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RTOG 9003 Protocol Information

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A Phase III Randomized Study to Compare Twice Daily Hyperfractionation, Accelerated Hyperfractionation with a Split and Accelerated Fractionation with Concomitant Boost to Standard Fractionation Radiotherapy for Squamous Cell Carcinomas of the Head and Neck
Protocol Documents
Current Version Date: 12/16/2005
Principal Investigator: K. Kian Ang, M.D.
Primary Objective:

To determine whether hyperfractionation and/or accelerated fractionation improves the local-regional control rate of advanced squamous cell carcinomas of the head and neck.

Patient Population:

Sites: Oral Cavity, Oropharynx, Hypopharynx, Supraglottic Larynx
Age: > = 18
Histology: Squamous cell or lymphoepithelioma
Stage: AJC Stage III or IV (Stage II base of tongue and hypopharynx), no distant metastases
Karnofsky Status: > = 60
Prior Therapy: No prior radiotherapy, chemotherapy or surgery other than biopsy.

Target Accrual: 1080
Current Accrual: 1113
Status: Terminated
Date: 11/5/2013
Participating Sites:
21st Century Oncology Ft. Myers FL
Adventist Medical Center Portland OR
Albany Medical Center Albany NY
Allegheny General Hospital Pittsburgh PA
Alta Bates Summit Medical Center-Herrick Campus Berkeley CA
Anchorage Radiation Therapy Center Anchorage AK
Atlanta Regional CCOP Atlanta GA
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Hospital of East Tennessee Knoxville TN
Bayfront Cancer Care Center St. Petersburg FL
Baylor College of Medicine Houston TX
Bayshore Cancer Center Pasadena TX
Borgess Medical Center Kalamazoo MI
Brandon Radiation Therapy Brandon FL
Brockton Hospital Brockton MA
Bronson Methodist Hospital Kalamazoo MI
California Cancer Center - North Fresno Fresno CA
California Pacific Medical Center-Pacific Campus San Francisco CA
Cancer Treatment Center Wooster OH
Capital Health Medical Center-Hopewell Pennington NJ
Case Western Reserve University Cleveland OH
Champlain Valley Physicians Hospital Medical Center Plattsburgh NY
Christ Hospital Jersey City NJ
Christiana Care Health System-Christiana Hospital Newark DE
City of Hope Comprehensive Cancer Center Duarte CA
Clarkson Hospital Omaha NE
Cleveland Clinic Akron General Akron OH
Coborn Cancer Center at Saint Cloud Hospital St. Cloud MN
Columbus CCOP Columbus OH
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Community Regional Medical Center Fresno CA
Cooper Hospital University Medical Center Camden NJ
Cross Cancer Institute Edmonton, Alberta
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
David Grant United States Air Force Medical Center Travis AFB CA
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
East Alabama Medical Center Opelika AL
Einstein Medical Center Philadelphia Philadelphia PA
Elizabeth General Medical Center Elizabeth NJ
Elliot Hospital Manchester NH
Emory University Hospital/Winship Cancer Institute Atlanta GA
Essentia Health Cancer Center-South University Clinic Fargo ND
Finley Hospital Dubuque IA
Florida Community Cancer Center Dunedin FL
Florida Community Cancer Centers New Port Richey FL
Florida Hospital Orlando Orlando FL
Florida Oncology Center Winter Park FL
Fox Chase Cancer Center Philadelphia PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Genessee Hospital Rochester NY
Glens Falls Hospital Queenbury NY
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Halifax Health Medical Center-Centers for Oncology Daytona Beach FL
Harbor Hospital Center Baltimore MD
Health Sciences North Sudbury, Ontario
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Horizon Health Network-Saint John Regional Hospital Saint John, NB
Hurley Medical Center Flint MI
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Ingalls Memorial Hospital Harvey IL
Inspira Medical Center Vineland Vineland NJ
Iowa Methodist Medical Center Des Moines IA
Jackson-Madison County General Hospital Jackson TN
Jersey Shore Medical Center Neptune NJ
John F Kennedy Medical Center Edison NJ
John Muir Medical Center-Concord Concord CA
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Kaiser Permanente Los Angeles Medical Center Los Angeles CA
Kaiser Permanente-San Diego Mission San Diego CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Lakeland Regional Health Hollis Cancer Center Lakeland FL
Lancaster General Hospital Lancaster PA
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Lewis Hall Singletary Oncology Cntr Thomasville GA
Liberty Hospital Liberty MO
Loma Linda University Medical Center Loma Linda CA
London Regional Cancer Program London Ontario
Long Island Jewish Medical Center Lake Success NY
Loyola University Medical Center Maywood IL
M D Anderson Cancer Center Houston TX
Mainline Health CCOP Wynnewood PA
Marin General Hospital Greenbrae CA
Mayo Clinic Rochester MN
McGill University Department of Oncology Montreal
McLaren Northern Michigan Petoskey MI
Medical University of South Carolina Charleston SC
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Joplin Joplin MO
Mercy San Juan Medical Center Carmichael CA
Meridian Radiation Oncology Meridian MS
Merle West Cancer Treatment Center Klamath Falls OR
Methodist Medical Center of Illinois Peoria IL
MetroHealth Medical Center Cleveland OH
Metro-Minnesota CCOP St. Louis Park MN
Miami Cancer Institute Miami FL
Mills-Peninsula Medical Center San Mateo CA
Missouri Valley Cancer Consortium Omaha NE
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Montefiore Medical Center - Moses Campus Bronx NY
