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RTOG 0925 Protocol Information

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Natural History of Postoperative Cognitive Function, Quality of Life, and Seizure Control in Patients With Supratentorial Low-Risk Grade II Glioma
Protocol Documents
Current Version Date: 8/15/2013
Principal Investigator: Ali K. Choucair, MD
Primary Objective:

To determine if there is difference in the average changes of neurocognitive function (NCF) scores from baseline to the time of radiologic tumor progression or up to 5 years (whichever occurs first), between radiologically progressed and non-progressed patients.

Patient Population:

 

Central pathology‑confirmed diagnosis of supratentorial grade II oligodendroglioma, astrocytoma, or mixed oligoastrocytoma prior to Step 2 registration.

The patient must be within one of the following categories:

  • Maximal safe resection with minimal residual disease defined as follows:
    ► Removal of T2/FLAIR abnormalities thought to be primarily tumor, with a  residual ≤ 2 cm maximal tumor diameter/T2 FLAIR abnormality on MRI to be done within 84 days post-operatively.
    ► If there is > 2 cm post-operative residual T2/FLAIR abnormality and the neurosurgeon believes this represents edema and not primarily tumor; the neurosurgeon is encouraged to repeat imaging within the allowed study period (up to 84 days post-operatively) to confirm resolution of edema. MRI at the time of enrollment must document a ≤ 2 cm residual maximal tumor diameter/T2 FLAIR abnormality.
    ► Patients who required a second surgery to obtain a maximal safe resection will be eligible if the second surgery is performed within 84 days of the initial diagnostic procedure.

 

