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RTOG 9512 Protocol Information

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A Randomized Study of Hyperfractionation Versus Conventional Fractionation in T2 Squamous Cell Carcinoma of the Vocal Cord
Protocol Documents
Current Version Date: 4/3/2014
Principal Investigator: Andy Trotti, M.D.
Primary Objective:

To test whether hyperfractionation improves the local control rate for early stage (T2N0) squamous cell carcinoma of the true vocal cord (compared to conventional fractionation).

Patient Population:

Histopathologically-proven squamous cell glottic larynx (verrucal and adenocarcinoma are excluded) Age > = 18 Modified AJCC Stage II (T2a, T2b, N0) Karnofsky > =  60 No prior radiotherapy, chemotherapy or surgery other than biopsy No prior (< = 5 years) or concurrent malignancy.

Target Accrual: 240
Current Accrual: 250
Status: Terminated
Date: 12/15/2016
Participating Sites:
21st Century Oncology Ft. Myers FL
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Albany Medical Center Albany NY
Anchorage Radiation Therapy Center Anchorage AK
Anne Arundel Medical Center Annapolis MD
Arizona Oncology Associates-Deer Valley Center Phoenix AZ
Arizona Oncology Services Foundation Scottsdale AZ
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Health Madisonville/Merle Mahr Cancer Center Madisonville KY
Baptist Health Paducah Paducah KY
Baptist Hospital of East Tennessee Knoxville TN
Baptist Medical Center South Jacksonville FL
Bay Area Tumor Institute Oakland CA
Bay Medical Center Panama City FL
Bayshore Cancer Center Pasadena TX
Bixby Medical Center Adrian MI
Boston Veteran's Affairs Medical Center Boston MA
Cancer Treatment Center Wooster OH
Caritas Regional Cancer Center Louisville KY
Carle Cancer Center Urbana IL
Case Western Reserve University Cleveland OH
Champlain Valley Physicians Hospital Medical Center Plattsburgh NY
Christiana Care Health System-Christiana Hospital Newark DE
Clarkson Hospital Omaha NE
Cleveland Clinic Foundation Cleveland OH
Colorado Cancer Research Program CCOP Denver CO
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Community Cancer Center East Indianapolis IN
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Cooper Hospital University Medical Center Camden NJ
Cottonwood Hospital Medical Center Murray UT
Covenant Medical Center-Lakeside Lubbock TX
Cross Cancer Institute Edmonton, Alberta
David Grant United States Air Force Medical Center Travis AFB CA
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Doctor H. Bliss Murphy Cancer Centre St. John's, NL
Drexel University School of Medicine Philadelphia PA
East Jefferson General Hospital Metairie LA
Edwards Cancer Cntr Bedford TX
Einstein Medical Center Philadelphia Philadelphia PA
Elkhart General Hospital Elkhart IN
Emory University Hospital/Winship Cancer Institute Atlanta GA
Enloe Medical Center Chico CA
Florida Oncology Center Winter Park FL
Fox Chase Cancer Center Philadelphia PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Froedtert Memorial Lutheran Hospital Milwaukee WI
Geisinger Medical Center Danville PA
Glendale Memorial Hospital and Health Center Glendale CA
Good Samaritan Hospital Corvallis OR
Good Samaritan Hospital - Cincinnati Cincinnati OH
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Halifax Health Medical Center-Centers for Oncology Daytona Beach FL
Harbin Clinic Rome GA
Harbor Hospital Center Baltimore MD
Health Sciences North Sudbury, Ontario
Henry Ford Hospital Detroit MI
Hillcrest Hospital Cancer Center Mayfield Heights OH
Horizon Health Network-Saint John Regional Hospital Saint John, NB
Hunter Holmes McGuire Veterans Administration Medical Center Richmond VA
Huntsman Cancer Institute/University of Utah Salt Lake City UT
Huntsville Hospital Huntsville AL
Hurley Medical Center Flint MI
Huron Valley Hospital Commerce Township MI
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Inspira Medical Center Vineland Vineland NJ
