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RTOG 9708 Protocol Information

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A Phase II Study of Adjuvant Postoperative Irradiation Combined with Cisplatin/Taxol chemotherapy Following TAH/BSO for Patients with High-Risk Endometrial Cancer
Protocol Documents
Current Version Date: 1/8/1999
Principal Investigator: Kathryn M. Greven, M.D.
Primary Objective:

To establish the safety and toxicity of this combination of chemotherapy and irradiation when given following surgery for endometrial carcinoma.

Patient Population:

Patients must have had a hysterectomy (total abdominal, vaginal hysterectomy, or laporoscopic-assisted vaginal hysterectomy) and bilateral salpingo-oophorectomy no more than 8 weeks prior to start of radiation therapy. Additional surgical staging procedures are permissible but not required.
No prior chemotherapy or radiation therapy.
Risk factors: patients must fit one of the following:

  • Grade 2 or 3 with myometrial invasion >50%
  • Grade 2 or 3 with stromal invasion of cervix
  • Known extrauterine disease (excluding second primary) confined to the pelvis. Positive peritoneal cytology is acceptable.

No known metastases above the iliac bifurcation, no known gross residual disease, or distant metastases.

Target Accrual: 40
Current Accrual: 46
Status: Terminated
Date: 6/30/2010
Participating Sites:
21st Century Oncology Ft. Myers FL
21st Century Oncology-Orange Park Orange Park FL
21st Century Oncology-Palatka Palatka FL
Arizona Oncology Services Foundation Scottsdale AZ
Atlanta Regional CCOP Atlanta GA
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Cancer Institute CCOP Memphis TN
Baptist Health Paducah Paducah KY
Baptist Hospital of East Tennessee Knoxville TN
Baptist Medical Center South Jacksonville FL
Bridgeport Hospital Bridgeport CT
Cape Cod Hospital Hyannis MA
Columbus CCOP Columbus OH
Cooper Hospital University Medical Center Camden NJ
Cottonwood Hospital Medical Center Murray UT
Covenant Medical Center-Lakeside Lubbock TX
Dayton CCOP Kettering OH
Dixie Medical Center Regional Cancer Center East St. George UT
Don & Sybil Harrington Cancer Center Amarillo TX
East Jefferson General Hospital Metairie LA
Einstein Medical Center Philadelphia Philadelphia PA
Elizabeth General Medical Center Elizabeth NJ
Finley Hospital Dubuque IA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Geisinger Medical Center Danville PA
Genessee Hospital Rochester NY
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Harbor Hospital Center Baltimore MD
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Indiana University Health Methodist Hospital Indianapolis IN
Inspira Medical Center Vineland Vineland NJ
Integrated Community Oncology Network-Flager Cancer Center St Augustine FL
Integrated Community Oncology Network-Florida Cancer Center Beaches Jacksonville Beach FL
Integrated Community Oncology Network-Southside Cancer Center Jacksonville FL
Intermountain Medical Center Murray UT
Joint Center For Radiation Therapy Boston MA
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
Loma Linda University Medical Center Loma Linda CA
M D Anderson Cancer Center Houston TX
M.D.Anderson Cancer Network-Tarrant County Forth Worth TX
Mainline Health CCOP Wynnewood PA
Mary Bird Perkins Cancer Center Baton Rouge LA
McKay-Dee Hospital Center Ogden UT
Mercy Hospital Pittsburgh PA
Mercy Regional Cancer Center Redding CA
Mesa Lutheran Hospital Mesa AZ
Methodist Cancer Center Omaha NE
Methodist Hospital Philadelphia PA
Methodist Medical Center of Illinois Peoria IL
Miami Cancer Institute Miami FL
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Monmouth Medical Center Long Branch NJ
Montefiore Medical Center - Moses Campus Bronx NY
Mount Sinai Medical Center Miami Beach FL
New York Medical College Valhalla NY
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northern Indiana Cancer Research Consortium South Bend IN
Norwalk Hospital Norwalk CT
Ochsner Medical Center Jefferson New Orleans LA
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Pomona Valley Hospital Medical Center Pomona CA
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank CA
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
Radiological Associates of Sacramento Sacramento CA
Regional Hospital of Scranton Scranton PA
Saint Agnes Medical Center Fresno CA
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sandra L Maxwell Cancer Center Cedar City UT
Santa Rosa Memorial Hospital CCOP Santa Rosa CA
Southeast Cancer Control Consortium CCOP Winston Salem NC
St Joseph's Hospital Milwaukee WI
St. Francis Medical Center Trenton NJ
Summa Akron City Hospital/Cooper Cancer Center Akron OH
The Cancer Center for Southern Kentucky Bowling Green KY
Thomas Jefferson University Hospital Philadelphia PA
Toledo Community Hospital Oncology Program CCOP Toledo OH
Tulane University Medical Center New Orleans LA
UCSF Medical Center-Mount Zion San Francisco CA
UF Cancer Center at Orlando Health Orlando FL
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Chicago Comprehensive Cancer Center Chicago IL
University of Iowa/Holden Comprehensive Cancer Center Iowa City IA
University of Kentucky/Markey Cancer Center Lexington KY
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Pennsylvania Medical Center Philadelphia PA
University of South Alabama Mobile AL
University of Wisconsin Hospital and Clinics Madison WI
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virtua Memorial Mount Holly NJ
Wake Forest University Health Sciences Winston-Salem NC
Washington University School of Medicine St. Louis MO
West Penn Hospital Pittsburgh PA
Western Oncology Research Consortium Portland OR
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Updated: 4/13/2011

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