Minimize
 

RTOG 0929 Protocol Information

Minimize
A Randomized Phase I/II Study of ABT-888 in Combination with Temozolomide in Recurrent (Temozolomide Resistant) Glioblastoma
Principal Investigator: H. Ian Robins MD, PhD
Primary Objective:

To define the maximum tolerated doses of the combination of temozolomide and ABT-888 in patients with recurrent glioblastoma who have been previously treated with temozolomide.

Patient Population:

Histologically proven intracranial glioblastoma or gliosarcoma (phase II) or any high-grade glioma (phase I). There must be imaging confirmation of tumor progression or regrowth. Patients must have completed a course of radiation therapy (phases I and II and at least 2 adjuvant cycles of temozolomide (phase II). Phase II patients may not have more than 2 prior regimens for recurrent disease for glioblastoma/gliosarcoma; phase I patients may not have more than 3 prior treatments.
 

 

 

Target Accrual: 240
Current Accrual: 257
Status: Terminated
Date: 4/3/2017
Participating Sites:
Abbott-Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
Academic Urology Prostate Center King of Prussia PA
Adams Cancer Center Gettysburg PA
Allegiance Health Jackson MI
Alta Bates Summit Medical Center - Summit Campus Oakland CA
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Baptist Health Lexington Lexington KY
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute Oakland CA
Beaumont Hospital - Dearborn Dearborn MI
Borgess Medical Center Kalamazoo MI
Boston Medical Center Boston MA
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
Cape Radiation Oncology Cape Girardeau MO
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Cedars-Sinai Medical Center Los Angeles CA
Cherry Tree Cancer Center Hanover PA
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
City of Hope Comprehensive Cancer Center Duarte CA
Columbia University/Herbert Irving Cancer Center New York NY
Community Cancer Center Foundation Normal IL
Cooper Health System-Voorhees Voorhees NJ
Cooper Hospital University Medical Center Camden NJ
Covenant Medical Center-Lakeside Lubbock TX
CoxHealth South Hospital Springfield MO
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Delbert Day Cancer Institute at PCRMC Rolla MO
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo CA
East Bay Radiation Oncology Center Castro Valley CA
Epic Care Pleasant Hill - Partners in Cancer Care Pleasant Hill CA
Epic Care-Dublin Dublin CA
Fairbanks Memorial Hospital Fairbanks AK
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Florida Hospital Orlando Orlando FL
Fox Chase Cancer Center Philadelphia PA
Fox Chase Cancer Center Buckingham Furlong PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Genesys Hurley Cancer Institute Flint MI
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Greenville Health System Cancer Institute-Eastside Greenville SC
Greenville Health System Cancer Institute-Faris Greenville SC
Greenville Health System Cancer Institute-Greer Greer SC
Greenville Health System Cancer Institute-Seneca Seneca SC
Gundersen Lutheran Medical Center La Crosse WI
Heartland Regional Medical Center St. Joseph MO
Hennepin County Medical Center Minneapolis MN
Highland Hospital Rochester NY
Huntsman Cancer Institute/University of Utah Salt Lake City UT
Hurley Medical Center Flint MI
Illinois CancerCare-Peoria Peoria IL
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Intermountain Medical Center Murray UT
IU Health Central Indiana Cancer Centers Indianapolis IN
IU Health West Hospital Avon IN
Jameson Health System North Campus New Castle PA
John F Kennedy Medical Center Edison NJ
John H Stroger Jr Hospital of Cook County Chicago IL
John Muir Medical Center-Concord Concord CA
John Muir Medical Center-Walnut Creek Concord CA
Kaiser Permanente Cancer Treatment Center South San Francisco CA
Kaiser Permanente Medical Center - Santa Clara Santa Clara CA
Kaiser Permanente Oakland-Broadway Oakland CA
Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Lake Huron Medical Center Port Huron MI
Langlade Hospital Cancer Center Antigo WI
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Legacy Good Samaritan Hospital and Medical Center Portland OR
Legacy Mount Hood Medical Center Gresham OR
Legacy Salmon Creek Hospital Vancouver WA
Liberty Hospital Liberty MO
Liberty Radiation Oncology Center Liberty MO
Logan Regional Hospital Logan UT
Louisiana State University Health Science Center New Orleans LA
Loyola University Medical Center Maywood IL
M D Anderson Cancer Center Houston TX
Maimonides Medical Center Brooklyn NY
Maine Medical Center- Scarborough Campus Scarborough ME
Mainline Health CCOP Wynnewood PA
Mary Bird Perkins Cancer Center Baton Rouge LA
McKay-Dee Hospital Center Ogden UT
Medical University of South Carolina Charleston SC
Menorah Medical Center Overland Park KS
Mercy Hospital Coon Rapids MN
Mercy Hospital Saint Louis St Louis MO
Mercy Hospital Springfield Springfield MO
Methodist Medical Center of Illinois Peoria IL
Metro-Minnesota CCOP St. Louis Park MN
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Montefiore Medical Center - Moses Campus Bronx NY
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
