sacramento CA
Radiological Physics Center (RPC) Houston TX
Reid Health Richmond IN
Renown Regional Medical Center Reno NV
Rhode Island Hospital Providence RI
Ridgeview Medical Center Waconia MN
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital New Brunswick NJ
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Sandra L Maxwell Cancer Center Cedar City UT
Singing River Hospital Pascagoula MS
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital St. Louis MO
Southside Hospital Bayshore NY
Southwest VA Regional Cancer Center Norton VA
St Anne's Hospital Fall River MA
St Johns Hospital, Cancer Institute Springfield IL
St. Vincent Hospital and Health Care Centers, Inc. Indianapolis IN
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
The Nebraska Medical Center Omaha NE
Thomas Jefferson University Hospital Philadelphia PA
UC San Diego Moores Cancer Center LaJolla CA
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
United Hospital St. Paul MN
Unity Hospital Fridley MN
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Nebraska Medical Center Omaha NE
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Virginia Cancer Center Charlottesville VA
University Pointe West Chester OH
Upper Delaware Valley Cancer Center Milford PA
Upper Valley Medical Center Troy OH
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Veteran Affairs Medical Center Dayton OH
Virtua Memorial Mount Holly NJ
Virtua Voorhees Voorhees NJ
Washington University School of Medicine St. Louis MO
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Updated: 12/15/2016

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