Target Accrual: 170
Current Accrual: 82
Status: Terminated
Date: 12/1/2014
Participating Sites:
Adams Cancer Center Gettysburg PA
Adams Cancer Center Gettysburg PA
Adena Regional Medical Center Chillicothe OH
Adena Regional Medical Center Chillicothe OH
American Fork Hospital / Huntsman Intermountain Cancer Center American Fork UT
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Bay Area Medical Center Marinette WI
Bay Area Medical Center Marinette WI
Beebe Health Campus Rehoboth Beach DE
Beebe Medical Center Lewes DE
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Big Horn Basin Cancer Center Cody WY
Billings Clinic Cancer Center Billings MT
Billings Clinic Cancer Center Billings MT
Billings Clinic-Cody Cody WY
Boulder Community Hospital Boulder CO
Bozeman Deaconess Hospital Bozeman MT
Bozeman Deaconess Hospital Cancer Center Bozeman MT
Bronson Battle Creek Battle Creek MI
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Cedar Rapids Oncology Association
Centerpoint Medical Center LLC Independence MO
Charleston Hematology Oncology Associates PA-Saint Francis Charleston SC
Charleston Hematology Oncology Associates-Roper Charleston SC
Cherry Tree Cancer Center Hanover PA
Cherry Tree Cancer Center Hanover PA
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Cheyenne Regional Medical Center-West Cheyenne WY
Christiana Care Health System-Christiana Hospital Newark DE
Christiana Care Health System-Christiana Hospital Newark DE
Christiana Care Health System-Wilmington Hospital Wilmington DE
Christiana Gynecologic Oncology LLC Newark DE
CHUM - Centre Hospitalier de l'Universite de Montreal Montreal
CHUM - Hopital Notre-Dame Montreal
CHUM - Hopital Notre-Dame Montreal Quebec
Cleveland Clinic Foundation Cleveland OH
Cleveland Clinic Foundation Cleveland OH
Colorado Blood Cancer Institute Denver CO
Colorado Cancer Research Program CCOP Denver CO
Colorado Cancer Research Program NCORP Denver CO
Columbus CCOP Columbus OH
Columbus CCOP Columbus OH
Columbus NCI Community Oncology Research Program Columbus OH
Columbus Oncology and Hematology Associates Inc Columbus OH
Community Medical Hospital Missoula MT
Community Memorial Hospital Menomonee Falls WI
Comprehensive Cancer Care and Research Institute of Colorado LLC Englewood CO
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Delaware Clinical and Laboratory Physicians PA Newark DE
Delaware Health Center-Grady Cancer Center Delaware OH
Delaware Radiation Oncology Delaware OH
Dixie Medical Center Regional Cancer Center Saint George UT
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Hospital Columbus OH
Doctors Hospital Columbus OH
Emory University Hospital/Winship Cancer Institute Atlanta GA
Emory University Hospital/Winship Cancer Institute Atlanta GA
Fairfield Medical Center Lancaster OH
Florida Hospital Orlando Orlando FL
Florida Hospital Orlando Orlando FL
Froedtert and the Medical College of Wisconsin Milwaukee WI
Geisinger Medical Center Danville PA
Geisinger Medical Center Danville PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes Barre PA
Genesis Healthcare System Cancer Care Center Zanesville OH
Genesis Healthcare System Cancer Care Center Zainesville OH
Glen Cove Hospital Glen Cove NY
Grady Memorial Hospital Delaware OH
Grady Memorial Hospital Delaware OH
Grand Rapids Clinical Oncology Program Grand Rapids MI
Grant Medical Center Columbus OH
Grant Medical Center Columbus OH
Great Falls Clinic Great Falls MT
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay WI
Greenville Health System Cancer Institute-Andrews Greenville SC
Greenville Health System Cancer Institute-Butternut Greenville SC
Greenville Health System Cancer Institute-Eastside Greenville SC
Greenville Health System Cancer Institute-Faris Greenville SC
Greenville Health System Cancer Institute-Greer Greer SC
Greenville Health System Cancer Institute-Seneca Seneca SC
Greenville Health System Cancer Institute-Spartanburg Spartanburg SC
Heartland Hematology and Oncology Associates Incorporated Kansas City MO
Heartland Regional Medical Center Saint Joseph MO
Heartland Regional Medical Center St. Joseph MO
Helen F Graham Cancer Center Newark DE
Henry Ford Cancer Institute-Downriver Brownstown MI
Henry Ford Hospital Detroit MI
Henry Ford Hospital Detroit MI
Henry Ford Macomb Hospital-Clinton Township Clinton Township MI
