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RTOG 9111 Protocol Information

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Phase III Trial to Preserve the Larynx: Induction Chemotherapy and Radiation Therapy versus Concomitant Chemotherapy and Radiation Therapy versus Radiation Therapy
Protocol Documents
Current Version Date: 9/8/1998
Principal Investigator: Helmut Goepfert, M.D.
Primary Objective:

The primary endpoint is survival with preservation of laryngeal function.

Patient Population:

Stages III and IV (excluding T1) squamous cell cancer of the glottic and supraglottic larynx as assessed by CT scan and clinical evaluation. Resectable disease No prior surgery, chemotherapy, or radiotherapy KPS > = 60

Target Accrual: 546
Current Accrual: 547
Status: Terminated
Date: 11/5/2013
Participating Sites:
21st Century Oncology Ft. Myers FL
Abbott-Northwestern Hospital Minneapolis MN
Advocate Lutheran General Hospital Park Ridge IL
Albany Medical Center Albany NY
Allegheny General Hospital Pittsburgh PA
Alta Bates Summit Medical Center - Summit Campus Oakland CA
Anchorage Radiation Therapy Center Anchorage AK
Arizona Oncology Services Foundation Scottsdale AZ
Aultman Health Foundation Canton OH
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Cancer Institute CCOP Memphis TN
Baptist Health Madisonville/Merle Mahr Cancer Center Madisonville KY
Baptist Health Paducah Paducah KY
Baptist Hospital St Pensacola FL
Baptist Hospital of East Tennessee Knoxville TN
Bay Area Tumor Institute Oakland CA
Bayfront Cancer Care Center St. Petersburg FL
Bayshore Cancer Center Pasadena TX
Boca Raton Regional Hospital Boca Raton FL
Boston Veteran's Affairs Medical Center Boston MA
California Cancer Center - Fresno Fresno CA
Cancer Care Center Winter Park FL
Cancer Treatment Center Wooster OH
Case Western Reserve University Cleveland OH
Champlain Valley Physicians Hospital Medical Center Plattsburgh NY
Christiana Care Health System-Christiana Hospital Newark DE
CHUM - Centre Hospitalier de l'Universite de Montreal Montreal
CHUM - Hopital Notre-Dame Montreal Quebec
City of Hope Comprehensive Cancer Center Duarte CA
Clarkson Hospital Omaha NE
Cleveland Clinic Akron General Akron OH
Cleveland Clinic Foundation Cleveland OH
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Cooper Hospital University Medical Center Camden NJ
Covenant Medical Center-Lakeside Lubbock TX
Cross Cancer Institute Edmonton, Alberta
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
David Grant United States Air Force Medical Center Travis AFB CA
Deaconess Medical Center Spokane WA
Dekalb General Hospital Decatur GA
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo CA
East Carolina University Greenville NC
East Alabama Medical Center Opelika AL
East Bay Radiation Oncology Center Castro Valley CA
East Jefferson General Hospital Metairie LA
Eastern Maine Medical Center Bangor ME
Einstein Medical Center Philadelphia Philadelphia PA
Elizabeth General Medical Center Elizabeth NJ
Elliot Hospital Manchester NH
Emory University Hospital/Winship Cancer Institute Atlanta GA
Enloe Medical Center Chico CA
Erlanger Medical Center Chattanooga TN
Fairview Ridges Hospital Burnsville MN
Fairview-Southdale Hospital Edina MN
Finley Hospital Dubuque IA
Florida Community Cancer Centers New Port Richey FL
Florida Hospital Orlando Orlando FL
Florida Oncology Center Winter Park FL
Fox Chase Cancer Center Philadelphia PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Geisinger Medical Center Danville PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes Barre PA
Genessee Hospital Rochester NY
Glendale Memorial Hospital and Health Center Glendale CA
Glens Falls Hospital Queenbury NY
Good Samaritan Hospital - Cincinnati Cincinnati OH
Greater Baltimore Medical Center Baltimore MD
Greater Baltimore Medical Center Baltimore MD
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Halifax Health Medical Center-Centers for Oncology Daytona Beach FL
Harbor Hospital Center Baltimore MD
Hennepin County Medical Center Minneapolis MN
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Holy Cross Hospital Fort Lauderdale FL
