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RTOG 1115 Protocol Information

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Phase III Trial of Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) with a GnRH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a GnRH Agonist and TAK-700 for Men with High Risk Prostate Cancer
Principal Investigator: M. Dror Michaelson, MD, PhD
Primary Objective:

To evaluate the difference in overall survival in men with clinically localized prostate cancer with unfavorable prognostic features between a) standard treatment (ADT + radiotherapy) and b) standard treatment with the addition of 24 months of TAK-700.

Patient Population:

Histologically confirmed diagnosis of adenocarcinoma of the prostate within 180 days prior to registration at high risk for recurrence as determined by one of the following combinations:

Gleason score                      PSA                                 T-Stage
> 9                            and        < 150                  and          Any
8                               and        < 20                     and         > T2
8                               and         > 20-150            and         Any
7                               and         > 20-150            and         Any


 

Target Accrual: 900
Current Accrual: 239
Status: Closed to Accrual
Date: 9/30/2014
Participating Sites:
Abbott-Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
Adams Cancer Center Gettysburg PA
Akron General Medical Center Akron OH
Allan Blair Cancer Centre Regina
Allan Blair Cancer Centre Regina, SK
Allegiance Health Jackson MI
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
AnMed Health Cancer Center Anderson SC
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Atlanta VA Medical Center Decatur GA
Atlanta VA Medical Center Decatur GA
Bay Area Medical Center Marinette WI
BCCA-Cancer Centre for the Southern Interior Kelowna, BC
Beaumont Hospital-Dearborn Dearborn MI
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Beth Israel Deaconess Medical Center Boston MA
Beth Israel Deaconess Medical Center Boston MA
Billings Clinic Cancer Center Billings MT
Bixby Medical Center Adrian MI
Borgess Medical Center Kalamazoo MI
Brigham and Women's Hospital Boston MA
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
California Pacific Medical Center-Pacific Campus San Francisco CA
Carle Cancer Center Urbana IL
Case Western Reserve University Cleveland OH
Case Western Reserve University Cleveland OH
Cedars-Sinai Medical Center Los Angeles CA
Centre Hospitalier de l`Universite de Montreal-Notre Dame Montreal Quebec
Cherry Tree Cancer Center Hanover PA
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Christiana Care Health System-Christiana Hospital Newark DE
Cleveland Clinic Foundation Cleveland OH
Community Cancer Center Foundation Normal IL
Community Memorial Hospital Menomonee Falls WI
Concord Hospital Concord NH
Concord Hospital Payson Center for Cancer Care Concord NH
Cooper CyberKnife Center Mt. Laurel NJ
Cooper Health System-Voorhees Voorhees NJ
Cooper Hospital University Medical Center Camden NJ
CoxHealth South Hospital Springfield MO
Dana Farber/Brigham & Woman's CC at Milford Regional Milford MA
Dana Farber/Brigham & Women's Center at South Shore South Weymouth MA
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Milford MA
Dana-Farber/Harvard Cancer Center Boston MA
Danville Regional Medical Center Danville VA
Dartmouth Hitchcock Medical Center Lebanon NH
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Decatur Memorial Hospital Decatur IL
Delaware County Memorial Hospital Drexel Hill PA
Delbert Day Cancer Institute at PCRMC Rolla MO
Dixie Medical Center Regional Cancer Center East St. George UT
Dubs Cancer Center @ Rogue Valley Medical Center Medford OR
Elliot Hospital Manchester NH
Emory University Hospital Midtown Atlanta GA
Emory University Hospital/Winship Cancer Institute Atlanta GA
Exeter Hospital Exeter NH
Fairbanks Memorial Hospital Fairbanks AK
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Florida Hospital Orlando Orlando FL
Flower Hospital Sylvania OH
Fox Chase Cancer Center Philadelphia PA
Fox Chase Cancer Center Philadelphia PA
Fox Chase Cancer Center Buckingham Furlong PA
Freeman Health System Joplin MO
Froedtert and the Medical College of Wisconsin Milwaukee WI
Geauga Hospital Chardon OH
Genesys Hurley Cancer Institute Flint MI
Gibbs Cancer Center-Pelham Greer SC
Gibbs Cancer Center-Pelham Greer SC
Good Samaritan Hospital - Dayton Dayton OH
Grady Health System Atlanta GA
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Hartford Hospital Hartford CT
Hartford Hospital Hartford CT
Helen F Graham Cancer Center Newark DE
Hennepin County Medical Center Minneapolis MN
