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RTOG 9413 Protocol Information

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A Phase III Trial Comparing Whole Pelvic Irradiation Followed by a Conedown Boost to Boost Irradiation Only and Comparing Neoadjuvant to Adjuvant Total Androgen Suppression (TAS)
Protocol Documents
Current Version Date: 9/8/1998
Principal Investigator: Mack Roach III, M.D.
Primary Objective:

To test the hypothesis that TAS and whole pelvic irradiation followed by a conedown boost to the prostate improves the progression-free survival (an "early endpoint") by at least 10% at 5 years compared to TAS and prostate only irradiation

Patient Population:

Histologically confirmed localized adenocarcinoma of the prostate with an elevated PSA. 
Estimated risk of lymph node involvement > 15%
No involved common iliac or para-aortic nodes or distant mets.
Pathological lymph-node-positive patients are ineligible.
No prior cryosurgery for prostate cancer.
Karnofsky performance status > = 70.

Target Accrual: 1200
Current Accrual: 1322
Status: Terminated
Date: 12/15/2016
Participating Sites:
21st Century Oncology Ft. Myers FL
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Adena Regional Medical Center Chillicothe OH
Advocate Lutheran General Hospital Park Ridge IL
Albany Medical Center Albany NY
Allegiance Health Jackson MI
Anne Arundel Medical Center Annapolis MD
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Ascension Saint John Hospital Grosse Pointe Woods MI
Atlanta Regional CCOP Atlanta GA
Atlanta VA Medical Center Decatur GA
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Cancer Institute CCOP Memphis TN
Baptist Health Madisonville/Merle Mahr Cancer Center Madisonville KY
Baptist Hospital of East Tennessee Knoxville TN
Baptist Medical Center South Jacksonville FL
Bay Area Tumor Institute Oakland CA
Bayfront Cancer Care Center St. Petersburg FL
Bayshore Cancer Center Pasadena TX
Beaumont Hospital - Dearborn Dearborn MI
Bixby Medical Center Adrian MI
Boca Raton Regional Hospital Boca Raton FL
Boston Veteran's Affairs Medical Center Boston MA
Brandon Radiation Therapy Brandon FL
Bridgeport Hospital Bridgeport CT
Brockton Hospital Brockton MA
California Cancer Center - Fresno Fresno CA
Cancer Care Center Winter Park FL
Cancer Treatment Center Wooster OH
Capital Health Medical Center-Hopewell Pennington NJ
Caritas Regional Cancer Center Louisville KY
Carle Cancer Center Urbana IL
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
CaroMont Regional Medical Center Gastonia NC
Case Western Reserve University Cleveland OH
Champlain Valley Physicians Hospital Medical Center Plattsburgh NY
Christiana Care Health System-Christiana Hospital Newark DE
CHUM - Centre Hospitalier de l'Universite de Montreal Montreal
CHUM - Hopital Notre-Dame Montreal Quebec
Cleveland Clinic Akron General Akron OH
Cleveland Clinic Foundation Cleveland OH
Clifton Springs Hospital and Clinic Clifton Springs NY
Coborn Cancer Center at Saint Cloud Hospital St. Cloud MN
Columbia Saint Mary's Hospital - Ozaukee Mequon WI
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Columbus CCOP Columbus OH
Community Cancer Center East Indianapolis IN
Community Howard Regional Health Kokomo IN
Community Memorial Hospital Menomonee Falls WI
Cooper Health System-Voorhees Voorhees NJ
Cooper Hospital University Medical Center Camden NJ
Cross Cancer Institute Edmonton, Alberta
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
David Grant United States Air Force Medical Center Travis AFB CA
Dayton CCOP Kettering OH
Deaconess Medical Center Spokane WA
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Doctors Hospital Columbus OH
Duke University Medical Center Durham NC
East Carolina University Greenville NC
East Alabama Medical Center Opelika AL
East Jefferson General Hospital Metairie LA
Einstein Medical Center Philadelphia Philadelphia PA