National Cancer Institute Radiation Oncology Branch Bethesda MD
National Institutes of Health Clinical Center Bethesda MD
Norris Cotton Cancer Center-North Saint Johnsbury VT
North Kansas City Hospital North Kansas City MO
North Main Radiation Oncology Providence RI
North Memorial Medical Health Center Robbinsdale MN
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northeast Georgia Medical Center-Gainesville Gainesville GA
Northwestern University Chicago IL
Norton Hospital Pavilion and Medical Campus Louisville KY
Norton Suburban Hospital and Medical Campus Louisville KY
Novant Health Forsyth Medical Center Winston Salem NC
Ohio State University Comprehensive Cancer Center Columbus OH
OSF Saint Francis Medical Center Peoria IL
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin IL
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria IL
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Paoli Memorial Hospital Paoli PA
PeaceHealth Saint Joseph Medical Center Bellingham WA
Penn State Milton S Hershey Medical Center Hershey PA
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Poudre Valley Hospital Radiation Oncology Fort Collins CO
ProHealth D N Greenwald Center Mukwonago WI
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
Providence Hospital Mobile AL
Queen's Medical Center Honolulu HI
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Regions Hospital St. Paul MN
Renown Regional Medical Center Reno NV
Research Medical Center Kansas City MO
Rhode Island Hospital Providence RI
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Rohnert Park Cancer Center Rohnert Park CA
Rush University Medical Center Chicago IL
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital New Brunswick NJ
Saint Agnes Hospital Baltimore MD
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Francis Hospital Federal Way WA
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint John's Hospital - Healtheast Maplewood MN
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary Mercy Hospital Livonia MI
Saint Mary's Hospital and Regional Medical Center Grand Junction CO
Saint Mary's of Michigan Saginaw MI
Saint Vincent Hospital and Health Care Center Indianapolis IN
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sandra L Maxwell Cancer Center Cedar City UT
Sands Cancer Center Canandaigua NY
Singing River Hospital Pascagoula MS
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
South Sacramento Cancer Center Sacramento CA
Sparrow Hospital Lansing MI
Sparta Cancer Center Sparta NJ
St. Vincent Hospital and Health Care Centers, Inc. Indianapolis IN
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
The Cancer Center of Hawaii-Liliha Honolulu HI
The Cancer Center of Hawaii-Pali Momi Ewa Beach HI
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Methodist Hospital System Houston TX
The Permanente Medical Group-Roseville Radiation Oncology Roseville CA
The University of Kansas Cancer Center-Lee's Summit Lee's Summit MO
The University of Kansas Cancer Center-North Kansas City MO
The University of Kansas Cancer Center-South Kansas City MO
Thomas Jefferson University Hospital Philadelphia PA
UC San Diego Moores Cancer Center LaJolla CA
United Hospital St. Paul MN
Unity Hospital Fridley MN
University Medical Center New Orleans New Orleans LA
University of Arizona Medical Center-University Campus Tucson AZ
University of Chicago Comprehensive Cancer Center Chicago IL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Florida Health Science Center - Gainesville Gainesville FL
University of Hawaii Cancer Center Honolulu HI
University of Kansas Cancer Center Kansas City KS
University of Kansas Cancer Center-Overland Park Overland Park KS
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Nebraska Medical Center Omaha NE
University of Nebraska Medical Center Omaha NE
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Vermont Medical Center Burlington VT
University of Wisconsin Hospital and Clinics Madison WI
University Pointe West Chester OH
University Radiation Oncology Rochester NY
UPMC Cancer Center at UPMC McKeesport McKeesport PA
UPMC Cancer Center at UPMC Northwest Seneca PA
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Cancer Centre at Clarion Hospital Clarion PA
UPMC Jameson New Castle PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-HVHS Cancer Center (Moon) Coraopolis PA
UPMC-Passavant Hospital Pittsburgh PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Saint Margaret Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-The Washington Hospital Washington PA
UPMC-Uniontown / Robert E. Eberly Pavilion Uniontown PA
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
UW Cancer Center at ProHealth Care Waukesha WI
UW Cancer Center Johnson Creek Johnson Creek WI
Valley Medical Oncology Consultants Pleasanton CA
Virginia Mason CCOP Seattle WA
Wausau Hospital Center Wausau WI
WellSpan Health-York Hospital York PA
William Beaumont Hospital - Troy Troy MI
William Beaumont Hospital-Royal Oak Royal Oak MI
Updated: 4/5/2017

You must be logged in to view this file.

Login  |  Close

You must be logged in to view this file.

Login  |  Close