Henry Ford West Bloomfield Hospital West Bloomfield MI
Holy Family Memorial Hospital Manitowoc WI
Holy Family Memorial Hospital Manitowoc WI
Huntsman Cancer Institute/University of Utah Salt Lake City UT
Intermountain Medical Center Murray UT
Intermountain Medical Center Murray UT
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario
Kalispell Regional Medical Center Kalispell MT
Kalispell Regional Medical Center Kalispell MT
Kansas City CCOP Prairie Village KS
KCC Radiation Oncology at Monroe Cancer Center Monroe MI
Knox Community Hospital Mount Vernon OH
Kootenai Cancer Center Post Falls ID
Kootenai Cancer Clinic Sandpoint ID
Kootenai Medical Center Coeur D'Alene ID
Lancaster Radiation Oncology Lancaster OH
LDS Hospital Salt Lake City UT
LDS Hospital Salt Lake City UT
Liberty Radiation Oncology Center Liberty MO
Liberty Radiation Oncology Center Liberty MO
Licking Memorial Hospital Newark OH
Licking Memorial Hospital Newark OH
Littleton Adventist Hospital Littleton CO
Logan Regional Hospital Logan UT
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Long Island Jewish Medical Center Lake Success NY
Long Island Jewish Medical Center New Hyde Park NY
Longmont United Hospital Longmont CO
Lowcountry Hematology Oncology PA-Mount Pleasant Mount Pleasant SC
Lowcountry Hematology Oncology PA-North Charleston Charleston SC
Lowcountry Hematology Oncology PA-West Ashley Charleston SC
Marietta Memorial Hospital Marietta OH
Marietta Memorial Hospital Marietta OH
Mayo Clinic Rochester MN
Mayo Clinic Rochester MN
Mayo Clinic Hospital Phoenix AZ
Mayo Clinic Hospital Phoenix AZ
Mayo Clinic in Arizona Scottsdale AZ
Mayo Clinic in Arizona Scottsdale AZ
McGill University Department of Oncology Montreal
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
McKay-Dee Hospital Center Ogden UT
McKee Medical Center Loveland CO
Medical Oncology Hematology Consultants PA Newark DE
Menorah Medical Center Overland Park KS
Menorah Medical Center Overland Park KS
Mercy Health Mercy Campus Muskegon MI
Mercy Health Saint Mary's Grand Rapids MI
Mercy Hospital Cedar Rapids IA
Mercy Medical Center Durango CO
Mercy Medical Center-Sioux City Sioux City IA
Montana Cancer Consortium CCOP SOUTH GREAT FALLS MT
Montana Cancer Consortium CCOP Billings MT
Montefiore Medical Center - Moses Campus Bronx NY
Mount Carmel Health Center West Columbus OH
Mount Carmel Health Center West Columbus OH
Mountain Blue Cancer Care Center Golden CO
Munson Medical Center Traverse City MI
Nanticoke Memorial Hospital Seaford DE
Newark Radiation Oncology Newark OH
North Colorado Medical Center Greeley CO
North Kansas City Hospital Kansas City MO
North Kansas City Hospital North Kansas City MO
North Shore University Hospital Manhasset NY
NorthShore University HealthSystem-Evanston Hospital Evanston IL
NorthShore University HealthSystem-Evanston Hospital Evanston IL
NorthShore University HealthSystem-Glenbrook Hospital Glenview IL
NorthShore University HealthSystem-Glenbrook Hospital Glenview IL
NorthShore University HealthSystem-Highland Park Hospital Highland Park IL
Northwell Health/Center for Advanced Medicine Lake Success NY
Northwestern University Chicago IL
Northwestern University Chicago IL
Norton Hospital Pavilion and Medical Campus Louisville KY
Norton Hospital Pavilion and Medical Campus Louisville KY
Norton Suburban Hospital and Medical Campus Louisville KY
Norton Suburban Hospital and Medical Campus Louisville KY
Oncology Associates at Mercy Medical Center
Parker Adventist Hospital Parker CO
Penn State Milton S Hershey Medical Center Hershey PA
Penrose-Saint Francis Healthcare Colorado Springs CO
Piedmont Fayette Hospital Fayetteville GA
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Piedmont Hospital Atlanta GA
Porter Adventist Hospital Denver CO
Presbyterian - Saint Lukes Medical Center - Health One Denver CO
ProHealth D N Greenwald Center Mukwonago WI
ProHealth D N Greenwald Center Mukwonago WI
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
ProHealth Waukesha Memorial Hospital Waukesha WI
Providence Hospital Mobile AL
Queen's Medical Center Honolulu HI
Regional Hematology and Oncology PA Newark DE
Research Medical Center Kansas City MO
Research Medical Center Kansas City MO
Riverside Methodist Hospital Columbus OH