Elizabeth General Medical Center Elizabeth NJ
Elkhart General Hospital Elkhart IN
Emory University Hospital/Winship Cancer Institute Atlanta GA
Erlanger Medical Center Chattanooga TN
Essentia Health Cancer Center-South University Clinic Fargo ND
Finley Hospital Dubuque IA
Florida Oncology Center Winter Park FL
Froedtert and the Medical College of Wisconsin Milwaukee WI
Froedtert Memorial Lutheran Hospital Milwaukee WI
Geisinger Medical Center Danville PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes Barre PA
Genesis Healthcare System Cancer Care Center Zainesville OH
Genessee Hospital Rochester NY
Genesys Hurley Cancer Institute Flint MI
Glens Falls Hospital Queenbury NY
Good Samaritan Hospital - Cincinnati Cincinnati OH
Grady Health System Atlanta GA
Grady Memorial Hospital Delaware OH
Grand View Hospital Sellersville PA
Grant Medical Center Columbus OH
Greater Baltimore Medical Center Baltimore MD
Greater Baltimore Medical Center Baltimore MD
Greenville Health System Cancer Institute-Eastside Greenville SC
Greenwich Hospital Greenwich CT
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Halifax Health Medical Center-Centers for Oncology Daytona Beach FL
Harbin Clinic Rome GA
Harbor Hospital Center Baltimore MD
Henry Ford Hospital Detroit MI
Highland Hospital Rochester NY
Holmes Regional Medical Center Melbourne FL
Holy Cross Hospital Fort Lauderdale FL
Horizon Health Network-Saint John Regional Hospital Saint John, NB
Hunter Holmes McGuire Veterans Administration Medical Center Richmond VA
Huntsville Hospital Huntsville AL
Hurley Medical Center Flint MI
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Inspira Medical Center Vineland Vineland NJ
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intermountain Medical Center Murray UT
Iowa Methodist Medical Center Des Moines IA
IU Health La Porte Hospital La Porte IN
Jackson-Madison County General Hospital Jackson TN
Jersey Shore Medical Center Neptune NJ
John F Kennedy Medical Center Edison NJ
John Muir Medical Center-Concord Concord CA
John Muir Medical Center-Walnut Creek Concord CA
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Jupiter Medical Center Jupiter FL
Kaiser Permanente Los Angeles Medical Center Los Angeles CA
Kaiser Permanente-San Diego Mission San Diego CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Keesler Medical Center Keesler AFB MS
Lake Huron Medical Center Port Huron MI
Lakeland Regional Health System St. Joseph MI
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Lehigh Valley Hospital - Muhlenberg Bethlehem PA
Lehigh Valley Hospital-Cedar Crest Allentown PA
Lewis and Faye Manderson Cancer Center Tuscaloosa AL
Liberty Hospital Liberty MO
Licking Memorial Hospital Newark OH
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Long Beach Memorial Medical Center-Todd Cancer Institute Long Beach CA
Los Angeles County-USC Medical Center Los Angeles CA
Louisiana State University Health Science Center New Orleans LA
Loyola University Medical Center Maywood IL
Maine Medical Center- Scarborough Campus Scarborough ME
Mainline Health CCOP Wynnewood PA
Marietta Memorial Hospital Marietta OH
Marshfield Clinic Marshfield WI
Mary Bird Perkins Cancer Center Baton Rouge LA
Mayo Clinic Rochester MN
Mayo Clinic in Arizona Scottsdale AZ
Mayo Clinic in Florida Jacksonville FL
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute-Flint Flint MI
McLaren Cancer Institute-Northern Michigan Petoskey MI
Medical University of Ohio Toledo OH
Memorial Health University Medical Center Savannah GA
Memorial Hospital of South Bend South Bend IN
Memorial Sloan Kettering Cancer Center New York NY
Mercy Cancer Center-Elyria Elyria OH
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Rockville Centre NY
Mercy Hospital Joplin Joplin MO
Mercy Hospital Springfield Springfield MO
Mercy Saint Anne Hospital Toledo OH
