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RTOG 1201 Protocol Information

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A Phase II Randomized Trial of High Versus Standard Intensity Local or Systemic Therapy for Unresectable Pancreatic Cancer
Protocol Documents
Current Version Date: 11/3/2014
Principal Investigator: Edgar Ben-Josef, MD
Primary Objective:

To determine if intenstified radiochemotherapy following gemcitabine and nab-Paclitaxel in patients with unresectable pancreatic cancer will show a signal for improved 2-year overall survival from 10% to 22.5 % as compared to chemotherapy with gemcitabine and nab-Paclitaxel alone

To determine if standard radiochemotherapy, following gemcitabine and nab-Paclitaxel, in patietns with unresectable pancreatic cancer will show a signal for improved 2- year overall survival from 10% to 22.5 % as compared to chemotherapy with gemcitabine and nab-Paclitaxel alone

Patient Population:

Histopathological or cytological diagnosis of adenocarcinoma of the pancreas; tumor diameter ≤7 cm, unresectable by radiographic criteria (pancreas protocol CT or MRI) or exploration, no distant metastases

A cell block or core biopsy must be submitted for central review and analysis of SMAD4 status as soon as possible following step 1 registration

 

Target Accrual: 288
Current Accrual: 20
Status: Terminated
Date: 6/30/2016
Participating Sites:
Abbott-Northwestern Hospital Minneapolis MN
Allegiance Health Jackson MI
Ascension Saint John Hospital Grosse Pointe Woods MI
Aspirus Langlade Hospital Antigo WI
Aspirus Regional Cancer Center Wausau WI
Bay Area Medical Center Marinette WI
Beaumont Hospital - Dearborn Dearborn MI
Bellin Memorial Hospital Green Bay WI
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Billings Clinic Cancer Center Billings MT
Bryn Mawr Hospital Bryn Mawr PA
Capital Health Medical Center-Hopewell Pennington NJ
CHI Health Saint Francis Grand Island NE
Cleveland Clinic Akron General Akron OH
CoxHealth South Hospital Springfield MO
Delaware County Memorial Hospital Drexel Hill PA
Delbert Day Cancer Institute at PCRMC Rolla MO
Dixie Medical Center Regional Cancer Center East St. George UT
Emory University Hospital Midtown Atlanta GA
Emory University Hospital/Winship Cancer Institute Atlanta GA
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Genesys Hurley Cancer Institute Flint MI
Heartland Regional Medical Center St. Joseph MO
Hennepin County Medical Center Minneapolis MN
Holy Family Memorial Hospital Manitowoc WI
Huntsman Cancer Institute/University of Utah Salt Lake City UT
Huntsman Cancer Institute/University of Utah Salt Lake City UT
Hurley Medical Center Flint MI
Intermountain Medical Center Murray UT
Jewish Hospital Medical Center Northeast Louisville KY
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Kaiser Permanente Cancer Treatment Center South San Francisco CA
Kaiser Permanente Medical Center - Santa Clara Santa Clara CA
Kaiser Permanente Oakland-Broadway Oakland CA
Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova CA
Kansas City CCOP Prairie Village KS
Lake Huron Medical Center Port Huron MI
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Liberty Radiation Oncology Center Liberty MO
Logan Regional Hospital Logan UT
M D Anderson Cancer Center Houston TX
Mainline Health CCOP Wynnewood PA
Mayo Clinic Rochester MN
McKay-Dee Hospital Center Ogden UT
Memorial Health University Medical Center Savannah GA
Menorah Medical Center Overland Park KS
Mercy Hospital Coon Rapids MN
Mercy Hospital Saint Louis St Louis MO
Mercy Hospital Springfield Springfield MO
Metro-Minnesota CCOP St. Louis Park MN
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Montana Cancer Consortium CCOP Billings MT
North Kansas City Hospital North Kansas City MO
North Memorial Medical Health Center Robbinsdale MN
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria IL
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Paoli Memorial Hospital Paoli PA
Parkview Hospital Randallia Fort Wayne IN
Peninsula Regional Medical Center Salisbury MD
Presence Saint Joseph Hospital-Chicago Chicago IL
Radiation Oncology Associates PC Fort Wayne IN
Reading Hospital Reading PA
Regions Hospital St. Paul MN
Research Medical Center Kansas City MO
Rhode Island Hospital Providence RI
Rhode Island Hospital Providence RI
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Robinson Radiation Oncology Ravenna OH
Rocky Mountain Oncology Casper WY
Rohnert Park Cancer Center Rohnert Park CA
Saint Agnes Hospital Baltimore MD
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint John Macomb-Oakland Hospital Warren MI
Saint John's Hospital - Healtheast Maplewood MN
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Luke's Hospital of Kansas City Kansas City MO
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Peter's University Hospital New Brunswick NJ
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sanford USD Medical Center - Sioux Falls Sioux Falls SD
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
South Sacramento Cancer Center Sacramento CA
Southwest VA Regional Cancer Center Norton VA
Sparrow Hospital Lansing MI
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Summa Health Center at Lake Medina Medina OH
The Permanente Medical Group-Roseville Radiation Oncology Roseville CA
Thompson Cancer Survival Center Knoxville TN
United Hospital St. Paul MN
Unity Hospital Fridley MN
University of Kentucky/Markey Cancer Center Lexington KY
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Pennsylvania Medical Center Philadelphia PA
University of Rochester Rochester NY
University of Vermont Medical Center Burlington VT
University of Vermont Medical Center Burlington VT
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Hospital and Medical Center Kingsport TN
Updated: 6/30/2016

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