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RTOG 8903 Protocol Information

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A PHASE III TRIAL TO STUDY THE ROLE OF NEOADJUVANT MCV* CHEMOTHERAPY COMBINED WITH TRANSURETHRAL SURGERY PLUS CISPLATIN WITH RADIATION THERAPY FOR SELECTIVE BLADDER PRESERVATION IN PATIENTS WITH MUSCLE-INVADING BLADDER CANCER * MCV: Methotrexate, Cisplatin, Vinblastine
Protocol Documents
Current Version Date: 6/3/1996
Principal Investigator: William U. Shipley, MD
Primary Objective:

To determine in a prospective trial whether neoadjuvant MCV chemotherapy provides patients with muscle-invading bladder cancer a significantly improved  rate of successful bladder preservation (tumor-free and with good function) at 3 years.

Patient Population:

Patients with muscle-invading carcinoma of the bladder, all histologies, AJC stages c T2-4a, cNX, M0. Patients must have Karnofsky status of at least 70.

Target Accrual: 174
Current Accrual: 126
Status: Terminated
Date: 12/15/2016
Participating Sites:
21st Century Oncology, Inc. Ft. Myers FL
Albany Medical Center Albany NY
Allegheny General Hospital Pittsburgh PA
Anne Arundel Medical Center Annapolis MD
Baptist Cancer Institute Jacksonville FL
Baptist Hospital of Miami Miami FL
Baptist Memorial Hospital Kansas City MO
Bethesda Memorial Hospital Boynton Beach FL
Boca Raton Community Hospital-Lynn Regional Cancer Center Boca Raton FL
Borgess Medical Center Kalamazoo MI
Boston Medical Center MBCCOP Boston MA
Cancer Care Center Winter Park FL
Cancer Care Manitoba Foundation Winnipeg, Manitoba
Central Illinois CCOP Decatur IL
Champlain Valley Physicians Hospital Medical Center Plattsburgh NY
Chester County Hospital West Chester PA
Columbia Saint Mary's Hospital - Ozaukee Mequon WI
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Columbia University/Herbert Irving Cancer Center New York NY
Community Cancer Center East Indianapolis IN
Cooper Hospital University Medical Center Camden NJ
Cottonwood Hospital Medical Center Murray UT
Cross Cancer Institute Edmonton, Alberta
Dartmouth Hitchcock Medical Center Lebanon NH
Delaware County Memorial Hospital Drexel Hill PA
Desert Hospital Comprehensive Ca Cn Palm Springs CA
Dixie Medical Center Regional Cancer Center East St. George UT
Don & Sybil Harrington Cancer Center Amarillo TX
Drexel University School of Medicine Philadelphia PA
Einstein Medical Center Philadelphia Philadelphia PA
Elizabeth General Medical Center Elizabeth NJ
Florida Community Cancer Center Dunedin FL
Florida Hospital Orlando Orlando FL
Fox Chase Cancer Center Philadelphia PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Geisinger Medical Center Danville PA
Genessee Hospital Rochester NY
Greater Baltimore Medical Center Baltimore MD
Greenville Health System Cancer Institute-Eastside Greenville SC
Gundersen Lutheran Medical Center La Crosse WI
Halifax Hospital ROC Daytona Beach FL
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Hoag Memorial Hospital Presbyterian Newport Beach CA
ICCA of Western Illinois Galesburg IL
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Jackson-Madison County General Hospital Jackson TN
Jersey Shore Medical Center Neptune NJ
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
Loma Linda University Medical Center Loma Linda CA
London Regional Cancer Program London Ontario
Mary Bird Perkins Cancer Center Baton Rouge LA
Massachusetts General Hospital Boston MA
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Menorah Medical Center Kansas City MO
Merle West Cancer Treatment Center Klamath Falls OR
Mesa Lutheran Hospital Mesa AZ
Methodist Medical Center of Illinois Peoria IL
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Moffitt Cancer Center Tampa FL
Montefiore Medical Center - Moses Campus Bronx NY
Mount Sinai Medical Center Miami Beach FL
Munson Medical Center Traverse City MI
Nevada Cancer Research Foundation CCOP Las Vegas NV
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
Northern Indiana Cancer Research Consortium South Bend IN
Northwest Community Clinical Oncology Program Tacoma WA
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Piedmont Hospital Atlanta GA
Providence Sacred Heart Medical Center and Children's Hospital Spokane WA
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
Radiation Therapy Partnership Inc Columbia MO
Radiological Associates of Sacramento Sacramento CA
Reading Hospital Reading PA
Regional Hospital of Scranton Scranton PA
Rex Cancer Center Raleigh NC
Rex Cancer Center Raleigh NC
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph's Hospital/Children's Hospital-Tampa Tampa FL
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Santa Cruz Radiation Oncology Santa Cruz CA
Southern Wisconsin Radiotherapy Center Madison WI
St Francis Radiation Oncology Cntr Topeka KS
St Johns Hospital, Cancer Institute Springfield IL
St Mary Regional Cancer Center Langhorne PA
St. Francis Medical Center Trenton NJ
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Medical Center Sacramento Sacramento CA
The Christ Hospital Cincinnati OH
The James Graham Brown Cancer Center at University of Louisville Louisville KY
Thomas Jefferson University Hospital Philadelphia PA
Trinity Cancer Care Center Minot ND
Trinity Lutheran Hospital Kansas City MO
Tufts Medical Center Boston MA
UCSF Medical Center-Mount Zion San Francisco CA
United Hospital St. Paul MN
University of California Davis Comprehensive Cancer Center Sacramento CA
University of California, San Diego Medical Center LaJolla CA
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Minnesota/Masonic Cancer Center Minneapolis MN
University of Pennsylvania Medical Center Philadelphia PA
University of Rochester Rochester NY
University of Southern California Los Angeles CA
University of Utah Health Science Center Salt Lake City UT
University of Wisconsin Hospital and Clinics Madison WI
UP Health System Marquette Marquette MI
UPMC-Arnold Palmer Pavilion Greensburg PA
USON-Williamette Valley Cancer Center Eugene OR
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Valley Regional Cancer Center Modesto CA
Virtua Memorial Mount Holly NJ
Washington University School of Medicine St. Louis MO
Wayne State University/Karmanos Cancer Institute Detroit MI
West Penn Hospital Pittsburgh PA
Updated: 12/15/2016

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