Minimize
 

RTOG 1012 Protocol Information

Minimize
Phase II Randomized Trial of Prophylactic Manuka Honey for the Reduction of Chemoradiation Therapy Induced Esophagitis-Related Pain During the Treatment of Lung Cancer - RTOG CCOP Study (open to U.S. sites only)
Protocol Documents
Current Version Date: 9/5/2013
Principal Investigator: Lawrence B. Berk, MD, PhD
Primary Objective:

Evaluate the relative efficacy of 4 times a day consumption of liquid or lozenge Manuka honey to delay or prevent radiation esophagitis-related pain (during combined chemotherapy and radiation therapy for lung cnancer) as compared to standard supportive treatment, as measured at week 4 by Numerical Rating Pain Scale (NRPS) for pain upon swallowing

NOTE: This trial is open to U.S. institutions only; see Section 5.2 of the protocol for details.

Patient Population:

Patients being treated with combination chemotherapy (definitive or adjuvant) and radiation therapy once daily for small cell or non-small cell lung cancer; at least 5 cm of the esophagus must be in the 60 Gy isodose volume

Target Accrual: 150
Current Accrual: 163
Status: Terminated
Date: 11/17/2014
Participating Sites:
21st Century Oncology Las Vegas NV
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Abbott-Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
Adams Cancer Center Gettysburg PA
Adena Regional Medical Center Chillicothe OH
Allegiance Health Jackson MI
Alta Bates Summit Medical Center - Summit Campus Oakland CA
AnMed Health Cancer Center Anderson SC
Aria Health Philadelphia PA
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Augusta Health Cancer Center Fishersville VA
Aultman Hospital Canton OH
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Bay Area Medical Center Marinette WI
Bay Area Tumor Institute Oakland CA
Beaumont Hospital - Dearborn Dearborn MI
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Billings Clinic Cancer Center Billings MT
Bixby Medical Center Adrian MI
Boston Medical Center Boston MA
Bozeman Deaconess Hospital Cancer Center Bozeman MT
Bronson Battle Creek Battle Creek MI
Bryn Mawr Hospital Bryn Mawr PA
Cape Cod Hospital Hyannis MA
Carle Cancer Center Urbana IL
Carolinas HealthCare System NorthEast Concord NC
Carolinas HealthCare System Union Monroe NC
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
CaroMont Regional Medical Center Gastonia NC
Case Western Reserve University Cleveland OH
Central Maine Medical Center Lewiston ME
Central Maryland Radiation Oncology in Howard County Columbia MD
Champlain Valley Physicians Hospital Medical Center Plattsburgh NY
Cherry Tree Cancer Center Hanover PA
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
CHI Health Good Samaritan Kearney NE
Christiana Care Health System-Christiana Hospital Newark DE
Clackamas Radiation Oncology Center Clackamas OR
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland OH
Cleveland Clinic Cancer Center-Independence Independence OH
Cleveland Clinic Foundation Cleveland OH
Cleveland Clinic Wooster Specialty Center Wooster OH
Cleveland Clinic-Strongsville Strongsville OH
Coborn Cancer Center at Saint Cloud Hospital St. Cloud MN
Columbia Saint Mary's Hospital - Ozaukee Mequon WI
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Columbia University/Herbert Irving Cancer Center New York NY
Columbus CCOP Columbus OH
Community Cancer Center Foundation Normal IL
Community Medical Center Toms River NJ
Compass Oncology Vancouver Vancouver WA
Comprehensive Cancer Centers of Nevada Las Vegas NV
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas NV
Comprehensive Cancer Centers of Nevada - Henderson Henderson NV
Comprehensive Cancer Centers of Nevada - Northwest Las Vegas NV
Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas NV
Concord Hospital Payson Center for Cancer Care Concord NH
Cooper Health System-Voorhees Voorhees NJ
Cooper Hospital University Medical Center Camden NJ
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Hospital Columbus OH
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo CA
Duke University Medical Center Durham NC
East Bay Radiation Oncology Center Castro Valley CA
Einstein Medical Center Philadelphia Philadelphia PA
Elkhart General Hospital Elkhart IN
Elliot Hospital Manchester NH
Enloe Medical Center Chico CA
Epic Care Pleasant Hill - Partners in Cancer Care Pleasant Hill CA
Epic Care-Dublin Dublin CA
Fairbanks Memorial Hospital Fairbanks AK
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst NC
Florida Hospital Orlando Orlando FL
Flower Hospital Sylvania OH
Geauga Hospital Chardon OH
Geisinger Medical Center Danville PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes Barre PA
Genesis Healthcare System Cancer Care Center Zainesville OH