Mercy Saint Anne Hospital Toledo OH
Mercy San Juan Medical Center Carmichael CA
Meridian Radiation Oncology Meridian MS
Mesa Lutheran Hospital Mesa AZ
Methodist Hospital Philadelphia PA
Methodist Medical Center of Illinois Peoria IL
MetroHealth Medical Center Cleveland OH
Miami Cancer Institute Miami FL
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Missouri Baptist Medical Center St. Louis MO
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Monmouth Medical Center Long Branch NJ
Montana Cancer Consortium CCOP Billings MT
Montefiore Medical Center - Moses Campus Bronx NY
Montgomery Cancer Center, LLC Montgomery AL
Mount Carmel Health Center West Columbus OH
Mount Sinai Medical Center Miami Beach FL
Munson Medical Center Traverse City MI
Naval Medical Center - Portsmouth Portsmouth VA
Nebraska Methodist Hospital Omaha NE
Nevada Cancer Research Foundation CCOP Las Vegas NV
New York Medical College Valhalla NY
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
North Coast Cancer Care Sandusky OH
North Shore-LIJ Health System CCOP Manhasset NY
Northeast Alabama Regional Medical Center Anniston AL
Northeast Radiation Oncology Center Dunmore PA
Northern Indiana Cancer Research Consortium South Bend IN
Northridge Hospital Medical Center Northridge CA
Northwest Community Clinical Oncology Program Tacoma WA
Northwestern University Chicago IL
Ochsner Medical Center Jefferson New Orleans LA
Ohio State University Comprehensive Cancer Center Columbus OH
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Palmetto Health Richland Columbia SC
Palms of Pasadena Hospital St. Petersburg FL
Parkview Hospital Randallia Fort Wayne IN
Piedmont Radiation Oncology Associates Greenville SC
Presence Resurrection Medical Center Chicago IL
ProMedica Flower Hospital Sylvania OH
ProMedica Flower Hospital Toledo OH
QEII Health Sciences Centre/Nova Scotia Health Authority Halifax, Nova Scotia
Radiation Oncology Associates of W. Alabama PC Tuscaloosa AL
Radiation Oncology Associates PC Fort Wayne IN
Radiation Oncology Center Alliance OH
Radiation Therapy Oncology Group Philadelphia PA
Radiological Associates of Sacramento Sacramento CA
Reading Hospital Reading PA
Regional Hospital of Scranton Scranton PA
Rex Cancer Center Raleigh NC
Rex Cancer Center Raleigh NC
Riverside Methodist Hospital Columbus OH
Robinson Radiation Oncology Ravenna OH
Roswell Park Cancer Institute Buffalo NY
Saint Agnes Medical Center Fresno CA
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Ann's Hospital Westerville OH
Saint Anthony's Hospital Cancer Care Center St. Petersburg FL
Saint Charles Hospital Oregon OH
Saint Elizabeth Medical Center South Edgewood KY
Saint Francis Medical Center Trenton NJ
Saint John Macomb-Oakland Hospital Warren MI
Saint John Medical Center Tulsa OK
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Louis University Hospital St. Louis MO
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary Mercy Hospital Livonia MI
Saint Mary's of Michigan Saginaw MI
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Saint Vincent Mercy Medical Center Toledo OH
Saint Vincent's Medical Center Jacksonville FL
Sandra L Maxwell Cancer Center Cedar City UT
Sanford Roger Maris Cancer Center Fargo ND
Santa Cruz Radiation Oncology Santa Cruz CA
Santa Rosa Memorial Hospital Santa Rosa CA
Saskatoon Cancer Centre Saskatoon, Saskatchew
Scott and White Memorial Hospital Temple TX
Scripps Clinic and Research Foundation La Jolla CA
Scripps Memorial Hospital La Jolla CA
Sentara Martha Jefferson Hospital Charlottesville VA
Sequoia Regional Cancer Center Visalia CA
Sharp Health Care/Grossmont La Mesa CA
Sinai-Grace Hospital Detroit MI
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Siteman Cancer Center at West County Hospital St. Louis MO
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southern Ohio Medical Center Portsmouth OH
