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RTOG 1114 Protocol Information

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Phase II Randomized Study of Rituximab, Methotrexate, Procarbazine, Vincristine, and Cytarabine With and Without Low-Dose Whole-Brain Radiotherapy for Primary Central Nervous System Lymphoma
Protocol Documents
Current Version Date: 8/25/2015
Principal Investigator: Antonio Omuro, MD
Primary Objective:

To determine median progression-free survival (PFS) in both arms on an intent-to-treat basis. PFS will be defined as the interval from randomization to progression or death, whichever occurs first.

Patient Population:

B-cell non-Hodgkin's lymphoma involving the brain, as demonstrated by contrasted MRI and histologic confirmation by one of the following within 6 weeks prior to registration:

  • A positive CSF cytology for lymphoma or a monoclonal lymphocyte population as defined by cell surface markers
  • A biopsy of the vitreous or uvea demonstrating non-Hodgkin's lymphoma
  • Brain biopsy

 

Target Accrual: 89
Current Accrual: 91
Status: Closed to Accrual
Date: 1/15/2016
Participating Sites:
21st Century Oncology Las Vegas NV
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Allegiance Health Jackson MI
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Baptist Cancer Institute Jacksonville FL
Baptist Medical Center South Jacksonville FL
Beaumont Hospital-Dearborn Dearborn MI
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
Case Western Reserve University Cleveland OH
Case Western Reserve University Cleveland OH
Chaim Sheba Medical Center Tel Hashomer
Cleveland Clinic Foundation Cleveland OH
Cleveland Clinic Foundation Cleveland OH
Columbia University/Herbert Irving Cancer Center New York NY
Columbia University/Herbert Irving Cancer Center New York NY
Community Memorial Hospital Menomonee Falls WI
Comprehensive Cancer Centers of Nevada Las Vegas NV
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas NV
Comprehensive Cancer Centers of Nevada - Henderson Henderson NV
Comprehensive Cancer Centers of Nevada - Northwest Las Vegas NV
Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas NV
Florida Hospital Orlando Orlando FL
Froedtert and the Medical College of Wisconsin Milwaukee WI
Froedtert and the Medical College of Wisconsin Milwaukee WI
Geisinger Medical Center Danville PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes Barre PA
Genesys Hurley Cancer Institute Flint MI
Hurley Medical Center Flint MI
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Kaiser Permanente Cancer Treatment Center South San Francisco CA
Kaiser Permanente Los Angeles Medical Center Los Angeles CA
Kaiser Permanente Medical Center - Santa Clara Santa Clara CA
Kaiser Permanente Medical Center - Santa Clara Santa Clara CA
Kaiser Permanente Oakland-Broadway Oakland CA
Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova CA
Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Lake Huron Medical Center Port Huron MI
Loyola University Medical Center Maywood IL
M D Anderson Cancer Center Houston TX
M D Anderson Cancer Center Houston TX
Maine Medical Center- Scarborough Campus Scarborough ME
Memorial Sloan Kettering Basking Ridge Basking Ridge NJ
Memorial Sloan Kettering Cancer Center New York NY
Memorial Sloan Kettering Cancer Center New York NY
Memorial Sloan Kettering Commack Commack NY
Memorial Sloan Kettering Rockville Centre Rockville NY
Memorial Sloan Kettering Sleepy Hollow Sleepy Hollow NY
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Moffitt Cancer Center Tampa FL
Moffitt Cancer Center Tampa FL
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Nevada Cancer Research Foundation CCOP Las Vegas NV
Northwestern University Chicago IL
Northwestern University Chicago IL
Penrose-Saint Francis Healthcare Colorado Springs CO
Piedmont Hospital Atlanta GA
ProHealth D N Greenwald Center Mukwonago WI
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
Radiation Oncology Centers of Nevada Central Las Vegas NV
Rohnert Park Cancer Center Rohnert Park CA
Rohnert Park Cancer Center Rohnert Park CA
Rush University Medical Center Chicago IL
Rush University Medical Center Chicago IL
Saint Agnes Hospital Baltimore MD
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Joseph's Hospital and Medical Center Phoenix AZ
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
South Sacramento Cancer Center Sacramento CA
South Sacramento Cancer Center Sacramento CA
Sparrow Hospital Lansing MI
Tel-Aviv Sourasky Medical Center Tel-Aviv
The Kirklin Clinic at Acton Road Birmingham AL
The Permanente Medical Group-Roseville Radiation Oncology Roseville CA
The Permanente Medical Group-Roseville Radiation Oncology Roseville CA
Thomas Jefferson University Hospital Philadelphia PA
Thomas Jefferson University Hospital Philadelphia PA
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Rochester Rochester NY
University of Texas Health Science Center at San Antonio San Antonio TX
University Pointe-Precision Radiotherapy West Chester OH
West Michigan Cancer Center Kalamazoo MI
Updated: 1/15/2016

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