Horizon Health Network-Saint John Regional Hospital Saint John, NB
Huntsman Cancer Institute/University of Utah Salt Lake City UT
Hurley Medical Center Flint MI
Indiana University Health Methodist Hospital Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Inspira Medical Center Vineland Vineland NJ
Jackson-Madison County General Hospital Jackson TN
John F Kennedy Medical Center Edison NJ
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Julie and Ben Rogers Cancer Institute Beaumont TX
Jupiter Medical Center Jupiter FL
Kaiser Permanente Los Angeles Medical Center Los Angeles CA
Kaiser Permanente-San Diego Mission San Diego CA
Kansas City CCOP Prairie Village KS
Kingston Health Sciences Centre Kingston, Ontario
Lakeland Regional Health Hollis Cancer Center Lakeland FL
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Lehigh Valley Hospital-Cedar Crest Allentown PA
Lewis and Faye Manderson Cancer Center Tuscaloosa AL
Liberty Hospital Liberty MO
Loma Linda University Medical Center Loma Linda CA
London Regional Cancer Program London Ontario
Long Beach Memorial Medical Center-Todd Cancer Institute Long Beach CA
Long Island Jewish Medical Center Lake Success NY
Los Angeles County-USC Medical Center Los Angeles CA
Louisiana State University Health Science Center New Orleans LA
M D Anderson Cancer Center Houston TX
Maine General Medical Center-Thayer Waterville ME
Maine Medical Center- Scarborough Campus Scarborough ME
Mainline Health CCOP Wynnewood PA
McGill University Department of Oncology Montreal
McLaren Cancer Institute-Flint Flint MI
Medical University of South Carolina Charleston SC
MedStar Georgetown University Hospital Washington DC
Mercy Fitzgerald Hospital Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Coon Rapids MN
Mercy Hospital Rockville Centre NY
Mercy Hospital Joplin Joplin MO
Mercy San Juan Medical Center Carmichael CA
Meridian Radiation Oncology Meridian MS
Merle West Cancer Treatment Center Klamath Falls OR
Mesa Lutheran Hospital Mesa AZ
Methodist Medical Center of Illinois Peoria IL
MetroHealth Medical Center Cleveland OH
Metro-Minnesota CCOP St. Louis Park MN
Miami Cancer Institute Miami FL
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Minnesota Oncology Hematology PA-Maplewood Maplewood MN
Missouri Baptist Medical Center St. Louis MO
Missouri Valley Cancer Consortium Omaha NE
Moffitt Cancer Center Tampa FL
Montefiore Medical Center - Moses Campus Bronx NY
Morton Plant Hospital Clearwater FL
Mount Sinai Medical Center Miami Beach FL
Mount Sinai Union Square New York NY
Munson Medical Center Traverse City MI
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Nevada Cancer Research Foundation CCOP Las Vegas NV
New York Medical College Valhalla NY
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
North Memorial Medical Health Center Robbinsdale MN
North Shore-LIJ Health System CCOP Manhasset NY
Northeast Alabama Regional Medical Center Anniston AL
Northern Indiana Cancer Research Consortium South Bend IN
Northern Rockies Radiation Oncology Center Billings MT
Northwest Community Clinical Oncology Program Tacoma WA
Northwestern University Chicago IL
Norwalk Hospital Norwalk CT
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Penn State Milton S Hershey Medical Center Hershey PA
Pennsylvania Hospital Philadelphia PA
Piedmont Radiation Oncology Associates Greenville SC
Pomona Valley Hospital Medical Center Pomona CA
Presence Resurrection Medical Center Chicago IL
Providence Sacred Heart Medical Center and Children's Hospital Spokane WA
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank CA
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
Radiation Oncology Associates of W. Alabama PC Tuscaloosa AL
Radiation Therapy Partnership Inc Columbia MO
Radiological Associates of Sacramento Sacramento CA
Reading Hospital Reading PA
Regional Hospital of Scranton Scranton PA
Regions Hospital St. Paul MN
Rex Cancer Center Raleigh NC
Ridgeview Medical Center Waconia MN
Romagosa Radiation Oncology Center Lafayette LA
Saint Agnes Medical Center Fresno CA
Saint Barnabas Medical Center Livingston NJ
