RTOG 1203 Protocol Information

A Randomized Phase III Study Of Standard Vs. IMRT Pelvic Radiation For Post-Operative Treatment Of Endometrial And Cervical Cancer (TIME-C)--RTOG CCOP Study
Principal Investigator: Ann Klopp M.D, PhD and Anamaria Yeung,MD
Primary Objective:

To determine if IMRT reduces acute gastrointestinal toxicity in the 5th week (after 23-25 fractions) of pelvic radiation as measured with EPIC.

Patient Population:

Pathologically proven diagnosis of endometrial and cervical cancer who require post-operative radiation or chemoradiation; Zubrod performance status of 0–2.   

Dual Enrollment to RTOG 0724 and RTOG 1203

Patients are permitted to be enrolled onto both RTOG 0724 and RTOG 1203, however careful consideration must be made to the following:

  • In order to avoid protocol deviations, patients MUST be registered to 1203 first. The treatment arm that the patient is assigned to on 1203 will be the same treatment option used for stratification in 0724.
  • Patients MUST meet eligibility criteria for both studies.
  • The radiation guidelines (Section 6) in 1203 should be followed for BOTH studies.


Patients are not able to be enrolled on RTOG 1203 and GOG 0263 concurrently.



Target Accrual: 281
Current Accrual: 270
Status: Open to Accrual
Date: 11/28/2012
Participating Sites:
Abbott Northwestern Hospital Minneapolis MN
Abington Memorial Hospital Abington PA
Adena Regional Medical Center Chillicothe OH
Akron City Hospital Akron OH
Akron General Medical Center Akron OH
Allan Blair Cancer Centre Regina, SK
Allan Blair Cancer Centre Regina
Allegiance Health/W.A. Foote Memorial Hospital Jackson MI
Arizona Oncology - Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Aurora BayCare Medical Center Green Bay WI
Aurora Saint Luke's Medical Center Milwaukee WI
Baystate Health-D'Amour Springfield MA
Baystate Medical Center Springfield MA
BC Cancer Agency Center for Southern Interior Kelowna, BC
BCCA-Cancer Centre for the Southern Interior Kelowna
BCCA-Vancouver Island Cancer Centre Victoria, British Columbia
Benefis Healthcare-Sletten Cancer Institute Great Falls MT
Billings Clinic Billings MT
Billings Clinic Cancer Center Billings MT
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Brigham and Women's Hospital Boston MA
Brigham and Women's Hospital/Dana Farber Cancer Institute Boston MA
Bronson Methodist Hospital Kalamazoo MI
Bryn Mawr Hospital Bryn Mawr PA
California Cancer Center - North Fresno Fresno CA
California Cancer Center CGOP Fresno CA
Cancer Research for the Ozarks CCOP Springfield MO
Capital Health Medical Center-Hopewell Pennington NJ
Case Western Reserve University Cleveland OH
Christiana Care Health Services, Inc. CCOP Newark DE
Christiana Care Health System-Christiana Hospital Newark DE
Columbus Community Clinical Oncology Program Columbus OH
Cox Health System Springfield MO
CoxHealth South Hospital Springfield MO
Dana Farber/Brigham & Woman's CC at Milford Regional Milford MA
Dana Farber/Brigham & Women's Center at South Shore South Weymouth MA
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Cancer Center East St. George UT
Doctor's Hospital Columbus OH
Fairbanks Memorial Hospital Fairbanks AK
Fairview Ridges Hospital Burnsville MN
Fairview Southdale Hospital Edina MN
Florida Hospital Orlando FL
Fox Chase Virtua Health Cancer Treatment Center Voorhees NJ
Franciscan St. Margaret Health Hammond IN
Franciscan St. Margaret Health-Dyer Campus Dyer IN
Geisinger Medical Center Danville PA
Geisinger Medical Center CCOP Danville PA
Geisinger Wyoming Valley Medical Center Wilkes Barre PA
Genesis Healthcare System Zainesville OH
Genesys Regional Medical Center Flint MI
Georgia Regents University Augusta GA
Grady Health System Atlanta GA
Grady Memorial Hospital Delaware OH
Grant Medical Center Columbus OH
Greater Baltimore Medical Center Baltimore MD
Greater Baltimore Medical Center Baltimore MD
Hennepin County Medical Center Minneapolis MN
Huntsman Cancer Institute/University of Utah Salt Lake City UT
Hurley Cancer Center Flint MI
Idaho Urologic Institute Meridian ID
Ingalls Memorial Hospital Harvey IL
Intermountain Medical Center Murray UT
