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RTOG 1106 Protocol Information

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RTOG 1106/ACRIN 6697, Randomized Phase II Trial of Individualized Adaptive Radiotherapy Using During-Treatment FDG-PET/CT and Modern Technology in Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Principal Investigator: Feng-Ming (Spring) Kong, MD, PhD
Primary Objective:

RTOG: To determine whether tumor dose can be escalated to improve the LRPF rate at 2 years when an individualized adaptive radiation treatment (RT) plan is applied by the use of a FDG-PET/CT scan acquired at 40-46 Gy initial dose of RT in patients with inoperable or unresectable stage III NSCLC

ACRIN: To determine whether the relative change in SUV/peak from the baseline to the during-treatment FDG-PET/CT, defined as (during-treatment SUVpeak - baseline SUVpeak) baseline SUVpeak X 100%, can predict the LRPF with a 2-year follow up.

See "ACRIN Information" in the left column of this page.

RT Credentialing: Please see section 5 for specific details

Lung Atlas

 

Patient Population:

Patients with FDG-avid and histologically or cytologically proven AJCC stage IIIA or IIIB, non-operable NSCLC

Target Accrual: 138
Current Accrual: 138
Status: Closed to Accrual
Date: 3/8/2017
Participating Sites:
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Augusta University Medical Center Augusta GA
Augusta University Medical Center Augusta GA
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Case Western Reserve University Cleveland OH
Case Western Reserve University Cleveland OH
Centre Hospitalier de l`Universite de Montreal-Notre Dame Montreal Quebec
Cleveland Clinic Foundation Cleveland OH
Cleveland Clinic Foundation Cleveland OH
Community Cancer Center Foundation Normal IL
Community Medical Center Toms River NJ
Dixie Medical Center Regional Cancer Center East St. George UT
Fox Chase Cancer Center Philadelphia PA
Fox Chase Cancer Center Philadelphia PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Froedtert and the Medical College of Wisconsin Milwaukee WI
Heartland Regional Medical Center St. Joseph MO
Hines Veterans Administration Hospital Hines IL
Illinois CancerCare-Peoria Peoria IL
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intermountain Medical Center Murray UT
Kansas City CCOP Prairie Village KS
LDS Hospital Salt Lake City UT
Legacy Good Samaritan Hospital & Medical Center Portland OR
Legacy Mount Hood Medical Center Gresham OR
Legacy Salmon Creek Hospital Vancouver WA
Liberty Radiation Oncology Center Liberty MO
Logan Regional Hospital Logan UT
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Medical University of South Carolina Charleston SC
Medical University of South Carolina Charleston SC
Memorial Sloan Kettering Basking Ridge Basking Ridge NJ
Memorial Sloan Kettering Cancer Center New York NY
Memorial Sloan Kettering Commack Commack NY
Memorial Sloan Kettering Westchester West Harrison NY
Menorah Medical Center Overland Park KS
North Kansas City Hospital North Kansas City MO
OSF Saint Francis Medical Center Peoria IL
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin IL
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria IL
Parkview Hospital Randallia Fort Wayne IN
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Pocono Medical Center East Strousburg PA
Queen's Medical Center Honolulu HI
Radiation Oncology Associates PC Fort Wayne IN
Reading Hospital Reading PA
Research Medical Center Kansas City MO
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Luke's Hospital of Kansas City Kansas City MO
Saskatoon Cancer Centre Saskatoon
Siteman Cancer Center at West County Hospital St. Louis MO
Stanford Cancer Institute Palo Alto Palo Alto CA
Stanford Cancer Institute Palo Alto Palo Alto CA
Temple University Hospital Philadelphia PA
The Cancer Center of Hawaii-Liliha Honolulu HI
The Cancer Center of Hawaii-Pali Momi Ewa Beach HI
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Research Institute of the McGill University Health Centr Montreal
Thomas Jefferson University Hospital Philadelphia PA
Trinity Cancer Care Center Minot ND
UC San Diego Moores Cancer Center LaJolla CA
UCSF Medical Center-Mount Zion San Francisco CA
UF Cancer Center at Orlando Health Orlando FL
UH Seidman Cancer Center at Geauga Medical Center Chardon OH
University of Hawaii Cancer Center Honolulu HI
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Mississippi Medical Center Jackson MS
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Wisconsin Hospital and Clinics Madison WI
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Washington University School of Medicine St. Louis MO
Washington University School of Medicine Saint Louis MO
Updated: 3/8/2017

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