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RTOG 9706 Protocol Information

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A Phase I/II Trial in Operable Patients with Muscle-Invading Bladder Cancer of Transurethral Surgery and Cisplatinum/ Bid Irradiation Followed either by Selective Bladder Preservation or Radical Cystectomy and Adjuvant Chemotherapy
Protocol Documents
Current Version Date: 4/1/1999
Principal Investigator: Michael P. Hagan, M.D.
Primary Objective:

To evaluate the safety and tolerance for induction chemoradiotherapy by CI to be followed by radical cystectomy if the initial tumor response is incomplete, or by consolidation CI if the tumor has cleared. Three cycles of outpatient adjuvant MCV hemotherapy is then given. A protocol completion rate of 90% is sought.

Patient Population:

Patients with muscle invading carcinoma of the bladder, all histologies. AJC Stages cT2-T4a, cNX or pN0, M0, no hydronephrosis; creatinine clearance >= 60ml/minute, platelets > = 100,000, Karnofsky status > = 70, adequately functioning bladder, no prior chemotherapy or pelvic RT

Target Accrual: 40
Current Accrual: 52
Status: Terminated
Date: 11/5/2013
Participating Sites:
21st Century Oncology Ft. Myers FL
Advocate Lutheran General Hospital Park Ridge IL
Anchorage Radiation Therapy Center Anchorage AK
AnMed Health Cancer Center Anderson SC
Aultman Health Foundation Canton OH
Baptist Cancer Institute Jacksonville FL
Baptist Health Paducah Paducah KY
Bay Area Tumor Institute Oakland CA
Bayshore Cancer Center Pasadena TX
Bryn Mawr Hospital Bryn Mawr PA
Cape Cod Hospital Hyannis MA
Carle Cancer Center Urbana IL
Case Western Reserve University Cleveland OH
Christiana Care Health System-Christiana Hospital Newark DE
Cleveland Clinic Akron General Akron OH
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Community Medical Center Toms River NJ
Cooper Hospital University Medical Center Camden NJ
Cross Cancer Institute Edmonton, Alberta
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Deaconess Medical Center Spokane WA
Dixie Medical Center Regional Cancer Center East St. George UT
East Jefferson General Hospital Metairie LA
Einstein Medical Center Philadelphia Philadelphia PA
Essentia Health Cancer Center-South University Clinic Fargo ND
Finley Hospital Dubuque IA
Florida Oncology Center Winter Park FL
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Halifax Health Medical Center-Centers for Oncology Daytona Beach FL
Holmes Regional Medical Center Melbourne FL
Holy Cross Hospital Fort Lauderdale FL
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Joint Center For Radiation Therapy Boston MA
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Lankenau Medical Center Wynnewood PA
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
M D Anderson Cancer Center Houston TX
M.D.Anderson Cancer Network-Tarrant County Forth Worth TX
Mainline Health CCOP Wynnewood PA
Massachusetts General Hospital Cancer Center Boston MA
McGill University Department of Oncology Montreal
McLaren Cancer Institute-Flint Flint MI
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood FL
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy San Juan Medical Center Carmichael CA
Mesa Lutheran Hospital Mesa AZ
Methodist Medical Center of Illinois Peoria IL
Metro-Minnesota CCOP St. Louis Park MN
Miami Cancer Institute Miami FL
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mobile Infirmary Medical Center Mobile AL
Mount Sinai Medical Center Miami Beach FL
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
Northwest Community Hospital Arlington Heights IL
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Paoli Memorial Hospital Paoli PA
Pomona Valley Hospital Medical Center Pomona CA
Providence Alaska Medical Center Anchorage AK
Radiological Associates of Sacramento Sacramento CA
Regional Hospital of Scranton Scranton PA
Rutherford Hospital Rutherfordton NC
Saint Agnes Medical Center Fresno CA
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Santa Rosa Memorial Hospital CCOP Santa Rosa CA
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southern Wisconsin Radiotherapy Center Madison WI
Southwestern Vermont Medical Center Bennington VT
Spartanburg Medical Center Spartanburg SC
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Medical Center Sacramento Sacramento CA
The Cancer Center for Southern Kentucky Bowling Green KY
The Research Institute of the McGill University Health Centr Montreal
Thomas Jefferson University Hospital Philadelphia PA
Toledo Community Hospital Oncology Program CCOP Toledo OH
UCHealth Memorial Hospital Central Colorado Springs CO
UCLA / Jonsson Comprehensive Cancer Center Los Angeles CA
University of Florida Health Science Center - Gainesville Gainesville FL
University of Kentucky/Markey Cancer Center Lexington KY
University of Missouri - Ellis Fischel Columbia MO
University of South Alabama Mobile AL
Upstate Carolina CCOP Spartanburg SC
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Virtua Memorial Mount Holly NJ
Washington Cancer Institute Washington DC
West Penn Hospital Pittsburgh PA
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Updated: 11/15/2013

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