IU Health Ball Memorial Hospital Muncie IN
John H. Stroger, Jr. Hospital of Cook County MBCCOP Chicago IL
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton
Kaiser Permanent Northern California-Rancho Cordova Rancho Cordova CA
Kaiser Permanente Cancer Treatment Center South San Francisco CA
Kaiser Permanente Northern California Santa Clara CA
Kaiser Permanente Northern California-Oakland Oakland CA
Kaiser Permanente Northern California-Rohnert Park Rohnert Park CA
Kaiser Permanente Northern California-Roseville Roseville CA
Kaiser Permanente Northern California-South Sacramento Sacramento CA
Kaiser Permanente Northern California-South San Francisco South San Francisco CA
Kaiser Permanente Oakland-Broadway Oakland CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kalispell Regional Medical Center Kalispell MT
King Faisal Specialist Hospital and Research Centre Riyadh
Lake/University Seidman Cancer Center Mentor OH
Lankenau Hospital Wynnewood PA
LDS Hospital Salt Lake City UT
Lewis Cancer & Research Pavilion at St. Joseph's/Candler Savannah GA
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah GA
Licking Memorial Hospital Newark OH
Logan Regional Hospital Logan UT
London Regional Cancer Program London
Long Island Jewish Hospital Lake Success NY
Long Island Jewish Medical Center New Hyde Park NY
Lowell General Hospital Lowell MA
Lowell General Hospital Cancer Center Lowell MA
Main Line CCOP Wynnewood PA
Maplewood Cancer Center Maplewood MN
Marietta Memorial Hospital Marietta OH
Mary Bird Perkins Cancer Center Baton Rouge LA
McKay-Dee Hospital Ogden UT
McMaster Univ, Juravinski Can Ctr, Hamilton Health Sciences Hamilton, Ontario
Medical University of South Carolina Charleston SC
Mercy Hospital Coon Rapids MN
Mercy Hospital Port Huron Port Huron MI
Mercy Hospital St. Louis St Louis MO
Mercy-Springfield Springfield MO
Metro-MN CCOP St. Louis Park MN
Michigan Cancer Research Consortium CCOP Ann Arbor MI
Mid Ohio Oncology Hematology Inc- Mark H. Zangmeister Ctr Cols OH
Montana Cancer Consortium CCOP Billings MT
Mount Carmel Medical Center-State Street Columbus OH
Mount Carmel-St. Ann's Cancer Center Westerville OH
Mount Nittany Medical Center State College PA
National University Cancer Institute Singapore Singapore
National University Hospital Singapore
New Mexico Cancer Care Alliance Albuquerque NM
North Memorial Medical Center Robbinsdale MN
North Shore-LIJ Health System/Center for Advanced Medicine Lake Success NY
Northeast Georgia Medical Center Gainesville GA
Northside Hospital Atlanta GA
Northside Hospital Cancer Center Atlanta GA
Northside Hospital Forsyth Cumming GA
Northwest Cancer Clinic Kennewich WA
Northwestern Memorial Hospital Chicago IL
Northwestern University Chicago IL
Novant Health Presbyterian Medical Center Charlotte NC
Oakwood Healthcare Inc Dearborn MI
Ochsner Clinic CCOP New Orleans LA
Ochsner Medical Center Jefferson New Orleans LA
Pamela Youde Nethersole Eastern Hospital Chai Wan
Pamela Youde Nethersole Eastern Hospital Chai Wan
Paoli Memorial Hospital Paoli PA
Paoli Memorial Hospital Paoli PA
Parkview Cancer Center - Parkview Hospital Fort Wayne IN
Parkview Hospital Fort Wayne IN
Peninsula Regional Medical Center Salisbury MD
Peninsula Regional Medical Center Salisbury MD
Penrose Cancer Center, Penrose-St. Francis Health Services Colorado Springs CO
Piedmont Fayette Hospital Fayetteville GA
Piedmont Hospital Atlanta GA
Pomona Valley Hospital Medical Center Pomona CA
Presbyterian Hospital Charlotte NC
Presence Saint Joseph Hospital-Chicago Chicago IL
Presence Saint Joseph Hospital-Chicago Chicago IL
Radiation Oncology Associates Fort Wayne IN
Radiation Oncology Associates PC Fort Wayne IN
Rapid City Regional Hospital Rapid City SD
Reading Hospital West Reading PA
Reading Hospital Reading PA
Regions Radiation Therapy St. Paul MN
Rice Memorial Hospital Willmar MN
Ridgeview Medical Center Waconia MN
Riverside Methodist Hospital Columbus OH
Robinson Radiation Oncology Ravenna OH
Rocky Mountain Oncology Center Casper WY
Saint Alphonsus Regional Medical Center Boise ID
Saint John's Hospital - HealthEast Maplewood MN
Saint Mary Mercy Hospital Livonia MI