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
IU Health Ball Memorial Hospital Muncie IN
IU Health La Porte Hospital La Porte IN
Jackson-Madison County General Hospital Jackson TN
John F Kennedy Medical Center Edison NJ
John Muir Medical Center-Concord Concord CA
Julie and Ben Rogers Cancer Institute Beaumont TX
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario
Kaiser Permanente Los Angeles Medical Center Los Angeles CA
Kaiser Permanente-San Diego Mission San Diego CA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Keesler Medical Center Keesler AFB MS
Kingston Health Sciences Centre Kingston, Ontario
Lake University Ireland Cancer Center Mentor OH
Lakeland Medical Center Saint Joseph St Joseph MI
Lakeland Regional Health System St. Joseph MI
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Lewis Hall Singletary Oncology Cntr Thomasville GA
Liberty Hospital Liberty MO
Lima Memorial Hospital Lima OH
Loma Linda University Medical Center Loma Linda CA
Long Beach Memorial Medical Center-Todd Cancer Institute Long Beach CA
Louisiana State University Health Science Center New Orleans LA
Loyola University Medical Center Maywood IL
M D Anderson Cancer Center Houston TX
M.D.Anderson Cancer Network-Tarrant County Forth Worth TX
Maine Medical Center- Scarborough Campus Scarborough ME
Mainline Health CCOP Wynnewood PA
Mary Bird Perkins Cancer Center Baton Rouge LA
Mayo Clinic Rochester MN
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute-Flint Flint MI
Medical University of Ohio Toledo OH
Medical University of South Carolina Charleston SC
Memorial Hospital of South Bend South Bend IN
Mercy Cancer Center-Elyria Elyria OH
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Joplin Joplin MO
Mercy Hospital Saint Louis St Louis MO
Mercy Saint Anne Hospital Toledo OH
Mercy San Juan Medical Center Carmichael CA
Mesa Lutheran Hospital Mesa AZ
Methodist Hospital Philadelphia PA
Methodist Medical Center of Illinois Peoria IL
Miami Cancer Institute Miami FL
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mid-Michigan Medical Center - Midland Midland MI
Missouri Baptist Medical Center St. Louis MO
Missouri Valley Cancer Consortium Omaha NE
Moffitt Cancer Center Tampa FL
Monmouth Medical Center Long Branch NJ
Montana Cancer Consortium CCOP Billings MT
Montefiore Medical Center - Moses Campus Bronx NY
Morton Plant Hospital Clearwater FL
Mount Sinai Medical Center Miami Beach FL
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Nebraska Methodist Hospital Omaha NE
New York Medical College Valhalla NY
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
North Coast Cancer Care Sandusky OH
Northeast Alabama Regional Medical Center Anniston AL
Northern Indiana Cancer Research Consortium South Bend IN
Northridge Hospital Medical Center Northridge CA
Northwest Community Clinical Oncology Program Tacoma WA
Ochsner Medical Center Jefferson New Orleans LA
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Piedmont Radiation Oncology Associates Greenville SC
ProMedica Flower Hospital Sylvania OH
Radiation Oncology Associates of W. Alabama PC Tuscaloosa AL
Radiological Associates of Sacramento Sacramento CA
Rapid City Regional Hospital Rapid City SD
Reading Hospital Reading PA
Regional Hospital of Scranton Scranton PA
Richard L. Roudebush VA Medical Center Indianapolis IN
Saint Agnes Medical Center Fresno CA
Saint Charles Hospital Oregon OH
Saint Francis Medical Center Trenton NJ
Saint John Medical Center Tulsa OK
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Louis University Hospital St. Louis MO
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary's of Michigan Saginaw MI
Saint Peter's University Hospital New Brunswick NJ
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Saint Vincent Mercy Medical Center Toledo OH
Sanford Roger Maris Cancer Center Fargo ND
Santa Cruz Radiation Oncology Santa Cruz CA
Santa Rosa Memorial Hospital Santa Rosa CA
Saskatoon Cancer Centre Saskatoon, Saskatchew
