Evaluation of the relative effectiveness of the elective versus therapeutic androgen deprivation with Zoladex and disease progression and survival in a population of patients with carcinoma of the prostate who are considered at a high risk of relapse and tumor related death. All patients would have been pre-treated with a combination of neoadjuvant total androgen suppression and external beam radiotherapy.

Histologically confirmed locally advanced adenocarcinoma of the prostate.
Confirmed bulky tumors confined to the prostate, clinical stage T2c-T4.
No involved common iliac or para-aortic nodes.
Karnofsky performance status > 70