Sanford USD Medical Center - Sioux Falls Sioux Falls SD
Saskatoon Cancer Centre Saskatoon
Saskatoon Cancer Centre Saskatoon, Saskatchew
Sheba Medical Center Tel Hashomer
Sinai Hospital of Baltimore Baltimore MD
Sinai Hospital of Baltimore Baltimore MD
Southern Ohio Medical Center - Cancer Center Portsmouth OH
Southside Hospital Bayshore NY
Southwest General Health Center Ireland Cancer Center Middleburg Heights OH
Southwest Virginia Regional Cancer Center Norton VA
Sparrow Regional Cancer Center Lansing MI
Spectrum Health at Butterworth Campus Grand Rapids MI
Spectrum Health-Grand Rapid Clinical Oncology Program Grand Rapids MI
Springfield Regional Medical Center Springfield OH
St Francis Hospital & Medical Center Hartford CT
St Johns Hospital, Cancer Institute Springfield IL
St. Francis Hospital Federal Way WA
St. Johns Hospital & Medical Center Grosse Pointe Woods MI
St. Joseph Hospital Orange CA
St. Joseph Mercy Hospital Ann Arbor MI
St. Joseph Mercy Oakland Pontac MI
St. Luke's Medical Center Milwaukee WI
St. Mary Mercy Hospital Livonia MI
St. Mary`s Medical Center Saginaw MI
St. Vincent Anderson Regional Hospital, Inc. Anderson IN
Stony Brook University Medical Center Stony Brook NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Health Center at Lake Medina Medina OH
Summa Health Center at Lake Medina Medina OH
Summa Health System Barberton Hospital Barberton OH
Swedish Medical Center Englewood CO
The Cancer Center of Hawaii-Leeward Ewa Beach HI
The Cancer Center of Hawaii-Liliha Honolulu HI
The Cancer Center of Hawaii-Liliha Honolulu HI
The Mark H Zangmeister Center Columbus OH
The Nebraska Medical Center Omaha NE
The New York Methodist Hospital Brooklyn NY
The Queen's Medical Center Honolulu HI
The Schiffler Cancer Center Wheeling WV
The University of Arizona Medical Center - University Campus Tucson AZ
UCSD – University of California, San Diego LaJolla CA
UH Seidman Cancer Center at Geauga Medical Center Chardon OH
UH Seidman Cancer Center at Southwest General Middleburgh OH
UHHS - Chagrin Highlands Orange Village OH
UHHS - Westlake Medical Center Westlake OH
UHHS-Westlake Medical Center Westlake OH
United Hospital St. Paul MN
Unity Hospital Fridley MN
Univ. of Miami Sylvester Comp Cancer Ctr-Deerfield Beach Deerfield Beach FL
University Hospitals of Cleveland Cleveland OH
University of California Davis Medical Center Sacramento CA
University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora CO
University of Colorado Denver Aurora CO
University of Florida College of Medicine Gainesville FL
University of Florida Health Science Center Jacksonville FL
University of Hawaii Cancer Research Center MBCCOP Honolulu HI
University of Illinois at Chicago Chicago IL
University of Kansas Cancer Center Kansas City KS
University of Miami Miller School of Medicine Miami FL
University of Nebraska Medical Center Omaha NE
University of New Mexico Albuquerque NM
University of North Carolina at Chapel Hill Chapel Hill NC
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Oklahoma Health Sciences Center Oklahoma City OK
University of Texas at San Antonio San Antonio TX
University of Texas Health Science Center San Antonio TX
University of Texas Southwestern Medical Center Dallas TX
University of Texas Southwestern Medical School Dallas TX
University of Texas-MD Anderson Cancer Center Houston TX
University of Utah Health Science Center Salt Lake City UT
University of Wisconsin Hospital Madison WI
Utah Cancer Specialists Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virginia Commonwealth University Richmond VA
Virginia Mason CCOP Seattle WA
Virtua West Jersey Hospital Voorhees Voorhees NJ
Virtua-Memorial Hospital Burlington County, Inc. Mount Holly NJ
Washington Cancer Institute Washington DC
Wayne State University-Karmanos Cancer Institute Detroit MI
Webber Cancer Center Warren MI
Weisberg Cancer Treatment Center Farmington Hills MI
Welch Cancer Center Sheridan WY
Wellmont Holston Valley Medical Center Kingsport TN
Windsor Regional Cancer Centre Windsor
Yonsei University Health System-Severance Hospital Seoul
Updated: 3/30/2015

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