Sentara Martha Jefferson Hospital Charlottesville VA
Sequoia Regional Cancer Center Visalia CA
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southern Wisconsin Radiotherapy Center Madison WI
Southwestern Vermont Medical Center Bennington VT
St Joseph Hospital Mishawaka IN
St Joseph's Hospital Medical Center Stockton CA
St Mary Regional Cancer Center Langhorne PA
St. Agnes Hospital/Agnesian Cancer Center Fond du Lac WI
St. Anthony's Health Alton IL
Stanford Cancer Institute Palo Alto Palo Alto CA
State University of New York Downstate Medical Center Brooklyn NY
State University of New York Upstate Medical University Syracuse NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Medical Center Sacramento Sacramento CA
Swedish Medical Center-First Hill Seattle WA
Tampa General Hospital Tampa FL
The Don and Sybil Harrington Cancer Center Amarillo TX
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Research Institute of the McGill University Health Centre (MUHC) Montreal
The Toledo Hospital/Toledo Children's Hospital Toledo OH
Thomas Jefferson University Hospital Philadelphia PA
Thunder Bay Regional Health Science Centre Thunder Bay, Ontario
Toledo Clinic Cancer Centers-Adrian Adrian MI
Toledo Clinic Cancer Centers-Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Trinity Cancer Care Center Minot ND
Trinity Cancer Care Center Minot ND
UCHealth Memorial Hospital Central Colorado Springs CO
UCLA / Jonsson Comprehensive Cancer Center Los Angeles CA
UCSF Medical Center-Mount Zion San Francisco CA
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
UHHS-Chagrin Highlands Medical Center Orange Village OH
UHHS-Westlake Medical Center Westlake OH
Union Hospital Terre Haute IN
University Health Network-Princess Margaret Hospital Toronto, Ontario
University Hospitals Parma Medical Center Parma OH
University Medical Center New Orleans New Orleans LA
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Arkansas for Medical Sciences Little Rock AR
University of Chicago Comprehensive Cancer Center Chicago IL
University of Hawaii Cancer Center Honolulu HI
University of Iowa/Holden Comprehensive Cancer Center Iowa City IA
University of Kentucky/Markey Cancer Center Lexington KY
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Minnesota/Masonic Cancer Center Minneapolis MN
University of Missouri - Ellis Fischel Columbia MO
University of Pennsylvania Medical Center Philadelphia PA
University of Pennsylvania/Abramson Cancer Center Philadelphia PA
University of South Alabama Mobile AL
University of Tennessee Health Science Center Memphis TN
University of Texas Medical Branch Galveston TX
University of Vermont Medical Center Burlington VT
UP Health System Marquette Marquette MI
UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg PA
Upstate Carolina CCOP Spartanburg SC
USC / Norris Comprehensive Cancer Center Los Angeles CA
Utah Valley Regional Medical Center Provo UT
Vanderbilt University/Ingram Cancer Center Nashville TN
Vassar Brothers Medical Center Poughkeepsie NY
Veterans Administration Long Beach Medical Center Long Beach CA
Veterans Administration New Jersey Health Care System East Orange NJ
Veterans Affairs Medical Center - Miami, Florida Miami FL
Virginia Baptist Hospital Lynchburg VA
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Virtua Memorial Mount Holly NJ
Wake Forest University Health Sciences Winston-Salem NC
Warren Radiation Therapy Center Warren NJ
Washington Cancer Institute Washington DC
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wayne State University/Karmanos Cancer Institute Detroit MI
West Allis Memorial Hospital West Allis WI
West Penn Hospital Pittsburgh PA
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wheaton Franciscan Healthcare - Saint Joseph Milwaukee WI
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Wichita CCOP Wichita KS
Wilford Hall Medical Center Lackland AFB TX
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 12/15/2016

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