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RTOG 0837 Protocol Information

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Randomized, Phase II, Double-Blind, Placebo-Controlled Trial of Conventional Chemoradiation and Adjuvant Temozolomide Plus Cediranib versus Conventional Chemoradiation and Adjuvant Temozolomide Plus Placebo in Patients with Newly Diagnosed Glioblastoma
Principal Investigator: Tracy Batchelor, MD
Primary Objective:

To determine if the addition of cediranib to chemoradiation treatment enhances treatment efficacy as measured by the 6-month progression-free survival rate.

Patient Population:

Histopathologically confirmed glioblastoma (WHO Grade IV) confirmed by central review  prior to Step 2 registration. Tumor tissue that is determined by central pathology review prior to Step 2 registration to be of sufficient size for analysis of MGMT status. The tumor must have a supratentorial component.

Target Accrual: 283
Current Accrual: 261
Status: Closed to Accrual
Date: 5/9/2012
Participating Sites:
Abbott-Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
ACR Clinical Research Center Philadelphia PA
Akron General Medical Center Akron OH
Allegheny General Hospital Pittsburgh PA
Allegheny Valley Hospital Natrona Heights PA
Allegiance Health Jackson MI
AnMed Health Cancer Center Anderson SC
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Baptist Health Lexington Lexington KY
Bay Medical Center Panama City FL
Beaumont Hospital-Dearborn Dearborn MI
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
Cancer Care Center, Inc Salem OH
Cancer Treatment Center Wooster OH
Cape Radiation Oncology Cape Girardeau MO
Carle Cancer Center Urbana IL
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Christiana Care Health System-Christiana Hospital Newark DE
City of Hope Comprehensive Cancer Center Duarte CA
City of Hope South Pasadena South Pasadena CA
Clackamas Radiation Oncology Center Clackamas OR
Community Cancer Center Foundation Normal IL
Compass Oncology Vancouver Vancouver WA
Dixie Medical Center Regional Cancer Center East St. George UT
Emory University Hospital Midtown Atlanta GA
Emory University Hospital/Winship Cancer Institute Atlanta GA
Fairbanks Memorial Hospital Fairbanks AK
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Florida Hospital Orlando Orlando FL
Froedtert and the Medical College of Wisconsin Milwaukee WI
Genesys Hurley Cancer Institute Flint MI
Grady Health System Atlanta GA
Heartland Regional Medical Center St. Joseph MO
Hennepin County Medical Center Minneapolis MN
Henry Ford Hospital Detroit MI
Henry Ford Macomb Hospital-Clinton Township Clinton Township MI
Hurley Medical Center Flint MI
Illinois CancerCare-Peoria Peoria IL
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University Health Methodist Hospital Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Inova Fairfax Hospital Falls Church VA
Intercommunity Cancer Center Monroeville PA
Intermountain Medical Center Murray UT
IU Health Central Indiana Cancer Centers Indianapolis IN
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Lake Huron Medical Center Port Huron MI
Langlade Hospital Cancer Center Antigo WI
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Legacy Good Samaritan Hospital & Medical Center Portland OR
Legacy Mount Hood Medical Center Gresham OR
Legacy Salmon Creek Hospital Vancouver WA
Liberty Hospital Liberty MO
Liberty Radiation Oncology Center Liberty MO
Logan Regional Hospital Logan UT
Maine Medical Center- Scarborough Campus Scarborough ME
Mainline Health CCOP Wynnewood PA
Massachusetts General Hospital Boston MA
McKay-Dee Hospital Center Ogden UT
Medical University of South Carolina Charleston SC
Menorah Medical Center Overland Park KS
Mercy Hospital Coon Rapids MN
Methodist Cancer Center Omaha NE
Methodist Medical Center of Illinois Peoria IL
Metro-Minnesota CCOP St. Louis Park MN
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
North Kansas City Hospital North Kansas City MO
North Memorial Medical Health Center Robbinsdale MN
Northeast Radiation Oncology Center Dunmore PA
Northwestern University Chicago IL
Novant Health Forsyth Medical Center Winston Salem NC
Ohio State University Medical Center Columbus OH
OSF Saint Francis Medical Center Peoria IL
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin IL
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria IL
Pacific Cancer Institute of Maui Wailuku HI
Paoli Memorial Hospital Paoli PA
Parkview Hospital Randallia Fort Wayne IN
PeaceHealth Southwest Medical Center Vancouver WA
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
Poudre Valley Hospital Fort Collins CO
Poudre Valley Hospital Radiation Oncology Fort Collins CO
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Saint Vincent Medical Center Portland OR
Queen's Medical Center Honolulu HI
Radiation Oncology Associates PC Fort Wayne IN
Radiation Oncology Center Alliance OH
Radiological Physics Center (RPC) Houston TX
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Regions Hospital St. Paul MN
Research Medical Center Kansas City MO
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Robinson Radiation Oncology Ravenna OH
Rush University Medical Center Chicago IL
Rutherford Hospital Rutherfordton NC
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Elizabeth Regional Medical Center Lincoln NE
Saint Francis Hospital Federal Way WA
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint Joseph Hospital - Orange Orange CA
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Sandra L Maxwell Cancer Center Cedar City UT
Seattle Cancer Care Alliance Seattle WA
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital St. Louis MO
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Sparrow Hospital Lansing MI
Sparta Cancer Center Sparta NJ
Spartanburg Medical Center Spartanburg SC
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
The Cancer Center of Hawaii-Liliha Honolulu HI
The Hospital of Central Connecticut New Britain CT
The Kirklin Clinic at Acton Road Birmingham AL
The University of Kansas Cancer Center-North Kansas City MO
The University of Kansas Cancer Center-South Kansas City MO
Thomas Jefferson University Hospital Philadelphia PA
Trinity's Tony Teramana Cancer Center Steubenville OH
United Hospital St. Paul MN
Unity Hospital Fridley MN
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Arizona Medical Center-University Campus Tucson AZ
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Hawaii Cancer Center Honolulu HI
University of Kansas Cancer Center Kansas City KS
University of Kansas Cancer Center-Overland Park Overland Park KS
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Rochester Rochester NY
University of Texas Health Science Center at San Antonio San Antonio TX
University of Texas Medical Branch San Antonio TX
University of Texas Medical Branch Galveston TX
University of Texas Southwestern Medical School Dallas TX
University of Washington Medical Center Seattle WA
University of Wisconsin Hospital and Clinics Madison WI
University Pointe-Precision Radiotherapy West Chester OH
UPMC Cancer Center at UPMC McKeesport McKeesport PA
UPMC Cancer Center at UPMC Northwest Seneca PA
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centre at Clarion Hospital Clarion PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-HVHS Cancer Center (Moon) Coraopolis PA
UPMC-Jameson Memorial Hospital New Castle PA
UPMC-Passavant Hospital Pittsburgh PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Saint Margaret Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-The Washington Hospital Washington PA
UPMC-Uniontown / Robert E. Eberly Pavilion Uniontown PA
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virginia Mason CCOP Seattle WA
Wake Forest University Health Sciences Winston-Salem NC
Washington University School of Medicine St. Louis MO
Wausau Hospital Center Wausau WI
Western Oncology Research Consortium Portland OR
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Yale University New Haven CT
Updated: 12/15/2014

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