Southern Wisconsin Radiotherapy Center Madison WI
Southwestern Vermont Medical Center Bennington VT
Sparrow Hospital Lansing MI
Springfield Regional Medical Center Springfield OH
St Joseph's Hospital Elgin IL
St Mary Regional Cancer Center Langhorne PA
St. Agnes Hospital/Agnesian Cancer Center Fond du Lac WI
Stanford Cancer Institute Palo Alto Palo Alto CA
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Medical Center Sacramento Sacramento CA
Swedish Medical Center-First Hill Seattle WA
Temple University Hospital Philadelphia PA
The Christ Hospital Cincinnati OH
The Don and Sybil Harrington Cancer Center Amarillo TX
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Mark H Zangmeister Center Cols OH
The New York Hospital Medical Center of Queens Flushing NY
The Research Institute of the McGill University Health Centre (MUHC) Montreal
The Toledo Hospital/Toledo Children's Hospital Toledo OH
The Vitalite Health Network - Dr Leon Richard Oncology Centre Moncton, NB
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers-Adrian Adrian MI
Toledo Clinic Cancer Centers-Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Tom Baker Cancer Centre Calgary, Alberta
Trinity Cancer Care Center Minot ND
UCHealth Memorial Hospital Central Colorado Springs CO
UCLA / Jonsson Comprehensive Cancer Center Los Angeles CA
UCSF Medical Center-Mount Zion San Francisco CA
UF Cancer Center at Orlando Health Orlando FL
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
UNC Lineberger Comprehensive Cancer Center Chapel Hill NC
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Arizona Medical Center-University Campus Tucson AZ
University of Arkansas for Medical Sciences Little Rock AR
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Chicago Comprehensive Cancer Center Chicago IL
University of Colorado Hospital Aurora CO
University of Iowa/Holden Comprehensive Cancer Center Iowa City IA
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Massachusetts Memorial Health Care Worcester MA
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Minnesota/Masonic Cancer Center Minneapolis MN
University of Missouri - Ellis Fischel Columbia MO
University of Pennsylvania Medical Center Philadelphia PA
University of Pennsylvania/Abramson Cancer Center Philadelphia PA
University of Rochester Rochester NY
University of South Alabama Mobile AL
University of Tennessee Health Science Center Memphis TN
University of Texas Southwestern Medical School Dallas TX
University of Vermont Medical Center Burlington VT
University of Wisconsin Hospital and Clinics Madison WI
UP Health System Marquette Marquette MI
UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg PA
UPMC-Shadyside Hospital Pittsburgh PA
Upstate Carolina CCOP Spartanburg SC
USC / Norris Comprehensive Cancer Center Los Angeles CA
USON-Williamette Valley Cancer Center Eugene OR
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Vanderbilt University/Ingram Cancer Center Nashville TN
Veterans Administration Long Beach Medical Center Long Beach CA
Veterans Administration New Jersey Health Care System East Orange NJ
Virginia Baptist Hospital Lynchburg VA
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Virtua Memorial Mount Holly NJ
Virtua Voorhees Voorhees NJ
Wake Forest University Health Sciences Winston-Salem NC
Walter Reed National Military Medical Center Bethesda MD
Washington University School of Medicine St. Louis MO
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wayne State University/Karmanos Cancer Institute Detroit MI
WellSpan Health-York Hospital York PA
West Allis Memorial Hospital West Allis WI
West Florida Cancer Institute Pensacola FL
West Penn Hospital Pittsburgh PA
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wilford Hall Medical Center Lackland AFB TX
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 1/12/2017

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