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RTOG 1308 Protocol Information

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Phase III Randomized Trial Comparing Overall Survival After Photon Versus Proton Chemoradiotherapy for Inoperable Stage II-IIIB NSCLC
Protocol Documents
Principal Investigator: Zhongxing Liao, MD
Primary Objective:

To compare the overall survival (OS) in patients with stage II-IIIB NSCLC after image guided, motion-managed photon radiotherapy (Arm 1) or after image guided, motion-managed proton radiotherapy (Arm 2) both given with concurrent platinum- based chemotherapy.

Patient Population:

Untreated histologically or cytologically proven diagnosis of non-small cell lung cancer prior to registration. Clinical AJCC (7th ed.) stage II-IIIB medically non-operable disease, or surgically unresectable disease, or patients who refuse surgery; patients who present with N2 or N3 disease and an undetectable NSCLC primary tumor also are eligible

Protocol documents are available on the CTSU website. Tracked versions are available from the CTSU Help Desk upon request.

Target Accrual: 560
Current Accrual: 106
Status: Open to Accrual
Date: 2/3/2014
Participating Sites:
M D Anderson Cancer Center Houston TX
Mass General/North Shore Cancer Center Danvers MA
Massachusetts General Hospital Cancer Center Boston MA
MD Anderson Regional Care Center-Katy Houston TX
Memorial Sloan Kettering Basking Ridge Basking Ridge NJ
Memorial Sloan Kettering Cancer Center New York NY
Northwestern Medicine Cancer Center Warrenville Warrenville IL
Siteman Cancer Center at West County Hospital Creve Coeur MO
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Pennsylvania/Abramson Cancer Center Philadelphia PA
University of Washington Medical Center Seattle WA
Upper Chesapeake Medical Center Bel Air MD
Washington University School of Medicine Saint Louis MO
Updated: 3/3/2017

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