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RTOG 9506 Protocol Information

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A Phase I/II Trial Of Transurethral Surgery Plus Induction Chemoradiotherapy Followed Either By Selective Bladder Preservation Or Radical Cystectomy As Determined By Initial Response And Operability In Patients With Muscle-Invading Bladder Cancer
Protocol Documents
Current Version Date: 10/1/1996
Principal Investigator: William U. Shipley, MD
Primary Objective:

To evaluate the safety and tolerance for induction chemoradiotherapy by CFI to be followed by radical cystectomy if the initial tumor response is incomplete and the patient is suited for cystectomy, or by consolidation CFI if the tumor has cleared and/or if the patient is not suited for cystectomy.  A protocol completion rate of 90% is sought.

Patient Population:

Patients with muscle invading carcinoma of the bladder, all histologies.  AJC Stages cT2-T4a, cNX or pN0, M0, no hydronephrosis; creatinine clearance greater than or equal to 60ml/minute, platelets greater than or equal to 100,000, Karnofsky status greater than or equal to 70, no prior chemotherapy or pelvic RT.

Target Accrual: 30
Current Accrual: 35
Status: Terminated
Date: 11/5/2013
Participating Sites:
21st Century Oncology, Inc. Ft. Myers FL
Atlanta Regional CCOP Atlanta GA
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Hospital of Miami Miami FL
Bayshore Cancer Center Pasadena TX
Cape Cod Hospital Hyannis MA
Carle Cancer Center Urbana IL
Christiana Care Health System-Christiana Hospital Newark DE
Coborn Cancer Center at Saint Cloud Hospital St. Cloud MN
Community Medical Center Toms River NJ
Comprehensive Cancer Institute Huntsville AL
Cottonwood Hospital Medical Center Murray UT
Cross Cancer Institute Edmonton, Alberta
Dartmouth Hitchcock Medical Center Lebanon NH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Einstein Medical Center Philadelphia Philadelphia PA
Elizabeth General Medical Center Elizabeth NJ
Emory University Hospital/Winship Cancer Institute Atlanta GA
Finley Hospital Dubuque IA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Gundersen Lutheran Medical Center La Crosse WI
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Inspira Medical Center Vineland Vineland NJ
Jackson-Madison County General Hospital Jackson TN
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
Mainline Health CCOP Wynnewood PA
Massachusetts General Hospital Boston MA
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy Regional Cancer Center Redding CA
Meridian Radiation Oncology Meridian MS
Mesa Lutheran Hospital Mesa AZ
Methodist Medical Center of Illinois Peoria IL
Metro-Minnesota CCOP St. Louis Park MN
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Montefiore Medical Center - Moses Campus Bronx NY
Nevada Cancer Research Foundation CCOP Las Vegas NV
Northeast Alabama Regional Medical Center Anniston AL
Ochsner Medical Center Jefferson New Orleans LA
Our Lady of Lourdes Memorial Hospital, Inc. Binghamton NY
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Piedmont Radiation Oncology Associates Greenville SC
Pomona Valley Hospital Medical Center Pomona CA
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
Radiation Oncology Associates of W. Alabama PC Tuscaloosa AL
Radiological Associates of Sacramento Sacramento CA
Regional Hospital of Scranton Scranton PA
Rex Cancer Center Raleigh NC
Saint Agnes Medical Center Fresno CA
Saint Anthony's Hospital Cancer Care Center St. Petersburg FL
Saint Vincent's Medical Center Jacksonville FL
Sequoia Regional Cancer Center Visalia CA
Sharp Health Care/Grossmont La Mesa CA
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southwestern Vermont Medical Center Bennington VT
St. Francis Medical Center Trenton NJ
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Research Institute of the McGill University Health Centr Montreal
Thomas Jefferson University Hospital Philadelphia PA
Toledo Community Hospital Oncology Program CCOP Toledo OH
UCHealth Memorial Hospital Central Colorado Springs CO
UCSF Medical Center-Mount Zion San Francisco CA
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Arkansas for Medical Sciences Little Rock AR
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Florida Health Science Center - Gainesville Gainesville FL
University of Massachusetts Memorial Health Care Worcester MA
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Rochester Rochester NY
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virginia Mason CCOP Seattle WA
Virtua Memorial Mount Holly NJ
West Penn Hospital Pittsburgh PA
Wilford Hall USAF Medical Center Lackland AFB TX
Updated: 11/12/2013

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