Hines Veterans Administration Hospital Hines IL
Holy Family Memorial Hospital Manitowoc WI
Hurley Medical Center Flint MI
Idaho Urologic Institute-Meridian Meridian ID
Illinois CancerCare-Peoria Peoria IL
Intermountain Medical Center Murray UT
Ireland Cancer Center at Firelands Regional Medical Center Sandusky OH
Kaiser Permanente Cancer Treatment Center South San Francisco CA
Kaiser Permanente Cancer Treatment Center South San Francisco CA
Kaiser Permanente Medical Center - Santa Clara Santa Clara CA
Kaiser Permanente Medical Center - Santa Clara Santa Clara CA
Kaiser Permanente Oakland-Broadway Oakland CA
Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kalispell Regional Medical Center Kalispell MT
Lake Huron Medical Center Port Huron MI
Lake/University Seidman Cancer Center Mentor OH
Lancaster General Hospital Lancaster PA
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah GA
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Los Angeles County-USC Medical Center Los Angeles CA
Los Angeles County-USC Medical Center Los Angeles CA
Louisiana State University Health Science Center New Orleans LA
Loyola University Medical Center Maywood IL
Loyola University Medical Center Maywood IL
M D Anderson Cancer Center Houston TX
M D Anderson Cancer Center Houston TX
Maine Medical Center- Scarborough Campus Scarborough ME
Mainline Health CCOP Wynnewood PA
Marin General Hospital Greenbrae CA
Mary Bird Perkins Cancer Center Baton Rouge LA
Mary Bird Perkins Cancer Center Baton Rouge LA
Mass General/ North Shore Cancer Center Danvers MA
Massachusetts General Hospital Boston MA
Massachusetts General Hospital Cancer Center Boston MA
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute - Flint Flint MI
McLaren Cancer Institute - Lapeer Lapeer MI
McLaren Cancer Institute - Owosso Owosso MI
Medical University of Ohio Toledo OH
Medical University of South Carolina Charleston SC
Medical University of South Carolina Charleston SC
Memorial Hermann Memorial City Medical Center Houston TX
Memorial Hermann Memorial City Medical Center Houston TX
Mercy Cancer Center Elyria OH
Mercy Cancer Center-Elyria Elyria OH
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Coon Rapids MN
Mercy Hospital Coon Rapids MN
Mercy Hospital Joplin Joplin MO
Mercy Hospital Saint Louis St Louis MO
Mercy Hospital Springfield Springfield MO
Mercy Hospital Springfield Springfield MO
Mercy Saint Anne Hospital Toledo OH
Mercy San Juan Medical Center Carmichael CA
Methodist Cancer Center Omaha NE
Methodist Medical Center of Illinois Peoria IL
Metro-Minnesota CCOP St. Louis Park MN
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Montana Cancer Consortium CCOP Billings MT
Mount Clemens Regional Medical Center Mount Clemens MI
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
New York Oncology Hematology PC - Albany Albany NY
Norris Cotton Cancer Center Saint Johnsbury VT
North Memorial Medical Health Center Robbinsdale MN
Ochsner Medical Center Jefferson New Orleans LA
Ochsner Medical Center Jefferson New Orleans LA
Ohio State University Medical Center Columbus OH
Oncology and Hematology Associates of Southwest Virginia Roanoke VA
OSF Saint Francis Medical Center Peoria IL
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin IL
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria IL
Ottawa Hospital and Cancer Center-General Campus Ottawa
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Paoli Memorial Hospital Paoli PA
Parkview Hospital Randallia Fort Wayne IN
Peninsula Regional Medical Center Salisbury MD
Penrose-Saint Francis Healthcare Colorado Springs CO
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Piedmont Hospital Atlanta GA
Pomona Valley Hospital Medical Center Pomona CA
Poudre Valley Hospital Fort Collins CO
Poudre Valley Hospital Radiation Oncology Fort Collins CO
Queen's Medical Center Honolulu HI
Radiation Oncology Associates PC Fort Wayne IN
Radiological Associates of Sacramento Sacramento CA
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Regions Hospital St Paul MN
Regions Hospital St. Paul MN
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Robinson Radiation Oncology Ravenna OH
Rocky Mountain Oncology Casper WY
Rohnert Park Cancer Center Rohnert Park CA
Rohnert Park Cancer Center Rohnert Park CA
Rush-Copley Medical Center Aurora IL
Saint Agnes Hospital Baltimore MD
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Charles Hospital Oregon OH
Saint Francis Hospital Federal Way WA
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint John's Hospital - Healtheast Maplewood MN
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Louis-Cape Girardeau CCOP Saint Louis MO
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Peter's University Hospital New Brunswick NJ