Riverside Methodist Hospital Columbus OH
Rocky Mountain Cancer Centers - Pueblo Pueblo CO
Rocky Mountain Cancer Centers-Aurora Aurora CO
Rocky Mountain Cancer Centers-Boulder Boulder CO
Rocky Mountain Cancer Centers-Greenwood Village Greenwood Village CO
Rocky Mountain Cancer Centers-Lakewood Lakewood CO
Rocky Mountain Cancer Centers-Littleton Littleton CO
Rocky Mountain Cancer Centers-Longmont Longmont CO
Rocky Mountain Cancer Centers-Midtown Denver CO
Rocky Mountain Cancer Centers-Parker Parker CO
Rocky Mountain Cancer Centers-Penrose Colorado Springs CO
Rocky Mountain Cancer Centers-Rose Denver CO
Rocky Mountain Cancer Centers-Sky Ridge Lone Tree CO
Rocky Mountain Cancer Centers-Thornton Thornton CO
Rocky Mountain Oncology Casper WY
Roper Hospital Charleston SC
Roper Hospital Charleston SC
Rose Medical Center Denver CO
Saint Ann's Hospital Westerville OH
Saint Ann's Hospital Westerville OH
Saint Anthony Hospital Lakewood CO
Saint James Community Hospital and Cancer Treatment Center Butte MT
Saint Luke's East - Lee's Summit Lee's Summit MO
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Luke's Regional Medical Center Sioux City IA
Saint Luke's South Hospital Overland Park KS
Saint Mary Corwin Medical Center Pueblo CO
Saint Patrick Hospital - Community Hospital Missoula MT
Saint Peter's Community Hospital Helena MT
Saint Vincent Frontier Cancer Center Billings MT
Saint Vincent Healthcare Billings MT
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sandra L Maxwell Cancer Center Cedar City UT
SCL Health Lutheran Medical Center Wheat Ridge CO
SCL Health Saint Joseph Hospital Denver CO
Siouxland Regional Cancer Center Sioux City IA
Siteman Cancer Center at Saint Peters Hospital Saint Peters MO
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital Creve Coeur MO
Siteman Cancer Center at West County Hospital St. Louis MO
Siteman Cancer Center-South County Saint Louis MO
Siteman Cancer Center-South County St Louis MO
Sky Ridge Medical Center Lone Tree CO
Southern Ohio Medical Center Portsmouth OH
Southern Ohio Medical Center Portsmouth OH
Southside Hospital Bay Shore NY
Southside Hospital Bayshore NY
Southwest Oncology PC Durango CO
Spectrum Health at Butterworth Campus Grand Rapids MI
Spectrum Health Reed City Hospital Reed City MI
Springfield Regional Medical Center Springfield OH
Springfield Regional Medical Center Springfield OH
Stanford Cancer Institute Palo Alto Palo Alto CA
Stanford Cancer Institute Palo Alto Palo Alto CA
Strecker Cancer Center-Belpre Belpre OH
Swedish Medical Center Englewood CO
The Cancer Center of Hawaii-Liliha Honolulu HI
The Cancer Center of Hawaii-Pali Momi Ewa Beach HI
The Kirklin Clinic at Acton Road Birmingham AL
The Kirklin Clinic at Acton Road Birmingham AL
The Mark H Zangmeister Center Columbus OH
The Mark H Zangmeister Center Cols OH
The Medical Center of Aurora Aurora CO
The Nebraska Medical Center Omaha NE
The Nebraska Medical Center Omaha NE
The Research Institute of the McGill University Health Centre (MUHC) Montreal
The University of Kansas Cancer Center-Lee's Summit Lee's Summit MO
The University of Kansas Cancer Center-North Kansas City MO
The University of Kansas Cancer Center-South Kansas City MO
Union Hospital of Cecil County Elkton MD
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Hawaii Cancer Center Honolulu HI
University of Kansas Cancer Center Kansas City KS
University of Kansas Cancer Center-Overland Park Overland Park KS
University of Nebraska Medical Center Omaha NE
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Rochester Rochester NY
University of Texas Health Science Center at San Antonio San Antonio TX
University of Texas Health Science Center at San Antonio San Antonio TX
University Pointe West Chester OH
University Pointe West Chester OH
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Utah Valley Regional Medical Center Provo UT
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Washington University School of Medicine Saint Louis MO
Washington University School of Medicine St. Louis MO
Welch Cancer Center Sheridan WY
Welch Cancer Center Sheridan WY
WellSpan Health-York Hospital York PA
WellSpan Health-York Hospital York PA
Wheaton Franciscan Cancer Care-All Saints Racine WI
Updated: 4/29/2016

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