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RTOG 1122 Protocol Information

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Phase II Double-Blinded Placebo-Controlled Study of Bevacizumab With or Without AMG 386 in Patients With Recurrent Glioblastoma or Gliosarcoma
Protocol Documents
Current Version Date: 10/3/2016
Principal Investigator: Eudocia Quant Lee, MD, MPH
Primary Objective:

To assess the safety and tolerability of AMG 386 15 mg/kg weekly in combination with bevacizumab 10 mg/kg every 2 weeks (Cohort 1)

To assess the efficacy of AMG 386 in combination with bevacizumab 10 mg/kg every 2 weeks compared to bevacizumab monotherapy in bevacizumab-naïve patients, as measured by 6-month progression-free survival (PFS6) (Cohort 2)

Patient Population:

Recurrent glioblastoma or variant (gliosarcoma, glioblastoma with oligodendroglial features, giant cell glioblastoma)

Target Accrual: 141
Current Accrual: 137
Status: Closed to Accrual
Date: 9/2/2014
Participating Sites:
Abbott-Northwestern Hospital Minneapolis MN
Adena Regional Medical Center Chillicothe OH
Akron General Medical Center Akron OH
Allan Blair Cancer Centre Regina, SK
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
American Fork Hospital / Huntsman Intermountain Cancer Center American Fork UT
AnMed Health Cancer Center Anderson SC
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Arizona Oncology Services Foundation Phoenix AZ
Bay Area Medical Center Marinette WI
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
California Pacific Medical Center-Pacific Campus San Francisco CA
Cape Radiation Oncology Cape Girardeau MO
Carle Cancer Center Urbana IL
Clackamas Radiation Oncology Center Clackamas OR
Columbia University/Herbert Irving Cancer Center New York NY
Columbus CCOP Columbus OH
Community Cancer Center Foundation Normal IL
Community Memorial Hospital Menomonee Falls WI
Compass Oncology Vancouver Vancouver WA
CoxHealth South Hospital Springfield MO
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Hospital Columbus OH
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Froedtert and the Medical College of Wisconsin Milwaukee WI
Genesis Healthcare System Cancer Care Center Zainesville OH
Gibbs Cancer Center-Pelham Greer SC
Grady Memorial Hospital Delaware OH
Grant Medical Center Columbus OH
Heartland Regional Medical Center St. Joseph MO
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse NY
Hennepin County Medical Center Minneapolis MN
Holy Family Memorial Hospital Manitowoc WI
Illinois CancerCare-Peoria Peoria IL
Intermountain Medical Center Murray UT
Kaiser Permanente Los Angeles Medical Center Los Angeles CA
Kaiser Permanente Los Angeles Medical Center Los Angeles CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Lancaster General Hospital Lancaster PA
Lancaster General Hospital Lancaster PA
Langlade Hospital Cancer Center Antigo WI
Lankenau Medical Center Wynnewood PA
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Liberty Radiation Oncology Center Liberty MO
Licking Memorial Hospital Newark OH
Logan Regional Hospital Logan UT
Los Angeles County-USC Medical Center Los Angeles CA
Maine Medical Center- Scarborough Campus Scarborough ME
Maine Medical Center- Scarborough Campus Portland ME
Mainline Health CCOP Wynnewood PA
Marietta Memorial Hospital Marietta OH
McKay-Dee Hospital Center Ogden UT
Menorah Medical Center Overland Park KS
Mercy Hospital Coon Rapids MN
Mercy Hospital Saint Louis Saint Louis MO
Mercy Hospital Saint Louis St Louis MO
Mercy Hospital Springfield Springfield MO
Methodist Cancer Center Omaha NE
Metro-Minnesota CCOP St. Louis Park MN
Mills-Peninsula Medical Center San Mateo CA
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Mission Hospital-Memorial Campus Asheville NC
Montefiore Medical Center - Moses Campus Bronx NY
Montefiore Medical Center - Moses Campus Bronx NY
Mount Carmel Health Center West Columbus OH
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
New York Oncology Hematology PC - Albany Albany NY
North Kansas City Hospital North Kansas City MO
North Memorial Medical Health Center Robbinsdale MN
Northeast Georgia Medical Center-Gainesville Gainesville GA
NorthShore University HealthSystem-Evanston Hospital Evanston IL
NorthShore University HealthSystem-Evanston Hospital Evanston IL
NorthShore University HealthSystem-Glenbrook Hospital Glenview IL
Northwestern Medicine Cancer Center Warrenville Warrenville IL
Northwestern Medicine Cancer Center Warrenville Warrenville IL
Northwestern University Chicago IL
Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa OK
OSF Saint Francis Medical Center Peoria IL
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin IL
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria IL
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Paoli Memorial Hospital Paoli PA
Park Nicollet Clinic - Saint Louis Park Saint Louis Park MN
PeaceHealth Southwest Medical Center Vancouver WA
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Poudre Valley Hospital Fort Collins CO
Poudre Valley Hospital Radiation Oncology Fort Collins CO
ProHealth D N Greenwald Center Mukwonago WI
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
Providence Alaska Medical Center Anchorage AK
Providence Portland Medical Center Portland OR
Providence Saint Vincent Medical Center Portland OR
Rapid City Regional Hospital Rapid City SD
Reading Hospital West Reading PA
Reading Hospital Reading PA
Regions Hospital St. Paul MN
Research Medical Center Kansas City MO
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Riverside Methodist Hospital Columbus OH
Robinson Radiation Oncology Ravenna OH
Rush University Medical Center Chicago IL
Rush-Copley Medical Center Aurora IL
Rush-Copley Medical Center Aurora IL
Rutherford Hospital Rutherfordton NC
Saint Ann's Hospital Westerville OH
Saint John's Hospital - Healtheast Maplewood MN
Saint Joseph Hospital - Orange Orange CA
Saint Joseph Hospital - Orange Orange CA
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Singing River Hospital Pascagoula MS
Southern Ohio Medical Center Portsmouth OH
Sparrow Hospital Lansing MI
Sparrow Hospital Lansing MI
Spartanburg Medical Center Spartanburg SC
Spartanburg Medical Center Spartanburg SC
Springfield Regional Medical Center Springfield OH
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Summa Health Center at Lake Medina Medina OH
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Solano Medical Center Vallejo CA
Texas Oncology - Central Austin Cancer Center Austin TX
Texas Oncology - Round Rock Cancer Center Round Rock TX
Texas Oncology - South Austin Cancer Center Austin TX
Texas Oncology Bedford Bedford TX
Texas Oncology Cancer Center Sugar Land Sugarland TX
Texas Oncology-Austin Midtown Austin TX
Texas Oncology-Longview Cancer Center Longview TX
Texas Oncology-Seton Williamson Round Rock TX
The Hospital of Central Connecticut New Britain CT
The Klabzuba Cancer Center Fort Worth TX
The Mark H Zangmeister Center Cols OH
Thomas Jefferson University Hospital Philadelphia PA
Thomas Jefferson University Hospital Philadelphia PA
Tyler Cancer Center Tyler TX
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange CA
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange CA
United Hospital St. Paul MN
Unity Hospital Fridley MN
University of Chicago Comprehensive Cancer Center Chicago IL
University of Chicago Comprehensive Cancer Center Chicago IL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Kentucky/Markey Cancer Center Lexington KY
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Southern California Los Angeles CA
University of Texas Southwestern Medical School Dallas TX
University of Wisconsin Hospital and Clinics Madison WI
University of Wisconsin Hospital and Clinics Madison WI
University Pointe-Precision Radiotherapy West Chester OH
UPMC Cancer Center at UPMC Horizon Farrell PA
UPMC Cancer Center at UPMC McKeesport McKeesport PA
UPMC Cancer Center at UPMC Northwest Seneca PA
UPMC Cancer Center-John P. Murtha Pavilion Johnstown PA
UPMC Cancer Center-Natrona Heights Natrona Heights PA
UPMC Jefferson Cancer Center Pittsburgh PA
UPMC-Arnold Palmer Pavilion Greensburg PA
UPMC-Cancer Center at St. Clair Hospital Pittsburgh PA
UPMC-Heritage Valley Health System-Medical Center, (Beaver) Beaver PA
UPMC-Jameson Memorial Hospital New Castle PA
UPMC-Passavant Hospital Pittsburgh PA
UPMC-Presbyterian Hospital Pittsburgh PA
UPMC-Saint Margaret Pittsburgh PA
UPMC-Shadyside Hospital Pittsburgh PA
UPMC-The Washington Hospital Washington PA
Upstate Carolina CCOP Spartanburg SC
USC / Norris Comprehensive Cancer Center Los Angeles CA
USON-Arizona Radiation Oncology Tucson AZ
USON-Cancer Care Northwest - Spokane Spokane WA
USON-Cancer Care Northwest-East Holland Spokane WA
USON-Williamette Valley Cancer Center Eugene OR
UT Southwestern/Simmons Cancer Center-Dallas Dallas TX
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Wausau Hospital Center Wausau WI
Western Oncology Research Consortium Portland OR
William Backus Hospital Norwich CT
Updated: 10/17/2016

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