Morton Plant Hospital Clearwater FL
Mount Sinai Medical Center Miami Beach FL
Munson Medical Center Traverse City MI
Nebraska Methodist Hospital Omaha NE
Nevada Cancer Research Foundation CCOP Las Vegas NV
New York Medical College Valhalla NY
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
North Shore-LIJ Health System CCOP Manhasset NY
Northeast Alabama Regional Medical Center Anniston AL
Northern Indiana Cancer Research Consortium South Bend IN
Northwest Community Clinical Oncology Program Tacoma WA
Northwestern University Chicago IL
Ochsner Medical Center Jefferson New Orleans LA
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Palms of Pasadena Hospital St. Petersburg FL
PeaceHealth Southwest Medical Center Vancouver WA
Piedmont Hospital Atlanta GA
Piedmont Radiation Oncology Associates Greenville SC
Providence Alaska Medical Center Anchorage AK
Providence Milwaukie Hospital Milwaukie OR
Providence Portland Medical Center Portland OR
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank CA
Providence Saint Vincent Medical Center Portland OR
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
QEII Health Sciences Centre/Nova Scotia Health Authority Halifax, Nova Scotia
Radiation Therapy Partnership Inc Columbia MO
Radiological Associates of Sacramento Sacramento CA
Reading Hospital Reading PA
Regional Hospital of Scranton Scranton PA
Rex Cancer Center Raleigh NC
Rex Cancer Center Raleigh NC
Romagosa Radiation Oncology Center Lafayette LA
Roswell Park Cancer Institute Buffalo NY
Saint Agnes Medical Center Fresno CA
Saint Anthony's Hospital Cancer Care Center St. Petersburg FL
Saint Elizabeth Medical Center South Edgewood KY
Saint Francis Medical Center Trenton NJ
Saint Joseph's Hospital/Children's Hospital-Tampa Tampa FL
Saint Louis University Hospital St. Louis MO
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary's Hospital and Regional Medical Center Grand Junction CO
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Saint Vincent's Medical Center Jacksonville FL
Sanford Roger Maris Cancer Center Fargo ND
Santa Cruz Radiation Oncology Santa Cruz CA
Santa Rosa Memorial Hospital CCOP Santa Rosa CA
Santa Rosa Radiation Oncology Center Santa Rosa CA
Saskatoon Cancer Centre Saskatoon, Saskatchew
Scott and White Memorial Hospital Temple TX
Scripps Clinic and Research Foundation La Jolla CA
Scripps Memorial Hospital La Jolla CA
Sequoia Regional Cancer Center Visalia CA
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southwest Illinois Health Services LLP Swansea IL
Southwestern Vermont Medical Center Bennington VT
St Francis Radiation Oncology Cntr Topeka KS
St Mary Regional Cancer Center Langhorne PA
St. Agnes Hospital/Agnesian Cancer Center Fond du Lac WI
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Medical Center Sacramento Sacramento CA
Sutter Solano Medical Center/Cancer Center Vallejo CA
The Cancer Center for Southern Kentucky Bowling Green KY
The Christ Hospital Cincinnati OH
The Don and Sybil Harrington Cancer Center Amarillo TX
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The New York Hospital Medical Center of Queens Flushing NY
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Research Institute of the McGill University Health Centr Montreal
Thomas Jefferson University Hospital Philadelphia PA
Tom Baker Cancer Centre Calgary, Alberta
Trinity Cancer Care Center Minot ND
UCHealth Memorial Hospital Central Colorado Springs CO
UCLA / Jonsson Comprehensive Cancer Center Los Angeles CA
UCSF Medical Center-Mount Zion San Francisco CA
UF Cancer Center at Orlando Health Orlando FL
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
United Hospital St. Paul MN
United Hospital St. Paul MN
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Arizona Medical Center-University Campus Tucson AZ
University of California Davis Comprehensive Cancer Center Sacramento CA
University of California San Diego LaJolla CA
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Iowa/Holden Comprehensive Cancer Center Iowa City IA
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Minnesota/Masonic Cancer Center Minneapolis MN
University of Missouri - Ellis Fischel Columbia MO
University of Pennsylvania Medical Center Philadelphia PA
University of Pennsylvania/Abramson Cancer Center Philadelphia PA
University of Puerto Rico San Juan PR
University of Rochester Rochester NY
University of Texas Medical Branch Galveston TX
University of Texas Southwestern Medical School Dallas TX
University of Wisconsin Hospital and Clinics Madison WI
UP Health System Marquette Marquette MI
Upstate Carolina CCOP Spartanburg SC
USC / Norris Comprehensive Cancer Center Los Angeles CA
USON-Williamette Valley Cancer Center Eugene OR
Utah Valley Regional Medical Center Provo UT
Val A Browning Ca Treatment Cntr East Ogden UT
Valley Regional Cancer Center Modesto CA
Vanderbilt University/Ingram Cancer Center Nashville TN
Virginia Baptist Hospital Lynchburg VA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Virtua Memorial Mount Holly NJ
Wake Forest University Health Sciences Winston-Salem NC
Washington University School of Medicine St. Louis MO
Wayne State University/Karmanos Cancer Institute Detroit MI
West Penn Hospital Pittsburgh PA
Western Oncology Research Consortium Portland OR
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wilford Hall Medical Center Lackland AFB TX
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Updated: 11/6/2013

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