Saint Francis Medical Center Trenton NJ
Saint John Medical Center Tulsa OK
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Louis University Hospital St. Louis MO
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary Medical and Regional Cancer Center Langhorne PA
Saint Mary's of Michigan Saginaw MI
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Saint Vincent's Medical Center Jacksonville FL
Sanford Roger Maris Cancer Center Fargo ND
Santa Cruz Radiation Oncology Santa Cruz CA
Santa Rosa Memorial Hospital Santa Rosa CA
Saskatoon Cancer Centre Saskatoon, Saskatchew
Sentara Norfolk General Hospital Norfolk VA
Sharp Health Care/Grossmont La Mesa CA
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southwest Illinois Health Services LLP Swansea IL
Southwestern Vermont Medical Center Bennington VT
St Michael's Hospital Milwaukee WI
St. Agnes Hospital/Agnesian Cancer Center Fond du Lac WI
Stanford Cancer Institute Palo Alto Palo Alto CA
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Medical Center Sacramento Sacramento CA
Swedish Medical Center-First Hill Seattle WA
The Cancer Center for Southern Kentucky Bowling Green KY
The Don and Sybil Harrington Cancer Center Amarillo TX
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Ottawa Hospital Regional Cancer Centre Ottawa, Ontario
The Research Institute of the McGill University Health Centre (MUHC) Montreal
The Toledo Hospital/Toledo Children's Hospital Toledo OH
Thomas Jefferson University Hospital Philadelphia PA
Toledo Community Hospital Oncology Program CCOP Toledo OH
Trinitas Hospital-Jersey Street Campus Newark NJ
Trinity Cancer Care Center Minot ND
Trinity Cancer Care Center Minot ND
UCHealth Memorial Hospital Central Colorado Springs CO
UCLA / Jonsson Comprehensive Cancer Center Los Angeles CA
UCSF Medical Center-Mount Zion San Francisco CA
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
UNC Lineberger Comprehensive Cancer Center Chapel Hill NC
United Hospital St. Paul MN
United Hospital St. Paul MN
Unity Hospital Fridley MN
University Medical Center New Orleans New Orleans LA
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Arizona Medical Center-University Campus Tucson AZ
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Iowa/Holden Comprehensive Cancer Center Iowa City IA
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Minnesota/Masonic Cancer Center Minneapolis MN
University of Missouri - Ellis Fischel Columbia MO
University of Pennsylvania Medical Center Philadelphia PA
University of Pennsylvania/Abramson Cancer Center Philadelphia PA
University of Rochester Rochester NY
University of Texas Health Science Center at San Antonio San Antonio TX
University of Texas Medical Branch Galveston TX
University of Vermont Medical Center Burlington VT
University of Virginia Cancer Center Charlottesville VA
University of Wisconsin Hospital and Clinics Madison WI
UP Health System Marquette Marquette MI
UPMC-Mercy Hospital Pittsburgh PA
UPMC-Presbyterian Hospital Pittsburgh PA
Upstate Carolina CCOP Spartanburg SC
USA Health Strada Patient Care Center Mobile AL
USC / Norris Comprehensive Cancer Center Los Angeles CA
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Valley Regional Cancer Center Modesto CA
Vanderbilt University/Ingram Cancer Center Nashville TN
Virginia Baptist Hospital Lynchburg VA
Virginia Mason CCOP Seattle WA
Virtua Memorial Mount Holly NJ
Wake Forest University Health Sciences Winston-Salem NC
Warren Radiation Therapy Center Warren NJ
Washington Cancer Institute Washington DC
Washington University School of Medicine St. Louis MO
Wayne State University/Karmanos Cancer Institute Detroit MI
West Florida Cancer Institute Pensacola FL
West Penn Hospital Pittsburgh PA
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wheaton Franciscan Healthcare - Saint Joseph Milwaukee WI
Wilford Hall Medical Center Lackland AFB TX
William Beaumont Hospital-Royal Oak Royal Oak MI
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Zablocki Veterans Administration Medical Center Milwaukee WI
Updated: 11/6/2013

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