Genesys Hurley Cancer Institute Flint MI
Gibbs Cancer Center-Pelham Greer SC
Grady Memorial Hospital Delaware OH
Grand Rapids Clinical Oncology Program Grand Rapids MI
Grant Medical Center Columbus OH
Greenville Health System Cancer Institute-Eastside Greenville SC
Greenville Health System Cancer Institute-Faris Greenville SC
Greenville Health System Cancer Institute-Greer Greer SC
Greenville Health System Cancer Institute-Seneca Seneca SC
Greenville Health System Cancer Institute-Spartanburg Spartanburg SC
Heartland Regional Medical Center St. Joseph MO
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse NY
Hennepin County Medical Center Minneapolis MN
Henry Ford Hospital Detroit MI
High Point Regional Hospital High Point NC
Highland Hospital Rochester NY
Hillcrest Hospital Cancer Center Mayfield Heights OH
Holy Cross Hospital Fort Lauderdale FL
Holy Redeemer Hospital and Medical Center Meadowbrook PA
Hurley Medical Center Flint MI
Idaho Urologic Institute-Meridian Meridian ID
Illinois CancerCare-Peoria Peoria IL
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Indiana University Health Methodist Hospital Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intermountain Medical Center Murray UT
Ireland Cancer Center at Firelands Regional Medical Center Sandusky OH
IU Health La Porte Hospital La Porte IN
Jersey Shore University Medical Center Neptune NJ
John B Amos Cancer Center Columbus GA
John Fitzgerald Kennedy Medical Center Lake Worth FL
John H Stroger Jr Hospital of Cook County Chicago IL
Jupiter Medical Center Jupiter FL
Kansas City CCOP Prairie Village KS
Kuakini Medical Center Honolulu HI
Lake Huron Medical Center Port Huron MI
Lake University Ireland Cancer Center Mentor OH
Lakeland Regional Health System St. Joseph MI
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Legacy Good Samaritan Hospital & Medical Center Portland OR
Legacy Mount Hood Medical Center Gresham OR
Legacy Salmon Creek Hospital Vancouver WA
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah GA
Liberty Radiation Oncology Center Liberty MO
Licking Memorial Hospital Newark OH
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
Maine Medical Center- Scarborough Campus Scarborough ME
Mainline Health CCOP Wynnewood PA
Margaret R Pardee Memorial Hospital Hendersonville NC
Marietta Memorial Hospital Marietta OH
Mayo Clinic Rochester MN
Mayo Clinic Hospital Phoenix AZ
Mayo Clinic in Arizona Scottsdale AZ
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute - Lapeer Lapeer MI
McLaren Cancer Institute - Owosso Owosso MI
McLaren Cancer Institute-Flint Flint MI
Medical University of Ohio Toledo OH
Memorial Health University Medical Center Savannah GA
Memorial Hospital South Bend IN
Memorial Sloan Kettering Basking Ridge Basking Ridge NJ
Memorial Sloan Kettering Cancer Center New York NY
Memorial Sloan Kettering Commack Commack NY
Memorial Sloan Kettering Rockville Centre Rockville NY
Memorial Sloan Kettering Sleepy Hollow Sleepy Hollow NY
Menorah Medical Center Overland Park KS
Mercy Cancer Center-Elyria Elyria OH
Mercy General Radiation Oncology Center Sacramento CA
Mercy Health Mercy Campus Muskegon MI
Mercy Health Saint Mary's Grand Rapids MI
Mercy Hospital Coon Rapids MN
Mercy Hospital Saint Louis St Louis MO
Mercy Medical Center Canton OH
Mercy Saint Anne Hospital Toledo OH
Mercy San Juan Medical Center Carmichael CA
Metro-Minnesota CCOP St. Louis Park MN
Michiana Hematology Oncology PC-Mishawaka Mishawaka IN
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Mission Hospital-Memorial Campus Asheville NC
Monmouth Medical Center Long Branch NJ
Montana Cancer Consortium CCOP Billings MT
Mount Carmel Health Center West Columbus OH
Mount Clemens Regional Medical Center Mount Clemens MI
Mount Nittany Medical Center - Penn State Cancer Institute State College PA
Mount Sinai Medical Center Miami Beach FL
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Nevada Cancer Research Foundation CCOP Las Vegas NV
New Hanover Regional Medical Center/Zimmer Cancer Center Wilmington NC
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
NHRMC Radiation Oncology - 16th Street Wilmington NC
NHRMC Radiation Oncology - Supply Supply NC
North Coast Cancer Care Sandusky OH
North Kansas City Hospital North Kansas City MO
North Memorial Medical Health Center Robbinsdale MN
Northeast Georgia Medical Center-Gainesville Gainesville GA
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium South Bend IN
Novant Health Presbyterian Medical Center Charlotte NC
Ocean Medical Center Brick NJ
Ohio State University Comprehensive Cancer Center Columbus OH
OSF Saint Francis Medical Center Peoria IL
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin IL
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria IL