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Saint Vincent Mercy Medical Center Toledo OH
Saskatoon Cancer Centre Saskatoon, Saskatchew
Saskatoon Cancer Centre Saskatoon
Sentara Norfolk General Hospital Norfolk VA
Sentara Virginia Beach General Hospital Virginia Beach VA
Shaw Regional Cancer Center Edwards CO
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital St. Louis MO
Siteman Cancer Center-South County St Louis MO
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
South Sacramento Cancer Center Sacramento CA
South Sacramento Cancer Center Sacramento CA
Southwest VA Regional Cancer Center Norton VA
Sparrow Hospital Lansing MI
Sparrow Hospital Lansing MI
Spartanburg Medical Center Spartanburg SC
Spartanburg Medical Center Spartanburg SC
St Anne's Hospital Fall River MA
St. Lukes Hospital Association of Duluth Duluth MN
Stanford Cancer Institute Palo Alto Palo Alto CA
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Medical Center Sacramento Sacramento CA
Sutter Solano Medical Center Vallejo CA
Temple University Hospital Philadelphia PA
Texas Cancer Center-Sherman Sherman TX
Texas Oncology Bedford Bedford TX
Texas Oncology Cancer Center Sugar Land Sugar Land TX
Texas Oncology Cancer Center Sugar Land Sugarland TX
Texas Oncology-Denton South Denton TX
Texas Oncology-Longview Cancer Center Longview TX
Texas Oncology-Plano West Plano TX
Texas Oncology-Plano West Plano TX
The Cancer Center of Hawaii-Liliha Honolulu HI
The Cancer Center of Hawaii-Pali Momi Ewa Beach HI
The Hospital of Central Connecticut New Britain CT
The Kirklin Clinic at Acton Road Birmingham AL
The Klabzuba Cancer Center Fort Worth TX
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Permanente Medical Group-Roseville Radiation Oncology Roseville CA
The Regional Cancer Center Erie PA
The Regional Cancer Center Erie PA
The University of Kansas Cancer Center-Lee's Summit Lee's Summit MO
The University of Kansas Cancer Center-North Kansas City MO
The University of Kansas Cancer Center-South Kansas City MO
Thedacare Cancer Institute Appleton WI
ThedaCare Regional Cancer Center Appleton WI
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers-Adrian Adrian MI
Toledo Clinic Cancer Centers-Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Tom Baker Cancer Centre Calgary, Alberta
Touro Infirmary New Orleans LA
Tulane University Medical Center New Orleans LA
UC San Diego Moores Cancer Center LaJolla CA
UC San Diego Moores Cancer Center La Jolla CA
UCSF Medical Center-Mount Zion San Francisco CA
UCSF Medical Center-Mount Zion San Francisco CA
UH Seidman Cancer Center at Geauga Medical Center Chardon OH
UH Seidman Cancer Center at Southwest General Middleburgh OH
UHHS - Chagrin Highlands Orange Village OH
UHHS-Westlake Medical Center Westlake OH
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach FL
United Hospital St. Paul MN
Unity Hospital Fridley MN
University Medical Center New Orleans New Orleans LA
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Colorado Hospital Aurora CO
University of Hawaii Cancer Center Honolulu HI
University of Iowa/Holden Comprehensive Cancer Center Iowa City IA
University of Kansas Cancer Center Kansas City KS
University of Kansas Cancer Center-Overland Park Overland Park KS
University of Kentucky/Markey Cancer Center Lexington KY
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Nebraska Medical Center Omaha NE
University of Nebraska Medical Center Omaha NE
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Southern California Los Angeles CA
University of Texas Medical Branch Galveston TX
University of Texas Southwestern Medical School Dallas TX
University of Vermont Medical Center Burlington VT
University of Wisconsin Hospital and Clinics Madison WI
University Pointe-Precision Radiotherapy West Chester OH
Upstate Carolina CCOP Spartanburg SC
USON-Arizona Radiation Oncology Tucson AZ
USON-Texas Oncology-Wichita Falls Texoma Cancer Center Wichita Falls TX
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
UTMB Cancer Center at Victory Lakes League City TX
Veterans Administration Long Beach Medical Center Long Beach CA
Virginia Mason CCOP Seattle WA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Washington University School of Medicine St. Louis MO
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
WellSpan Health-York Hospital York PA
West Michigan Cancer Center Kalamazoo MI
West Texas Cancer Center Odessa TX
Wheaton Franciscan Cancer Care-All Saints Racine WI
William Backus Hospital Norwich CT
William Backus Hospital Norwich CT
William Beaumont Hospital - Troy Troy MI
William Beaumont Hospital - Troy Troy MI
William Beaumont Hospital-Royal Oak Royal Oak MI
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 9/30/2014

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