Paoli Memorial Hospital Paoli PA
Parkview Hospital Randallia Fort Wayne IN
PeaceHealth Saint Joseph Medical Center Bellingham WA
PeaceHealth Southwest Medical Center Vancouver WA
Penrose-Saint Francis Healthcare Colorado Springs CO
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Pocono Medical Center East Strousburg PA
Providence Hospital Mobile AL
Providence Hospital-Southfield Cancer Center Southfield MI
Providence Portland Medical Center Portland OR
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank CA
Providence Saint Vincent Medical Center Portland OR
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
Queen's Medical Center Honolulu HI
Radiation Oncology Associates PC Fort Wayne IN
Radiation Oncology Centers of Nevada Central Las Vegas NV
Radiological Associates of Sacramento Sacramento CA
Rapid City Regional Hospital Rapid City SD
Regions Hospital St. Paul MN
Research Medical Center Kansas City MO
Rex Cancer Center Raleigh NC
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Riverview Medical Center/Booker Cancer Center Red Bank NJ
Rocky Mountain Oncology Casper WY
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Ann's Hospital Westerville OH
Saint Charles Hospital Oregon OH
Saint Francis Hospital Federal Way WA
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint John's Hospital - Healtheast Maplewood MN
Saint Joseph Hospital - Orange Orange CA
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Saint Vincent Mercy Medical Center Toledo OH
Sentara Rockingham Memorial Hospital Hahn Cancer Center Harrisonburg VA
Singing River Hospital Pascagoula MS
Siteman Cancer Center at West County Hospital St. Louis MO
Siteman Cancer Center-South County St Louis MO
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Southern Ohio Medical Center Portsmouth OH
Southwest General Health Center Ireland Cancer Center Middleburgh OH
Sparrow Hospital Lansing MI
Sparta Cancer Center Sparta NJ
Spartanburg Medical Center Spartanburg SC
Spectrum Health at Butterworth Campus Grand Rapids MI
Springfield Regional Medical Center Springfield OH
St. Anthony's Health Alton IL
St. Lukes Hospital Association of Duluth Duluth MN
Stanford Cancer Institute Palo Alto Palo Alto CA
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Tate Cancer Center Glen Burnie MD
Temple University Hospital Philadelphia PA
The Cancer Center of Hawaii-Liliha Honolulu HI
The Cancer Center of Hawaii-Pali Momi Ewa Beach HI
The Kirklin Clinic at Acton Road Birmingham AL
The Mark H Zangmeister Center Cols OH
The Radiation Oncology Center-Hilton Head/Bluffton Hilton Head Island SC
The University of Kansas Cancer Center-Lee's Summit Lee's Summit MO
The University of Kansas Cancer Center-North Kansas City MO
The University of Kansas Cancer Center-South Kansas City MO
Thedacare Cancer Institute Appleton WI
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers-Adrian Adrian MI
Toledo Clinic Cancer Centers-Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Trinity Cancer Care Center Minot ND
UCSF Medical Center-Mount Zion San Francisco CA
UF Cancer Center at Orlando Health Orlando FL
UHHS-Chagrin Highlands Medical Center Orange Village OH
UHHS-Westlake Medical Center Westlake OH
United Hospital St. Paul MN
Unity Hospital Fridley MN
University Hospitals Parma Medical Center Parma OH
University of Alabama at Birmingham Cancer Center Birmingham AL
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Hawaii Cancer Center Honolulu HI
University of Kansas Cancer Center Kansas City KS
University of Kansas Cancer Center-Overland Park Overland Park KS
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Rochester Rochester NY
University of Texas Health Science Center at San Antonio San Antonio TX
University of Texas Medical Branch Galveston TX
University Pointe-Precision Radiotherapy West Chester OH
Upper Delaware Valley Cancer Center Milford PA
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Veterans Administration Long Beach Medical Center Long Beach CA
Virginia Mason CCOP Seattle WA
Virtua Memorial Mount Holly NJ
Virtua Voorhees Voorhees NJ
Wake Forest University Health Sciences Winston-Salem NC
Washington University School of Medicine St. Louis MO
Wayne State University/Karmanos Cancer Institute Detroit MI
Weisberg Cancer Treatment Center Farmington Hills MI
Welch Cancer Center Sheridan WY
WellSpan Health-York Hospital York PA
Wentworth-Douglass Hospital Dover NH
Western Oncology Research Consortium Portland OR
William Beaumont Hospital - Troy Troy MI
William Beaumont Hospital-Royal Oak Royal Oak MI
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 11/17/2014

You must be logged in to view this file.

Login  |  Close

You must be logged in to view this file.

Login  |  Close